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Analisys of Immunohistochemical Prognostic Markers in Canine Mammary Cancer and Its Relation to Postsurgical Survival

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Open Journal of Pathology 2015年第3期5卷 90-99页

作者： Francisco Pedraza-Ordonez Luis Mauricio Montoya-Florez Camilo Bulla Noeme Sousa Rocha Department of Veterinary Clinics Laboratory of Investigative and Comparative PathologySchool of Veterinary Medicine and Animal ScienceUniversidade Estadual Paulista FMVZ-UNESPSao PauloBrazil Animal Pathology Research Group Animal Health DepartmentUniversidad de CaldasManizalesColombia Department of Pathology/Population Medicine-Mississippi College of Veterinary Medicine Mississippi State UniversityStarkvilleUSA Department of Pathology Botucatu Medical SchoolUniversidade Estadual Paulista–UNESPDistrito de Rubiao Junior s/nBotucatuBrazil

Background: Several animal models, including dogs, have been useful to compare the pathogenesis of mammary neoplasm in humans, showing biological parallelism in the growth and development of breast cancer. The causes of cancer could be attributed to change in several tumor suppressor genes. The relationship between molecule associated to senescence and clinical prognosis of patients affected by mammary cancer is little known. Beyond a collection of data, the major interest of the present study was to carry out a clinical follow-up of patients affected by these tumors, through association with new molecular markers by immunohistochemical technic. Upon completing the study, 15 patients survived, while 45 died. In the case of malignant neoplasms, 40 patients died because of the illness. The type of surgery most used by veterinarian surgeons was the simple lumpectomy, followed by the regional mastectomy. Sentinel node was removed by surgery only when clearly affected. Result: Markings against steroid hormones were positive. Regarding the markings against HER2 and Ki-67, they were negative in all cases. The markings against P53 and CD31 were all positives. Markings against molecules associated with cellular senescence were all positives. No statistical differences were found in immunomarcation for the different antigens used as clinical prognosis factors in mammary neoplasms. Conclusions: According to the study conditions, the survival of patients affected by breast tumors is directly related to diagnosis and malignancy histological grade, but not to animal breed, number of affected glands or patient reproductive status. On the other hand, immunohistochemical markings were not related to the patient prognosis. For this reason, it is important to highlight the persistance of a high percentage of mammary neoplasm cases clinically diagnosed with poor results on patient survival. Thus, educating owners and veterinarians for using diagnostic available tools to improve the pro

关键词： Celular Senescence Prognostic Markers Immunohistochemical Mammary Cancer Animal Model

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Region-based classification of PolSAR data using radial basis kernel functions with stochastic distances

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International Journal of Digital Earth 2019年第6期12卷 699-719页

作者： Rogerio G.Negri Alejandro C.Frery Wagner B.Silva Tatiana S.G.Mendes Luciano V.Dutra unesp-universidade estadual paulista ICT-Instituto de Ciencia e TecnologiaSão Jose dos CamposBrazil LaCCAN-Laboratorio de de Computacao Cientifica e Analise Numerica UFAL-Universidade Federal de AlagoasMaceioBrazil Secao de Ensino de Engenharia Cartografica IME-Instituto Militar de EngenhariaRio de JaneiroBrazil DPI-Divisao de Processamento de Imagens INPE-Instituto Nacional de Pesquisas EspaciaisSao Jose dos CamposBrazil

Region-based classification of PolSAR data can be effectively performed by seeking for the assignment that minimizes a distance between prototypes and *** et al.[“Classification of segments in PolSAR imagery by minimum stochastic distances between wishart distributions.”IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing 6(3):1263–1273]used stochastic distances between complex multivariate Wishart models which,differently from other measures,are computationally *** this work we assess the robustness of such approach with respect to errors in the training stage,and propose an extension that alleviates such *** introduce robustness in the process by incorporating a combination of radial basis kernel functions and stochastic distances with Support Vector Machines(SVM).We consider several stochastic distances between Wishart:Bhatacharyya,Kullback-Leibler,Chi-Square,Rényi,and *** perform two case studies with PolSAR images,both simulated and from actual sensors,and different classification scenarios to compare the performance of Minimum Distance and SVM classification *** this,we model the situation of imperfect training *** show that SVM with the proposed kernel functions achieves better performance with respect to Minimum Distance,at the expense of more computational resources and the need of parameter *** and data are provided for reproducibility.

关键词： PolSAR image classification stochastic distance minimum distance classifier SVM

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Triiodothyronine and breast cancer

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World Journal of Clinical Oncology 2014年第3期5卷 503-508页

作者： Maria Teresa De Sibio Miriane de Oliveira Fernanda Cristina Fontes Moretto Regiane Marques Castro Olimpio Sandro José Conde Aline Carbonera Luvizon Célia Regina Nogueira Department of Internal Medicine Botucatu Medical SchoolUniv Estadual PaulistaUNESPBotucatuSP 18618-970Brazil Department of Pathology Botucatu Medical School Univ Estadual Paulista-UNESP Botucatu SP 18618-970Brazil

The thyroid hormones(THs), triiodothyronine(T3) and thyroxine(T4), are essential for survival; they are involved in the processes of development, growth, and metabolism. In addition to hyperthyroidism or hypothyroidism, THs are involved in other diseases. The role of THs in the development and differentiation of mammary epithelium is well established; however, their specific role in the pathogenesis of breast cancer(BC) is controversial. Steroid hormones affect many human cancers and the abnormal responsiveness of the mammary epithelial cells to estradiol(E2) in particular is known to be an important cause for the development and progression of BC. The proliferative effect of T3 has been demonstrated in various types of cancer. In BC cell lines, T3 may foster the conditions for tumor proliferation and increase the effect of cell proliferation by E2; thus, T3 may play a role in the developmentand progression of BC. Studies show that T3 has effects similar to E2 in BC cell lines. Despite controversy regarding the relationship between thyroid disturbances and the incidence of BC, studies show that thyroid status may influence the development of tumor, proliferation and metastasis.

关键词： Thyroid hormone Triiodothyronine Breast cancer Mammary gland and metabolism

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Unsuitable use of spin and pseudospin symmetries with a pseudoscalar Cornell potential

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Chinese Physics B 2014年第9期23卷 60-61页

作者： L.B.Castro A.S.de Castro Departamento de Física CFM Universidade Federal de Santa Catarina Departamento de Física Universidade Federal do Maranho Campus Universtitrio do Bacanga Departamento de Física e Química Campus de Guaratinguet Universidade Estadual Paulista

The concepts of spin and pseudospin symmetries has been used as mere rhetorics to decorate the pseudoscalar potential [Chin. Phys. B 22 090301 （2013）]. It is also pointed out that a more complete analysis of the bou... 详细信息

关键词： Dirac equation pseudoscalar Comell potential spin symmetry pseudospin symmetry

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An Application of the Taguchi Method (Robust Design) to Environmental Engineering: Evaluating Advanced Oxidative Processes in Polyester-Resin Wastewater Treatment

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American Journal of Analytical Chemistry 2014年第13期5卷 828-837页

作者： Messias Borges Silva Livia Melo Carneiro Joã o Paulo Alves Silva Ivy dos Santos Oliveira Hélcio José Izário Filho Carlos Roberto de Oliveira Almeida Department of Chemical Engineering School of Engineering of Lorena EEL S&atilde o Paulo university USP Lorena Brazil Production Department Universidade Estadual Paulista-Faculdade de Engenharia do campus de Guaratinguetá—UNESP Guaratinguetá Brazil

This paper presents the Taguchi Method, a statistical design modelling for experiments applied in environmental engineering. This method was applied to optimize the treatment conditions of polyester-resin effluent by means of Advanced Oxidative Processes (AOPs) using chemical oxygen demand (COD) as response parameter. The influence of each independent parameter including respective interactions was evaluated by Taguchi Method, which allowed determining the most statistically significant variables and conditions to best fit the process. Results showed that Taguchi Method is a very useful tool for environmental engineering field and possible simplifications of analysis and calculations through commercially available software.

关键词： Taguchi Method Statistical Optimization Advanced Oxidative Processes Wastewater

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Congenital heart diseases trends in S?o Paulo State,Brazil:a national live birth data bank analysis

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World Journal of Pediatrics 2022年第7期18卷 472-481页

作者： Paola Soares Fernandes Larissa Rosario Magalhaes Tainara Rita Pezzini Edige Felipe de Sousa Santos Mauricio Giusti Calderon Medical School Nine of July University(Uni9).Sao Bernardo do CampoSPBrazil Epidemiology Department Public Health SchoolSao Paulo University(USP)Sao PauloSPBrazil Pediatric Surgery Department Hospital Benficencia Portuguesa de Sao PauloRua Maestro Cardim768Sao PauloSP CEP 01323-011Brazil Pediatric Surgery Department Hospital Santa Catarina PaulistaAv.Paulista200.Sao PauloSP CEP:01310-000Brazil

Background Congenital heart diseases(CHD)are the most common type of birth defects,affecting millions of newborns every year;no prevalence data are available in S?o Paulo State,Brazil's most populous *** objective is to identify trends in prevalence and risk factors for CHD in Sao Paulo State,*** We developed a population-based study to estimate the CHD trend of prevalence in recent years,stratified by maternal age and geographical clusters,using all cases of CHD identified by the Live Births Information System(SINASC-Sistema de Informa??o Sobre Nascidos Vivos)from January 1,2005,to December 31,*** calculated the trends of prevalence,the regression coefficient(β),the annual percent change(APC),and 95%confidence interval using the Prais-Winsten regression model,with the Durbin-Watson *** We found 10,594 cases of CHD among 8,536,101 live births(LB),a prevalence of 12.4/10,000 *** was no difference in the sex distribution;they are primarily Caucasian(60.2%),75.2%born at term,and 74.4%weight>2500 g,66.9%of births were by cesarean section.S?o Paulo State presented an increasing CHD trend of prevalence(APC=18.9%).The highest CHD prevalence rate was in mothers aged≥35 years(22.2/10,000 LB).There were 12,271 specific congenital heart defects among 10,594 patients(1.16 CHD/patient).Atrial septal defect has the highest number of cases(3835),with a prevalence of 4.49/10,000 LB,corresponding to 31.3%of all *** CHD had an increasing prevalence trend in recent years,being highest in S?o Paulo City and≥35-year mothers.

关键词： Congenital abnormalities Epidemiology Heart defects Interrupted time series PrevalencePublic health

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Some Critical Reflections About Politically Incorrect Humour at Contemporaneity

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Psychology Research 2015年第8期5卷 484-495页

作者： Mateus Pranzetti Paul Gruda unesp--univ estadual paulista Assis Brazil

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Identification of Bacterial Fish Pathogens in Brazil by Direct Colony PCR and 16S rRNA Gene Sequencing

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Advances in Microbiology 2015年第6期5卷 409-424页

作者： F.A.Sebastiao L.R.Furlan D.T.Hashimoto F.Pilarski Aquaculture Center of Sao Paulo State university—CAunesp Universidade Estadual PaulistaJaboticabalBrazil

Intensive fish farming systems in Brazil have increased the disease incidence, mainly of bacterial origin, due to higher stocking density, high organic matter levels and poor quality of the aquatic environment that causes high mortality rates during outbreaks. The identification of pathogenic species using a fast and reliable method of diagnosis is essential for successful epidemiological studies and disease control. The present study evaluated the use of direct colony PCR in combination with 16S rRNA gene sequencing to diagnose fish bacterial diseases, with the goal of reducing the costs and time necessary for bacterial identification. The method was successful for all 178 isolates tested and produced bands with the same intensity as the standard PCR performed using pure DNA. In conclusion, the genetics methods allowed detecting the most common and important pathogens in Aquaculture, including 12 species of occurrence in Brazilian fish farms. The results of the present study constitute an advance in the available diagnostic methods for bacterial pathogens in fish farms.

关键词： Direct Colony PCR 16S rRNA Sequencing Bacterial Fish Pathogens

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纳特竖蟾(无尾目:滑背蟾科)的细胞遗传、与相关属物种的核型相似性并兼论其分类地位(英文)

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动物学报 2007年第2期53卷 285-293页

作者： Fernando ANANIAS André Luis BOMBEIRO Catia Donizete Brunaikovics da SILVA Ana Paula Zampieri SILVA Célio Fernando Baptista HADDAD Sanae KASAHARA Curso de Ciências Biológicas Universidade S■o Francisco (USF) Av. S■o Francisco de Assis 218-Jardim S■o José 12916-900 Bragana Paulista SP Brasil Departamento de Biologia Instituto de Biociências Universidade Estadual Paulista (UNESP) Rio Claro SP Brasil Curso de Ciências Biológicas Universidade Braz Cubas (UBC) Mogi das CruzesSPBrasil Departamento de Zoologia Instituto de Biociências Universidade Estadual Paulista (UNESP) Rio Claro SP Brasil

本文报道纳特竖蟾(Eupemphix nattereri Steindachner,1863)巴西3个产地标本的核型,均为2n=22,由1对端部和10对中或亚中部着丝点染色体组成。仅一对NORs位于No.11染色体对长臂端部,而其位置有别于常见的具有标志性意义的近着丝点位置。... 详细信息

本文报道纳特竖蟾(Eupemphix nattereri Steindachner,1863)巴西3个产地标本的核型,均为2n=22,由1对端部和10对中或亚中部着丝点染色体组成。仅一对NORs位于No.11染色体对长臂端部,而其位置有别于常见的具有标志性意义的近着丝点位置。该NORs的位置为rDNA为探针的荧光原位杂交(FISH)所确认。各染色体对中,着丝点C-带明显,插入或端带偶见。某些标本的No.8同源染色体对间C-带的大小随异染色质化的程度不同而变化。居于较小的实验标本量,这种在3个产地的雌或雄性标本之一中观察到的C-带异型现象可能为种下细胞地理学变异,亦或为细胞学意义的性染体分化。3产地之一的标本核型的No.11着丝点C-带异染色质化的程度较高。CMA3染色检测到部分GC-rich区域,DAPI染色未显示任何AT-rich区。成功获得BrdU复制带,并将其与滑背蟾类动物(leiuperid)中近缘属及物种进行对比分析。比较结果表明,纳特竖蟾的核型与斑符泡蟾种组(Physalaemus signifergroup)难以相互区别,而与肿肋蟾属(Pleurodema Tschudi,1838)极为相似。核型数据支持形态学上将纳特竖蟾、二光肿肋蟾[Pleurodema diplolister(Peters,1870)]和短头肿肋蟾[***(Cope,1869)

关键词：纳特竖蟾染色体 Ag-NOR C-带荧光染色荧光原位杂交

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Student’s Academic Efficacy or Inefficacy?An Example on How to Evaluate the Psychometric Properties of a Measuring Instrument and Evaluate the Effects of Item Wording

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Open Journal of Statistics 2014年第6期4卷 484-493页

作者： Joao Maroco Ana Lucia Maroco Juliana Alvares Duarte Bonini Campos Unidade de Investigacao em Psicologia e Saude Instituto Superior de Psicologia Aplicada(ISPA)LisboaPortugal Departamento de Odontologia Social Faculdade de Odontologia de AraraquaraUNESPUniversidade Estadual PaulistaAraraquaraBrazil

This study evaluated the effect of item inversion on the construct validity and reliability of psychometric scales and proposed a theoretical framework for the evaluation of the psychometric properties of data gathered with psychometric instruments. To this propose, we used the Maslach Burnout Inventory, which is the most used psychometric inventory to measure burnout in different professional context (Students, Teachers, Police, Doctors, Nurses, etc…). The version of the MBI used was the MBI-Student Survey (MBI-SS). This inventory is composed of three key dimensions: Exhaustion, Cynicism and Professional Efficacy. The two first dimensions—which have positive formulated items—are moderate to strong positive correlated, and show moderate to strong negative correlations with the 3rd dimension—which has negative formulated items. We tested the hypothesis that, in college students, formulating the 3rd dimension of burnout as Inefficacy (reverting the negatively worded items in the Efficacy dimension) improves the correlation of the 3rd dimension with the other two dimensions, improves its internal consistency, and the overall MBI-SS’ construct validity and reliability. Confirmatory factor analysis results, estimated by Maximum Likelihood, revealed adequate factorial fit for both forms of the MBI-SS (with Efficacy) vs. the MBI-SSi (with Inefficacy). Also both forms showed adequate convergent and discriminant related validity. However, reliability and convergent validity were higher for the MBI-SSi. There were also stronger (positive) correlations between the 3 factors in MBI-SSi than the ones observed in MBI-SS. Results show that positively rewording of the 3rd dimension of the MBI-SS improves its validity and reliability. We therefore propose that the 3rd dimension of the MBI-SS should be named Professional Inefficacy and its items should be positively worded.

关键词： Burnout Maslach Burnout Inventory-Student Survey Validity Reliability Item Inversion

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