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Neural Regeneration Research 2025年第8期20卷 2302-2303页

作者： Asma Boulksibat Alessandra Tempio Barbara Bardoni Institut de Pharmacologie Moléculaire et Cellulaire CNRS UMR7275Inserm U1323ValbonneFrance

The second messengers 3',5'-cyclic adenosine monophosphate(cAMP)and 3',5'-cyclic guanosine monophosphate(cGMP)modulate molecular pathways that are involved in a large variety of cellular *** the brain,these processes include neurogenesis,neuronal differentiation,activation and function of microglia,and synaptic plasticity,finally resulting in memory formation.

关键词： formation processes finally

Dust pollen distribution on a continental scale and its relation to present-day vegetation along north-south transects in east China

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Science China Earth Sciences 2007年第2期50卷 236-246页

作者： P. COUR D. DUZER G. ROBERT M. CALLEJA C. BEAUDOUIN Ecole Nationale Supérieure Agronomique de Montpellier 34000 Montpellier France umr cnrs 5554 isem Université Montpellier 2 34000 Montpellier France Department of Earth Sciences Sun Yat-sen University

A series of dust pollen samples was collected along N-S transects in east China (18°N to 53°N latitudes). Sample sites extend from the cold-temperate zone in the north to the tropical region in the south. Pollen taxa characterize each region and reflect the natural and devastated vegetation as well as corre- sponding climatic zones. The quantitative pollen data can be used to estimate the spatial distribution of planted and introduced species. Valuable information of human disturbance of the natural forest is evaluated by quantitative comparison between dust pollen and in-situ pollen of protected forest. In addition, percentages of grass pollen vary regularly from north to south that is consistent with spatial distribution of net primary productivity in east China. Among all grasses, Artemisia and the Gramineae carry the clearest signal: their ratio increases northwards and therefore represent a suitable and con- venient tool for palaeoclimate reconstructions.

关键词： dust pollen vegetation east China human impact climate zones

Dedicated population genomics for the silent world： the specific questions of marine population genetics

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Current Zoology 2016年第6期62卷 545-550页

作者： Nicolas BIERNE Francois BONHOMME Sophie ARNAUD-HAOND Universite de Montpellier Montpellier France UMR 5554 UM - CNRS - IRD - EPHE Station Marine OREME Sete France cnrs - Institut des Sciences de I'Evolution Montpellier UMR 5554 UM - CNRS - IRD - EPHE Station Marine OREME Sete France Ifremer - MARine Biodiversity Exploitation and Conservation UMR 9190 IRD - IFREMER - UM - CNRS Sete France

Introduction The life cycle of most marine species is characterized by high fecundity, dispersal during a planktonic larval phase and a sessile or sedentary adult phase with large census population size （Figure 1 ）.... 详细信息

关键词：种群遗传学基因组学海洋人群世界

Decoding the nexus:branched-chain amino acids and their connection with sleep,circadian rhythms,and cardiometabolic health

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Neural Regeneration Research 2025年第5期20卷 1350-1363页

作者： Hui Li Laurent Seugnet Department of Neurology Xijing HospitalXi’anShaanxi ProvinceChina Centre de Recherche en Neurosciences de Lyon Integrated Physiology of the Brain Arousal Systems(WAKING)UniversitéClaude Bernard Lyon 1INSERM U1028CNRS UMR 5292BronFrance

The sleep-wake cycle stands as an integrative process essential for sustaining optimal brain function and,either directly or indirectly,overall body health,encompassing metabolic and cardiovascular *** the heightened metabolic activity of the brain,there exists a considerable demand for nutrients in comparison to other *** these,the branched-chain amino acids,comprising leucine,isoleucine,and valine,display distinctive significance,from their contribution to protein structure to their involvement in overall metabolism,especially in cerebral *** the first amino acids that are released into circulation post-food intake,branched-chain amino acids assume a pivotal role in the regulation of protein synthesis,modulating insulin secretion and the amino acid sensing pathway of target of ***-chain amino acids are key players in influencing the brain's uptake of monoamine precursors,competing for a shared *** their involvement in protein synthesis,these amino acids contribute to the metabolic cycles ofγ-aminobutyric acid and glutamate,as well as energy ***,they impact GABAergic neurons and the excitation/inhibition *** rhythmicity of branchedchain amino acids in plasma concentrations,observed over a 24-hour cycle and conserved in rodent models,is under circadian clock *** mechanisms underlying those rhythms and the physiological consequences of their disruption are not fully *** sleep,obesity,diabetes,and cardiovascular diseases can elevate branched-chain amino acid concentrations or modify their oscillatory *** mechanisms driving these effects are currently the focal point of ongoing research efforts,since normalizing branched-chain amino acid levels has the ability to alleviate the severity of these *** this context,the Drosophila model,though underutilized,holds promise in shedding new light on these *** findings indicate its po

关键词： branched-chain amino acids cardiovascular health circadian clock drosophila insulin metabolism sleep γ-aminobutyric acid

Detecting polygenic selection in marine populations by combining population genomics and quantitative genetics approaches

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Current Zoology 2016年第6期62卷 603-616页

作者： Pierre-Alexandre GAGNAIRE Oscar E. GAGGIOTTI Universite Montpellier 2 Place Eugene Bataillon 34095 Montpellier Cedex 5 France isem - cnrs UMR 5554 SMEL 2 rue des Chantiers Sete 34200 France Scottish Oceans Institute University of St Andrews East Sands St Andrews KY16 9LB UK

Highly fecund marine species with dispersive life-history stages often display large population sizes and wide geographic distribution ranges. Consequently, they are expected to experience reduced genetic drift, efficient selection fueled by frequent adaptive mutations, and high migration loads. This has important consequences for understanding how local adaptation proceeds in the sea. A key issue in this regard, relates to the genetic architecture underlying fitness traits. Theory predicts that adaptation may involve many genes but with a high variance in effect size. Therefore, the effect of selection on allele frequencies may be substantial for the largest effect size loci, but insignificant for small effect genes. In such a context, the performance of population genomic methods to unravel the genetic basis of adaptation depends on the fraction of adaptive genetic variance explained by the cumulative effect of outlier loci. Here, we address some methodological challenges associated with the detection of local adaptation using molecular approaches. We provide an overview of genome scan methods to detect selection, including those assuming complex demographic models that better describe spatial population structure. We then focus on quantitative genetics approaches that search for genotype-phenotype associations at different genomic scales, including genome-wide methods evaluating the cumulative effect of variants. We argue that the limited power of single locus tests can be alleviated by the use of polygenic scores to estimate the joint contribution of candidate variants to phenotypic variation.

关键词： local adaptation genome scans quantitative genetics genotype-phenotype association polygenic scores.

Do endemic species always have a low competitive ability? A test for two Mediterranean plant species under controlled conditions

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Journal of Plant Ecology 2012年第3期5卷 305-312页

作者： Eric Imbert Sami Youssef David Carbonell Alex Baumel Institut des Sciences de l’Evolution CNRS 5554Universite Montpellier 2France Institut Mediterraneen d’Ecologie et de Paleoecologie UMR CNRS/IRD 6116Universite Aix MarseilleFrance

Aims Many observations concerning biological and ecological differentiation between narrow endemic and widespread congeneric plant species suggest that narrow endemic species are constrained to colonize marginal habitats because of a low tolerance to *** this topic being an important issue both for understanding evolutionary processes leading to endemism and for conservation purposes,few studies have been performed to compare competitive abilities between endemic and widespread ***,we present two independent experiments performed under controlled conditions using two different pairs of endemic and widespread congeneric species:Centaurea corymbosa/Centaurea maculosa and Arenaria provincialis/Arenaria serpyllifolia,both endemic species occurring in rocky calcareous *** Mature seeds of *** and *** were sown in pots containing ramets of the common grass,Brachypodium *** were sorted in three treatments according to grass cover(low,intermediate and high).A control treatment(without competition)was also ***,seedling survival and rosette growth were *** the comparisons between *** and ***,seeds from natural populations were first sown without a *** week after germination,healthy seedlings were transplanted in pots without Brachypodium seedling(control)or containing two Brachypodium seedlings(low competition)or four seedlings(high competition).We checked the number of capsules per individual,and we harvested the biomass after capsule *** Findings Despite differences in the protocol design,results are congruent,and in both cases,endemic species are highly affected by the presence of a competitor,as are the widespread species,although we did not detect any differences between species for response to *** results are discussed in relation to processes leading to endemism,suggesting that the specialist model is more likely for both the

关键词： endemism conservation biology Mediterranean area competitive response

Role of Aedes aegypti and Aedes albopictus during the 2011 dengue fever epidemics in Hanoi, Vietnam

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Asian Pacific Journal of Tropical Medicine 2015年第7期8卷 541-546页

作者： Pham Thi Kim Lien Vu Trong Duoc Laurent Gavotte Emmanuel Cornillot Phan Thi Nga Laurence Briant Roger Frutos Tran Nhu Duong National Institute of Hygiene and Epidemiology CPBS UMR 5236 CNRS-UM1-UM2 1919 route de Mende 34293 Montpellier Cedex 5France isem UMR 5554 CNRS-UM2-IRD Université Montpellier 2 CC065 Place E. Bataillon34095 Montpellier Cedex 5 France CPBS UMR 5236 CNRS-UM1-UM2 1919 route de Mende 34293 Montpellier Cedex 5France Intertryp UMR 17 Cirad-IRD Campus International de Baillarguet34398 Montpellier Cedex 5 France

Objective: To record the human cases of dengue fever(DF) and investigate the Aedes mosquito species circulating during the Hanoi 2011 DF epidemics. Methods: 24 different outbreak points were recorded in 8 districts between August and December 2011. Results: 140 patients were hospitalized following dengue diagnostic with a predominance of males(59.3%) and the 15-34 age class. Only DENV-1(11.27%) and DENV-2(88.73%) serotypes were detected in human samples. Mosquito sampling performed in and around patients households revealed the predominance of Aedes aegypti(95.15%) versus Aedes albopictus(4.85%). There is a positive correlation between the population density of Aedes aegypti and the number of human cases and duration of outbreaks. Conclusions: This was not observed for Aedes albopictus. 3 pools of Aedes aegypti were positive with dengue virus, two with DENV-1 and one with DENV-2.

关键词： Aedes aegypti Aedes albopictus Dengue Vector density

Experimental evidence of Wolbachia introgressive acquisition between terrestrial isopod subspecies

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Current Zoology 2021年第4期67卷 455-464页

作者： Nicolas Bech Sophie Beltran-Bech Cassandre Chupeau Jean Peccoud Magali Thierry Roland Raimond Yves Caubet Mathieu Sicard Pierre Greve Laboratoire Ecologie et Biologie des Interactions EBI UMR CNRS 7267Universitéde Poitiers5 rue Albert TurpainTSA *** POITIERSCedex 9France isem CNRSIRDEPHEUniversite de MontpellierMontpellierFrance

Wolbachia are the most widespread endosymbiotic bacteria in *** many arthropod host species,they manipulate reproduction via several mechanisms that favor their maternal transmission to *** them,cytoplasmic incompatibility(Cl)promotes the spread of the symbiont by specifically decreasing the fertility of crosses involving infected males and uninfected females,via embryo *** differences in reproductive efficiency may select for the avoidance of incompatible mating,a process called reinforcement,and thus contribute to population *** the terrestrial isopod Porcellio dilatatus,the Wolbachia wPet strain infecting the subspecies *** induces unidirectional Cl with uninfected individuals of the subspecies *** study the consequences of Cl on *** and *** hybridization,mitochondrial haplotypes and Wolbachia infection dynamics,we used population cages seeded with different proportions of the 2 subspecies in which we monitored these genetic parameters 5 and 7 years after the initial *** of microsatellite markers allowed evaluating the degree of hybridization between individuals of the 2 *** markers revealed an increase in *** nuclear genetic signature in all mixed cages,reflecting an asymmetry in *** led to the introgressive acquisition of Wolbachia and mitochondrial haplotype from *** into nuclear genomes dominated by alleles of *** discuss these results with regards to Wolbachia effects on their host(Cl and putative fitness cost),and to a possible reinforcement that may have led to assortative mating,as possible factors contributing to the observed results.

关键词： cytoplasmic incompatibility introgressive acquisition terrestrial isopod Wolbachia

Selecting and optimal sizing of hybridized energy storage systems for tidal energy integration into power grid

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Journal of Modern Power Systems and Clean Energy 2019年第1期7卷 113-122页

作者： Seifeddine BEN ELGHALI Rachid OUTBIB Mohamed BENBOUZID LIS-umr cnrs 7020 University of Aix-Marseille umr cnrs 6027 IRDL University of Brest Shanghai Maritime University

The high penetration of renewable energy systems with fluctuating power generation into the electric grids affects considerably the electric power quality and supply ***, energy storage resources are used to deal with the challenges imposed by power variability and demand-supply *** main focus of this paper is to investigate the appropriate storage technologies and the capacity needed for a successful tidal power ***, a simplified sizing method, integrating an energy management strategy, is *** method allows the selection of the adequate storage technologies and determines the required least-cost storage capacity by considering their technological limits associated with different power *** optimal solutions given by the multi-objective evolutionary algorithm are presented and analyzed.

关键词： Tidal energy Energy storage system Optimal sizing Selection

The geography of introgression in a patchy environment and the thorn in the side of ecological speciation

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Current Zoology 2013年第1期59卷 72-86页

作者： Nicolas BIERNE Pierre-Alexandre GAGNAIRE Patrice DAVID Universit6 Montpellier 2 Place Eugene Bataillon 34095 Montpellier Cedex 5 France isem - cnrs UMR 5554 SMEL 2 rue des Chantiers 34200 S6te France CEFE - cnrs UMR 5175 34293 MontpeUier Cedex 5 France

When incompletely isolated taxa coexist in a patchy environment （e.g. mosaic hybrid zones, host-race complexes）, patterns of variation may differ between selected traits/genes and neutral markers. While the genetic structure of selected traits/loci tends to coincide with habitat variables （producing Genetic-Environment Association or GEA）, genetic differentiation at neutral loci unlinked to any selected locus rather depends on geographic connectivity at a large scale （e.g. Isolation- By-Distance or IBD）, although these loci often display GEA at a small scale. This discrepancy has been repeatedly taken as evi- dence for parallel primary divergence driven by local adaptation. We argue that this interpretation needs to be addressed more thoroughly by considering the alternative hypothesis that speciation was initiated in allopatry and secondary introgression has subsequently erased the signal of past differentiation at neutral loci. We present a model of neutral introgression after secondary contact in a mosaic hybrid zone, which describes how GEAs dissipate with time and how neutral variation self-organizes accord- ing to the environmental and geographic structures. We show that although neutral loci can be affected by environmental selection they are often more affected by history and connectivity： the neutral structure retains the initial geographic separation more than it correlates with the environment during the colonization and introgression phases, and then converges to a migration-drift balance, the most frequent outcome of which is GEA at a local scale but IBD at a large scale. This is the exact pattern usually attributed to parallel ecological speciation. Introgression is heterogeneous in space and depends on the landscape structure （e.g. it is faster in small patches, which are more impacted by immigration）. Furthermore, there is no directionality in the association and it is possi- ble to observe reversed GEAs between distant regions. We argue that the his

关键词： Ecological speciation Local adaptation Mosaic hybrid zone Reproductive isolation Genetic-environment association