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Neuroprotective and anti-inflammatory effects of a therapy combining agonists of nicotinic α7 and σ1 receptors in a rat model of Parkinson’s disease

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Neural Regeneration Research 2021年第6期16卷 1099-1104页

作者： Steven Vetel Laura Foucault-Fruchard Claire Tronel Frédéric Buron Jackie Vergote Sylvie Bodard Sylvain Routier Sophie Sérrière Sylvie Chalon umr 1253 iBrainUniversitéde ToursInsermToursFrance CHU Tours Service pharmacieToursFrance Institut de Chimie Organique et Analytique ICOAUMR CNRS 7311Universitéd’OrléansOrléansFrance

To date there is no treatment able to stop or slow down the loss of dopaminergic neurons that characterizes Parkinson’s *** was recently observed in a rodent model of Alzheimer’s disease that the interaction between the α7 subtype of nicotinic acetylcholine receptor(α7-nAChR)and sigma-1 receptor(σ1-R)could exert neuroprotective effects through the modulation of neuroinflammation which is one of the key components of the pathophysiology of Parkinson’s *** this context,the aim of the present study was to assess the effects of the concomitant administration of N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxamide(PHA)543613 as an α7-nAChR agonist and 2-(4-morpholinethyl)1-phenylcyclohexanecarboxylate(PRE)-084 as aσ1-R agonist in a well-characterized 6-hydroxydopamine rat model of Parkinson’s *** animals received either vehicle separately or the dual therapy PHA/PRE once a day until day 14 *** no effect was noticed in the amphetamine-induced rotation test,our data has shown that the PHA/PRE treatment induced partial protection of the dopaminergic neurons(15-20%),assessed by the dopamine transporter density in the striatum and immunoreactive tyrosine hydroxylase in the substantia ***,this dual therapy reduced the degree of glial activation consecutive to the 6-hydroxydopamine lesion,i.e,the 18 kDa translocation protein density and glial fibrillary acidic protein staining in the striatum,and the CD11b and glial fibrillary acidic protein staining in the substantia ***,this study reports for the first time that concomitant activation of α7-nAChR andσ1-R can provide a partial recovery of the nigro-striatal dopaminergic neurons through the modulation of microglial *** study was approved by the Regional Ethics Committee(CEEA Val de Loire n°19)validated this protocol(Authorization N°00434.02)on May 15,2014.

关键词： 6-hydroxydopamine astrocytes microglial activation neurodegeneration neuroinflammation nicotinicα7 receptor Parkinson’s disease PHA 543613 PRE-084 sigma-1 receptor

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Cross-Talk between ROS and Calcium in Regulation of Nuclear Activities

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Molecular Plant 2010年第4期3卷 706-718页

作者： Christian Mazars Universite de Toulouse UPS UMR 5546 Surfaces Cellulaires et Signalisation chez les Vegetaux BP 42617 F-31326 Castanet-Tolosan France CNRS UMR 5546 BP 42617 F-31326 Castanet-Tolosan France Universite de Bourgogne UMR Plante-Microbe-Environnement BP 86510 21065 Dijon cedex France umr INRA 1088 CNRS 5184 Universite de Bourgogne Plante-Microbe-Environnement BP 86510 21065 Dijon cedex France

Calcium and Reactive Oxygen Species （ROS） are acknowledged as crucial second messengers involved in the response to various biotic and abiotic stresses. However, it is still not clear how these two compounds can play a role in different signaling pathways leading the plant to a variety of processes such as root development or defense against pathogens. Recently, it has been shown that the concept of calcium and ROS signatures, initially discovered in the cytoplasm, can also be extended to the nucleus of plant cells. In addition, it has been clearly proved that both ROS and calcium signals are intimately interconnected. How this cross-talk can finally modulate the translocation and/or the activity of nuclear proteins leading to the control of specific genes expression is the main focus of this review. We will especially focus on how calcium and ROS interact at the molecular level to modify their targets.

关键词： Nucleus Calcium ROS Crosstalk Signalling.

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First characterization of endophytic Corynespora cassiicola isolates with variant cassiicolin genes recovered from rubber trees in Brazil

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Fungal Diversity 2012年第3期54卷 87-99页

作者： Marine Déon Ana Scomparin Aude Tixier Carlos R.R.Mattos Thierry Leroy Marc Seguin Patricia Roeckel-Drevet Valérie Pujade-Renaud CIRAD UMR AGAP63000 Clermont-FerrandFrance Clermont Université UniversitéBlaise PascalUMR 547 PIAF63000 Clermont-FerrandFrance Plantações Michelin de Bahia Box 0245435-000 ItuberáBahiaBrazil CIRAD UMR AGAP34398 MontpellierFrance

Corynespora cassiicola is the causal agent of Corynespora Leaf Fall(CLF)*** is one of the most important fungal diseases of rubber trees in Asia and Africa but disease outbreaks have not been reported in South ***,a small cysteine-rich glycoprotein secreted by the pathogenic *** isolate CCP,was previously identified as a potential disease effector in rubber ***,the cassiicolin-encoding gene(Cas1)was characterized and shown to be expressed in the early phase of *** this study,we investigated whether previously undetected strains of *** are present in South American rubber plantations by examining the fungal endophyte population found in asymptomatic rubber tree *** isolates were identified as *** encoding new forms of the cassiicolin precursor protein(Cas3 and Cas4)were identified from these *** of four isolates were able to induce symptoms on the cultivar they were isolated from in a detached leaf assay,with different kinetics and *** isolate had the same pathogenicity profile as the pathogenic isolate CCP;the other two isolates developed symptoms late during the course of infection,suggesting saprotrophic ***,no Cas3 or Cas4 transcripts could be detected upon inoculation with the endophytic isolates,whereas the reference gene Cas1 was expressed upon inoculation with the CCP *** work demonstrated that *** is present in South America in an endophytic form and that it may evolve from an endophytic to a saprophytic or even potentially pathogenic life style.

关键词： Corynespora cassiicola Rubber tree Endophyte Brazil Cassiicolin

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Equidistribution for meromorphic transforms and the dd^c-method

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Science China Mathematics 2005年第Z1期48卷 180-194页

作者： Tien-Cuong Dinh Nessim Sibony Mathématique-Bt.425 umr 8628 Université Paris-Sud91405 OrsayFranceMathématique-Bt.425 UMR 8628Université Paris-Sud91405 OrsayFrance

In this paper we give an introduction to the notion of meromorphic *** describe some equidistribution problems and their solution, using the ddc-method. In particular, we give some statistical properties of the equilibrium measure for meromorphic maps on compact Kahler manifolds: K-mixing, exponential decay of correlations and central limit theorem.

关键词： meromorphic map, correspondence, compact Kahler manifold.

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Preparation, Characterization and Luminescent Properties of MCM-41 Type Materials Impregnated with Rare Earth Complex

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Journal of Materials Science & Technology 2001年第3期17卷 293-298页

作者： Lianshe FU and Hongjie ZHANG Key Laboratory of Rare Earth Chemistry and Physics, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China Philippe Boutinaud Laboratoire des Materiaux Inorganiques, umr 6002, Universite umr 6002 Univ. Blaise-Pascal et ENSCCF F-63177 Aubiére Cedex France

Hybrid materials incorporating Eu-(TTA)(3). 2H(2)O (7hereafter designated as Eu-TTA, with TTA: thenoyltrifluoroacetone) in unmodified or modified MCM-41 by 3-aminopropyl-triethoxysilane (APTES) were prepared by impregnation method. The obtained materials were characterized using X-ray diffraction (XRD), IR and diffuse reflectance spectroscopy and luminescence spectra. All the hybrid samples exhibited the characteristic emission bands of EU3+ under UV light excitation at room temperature, and the excitation spectra showed significant blue-shifts compared to the pure rare-earth complex. Although the red emission intensity in the modified hybrid was almost the half of the red emission intensity in the pure Eu-TTA complex at room temperature, the hybrid showed a much higher thermal stability due to the shielding character of the MCM-41 host.

关键词： MCM Characterization and Luminescent Properties of MCM-41 Type Materials Impregnated with Rare Earth Complex Preparation

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Global significance of oxygen and carbon isotope compositions of pedogenic carbonates since the Cretaceous

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Geoscience Frontiers 2021年第4期12卷 34-45页

作者： Marc Jolivet Philippe Boulvais Géosciences Rennes CNRSUniv RennesUMR 6118F-35000RennesFrance

Few global syntheses of oxygen and carbon isotope composition of pedogenic carbonates have been attempted,unlike marine *** carbonates represent in-situ indicators of the climate conditions prevailing on *** δ^(18)O and δ^(13)C values of pedogenic carbonates are controlled by local and global factors,many of them not affecting the marine carbonates largely used to probe global climate *** compile pedogenic oxygen and carbon isotopic data(N=12,167)fromCretaceous to Quaternary-aged paleosols to identify potential trends through time and tie them to possible controlling *** discrete events such as the Paleocene-Eocene Thermal Maximum are clearly evidenced,our analysis reveals an increasing complexity in the distribution of the δ^(18)O vs δ^(13)C values through the *** could be expected,the rise of C4 plants induces a shift towards higherδ13C values during the Neogene and *** also show that the increase in global hypsometry during the Neogene plays a major role in controlling the δ^(18)O and δ^(13)C values of pedogenic carbonates by increasing aridity downwind of orographic ***,during the Quaternary,an increase of 3‰in δ^(18)O values is recorded both by the pedogenic carbonates and the marine foraminifera suggesting that both indicators may be used to track global climate signal.

关键词： Global isotopic signal Cretaceous–Quaternary Pedogenic carbonates Topography

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Biomimetic Autopilot Based on Minimalistic Motion Vision for Navigating along Corridors Comprising U-shaped and S-shaped Turns

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Journal of Bionic Engineering 2015年第1期12卷 47-60页

作者： Julien R. Serres Franck Ruffier Aix-Marseille UniversitY CNRS ISM UMR 7287 Biorobotics Lab 13288 Marseille Cedex 09 France

A bioinspired autopilot is presented, in which body saccadic and intersaceadic systems are combined. This autopilot en- ables a simulated hovercraft to travel along corridors comprising L-junctions, U-shaped and S-shaped turns, relying on mini- realistic motion vision cues alone without measuring its speed or distance from walls, in much the same way as flies and bees manage their flight in similar situations. The saccadic system responsible for avoiding frontal collisions triggers yawing body saccades with appropriately quantified angles based simply on a few local optic flow measurements, giving the angle of inci- dence with respect to a frontal wall. The simulated robot negotiates stiff bends by triggering body saccades to realign its tra- jectory, thus traveling parallel with the wall along a corridor comprising sharp turns. Direct comparison shows that the per- formance of this new body saccade-based autopilot closely resembles the behavior of a fly using similar body saccade strategy when flying along a corridor with an S-shaped turn, despite the huge differences in terms of the inertia.

关键词： optic flow collision avoidance body saccades insect flight biorobotics biomimetics

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Late Quaternary clay minerals off Middle Vietnam in the western South China Sea: Implications for source analysis and East Asian monsoon evolution

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Science China Earth Sciences 2007年第11期50卷 1674-1684页

作者： Christophe COLIN Laboratoire IDES UMR 8148 CNRS Université de Paris XI Orsay 91405 France

High-resolution clay mineral records combined with oxygen isotopic stratigraphy over the past 450 ka during late Quaternary from Core MD05-2901 off Middle Vietnam in the western South China Sea are re-ported to reconstruct a history of East Asian monsoon evolution. Variations in Illite, chlorite, and kaolinite contents indicate a strong glacial-interglacial cyclicity, while changes in smectite content present a higher frequency cyclicity. The provenance analysis indicates a mixture of individual clay minerals from various sources surrounding the South China Sea. Smectite derived mainly from the Sunda shelf and its major source area of the Indonesian islands. Illite and chlorite originated mainly from the Mekong and Red rivers. Kaolinite was provided mainly by the Pearl River. Spectral analysis of the kaolin-ite/(illite+chlorite) ratio displays a strong eccentricity period of 100 ka, implying the ice sheet-forced win-ter monsoon evolution; whereas higher frequency changes in the smectite content show an ice sheet-forced obliquity period of 41 ka, and precession periods of 23 and 19 ka and a semi-precession period of 13 ka as well, implying the tropical-forced summer monsoon evolution. The winter monsoon evolution is generally in coherence with the glacial-interglacial cyclicity, with intensified winter monsoon winds during glacials and weakened winter monsoon winds during interglacials; whereas the summer monsoon evolution provides an almost linear response to the summer insolation of low latitude in the Northern Hemisphere, with strengthened summer monsoon during higher insolation and weakened summer monsoon during lower insolation. The result suggests that the high-latitude ice sheet and low-latitude tropical factor could drive the late Quaternary evolution of East Asian winter and summer monsoons, respectively, implying their diplex and self-contained forcing mechanism.

关键词： clay minerals,provenance,East Asian monsoon,late Quaternary,Middle Vietnam,South China Sea

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AP2/ERF transcription factors orchestrate very long chain fatty acid biosynthesis during Arabidopsis lateral root development

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Molecular Plant 2021年第2期14卷 205-207页

作者： Soazig Guyomarc'h Yohann Boutte Laurent Laplaze umr DIADE Universitéde MontpellierIRDMontpellierFrance LBM BordeauxFrance

One key factor defining root system architecture is root branching,i.e.,the process of the formation of new root axes,called lateral roots(LRs),from an existing *** the model plant Arabidopsis thaliana,LRs originate from preselected pericycle cells that divide to create an LR primordium(LRP)that grows and eventually forms a new root apical meristem(Banda et al.,2019).During this developmental process,cell-fate acquisition is very plastic and depends on positional information rather than on cell lineage(Banda et al.,2019).Importantly,LR formation occurs inside the parent root,and the LRP must grow through overlying tissues before emerging into the *** LR emergence process is controlled by dynamic intercellular signaling and involves a tight coordination of cellular responses in the LRP and surrounding tissues(Banda et al.,2019).In particular,the growing LRP rapidly pushes against the overlying endodermis,a layer of cells mechanically reinforced by the Casparian *** crossing of the endodermis by the LRP between stagesⅣand V has been proposed as an important developmental checkpoint during LR development(Banda et al.,2019).

关键词： eventually Arabidopsis branching

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An Accurate Cartesian Method for Incompressible Flows with Moving Boundaries

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Communications in Computational Physics 2014年第5期15卷 1266-1290页

作者： M.Bergmann J.Hovnanian A.Iollo Inria F-33400 TalenceFranceUniv.BordeauxIMBUMR 5251F-33400 TalenceFranceCNRSIMBUMR 5251F-33400 TalenceFrance.

An accurate cartesian method is devised to simulate incompressible viscous flows past an arbitrary moving *** Navier-Stokes equations are spatially discretized onto a fixed Cartesian *** body is taken into account via the ghost-cell method and the so-called penalty method,resulting in second-order accuracy in *** accuracy and the efficiency of the solver are tested through two-dimensional reference *** show the versatility of this scheme we simulate a threedimensional self propelled jellyfish prototype.

关键词： Viscous incompressible flow immersed boundary method penalty method cartesian grid self-propelled jellyfish.

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