检索结果-南通市图书馆

Central role of altered phosphodiesterase 2-dependent signaling in the pathophysiology of cognition-based brain disorders

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2302-2303页

作者： Asma Boulksibat Alessandra Tempio Barbara Bardoni Institut de Pharmacologie Moléculaire et Cellulaire CNRS UMR7275Inserm U1323ValbonneFrance

The second messengers 3',5'-cyclic adenosine monophosphate(cAMP)and 3',5'-cyclic guanosine monophosphate(cGMP)modulate molecular pathways that are involved in a large variety of cellular *** the brain,these processes include neurogenesis,neuronal differentiation,activation and function of microglia,and synaptic plasticity,finally resulting in memory formation.

关键词： formation processes finally

Prediction of Extractable Cd,Pb and Zn in Contaminated Woody Habitat Soils Using a Change Point Detection Method

在线全文

学校读者我要写书评

暂无评论

Pedosphere 2016年第3期26卷 282-298页

作者： Christophe WATERLOT Christelle PRUVOT Géraldine BIDAR Clémentine FRITSCH Annette DE VAUFLEURY Renaud SCHEIFLER Francis DOUAY Groupe ISA Laboratoire Genie Civil et geo-Environnement(LGCgE)Lille 59046(France) Departement chrono-environment UMR UFC/CNRS 6249 USC INRAUniversite Bourgogne Franche-ComteBesancon 25030(France)

Accumulation of heavy metals in soils poses a potential risk to plant production, which is related to availability of the metals in soil. The phytoavailability of metals is usually evaluated using extracting solutions such as salts, acids or chelates. The purpose of this study was to identify the most significant soil parameters that can be used to predict the concentrations of acetic and citric acidextractable cadmium(Cd), lead(Pb) and zinc(Zn) in contaminated woody habitat topsoils. Multiple linear regression models were established using two analysis strategies and three sets of variables based on a dataset of 260 soil samples. The performance of these models was evaluated using statistical parameters. Cation exchange capacity, CaCO_3, organic matter, assimilated P, free Al oxide,sand and the total metal concentrations appeared to be the main soil parameters governing the solubility of Cd, Pb and Zn in acetic and citric acid solutions. The results strongly suggest that the metal solubility in extracting solutions is extractable concentrationdependent since models were overall improved by incorporating a change point. This change point detection method was a powerful tool for predicting extractable Cd, Pb and Zn. Suitable predictions of extractable Cd, Pb and Zn concentrations were obtained, with correlation coefficient(adjusted r) ranging from 0.80 to 0.99, given the high complexity of the woody habitat soils studied. Therefore,the predictive models can constitute a decision-making support tool for managing phytoremediation of contaminated soils, making recommendations to control the potential bioavailability of metals. The relationships between acetic and/or citric acid-extractable concentrations and the concentrations of metals into the aboveground parts of plants need to be predicted, in order to make their temporal monitoring easier.

关键词： acetic acid citric acid contaminated soil extractability metals multiple linear regression model soil parameters

MARIE:One-Stage Object Detection Mechanism for Real-Time Identifying of Firearms

在线全文

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2025年第1期142卷 279-298页

作者： Diana Abi-Nader Hassan Harb Ali Jaber Ali Mansour Christophe Osswald Nour Mostafa Chamseddine Zaki Computer Science Department Faculty of SciencesLebanese UniversityBeirut146404Lebanon College of Engineering and Technology American University of the Middle EastEgaila54200Kuwait Lab-STICC CNRS UMR 6285ENSTA-BretagneBrest29200France

Security and safety remain paramount concerns for both governments and individuals *** today’s context,the frequency of crimes and terrorist attacks is alarmingly increasing,becoming increasingly intolerable to ***,there is a pressing need for swift identification of potential threats to preemptively alert law enforcement and security forces,thereby preventing potential attacks or violent *** advancements in big data analytics and deep learning have significantly enhanced the capabilities of computer vision in object detection,particularly in identifying *** paper introduces a novel automatic firearm detection surveillance system,utilizing a one-stage detection approach named MARIE(Mechanism for Realtime Identification of Firearms).MARIE incorporates the Single Shot Multibox Detector(SSD)model,which has been specifically optimized to balance the speed-accuracy trade-off critical in firearm detection *** SSD model was further refined by integrating MobileNetV2 and InceptionV2 architectures for superior feature extraction *** experimental results demonstrate that this modified SSD configuration provides highly satisfactory performance,surpassing existing methods trained on the same dataset in terms of the critical speedaccuracy *** these innovations,MARIE sets a new standard in surveillance technology,offering a robust solution to enhance public safety effectively.

关键词： Firearm and gun detection single shot multi-box detector deep learning one-stage detector MobileNet inception convolutional neural network

Impact of climate factors on contact rate of vector-borne diseases： Case study of malaria

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Biomathematics 2017年第1期10卷 77-97页

作者： Ezekiel Dangbe Antoine Perasso Damakoa Irepran David Bekol1e The University Institute of Technology University of Ngaoundere umr6249 chrono-environment Laboratory University of Franche-Comte The Faculty of Sciences University of Ngaoundere P. O. Boz 454 Ngaoundere Cameroon

Climate change influences more and more of our activities. These changes led to envi- ronmental changes which has in turn affected the spatial and temporal distribution of the incidence of vector-borne diseases. To establish the impact of climate on contact rate of vector-borne diseases, we examine the variation of prevalence of diseases according to season. In this paper, the goal is to establish that the basic reproductive number R0 depends on the duration of transmission period and the date of the first conta- mination case that was declared （to） in the specific ease of malaria. We described the dynamics of transmission of malaria by using non-autonomous differential equations. We analyzed the stability of endemic equilibrium （EE） and disease-free equilibrium （DFE）. We prove that the persistence of disease depends on minimum and maximum values of contact rate of vector-borne diseases.

关键词： SIR models vector-borne disease impact of climate factors malaria.

Increase in the variability of terrestrial carbon uptake in response to enhanced future ENSO modulation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Atmospheric and Oceanic Science Letters 2025年第1期18卷 32-38页

作者： Younong Li Li Dan Jing Peng Qidong Yang Fuqiang Yang Key Laboratory of Regional Climate-environment for Temperate East Asia Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina Key Laboratory of Atmospheric environment and Processes in the Boundary Layer over the Low-Latitude Plateau Region Department of Atmospheric ScienceYunnan UniversityKunmingChina

El Niño-Southern Oscillation(ENSO)is a major driver of climate change in middle and low latitudes and thus strongly influences the terrestrial carbon cycle through land-air *** the ENSO modulation and carbon flux variability are projected to increase in the future,but their connection still needs further *** investigate the impact of future ENSO modulation on carbon flux variability,this study used 10 CMIP6 earth system models to analyze ENSO modulation and carbon flux variability in middle and low latitudes,and their relationship,under different scenarios simulated by CMIP6 *** results show a high consistency in the simulations,with both ENSO modulation and carbon flux variability showing an increasing trend in the *** higher the emissions scenario,especially SSP5-8.5 compared to SSP2-4.5,the greater the increase in *** flux variability in the middle and low latitudes under SSP2-4.5 increases by 30.9%compared to historical levels during 1951-2000,while under SSP5-8.5 it increases by 58.2%.Further analysis suggests that ENSO influences mid-and low-latitude carbon flux variability primarily through *** occurrence may potentially be attributed to the increased responsiveness of gross primary productivity towards regional temperature fluctuations,combined with the intensified influence of ENSO on land surface temperatures.

关键词： Carbon variability ENSO modulation CMIP6 models

Decoding the nexus:branched-chain amino acids and their connection with sleep,circadian rhythms,and cardiometabolic health

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1350-1363页

作者： Hui Li Laurent Seugnet Department of Neurology Xijing HospitalXi’anShaanxi ProvinceChina Centre de Recherche en Neurosciences de Lyon Integrated Physiology of the Brain Arousal Systems(WAKING)UniversitéClaude Bernard Lyon 1INSERM U1028CNRS UMR 5292BronFrance

The sleep-wake cycle stands as an integrative process essential for sustaining optimal brain function and,either directly or indirectly,overall body health,encompassing metabolic and cardiovascular *** the heightened metabolic activity of the brain,there exists a considerable demand for nutrients in comparison to other *** these,the branched-chain amino acids,comprising leucine,isoleucine,and valine,display distinctive significance,from their contribution to protein structure to their involvement in overall metabolism,especially in cerebral *** the first amino acids that are released into circulation post-food intake,branched-chain amino acids assume a pivotal role in the regulation of protein synthesis,modulating insulin secretion and the amino acid sensing pathway of target of ***-chain amino acids are key players in influencing the brain's uptake of monoamine precursors,competing for a shared *** their involvement in protein synthesis,these amino acids contribute to the metabolic cycles ofγ-aminobutyric acid and glutamate,as well as energy ***,they impact GABAergic neurons and the excitation/inhibition *** rhythmicity of branchedchain amino acids in plasma concentrations,observed over a 24-hour cycle and conserved in rodent models,is under circadian clock *** mechanisms underlying those rhythms and the physiological consequences of their disruption are not fully *** sleep,obesity,diabetes,and cardiovascular diseases can elevate branched-chain amino acid concentrations or modify their oscillatory *** mechanisms driving these effects are currently the focal point of ongoing research efforts,since normalizing branched-chain amino acid levels has the ability to alleviate the severity of these *** this context,the Drosophila model,though underutilized,holds promise in shedding new light on these *** findings indicate its po

关键词： branched-chain amino acids cardiovascular health circadian clock drosophila insulin metabolism sleep γ-aminobutyric acid

Metals and metalloid bioconcentrations in the tissues of Typha latifolia grown in the four interconnected ponds of a domestic landfill site

在线全文

学校读者我要写书评

暂无评论

Journal of environmental Sciences 2017年第4期29卷 56-68页

作者： Zohra Ben Salem Xavier Laffray Ahmed Al-Ashoor Habib Ayadi Lotfi Aleya Bourgogne Franche-Comte University Chrono-Environnement Laboratory UMR CNRS 6249 F-25030 Besancon Cedex France Paris Est-Creteil University IPE team iEES Paris UMR 7618 F-94010 Creteil Cedex Prance Thi Qar University IQ-64001 AI Nasiriyah Iraq Sfax University LR/UR/05ES05 Biodiversity and Aquatic Ecosystem BP 1171 CP 3000 Sfax Tunisia

The uptake of metals in roots and their transfer to rhizomes and above-ground plant parts（stems, leaves） of cattails（Typha latifolia L.） were studied in leachates from a domestic landfill site（Etueffont, France） and treated in a natural lagooning system. Plant parts and corresponding water and sediment samples were taken at the inflow and outflow points of the four ponds at the beginning and at the end of the growing season. Concentrations of As, Cd, Cr, Cu, Fe, Mn, Ni and Zn in the different compartments were estimated and their removal efficiency assessed, reaching more than 90% for Fe, Mn and Ni in spring and fall as well in the water compartment. The above-and below-ground cattail biomass varied from 0.21 to 0.85, and 0.34 to 1.24 kg dry weight/m^2, respectively, the highest values being recorded in the fourth pond in spring 2011. The root system was the first site of accumulation before the rhizome, stem and leaves. The highest metal concentration was observed in roots from cattails growing at the inflow of the system＇s first pond. The trend in the average trace element concentrations in the cattail plant organs can generally be expressed as： Fe 〉 Mn 〉 As 〉 Zn 〉 Cr 〉 Cu 〉 Ni 〉 Cd for both spring and fall. While T. latifolia removes trace elements efficiently from landfill leachates, attention should also be paid to the negative effects of these elements on plant growth.

关键词： Landfill leachate Lagooning Trace elements Typha latifolia Phytoremediation

Cryptic diversity within three South American whip spider species(Arachnida, Amblypygi)

在线全文

学校读者我要写书评

暂无评论

Zoological Research 2020年第5期41卷 595-598页

作者： Florian Reveillion Remi Wattier Sophie Montuire Leonardo Sousa Carvalho Loic Bollache Universite de Bourgogne Franche Comte Dijon 21000France Laboratoire chrono-Environnement UMR CNRS 6249Universite de Bourgogne Franche-ComteBesangon Cedex 25030France Laboratoire Biogeosciences UMR CNRS 6282Universite de Bourgogne Franche-ComteDijon 21000France EPHE PSL UniversityParis 75014France Universidade Federal do Piaui Campus Amilcar Ferreira SobralFlorianoPiaui 64800-606Brazil

DEAR EDITOR,Cryptic diversity(CD),the presence of highly divergent phylogenetic lineages within closed morphological species,has been documented for many *** arachnid orders such as Araneae or Scorpiones are well studied and many cases of CD have been described therein;to date,however,related research on smaller arachnid orders,such as whip spiders(Amblypygi),remains lacking.

关键词： Cry whip Great

Toward a unified model of Altaids geodynamics:Insight from the Palaeozoic polycyclic evolution of West Junggar(NW China)

在线全文

学校读者我要写书评

暂无评论

Science China Earth Sciences 2016年第1期59卷 25-57页

作者： Flavien CHOULET Michel FAURE Dominique CLUZEL CHEN Yan LIN Wei WANG Bo XU Bei umr6249 Chrono-EnvironnementCNRS/Universite de Bourgogne Franche-ComteBesangonFrance umr 7327 Institut des Sciences de la Terre d'OrleansBRGM/CNRS/Universite d'OrleansOrleansFrance POle Pluridisciplinaire de la Matiere et de l'Environnement Universite de la Nouvelle CaledonieNoumeaFrance Institute of Geology and Geophysics Chinese Academy of SciencesBeijing 100029China Department of Earth Science University of NanjingNanjing 210093China Key Laboratory of Orogenic Belts and Crustal Evolution Peking UniversityBeijing 100871China

The Altaid tectonic collage extends over Central Asia, exposing numerous accretionary orogens that can account for the Palaeozoic continental crust growth. A pluridisciplinary approach, using geochronological, geochemical, structural and palaeomagnetic tools was carried out to unravel the architecture and the evolution of West Junggar （Northwestern China）, a segment of the Altaid Collage. A polycyclic geodynamic evolution is inferred and includes：（1） an Early Palaeozoic cycle, characterized by the closure of two oceanic basins bounded by island-arc systems; （2） an Early Devonian subduction jamming resulting in a minor-scale collision documented by thrusting, syntectonic sedimentation and subsequent crutal thinning associ- ated with alkaline magmatism; （3） a Late Palaeozoic cycle, driven by the evolution of two opposite subduction zones devel- oped upon the Early Palaeozoic basement. Detailed structural analysis and paleomagnetic data provide constraints for the late evolution of Junggar in the frame of the development of the Late Palaeozoic Kazakh orocline, which led to oblique subduction and transpression in the West Junggar accretionary complex. Progressive buckling of the Kazakh orocline further resulted in Late Carboniferous to Permian wrench tectonics, and lateral displacement of lithotectonic units. Block rotations that continued after the Late Triassic are due to diachronous intraplate reactivation. This scenario mirrors the Palaeozoic geodynamics of the Altaid Collage. Multiple Early Palaeozoic collisions of intra-oceanic arcs and micro continents have contributed to the formarion of the Kazakhstan Microconrinent. Since the Late Palaeozoic, subductions formed around this microcontinent and the final oblique closure of oceanic domains resulted in the transcurrent collage of Tarim and Siberia cratons. Palaeozoic strike-slip faults were later reactivated during Mesozoic intracontinental tectonics.

关键词： West Junggar Geodynamics Paleozoic Paleomagnetism Crustal growth