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Codiversification of gut microbiota with humans

四川生理科学杂志 2022年第9期44卷 1660-1660页

作者： Taichi A Suzuki Department of Microbiome Science Max Planck Institute for Biology Tübingen Germany. Interfaculty Institute of Microbiology and Infection Medicine University of Tübingen Tübingen Germany. Institute for Tropical Medicine University of Tübingen Tübingen Germany. Centre de Recherches Médicales de Lambaréné Lambaréné Gabon. German Center for Infection Research Tübingen Germany. Cluster of Excellence EXC 2124 Controlling Microbes to Fight Infections University of Tübingen Tübingen Germany. Vietnamese German Center for Medical Research Hanoi Vietnam. Fondation pour la Recherche Scientifique Cotonou Bénin. 108 Military Central Hospital Hanoi Vietnam. Department of Twin Research and Genetic Epidemiology King’s College London London UK. Department of Ecology Evolution and Behavior University of Minnesota Minneapolis MN USA. Eco-anthropologie Muséum National d’Histoire Naturelle CNRS Université de Paris Paris France. Department of Environmental Health Sciences Graduate School of Public Health Seoul National University Seoul Republic of Korea. Department of Genetics Cell Biology and Development University of Minnesota Minneapolis MN USA. Laboratoire de Biométrie et Biologie Evolutive CNRS Université Lyon 1 Villeurbanne France.

The gut microbiomes of human populations worldwide have many core microbial species in ***,within a species,some strains can show remarkable population *** question is whether such specificity arises from a shared evolutionary history(codiversification)between humans and their *** test for codiversification of host and microbiota,we analyzed paired gut metagenomes and human genomes for 1225 individuals in Europe,Asia,and Africa,including mothers and their *** and within countries,a parallel evolutionary history was evident for humans and their gut ***,species displaying the strongest codiversification independently evolved traits characteristic of host dependency,including reduced genomes and oxygen and temperature *** findings all point to the importance of understanding the potential role of population-specific microbial strains in microbiome-mediated disease phenotypes.

关键词： specificity mother gut

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COVAX-19 ■Vaccine:Completely blocks virus transmission to non-immune individuals

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Clinical Complementary Medicine and Pharmacology 2021年第1期1卷 28-31页

作者： Vivek P.Chavda Lalitkumar K.Vora Disha R.Vihol Department of Pharmaceutics and Pharmaceutical Technology L M College of PharmacyAhmedabad-380009GujaratIndia School of Pharmacy Queen’s University Belfast97 Lisburn RoadBT97BLUK Pharmacy Section L.M.College of PharmacyAhmedabad-380058GujaratIndia

Various vaccine platforms are geared against COVID-19 vaccine development to produce immunogens in *** design a recombinant protein-based COVID-19 vaccine,Vaxine pty ltd used computer models of the spike protein and its human receptor,ACE2,to identify how the virus infects human *** on this,the COVAX-19 ■vaccine is *** does reduce not only COVID-19 disease but also blocks virus shedding and *** are optimistic that this vaccine candidate could be clinically available soon with sufficient vaccine efficacy with a considerable amount of reduction in vaccination-related side effects.

关键词： COVAX-19■Vaccine SARS-CoV-2 Pandemic Advax^(TM) SpikoGen■etc

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如何进行医疗电话咨询

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英国医学杂志中文版 2018年第10期21卷 585-588页

作者： Louise S van Galen Josip Car 金一鹏(译) 高江平(校) Department of Internal Medicine VU University Medical Centre Amsterdam Netherlands Centre for Population Health Sciences (CePHaS) Lee Kong Chian School of Medicine Nanyang Technological University Singapore 308232 Global eHeahh Unit Department of Primary Care and Public Health School of Public Health Imperial College London London W6 8RP UK 解放军总医院附属第一医院泌尿外科

在美国的内科医疗和英国的初级保健中，约四分之一的医患交流沟通是通过电话进行的。电话咨询是除面对面咨询以外最常用的咨询方式，它在可用性、便利性和选择性等方面尚有改善的空间。比较性研究表明患者对两种咨询方式（电话咨询和面... 详细信息

在美国的内科医疗和英国的初级保健中，约四分之一的医患交流沟通是通过电话进行的。电话咨询是除面对面咨询以外最常用的咨询方式，它在可用性、便利性和选择性等方面尚有改善的空间。比较性研究表明患者对两种咨询方式（电话咨询和面对面咨询）均感到满意。然而，随机对照研究和时间序列研究显示电话咨询并不能减少医生的工作量.

关键词：医疗卫生行业发展现状医患关系医生

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研究方法和报告:普通医学何时将临床研究报告和监管文件纳入系统综述

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英国医学杂志中文版 2020年第3期23卷 159-166页

作者： Tom Jeferson Peter Doshi Isabelle Boutron Su Colder Carl Heneghan Alex Hodkinson Mark Jones Carol Lefebvre Lesley A Stewart 武泽昊(译) 杨瑀譞(译) 彭晓霞(校) Centre for Evidence Based Medicine Nuffield Department of Primary Care Health SciencesPrimary Sciences DivisionUniversity of OxfordOxfordUK Acute Respiratory Infections Group Cochrane Department of Pharmaceutical Health Services Research University of Maryland School of PharmacyBaltimoreMarylandUSA METHODs team Centre of Research in Epidemiology and Statistics Sorbonne Paris Cit6INSERM UMR 1153University Paris DescartesParisFrance Risk of Bias Methods group Cochrane Department of Health Sciences University of YorkYorkUK Adverse Effects Methods Group Cochrane Centre for Primary Care Division of Population HealthHealth Services Research&Primary CareUniversity of ManchesterManchesterUK Centre for Reviews and Dissemination University of YorkYorkUK School of Public Health University of QueenslandBrisbaneQueenslandAustralia Lefebvre Associates ltd OxfordUK Information Retrieval Methods Group Cochrane IPD meta-analysis group Cochrane 首都医科大学公共卫生学院流行病与卫生统计学系国家儿童医学中心首都医科大学附属北京儿童医院临床流行病学与循证医学中心

报告偏倚是影响系统综述真实性和可靠性的主要威胁。本文总结了获取临床研究报告和其他监管文件(监管数据)来应对报告偏倚的基本原理,以及有助于决定是否将监管数据纳入系统综述的决定因素。同时介绍了监管数据获取的来源和现状,并针对... 详细信息

报告偏倚是影响系统综述真实性和可靠性的主要威胁。本文总结了获取临床研究报告和其他监管文件(监管数据)来应对报告偏倚的基本原理,以及有助于决定是否将监管数据纳入系统综述的决定因素。同时介绍了监管数据获取的来源和现状,并针对当前系统综述的作者在考虑将监管数据纳入系统综述时的做法进行的调查进行了总结。本文没有解决如何获得和提取监管数据的问题。应鼓励像Cochrane这样的组织机构和利益相关者使用临床研究报告中的数据作为药品干预评价的重要数据来源,尤其是干预措施非常重要,且报告偏倚发生风险较大时。

关键词：临床研究报告利益相关者系统综述数据获取数据来源监管干预措施偏倚

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Signal transduction of bombesin-induced circular smooth muscle cell contraction in cat esophagus

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World Journal of Gastroenterology 2006年第14期12卷 2259-2263页

作者： Sung-uk Park Chang-Yell Shin Jung-Su Ryu Hyen-O La Sun-Young Park Hyun-Ju Song Young-Sil Min Dong-Seok Kim Uy-Dong Sohn Department of Pharmacology College of Pharmacy Chung Ang UniversitySeoul 156-756Republic of Korea Department of Pharmacology College of Pharmacy Chung Ang UniversitySeoul 156-756Republic of Korea Research LaboratoryDong-A Pharm. Co. LtdYongin 449-905Kyunggi-DoRepublic of Korea Department of Pharmacology College of Medicine The Catholic University of KoreaSeoul 137-701Republic of Korea Research Division for Human Life Sciences Seoul National University 28 Yongon-DongChongno-GuSeoul 110-744Republic of Korea

瞄准：在猫食管调查导致 bombesin 的圆形的平滑肌房间收缩的机制。方法：涉及猫食管收缩的特定的 G 蛋白质或磷脂酶 C 被识别，肌细胞是有皂甙的 permeabilized。在肌细胞的 permeabilization 以后， Gi3 抗体禁止了导致 bombesin 的... 详细信息

瞄准：在猫食管调查导致 bombesin 的圆形的平滑肌房间收缩的机制。方法：涉及猫食管收缩的特定的 G 蛋白质或磷脂酶 C 被识别，肌细胞是有皂甙的 permeabilized。在肌细胞的 permeabilization 以后， Gi3 抗体禁止了导致 bombesin 的平滑肌房间收缩。结果：有 PLC-beta3 抗体的 permeabilized 通报肌细胞的孵化能禁止导致 bombesin 的收缩。H-7，白屈菜红(PKC 禁止者) 和 genistein (蛋白质酷氨酸激酶禁止者) 禁止了导致 bombesin 的收缩，而是 DAG 激酶禁止者， R59949，不能禁止它。检验激活 mitogen 的蛋白质激酶(MAPK ) 哪个涉及导致 bombesin 的收缩，特定的 MAPK 禁止者(MEK 禁止者， PD98059 和 p38 MAPK 禁止者， SB202190 ) 被使用。PD98059 的 Preincubation 堵住了 bombesin 以一种集中依赖者方式导致的收缩。然而， SB202190 没在收缩上有效果。结论：在猫食管的导致 Bombesin 的圆形的肌肉房间收缩是经由 PKC 或一条 PTK 依赖的小径或 p44/p42 MAPK 小径的 madiated。

关键词：铃蟾肽平滑肌细胞蛋白激酶食管疾病

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Targets for high repetition rate laser facilities:needs,challenges and perspectives

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High Power Laser Science and Engineering 2017年第3期5卷 10-40页

作者： I.Prencipe J.Fuchs S.Pascarelli D.W.Schumacher R.B.Stephens N.B.Alexander R.Briggs M.Büscher M.O.Cernaianu A.Choukourov M.De Marco A.Erbe J.Fassbender G.Fiquet P.Fitzsimmons C.Gheorghiu J.Hund L.G.Huang M.Harmand N.J.Hartley A.Irman T.Kluge Z.Konopkova S.Kraft D.Kraus V.Leca D.Margarone J.Metzkes K.Nagai W.Nazarov P.Lutoslawski D.Papp M.Passoni A.Pelka J.P.Perin J.Schulz M.Smid C.Spindloe S.Steinke R.Torchio C.Vass T.Wiste R.Zaffino K.Zeil T.Tschentscher U.Schramm T.E.Cowan Institute of Radiation Physics Helmholtz–Zentrum Dresden–Rossendorf LULI–CNRS Ecole PolytechniqueCEA:UniversitéParis-Saclay European Synchrotron Radiation Facility Ohio State University University of Pennsylvania Inertial Fusion Technologies General Atomics Peter Grünberg Institute PGI-6 Forschungzentrum Jülich Heinrich-Heine-University Düsseldorf Horia Hulubei National Institute for R&D in Physics and Nuclear Engineering(IFIN-HH)–Extreme Light Infrastructure–Nuclear Physics(ELI-NP) Institute of Physics ASCR FZUELI-Beamlines project Department of Macromolecular Physics Faculty of Mathematics and PhysicsCharles University in Prague Institute of Ion Beam Physics and Materials Research Helmholtz–Zentrum Dresden–Rossendorf Technische Universitüt Dresden Institut de minéralogie de physique des matériaux et de cosmochimie Schafer Corporation European XFEL Laboratory for Chemistry and Life Science Institute of Innovative Research(IIR)Tokyo Institute of Technology ELI-ALPS ELI-HU Non-Profit Ltd. Department of Energy Politecnico di Milano INFN-Sezione di Milano CEA Grenoble INACService des Basses Temperatures Science and Technology Facilities Council Rutherford Appleton Laboratory Scitech Precision ltd Rutherford Appleton Laboratory Lawrence Berkeley National Laboratory Institute of Microelectronics of Barcelona National Center of MicroelectronicSpanish Research Council University of St.Andrews

A number of laser facilities coming online all over the world promise the capability of high-power laser experiments with shot repetition rates between 1 and 10 Hz. Target availability and technical issues related to the interaction environment could become a bottleneck for the exploitation of such facilities. In this paper, we report on target needs for three different classes of experiments: dynamic compression physics, electron transport and isochoric heating, and laser-driven particle and radiation sources. We also review some of the most challenging issues in target fabrication and high repetition rate operation. Finally, we discuss current target supply strategies and future perspectives to establish a sustainable target provision infrastructure for advanced laser facilities.

关键词： high-energy density physics target design and fabrication

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Constraints in Using Manufactured Sands in Concrete Pavements in Australia

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Journal of Civil Engineering and Architecture 2015年第11期9卷 1318-1324页

作者： Ion Dumitru Tony Song Bob Bornstein Vute Sirivivatnanon Materials Technical Services Department Boral Resources (New South Wales) Pty Ltd. New South Wales 2153 Australia School of Computing Engineering and Mathematics University of Western Sydney New South Wales 2751 Australia

Due to the shortages of natural sands along the east coast of Australia in particular and the need to fully utilise fines produced in quarry operations, progress has been made in utilising blends of manufactured sands and natural sands in concrete pavements. This paper documents some of the constraints in utilising larger proportions of manufactured sands in concrete pavements. These constraints are mainly caused by the current level of knowledge regarding the impact of manufactured sands on skid and abrasion resistance of concrete pavements. This paper presents a brief review of literature on this subject in the USA, France and uk. It also briefly documents work recently carried out in Australia by CCAA (Cement Concrete and Aggregates Australia), referring to the skid and abrasion resistance of concrete pavements using manufactured sands. The paper concludes that there is no relationship between the free silica content and the skid resistance. With regard to the abrasion resistance, it is rather the curing conditions and the compressive strength that are more important in achieving good results.

关键词：水泥混凝土路面澳大利亚人工砂二氧化硅含量混合生产知识水平路面防滑抗压强度

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Fungal diversity notes 603–708: taxonomic and phylogenetic notes on genera and species

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Fungal Diversity 2017年第6期87卷 1-235页

作者： Kevin D.Hyde Chada Norphanphoun Vanessa P.Abreu Anna Bazzicalupo K.W.Thilini Chethana Marco Clericuzio Monika C.Dayarathne Asha J.Dissanayake Anusha H.Ekanayaka Mao-Qiang He Sinang Hongsanan Shi-Ke Huang Subashini C.Jayasiri Ruvishika S.Jayawardena Anuruddha Karunarathna Sirinapa Konta Ivana Kusan Hyun Lee Junfu Li Chuan-Gen Lin Ning-Guo Liu Yong-Zhong Lu Zong-Long Luo Ishara S.Manawasinghe Ausana Mapook Rekhani H.Perera Rungtiwa Phookamsak Chayanard Phukhamsakda Igor Siedlecki Adriene Mayra Soares Danushka S.Tennakoon Qing Tian Saowaluck Tibpromma Dhanushka N.Wanasinghe Yuan-Pin Xiao Jing Yang Xiang-Yu Zeng Faten A.Abdel-Aziz Wen-Jing Li Indunil C.Senanayake Qiu-Ju Shang Dinushani A.Daranagama Nimali Ide Silva Kasun M.Thambugala Mohamed A.Abdel-Wahab Ali H.Bahkali Mary L.Berbee Saranyaphat Boonmee D.Jayarama Bhat Timur S.Bulgakov Bart Buyck Erio Camporesi Rafael F.Castaneda-Ruiz Putarak Chomnunti Minkwan Doilom Francesco Dovana Tatiana B.Gibertoni Margita Jadan Rajesh Jeewon E.B.Gareth Jones Ji-Chuan Kang Samantha C.Karunarathna Young Woon Lim Jian-Kui Liu Zuo-Yi Liu Helio Longoni Plautz Jr Saisamorn Lumyong Sajeewa S.N.Maharachchikumbura Neven Matocec Eric H.C.McKenzie Armin Mesic Daniel Miller Julia Pawłowska Olinto L.Pereira Itthayakorn Promputtha Andrea I.Romero Leif Ryvarden Hong-Yan Su Satinee Suetrong Zdenko Tkalcec Alfredo Vizzini Ting-Chi Wen Komsit Wisitrassameewong Marta Wrzosek Jian-Chu Xu Qi Zhao Rui-Lin Zhao Peter E.Mortimer Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand World Agroforestry Centre East and Central AsiaKunming 650201YunnanPeople’s Republic of China Mushroom Research Foundation 128 M.3 Ban Pa Deng T.Pa PaeA.Mae TaengChiang Mai 50150Thailand A.M.B Circolo Micologico“Giovanni Carini”C.P.314BresciaItaly A.M.B.Gruppo Micologico Forlivese“Antonio Cicognani”Via Roma 18Forlı`Italy Centre of Mountain Ecosystem Studies Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanPeople’s Republic of China College of Agriculture and Biological Sciences Dali UniversityDali 671003YunnanPeople’s Republic of China College of Life Sciences University of Chinese Academy of SciencesHuairou DistrictBeijing 100408China Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Department of Botany University of British ColumbiaVancouverCanada Department of Botany and Microbiology College of ScienceKing Saud UniversityP.O.Box:2455Riyadh 1145Saudi Arabia Department of Botany and Microbiology Faculty of ScienceSohag UniversitySohag 82524Egypt Department of Crop Sciences College of Agricultural and Marine SciencesSultan Qaboos UniversityP.O.Box 34123 Al-KhodOman Department of Entomology and Plant Pathology Faculty of AgricultureChiang Mai UniversityChiang Mai 50200Thailand Department of Health Sciences Faculty of ScienceUniversity of MauritiusReduit 80837Mauritius Department of Molecular Phylogenetics and Evolution Faculty of BiologyBiological and Chemical Research CentreUniversity of Warsaw_Zwirki i Wigury 10102-089 WarsawPoland Departamento de Micologia Centro de BiocienciasUniversidade Federal de PernambucoAv.da Engenharia s/nRecifePernambuco 50760-600Brazil Dipartimento

This is the sixth in a series of papers where we bring collaborating mycologists together to produce a set of notes of several taxa of *** this study we introduce a new family Fuscostagonosporaceae in *** also introduce the new ascomycete genera Acericola,Castellaniomyces,Dictyosporina and Longitudinalis and new species Acericola italica,Alternariaster trigonosporus,Amarenomyces dactylidis,Angustimassarina coryli,Astrocystis bambusicola,Castellaniomyces rosae,Chaetothyrina artocarpi,Chlamydotubeufia krabiensis,Colletotrichum lauri,Collodiscula chiangraiensis,Curvularia palmicola,Cytospora mali-sylvestris,Dictyocheirospora cheirospora,Dictyosporina ferruginea,Dothiora coronillae,Dothiora spartii,Dyfrolomyces phetchaburiensis,Epicoccum cedri,Epicoccum pruni,Fasciatispora calami,Fuscostagonospora cytisi,Grandibotrys hyalinus,Hermatomyces nabanheensis,Hongkongmyces thailandica,Hysterium rhizophorae,Jahnula guttulaspora,Kirschsteiniothelia rostrata,Koorchalomella salmonispora,Longitudinalis nabanheensis,Lophium zalerioides,Magnibotryascoma mali,Meliola clerodendri-infortunati,Microthyrium chinense,Neodidymelliopsis moricola,Neophaeocryptopus spartii,Nigrograna thymi,Ophiocordyceps cossidarum,Ophiocordyceps issidarum,Ophiosimulans plantaginis,Otidea pruinosa,Otidea stipitata,Paucispora kunmingense,Phaeoisaria microspora,Pleurothecium floriforme,Poaceascoma halophila,Periconia aquatica,Periconia submersa,Phaeosphaeria acaciae,Phaeopoacea muriformis,Pseudopithomyces kunmingnensis,Ramgea ozimecii,Sardiniella celtidis,Seimatosporium italicum,Setoseptoria scirpi,Torula gaodangensis and Vamsapriya *** also provide an amended account of Rhytidhysteron to include apothecial ascomata and a J?*** type species of Ascotrichella hawksworthii(Xylariales genera incertae sedis),Biciliopsis leptogiicola(Sordariomycetes genera incertae sedis),Brooksia tropicalis(Micropeltidaceae),Bryochiton monascus(Teratosphaeriaceae),Bryomyces scapaniae(Pseud

关键词： Ascomycota Basidiomycota Mucoromycota Phylogeny Taxonomy

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