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Mitochondria-targeted atovaquone promotes anti-lung cancer immunity by reshaping tumor microenvironment and enhancing energy metabolism of anti-tumor immune cells

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Cancer Communications 2024年第3期44卷 448-452页

作者： Donghai Xiong Zheng Yin Mofei Huang Yian Wang Micael Hardy Balaraman Kalyanaraman Stephen T Wong Ming You Center for Cancer Prevention Houston Methodist Neal Cancer CenterHouston Methodist HospitalWeill Cornell MedicineHoustonTexasUSA Department of Systems Medicine and Bioengineering Houston Methodist Cancer CenterHouston Methodist HospitalWeill Cornell MedicineHoustonTexasUSA Aix Marseille Univ Centre Nationaldela Recherche Scientifique(CNRS)Institut de Chimie Radicalaire(ICR)UnitéMixte de Recherche(UMR)7273MarseilleFrance Department of Biophysics Medical College of WisconsinMilwaukeeWisconsinUSA

Dear Editor,Atovaquone(ATO),a mitochondrial inhibitor,has anti-cancer effects[1].Based on ATO,we developed mitochondria-targeted atovaquone(Mito-ATO)that had even stronger anti-tumor efficacy than ATO[2].We syn-thesized Mito-ATO by attaching the bulky triphenylphos-phonium(TPP)group to ATO via a ten-carbon alkyl chain(Supplementary file of methods;Supplementary Figure S1).

关键词： metabolism immunity targeted

Exploring fs-laser irradiation damage subthreshold behavior of dielectric mirrors via electrical measurements

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High Power Laser Science and Engineering 2024年第2期12卷 24-32页

作者： Petrisor Gabriel Bleotu Radu Udrea Alice Dumitru Olivier Uteza Maria-Diana Mihai Dan Gh Matei Daniel Ursescu Stefan Irimiciuc Valentin Craciun Extreme Light Infrastructure-Nuclear Physics(ELI-NP) Horia Hulubei National Institute for R&D in Physics and Nuclear Engineering(IFIN-HH)MagureleRomania Doctoral School of Physics University of BucharestMagureleRomania LULI-CNRS CEAUniversite SorbonneEcole PolytechniqueInstitut Polytechnique de ParisPalaiseau CEDEXFrance Apel Laser IlfovRomania Aix-Marseille University CNRSLP3 UMR 7341MarseilleFrance Horia Hulubei National Institute for R&D in Physics and Nuclear Engineering(IFIN-HH) MagureleRomania University Politehnica of Bucharest BucharestRomania National Institute for Lasers Plasma and Radiation Physics MagureleRomania

With ultrafast laser systems reaching presently 10 PW peak power or operating at high repetition rates,research towards ensuring the long-term,trouble-free performance of all laser-exposed optical components is *** work is focused on providing insight into the optical material behavior at fluences below the standardized laser-induced damage threshold(LIDT)value by implementing a simultaneous dual analysis of surface emitted particles using a Langmuir probe(LP)and the target current(TC).HfO_(2) and ZrO_(2) thin films deposited on fused silica substrates by pulsed laser deposition at various O_(2) pressures for defect and stoichiometry control were irradiated by Gaussian,ultrashort laser pulses(800 nm,10 Hz,70 fs)in a wide range of *** TC and LP collected signals were in good agreement with the existing theoretical description of laser–matter interaction at an ultrashort time *** approach for an in situ LIDT monitoring system provides measurable signals for below-threshold irradiation conditions that indicate the endurance limit of the optical surfaces in the single-shot energy scanning *** LIDT value extracted from the LP-TC system is in line with the multipulse statistical analysis done with ISO 21254-2:2011(E).The implementation of the LP and TC as on-shot diagnostic tools for optical components will have a significant impact on the reliability of next-generation ultrafast and high-power laser systems.

关键词： HfO_(2) in situ detection Langmuir probe laser-induced damage threshold target current ZrO_(2)

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The interactive effect of temperature and fertilizer types determines the dominant microbes in nitrous oxide emissions and the dicyandiamide efﬁcacy in a vegetable soil

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Soil Ecology Letters 2024年第3期6卷 121-133页

作者： Xiaoya Xu Haiyang Liu Yaowei Liu Didier Lesueur Laetitia Herrmann Hongjie Di Caixian Tang Jianming Xu Yong Li Zhejiang Provincial Key Laboratory of Agricultural Resources and Environment College of Environmental and Resource SciencesZhejiang UniversityHangzhou 310058China College of Geography and Environment Shandong Normal UniversityJinan 250014China Centre de Coopération Internationale en Recherche Agronomique pour le Développement(CIRAD) UMR Eco&SolsHanoiVietnam Eco&Sols Universitéde Montpellier(UMR)CIRADInstitut National de Recherche pour l’Agriculturel’Alimentation et l’Environnement(INRAE)Institut de Recherche pour le Développement(IRD)Montpellier SupAgro34060 MontpellierFrance Alliance of Biodiversity International and International Center for Tropical Agriculture(CIAT) Asia hubCommon Microbial Biotechnology Platform(CMBP)HanoiVietnam School of Life and Environmental Sciences Faculty of ScienceEngineering and Built Environment–Deakin UniversityMelbourneVIC 3125Australia Rubber Research Institute Chinese Academy of Tropical Agricultural SciencesHaikou 571737China La Trobe Institute for Sustainable Agriculture and Food Department of AnimalPlant&Soil SciencesLa Trobe UniversityBundooraVic 3086Australia

Heat waves associated with global warming and extreme climates would arouse serious consequences on nitrogen(N)***,the responses of the functional guilds to different temperatures,especially high temperature and the cascading effect on N_(2)O emissions remain *** incubation study was conducted to examine the effect of different temperatures(20°C,30°C,and 40°C)and fertilizer types(urea and manure)on N_(2)O-producers and N_(2)O-reducers,as well as the efficacy of dicyandiamide(DCD)on N_(2)O emissions in a vegetable *** showed that ammonia oxidizers and nirS-type denitrifiers were well adapted to high temperature(40°C)with manure application,while the fungal nirK-denitrifiers had better tolerance with urea *** nosZ clade I microbes had a strong adaptability to various temperatures regardless of fertilization type,while the growth of nosZ clade II group microbes in non-fertilized soil(control)were significantly inhibited at higher *** N_(2)O emissions were significantly decreased with increasing temperature and DCD application(up to 60%,even at 40°C).Under high temperature conditions,fungal denitrifiers play a significant role in N-limited soils(non-fertilized)while nirS-type denitrifiers was more important in fertilized soils in N_(2)O emissions,which should be specially targeted when mitigating N_(2)O emissions under global warming climate.

关键词： nitrogen fertilizer microorganisms nitrification inhibitor bacteria archaea fungi

Best practices for model-based and simulation-aided engineering of power transmission and motion control systems

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Chinese Journal of Aeronautics 2019年第1期32卷 186-199页

作者： Jean-Charles MARE Institut Clément Ader (CNRS umr 5312)

This paper deals with the modelling and simulation of aircraft systems, in particular for power transmission and control. It is intended to review, propose and disseminate best practices for making model-based/simulation-aided engineering more efficient at any phase of the system life cycle. The proposals are aimed at creating value, not only by increasing the performance of the product under study but also by shortening the time to market, capitalizing knowledge, mitigating risks and facilitating concurrent engineering. The needs associated with the engineering activities are firstly identified to define a set of requirements for the models. Then, these requirements are used to drive the considerations leading to model development, focusing in particular on the process,modelled physical effects, modelling level, model architecting and concurrent engineering. The third part deals with the model implementation, giving special consideration to the different types of models, causalities, parameterization, implementation and verification. Each part is illustrated by examples related to safety critical actuators.

关键词： Actuator Aerospace Architecture Causality Modelling Motion control Power transmission Simulation

Design of bifunctional single-atom catalysts NiSA/ZIF-300 for CO_(2) conversion by ligand regulation strategy

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Nano Research 2024年第5期17卷 3827-3834页

作者： Wengang Fu Yapei Yun Hongting Sheng Xiaokang Liu Tao Ding Shuxian Hu Tao Yao Binghui Ge Yuanxin Du Didier Astruc Manzhou Zhu Department of Chemistry and Centre for Atomic Engineering of Advanced Materials Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of EducationCollege of Materials Science and EngineeringInstitutes of Physical Science and Information Technology and Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized MaterialsAnhui UniversityHefei 230601China Universitéde Bordeaux ISMUMR CNRS N°5255351 Cours de La Libération33405 Talence CedexFrance National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230026China Department of Physics University of Science and Technology BeijingBeijing 100083China Anhui Tongyuan Environment Energy Saving Co. LtdHefei 230041China

Carbon-supported noble-metal-free single-atom catalysts(SACs)have aroused widespread interest due to their green chemistry aspects and excellent ***,we propose a“ligand regulation strategy”and achieve the successful fabrication of bifunctional SAC/MOF(MOF=metal-organic framework)nanocomposite(abbreviated NiSA/ZIF-300;ZIF=ZIF-8)with exceptional catalytic performance and *** designed NiSA/ZIF-300 has a planar interfacial structure with the Ni atom,involving one S and three N atoms bonded to Ni(Ⅱ),fabricated by controllable pyrolysis of volatile Ni-S *** CO_(2) cycloaddition to styrene epoxide,NiSA/ZIF-300 exhibits ultrahigh activity(turnover number(TON)=1.18×105;turnover frequency(TOF)=9830 molSC·mol_(Ni)^(-1)·h^(-1);SC=styrene carbonate)and durability at 70℃ under 1 atm CO_(2) pressure,which is much superior to Ni complex/ZIF,NiNP/ZIF-300,and most reported *** study offers a simple method of bifunctional SAC/MOF nanocomposite fabrication and usage,and provides guidance for the precise design of additional original SACs with unique catalytic properties.

关键词： single atom catalyst bifunctional CO_(2)conversion cycloaddition

Influence of Organic Matter Content on Hydro-Structural Properties of Constructed Technosols

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Pedosphere 2016年第4期26卷 486-498页

作者： Maha DEEB Michel GRIMALDI Thomas Z.LERCH Anne PANDO Pascal PODWOJEWSKI Manuel BLOUIN UPEC Institute of Ecology and Environmental Sciences of Paris (UMR 7618) IRD Institute of Ecology and Environmental Sciences of Paris (UMR 242)

Constructed Technosols may be an alternative for creating urban green spaces. However, the hydro-structural properties emer- ging from the assembly of artefacts have never been documented. The soil shrinkage curve （SSC） could provide relevant structural information about constructed Technosols, such as the water holding capacity of each pore system （macropores and micropores）. The objectives of this study were （i） to evaluate the SSC and water retention curve （WRC） to describe the structure of constructed Tech- nosols and （ii） to understand the influence of organic matter content on soil hydro-structural properties. In this study, Technosols were obtained by mixing green waste compost （GWC） with the material excavated from deep horizons of soil （EDH）. The CWC was mixed with EDH in six different volumetric percentages from 0% to 50% （GWC/total）. The GWC and EDH exhibited highly divergent hydro-structural properties： the SSC was hyperbolic for GWC and sigmoid for EDH. All six mixture treatments （0%, 10%, 20%, 30%, 40% and 50% GWC） exhibited the classical sigmoid shape, revealing two embedded levels of pore systems. The 20% GWC treatment was hydro-structurally similar to the 30% and 40% GWC treatments; so, a large quantity of expansive GWC is unnecessary. The relation with the GWC percentage was a second-degree equation for volumetric available water in micropores, but was linear for volumetric available water in macropores and total volumetric available water. Total volumetric available water in the 50% GWC treatment was twice as high as that in the 0% GWC treatment. By combining SSCs and WRCs, increasing the GWC percentage increased water holding capacity by decreasing the maximum equivalent size of water-saturated micropores at the shrinkage limit and increasing the maximum equivalent size of water-saturated macropores, resulting in an increased range of pore diameter able to retain available water.

关键词： available water soil shrinkage curve soil water content water holding capacity water retention curve

Self-assembly of colloidal polymers from two-patch silica nanoparticles

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Nano Research 2020年第12期13卷 3371-3376页

作者： Weiya Li Bin Liu Céline Hubert Adeline Perro Etienne Duguet Serge Ravaine CNRS CRPPUMR 5031Univ.BordeauxPessac33600France CNRS ICMCBUMR 5026Univ.BordeauxPessac33600France CNRS Bordeaux INPISMUMR 5255Univ.BordeauxTalence33400France

We report the formation of colloidal polymers consisting of disk-like silica nanoparticles(NPs)with polystyrene(PS)chains at the bottom of their two cavities assembled through reduction of the solvent quality for the PS chains and linked by hydrophobic *** show that this NPs assembly exhibits a two-stage process involving reaction-controlled polymerization and diffusion-controlled *** polymer networks are produced by the incorporation of three-patch NPs,which serve as branching points between the colloidal *** co-assembling preformed homopolymers composed of patchy NPs of different sizes or surface chemical groups,block copolymers are also *** study provides insight into the process of self-assembly of two-patch NPs by precisely designing the components to generate colloidal analogues of linear macromolecular chains.

关键词： colloidal polymers nanoparticles patchy self-assembly

Textures and melt-crystal-gas interactions in granites

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Geoscience Frontiers 2015年第5期6卷 635-663页

作者： Jean-Louis Vigneresse GeoRessources UMR 7339Universite de Lorraine

Felsic intrusions present ubiquitous *** result from the differential interactions between the magma components(crystal,melt,gas phase) while it flows or when the flow is perturbed by a new magma *** most obvious structure consists in fabrics caused by the interactions of rotating grains in a flowing viscous *** magma inputs through dikes affect the buk massif flow,considered as global within each mineral facies.A review of the deformation and flow types developing in a magma chamber identifis the patterns that could be *** determines their controlling parameters and summarizes the tools for their ***,a brief review of the theology of a complex multiphase magma identifies and suggests interactions between the different *** specific responses each component presents lead to instability *** particular,the change in vorticity orientation,associated with the switch between monoclinic to triclinic flow is a cause of many *** are preferentially *** include fabric development,shear zones and flow *** depend of the underlying rheology of interacting ***,enclaves,schlieren and ladder dikes result from the interactions between the magma components and changing boundary ***,pegmatites,unidirectional solidification textures and miarolitic cavities result from the interaction of the melt with a gaseous *** illustrations examine what is relevant to the bulk flow,local structures or boundary *** each case a field observation illustrates the *** discussion reformulates instability observations,suggesting new trails for ther description and interpretation in terms of local departure to a bulk flow.A brief look at larger structures and at their evolution tries to relate these instabilities on a broader *** helical structures of the Ricany pluton,Czech Republic and by the multiple granitic intrusions of Dolbe

关键词： Granitic magma Instabilities Triclinic flow Struct

Influence of lithospheric thickness distribution on oil and gas basins,China seas and adjacent areas

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Acta Oceanologica Sinica 2024年第4期43卷 1-14页

作者： Jing Ma Wanyin Wang Hermann Zeyen Yimi Zhang Zhongsheng Li Tao He Dingding Wang School of Geology Engineering and Geomatics Key Laboratory of Western China’s Mineral Resources and Geological Engineering of Ministry of EducationChang’an UniversityXi’an 710054China umr8148 GEOPS CNRS/UniversitéParis-SaclayDépartement des Sciences de la TerreBât.50491405France CNOOC Research Institute Co. Ltd.Beijing 100027China Qingdao Institute of marine geology Qingdao 266071China Department of Earth Sciences Memorial University of NewfoundlandSt.John’sNewfoundland AlB3X5Canada University of Naples Federico Ⅱ Department of Earth SciencesNaples80138Italy

The distribution of oil and gas resources is intricately connected to the underlying structure of the ***,investigating the characteristics of lithospheric thickness and its correlation with oil and gas basins is highly *** research utilizes recently enhanced geological–geophysical data,including topographic,geoid,rock layer thickness,variable rock layer density,and interface depth *** the principles of lithospheric isostasy and heat conduction,we compute the laterally varying lithospheric thickness in the China seas and adjacent *** these results,two pivotal parameters for different types of oil and gas basins were statistically analyzed:the minimum lithospheric thickness and the relative fluctuation in lithospheric thickness.A semiquantitative analysis was used to explore the connection between these parameters and the hydrocarbon abundance within the oil and gas *** study unveils distinct variations in lithospheric thickness among basins,with oil and gas rich basins exhibiting a thicker lithosphere in the superimposed basins of central China and a thinner lithosphere in the rift basins of eastern ***,the relative fluctuations in lithospheric thickness in basins demonstrate significant disparities:basins rich in oil and gas often exhibit greater thickness ***,in the offshore basins of China,a conspicuous negative linear correlation is observed between the minimum lithospheric thickness and the relative fluctuation in lithospheric *** study posits that deep-seated thermal upwelling results in lithospheric undulations and extensional thinning in oil and gas ***,sustained deep-seated heat influences sedimentary materials in basins,creating favorable conditions for oil and gas *** insights derived from this study contribute to a quantitative understanding of the intricate relationships between deep lithospheric structures and oil and gas basins.

关键词： China seas and adjacent areas lithospheric thickness oil and gas basins