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Neural Regeneration Research 2025年第11期20卷 3217-3218页

作者： Laura Huggon Emma L.Clayton uk Dementia Research Institute at King’s college London LondonUK Department of Basic and Clinical Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal dementia and amyotrophic lateral sclerosis:Frontotemporal dementia(F T D)and amyo t rophic lateral sclerosis(ALS)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with FTD affecting neurons of the frontal and temporal lobes,and ALS affecting upper and lower motor neurons),these two diseases are complexly *** and ALS exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis

Harnessing therapeutic potential of induced pluripotent stem cell–derived endothelial cells for remyelination in the central nervous system

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Neural Regeneration Research 2025年第6期20卷 1715-1716页

作者： Dan Ma Nona Pop Aston Medical School College of Health and Life SciencesAston UniversityBirminghamUK

Myelin is the protective sheath surrounding nerve fibers, and its damage(demyelination) occurs in many central nervous system(CNS) diseases, including multiple sclerosis(MS), traumatic injury, neurodegenerative diseases such as Alzheimer's disease, and mental disorders such as schizophrenia(Barateiro et al., 2016). Repair of damaged myelin sheaths(remyelination) often fails in MS, leading to neuronal loss and irreversible functional deficits.

关键词： myelin protective diseases

Global transplantation:Lessons from organ transplantation organizations worldwide

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World Journal of Transplantation 2025年第1期15卷 44-56页

作者： Solonas Symeou Eleni Avramidou Vassilios Papalois Georgios Tsoulfas Medical School University of IoanninaIoannina 45110Greece Department of Transplantation Surgery Center for Research and Innovation in Solid Organ TransplantationSchool of MedicineAristotle University of ThessalonikiThessaloniki 54642Greece imperial college Renal and Transplant Centre Imperial College Healthcare NHS TrustHammersmith HospitalLondon W120HSUnited Kingdom Department of Surgery and Cancer Imperial College LondonLondon SW72AZUnited Kingdom

Although national transplant organizations share common visions and goals,the creation of a unified global organization remains *** in ethnicity,culture,religion,and education shape local practices and infrastructure,making the establishment of a single global entity *** with these social disparities aside,logistical factors such as time and distance between organ procurement and transplantation sites pose significant *** technological advancements have extended organ preservation times,they have yet to support the demands of transcontinental transplantations *** review presents a comparative analysis of the structures,operational frameworks,policies,and legislation governing various transplant organizations around the *** differences pertain to the administration of these organizations,trends in organ donation,and organ allocation policies,which reflect the financial,cultural,and religious diversity across different *** a global transplant organization may be out of reach,agreeing on best practices for the benefit of patients is essential.

关键词： Organ transplantation National transplant organizations Organ donation Global transplantation Transplant systems

Polyglutamine diseases: looking beyond the neurodegenerative universe

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Neural Regeneration Research 2021年第6期16卷 1186-1187页

作者： Michal Mielcarek Mark Isalan Department of Life Sciences Imperial College LondonLondonUK imperial college Centre for Synthetic Biology Imperial College LondonLondonUK

Multisystem disorders are often manifested by affecting more than one bodily system or *** have recently reported a significantly higher prevalence of coexisting conditions in the cohorts of both pre-and symptomatic Huntington’s disease(HD)gene *** reported that even pre-symptomatic HD patients had a significantly higher number of comorbid conditions,while the symptomatic group of HD patients was characterized by a significantly lower percentage of subjects without any comorbidity(7%)in comparison to the control group(50%).

关键词： Huntington diseases patients

Locally Enhanced Flow and Electric Fields Through a Tip Effect for Efficient Flow‑Electrode Capacitive Deionization

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Nano-Micro Letters 2025年第2期17卷 1-17页

作者： Ziquan Wang Xiangfeng Chen Yuan Zhang Jie Ma Zhiqun Lin Amor Abdelkader Maria‑Magdalena Titirici Libo Deng college of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060People’s Republic of China Research Center for Environmental Functional Materials College of Environmental Science and EngineeringTongji University1239 Siping RoadShanghai 200092People’s Republic of China Department of Chemical and Biomolecular Engineering National University of SingaporeSingapore 117585Singapore Department of Engineering Faculty of Science and TechnologyBournemouth UniversityTalbot CampusFern BarrowPooleEngland BH125BBUK Institut de Chimie de Nice UniversitéCôte d’AzurUMR CNRS 727228 Av.Valrose06108 NiceFrance Department of Chemical Engineering Imperial College LondonSouth Kensington CampusExhibition RdLondon SW72AZUK

Low-electrode capacitive deionization(FCDI)is an emerging desalination technology with great potential for removal and/or recycling ions from a range of ***,it still suffers from inefficient charge transfer and ion transport kinetics due to weak turbulence and low electric intensity in flow electrodes,both restricted by the current ***,a new tip-array current collector(designated as T-CC)was developed to replace the conventional planar current collectors,which intensifies both the charge transfer and ion transport *** effects of tip arrays on flow and electric fields were studied by both computational simulations and electrochemical impedance spectroscopy,which revealed the reduction of ion transport barrier,charge transport barrier and internal *** the voltage increased from 1.0 to 1.5 and 2.0 V,the T-CC-based FCDI system(T-FCDI)exhibited average salt removal rates(ASRR)of 0.18,0.50,and 0.89μmol cm^(-2) min^(-1),respectively,which are 1.82,2.65,and 2.48 folds higher than that of the conventional serpentine current collectors,and 1.48,1.67,and 1.49 folds higher than that of the planar current ***,with the solid content in flow electrodes increased from 1 to 5 wt%,the ASRR for T-FCDI increased from 0.29 to 0.50μmol cm^(-2) min^(-1),which are 1.70 and 1.67 folds higher than that of the planar current ***,a salt removal efficiency of 99.89%was achieved with T-FCDI and the charge efficiency remained above 95%after 24 h of operation,thus showing its superior long-term stability.

关键词： Flow-electrode Capacitive deionization Current collector Tip effect Desalination

Automatic Bone Surface Restoration for Markerless Computer-Assisted Orthopaedic Surgery

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Chinese Journal of Mechanical Engineering 2022年第1期35卷 85-90页

作者： Xue Hu Ferdinando Rodriguez y Baena Mechatronics in Medicine Laboratory Imperial College LondonLondonUK

An automatic markerless knee tracking and registration algorithm has been proposed in the literature to avoid the marker insertion required by conventional computer-assisted knee surgery,resulting in a shorter and less invasive surgical ***,such an algorithm considers intact femur geometry *** bone surface modification is inevitable due to intra-operative *** mismatched correspondences will degrade the reliability of registered target *** solve this problem,this work proposed a supervised deep neural network to automatically restore the surface of processed *** network was trained on a synthetic dataset that consists of real depth captures of a model leg and simulated realistic femur *** to the evaluation on both synthetic data and real-time captures,the registration quality can be effectively improved by surface *** improvement in tracking accuracy is only evident over test data,indicating the need for future enhancement of the dataset and network.

关键词： Bone surface reconstruction Computer assisted orthopedic surgery Markerless femur tracking

Improving the reaction mix of a Pichia pastoris cell-free system using a design of experiments approach to minimise experimental effort

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Synthetic and Systems Biotechnology 2020年第3期5卷 137-144页

作者： Alex J.Spice Rochelle Aw Daniel G.Bracewell Karen M.Polizzi Department of Chemical Engineering Imperial College LondonLondonUK imperial college Centre for Synthetic Biology Imperial College LondonUK Department of Biochemical Engineering University College LondonLondonUK

A renaissance in cell-free protein synthesis(CFPS)is underway,enabled by the acceleration and adoption of synthetic biology *** has emerged as a powerful platform technology for synthetic gene network design,biosensing and on-demand *** primarily of bacterial origin,cell-free extracts derived from a variety of host organisms have been explored,aiming to capitalise on cellular diversity and the advantageous properties associated with those ***,cell-free extracts produced from eukaryotes are often overlooked due to their relatively low yields,despite the potential for improved protein folding and posttranslational *** we describe further development of a Pichia pastoris cell-free platform,a widely used expression host in both academia and the biopharmaceutical *** a minimised Design of Experiments(DOE)approach,we were able to increase the productivity of the system by improving the composition of the complex reaction *** was achieved in a minimal number of experimental runs,within the constraints of the design and without the need for liquid-handling *** doing so,we were able to estimate the main effects impacting productivity in the system and increased the protein synthesis of firefly luciferase and the biopharmaceutical HSA by 4.8-fold and 3.5-fold,*** study highlights the ***-based cell-free system as a highly productive eukaryotic platform and displays the value of minimised DOE designs.

关键词： Cell-free protein synthesis Pichia pastoris Synthetic biology Design of experiments(DOE)

Business cases for energy storage with multiple service provision

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Journal of Modern Power Systems and Clean Energy 2016年第4期4卷 615-625页

作者： Fei TENG Goran STRBAC imperial college London South Kensington CampusLondonUK

Energy storage(ES)has been considered as the key source of flexibility to support the integration of renewable *** studies have demonstrated the substantial system cost savings by the deployment of ES,including both investment and operation of generation,transmission and distribution ***,this societal benefit may not be realized if industry actors do not have a viable business case to appropriately capture these multiple value *** this context,this paper investigates the value that ES may deliver to its owner over two specific business cases in a 2030 uk ***,the application of large-scale ES in the wholesale market is *** is demonstrated that the optimal allocation of ES to provide multiple services is the key element for ES to become competitive in the electricity *** the second business case,this paper analyses the value of kilowattscale ES combined with roof photovoltaic(PV)system in the household and community *** study shows that multiple service provision of ES through advanced pricing schemes,for example time-of-use(ToU)tariff and dynamic distribution use of system(DUoS),lead to higher value and the coordination in the community level could further justify the application of domestic ES.

关键词： Energy storage Wind generation Business case Electricity market Multiple service provision

Machine learning based GNSS signal classifcation and weighting scheme design in the built environment:a comparative experiment

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Satellite Navigation 2023年第1期4卷 54-76,I0003页

作者： Lintong Li Mireille Elhajj Yuxiang Feng Washington Yotto Ochieng Department of Civil and Environmental Engineering Imperial College LondonLondonUK Astra-Terra Limited LondonUK

None-Line-of-Sight(NLOS)signals denote Global Navigation Satellite System(GNSS)signals received indirectly from satellites and could result in unacceptable positioning *** meet the high mission-critical transportation and logistics demand,NLOS signals received in the built environment should be detected,corrected,and *** paper proposes a cost-efective NLOS impact mitigation approach using only GNSS *** exploiting more signal Quality Indicators(QIs),such as the standard deviation of pseudorange,Carrier-to-Noise Ratio(C/N0),elevation and azimuth angle,this paper compares machine-learning-based classifcation algorithms to detect and exclude NLOS signals in the pre-processing *** probability of the presence of NLOS is predicted using regression *** a pre-defned threshold,the signals can be classifed as Line-of-Sight(LOS)or *** probability of the occurrence of NLOS is also used for signal subset selection and specifcation of a novel weighting *** novel weighting scheme consists of both C/N0 and elevation angle and NLOS *** results show that the best LOS/NLOS classifcation algorithm is the random *** best QI set for NLOS classifcation is the frst three QIs mentioned above and the diference of azimuth *** classifcation accuracy obtained from this proposed algorithm can reach 93.430%,with 2.810%false *** proposed signal classifer and weighting scheme improved the positioning accuracy by 69.000%and 40.700%in the horizontal direction,79.361%and 75.322%in the vertical direction,and 75.963%and 67.824%in the 3D direction.

关键词： GNSS NLOS FDE Decision tree Weighting scheme

Cerebral microhaemorrhage in COVID-19: a critical illness related phenomenon?

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Stroke & Vascular Neurology 2020年第4期5卷 315-322页

作者： Luke Dixon Cillian McNamara Pritika Gaur Dermot Mallon Christopher Coughlan Francesca Tona Wajanat Jan Mark Wilson Brynmor Jones Department of Neuroradiology Imperial College Healthcare NHS TrustLondonUK Department of Cardiac Intensive Care Imperial College Healthcare NHS TrustLondonUK Department of Neurosurgery Imperial College Healthcare NHS TrustLondonUK

Background Cerebral microhaemorrhages are increasingly being recognised as a complication of *** observational retrospective study aims to further investigate the potential pathophysiology through assessing the pattern of microhaemorrhage and clinical characteristics of patients with COVID-19 and *** comparing with similar patterns of microhaemorrhage in other non-COVID-19 disease,this study aims to propose possible common pathogenic *** A retrospective observational case series was performed identifying all patients with COVID-19 complicated by cerebral microhaemorrhage on *** distribution and number of microhaemorrhages were recorded using the microbleed anatomical scale,and patients’baseline characteristics and salient test results were also *** Cerebral microhaemorrhages were noted to have a predilection for the corpus callosum,the juxtacortical white matter and *** patients had a preceding period of critical illness with respiratory failure and severe hypoxia necessitating intubation and mechanical *** This study demonstrates a pattern of cerebral microhaemorrhage that is similar to the pattern reported in patients with non-COVID-19 related critical illness and other causes of severe *** raises questions regarding whether microhaemorrhage occurs from endothelial dysfunction due the direct effect of SARS-CoV-2 infection or from the secondary effects of critical illness and hypoxia.

关键词： Cerebral pattern critical