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The impact of chemotherapy-naïve open radical cystectomy delay and perioperative transfusion on the recurrence-free survival: A perioperative parameters-based nomogram

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Asian Journal of Urology 2024年第2期11卷 294-303页

作者： Ahmed M.Harraz Ahmed Elkarta Mohamed H.Zahran Ahmed Mosbah Atallah A.Shaaban Hassan Abol-Enein Urology and nephrology center Mansoura UniversityEgypt

Objective: To develop and internally validate a nomogram to predict recurrence-free survival (RFS) including the time to radical cystectomy (RC) and perioperative blood transfusion (PBT) as potential ***: Patients who underwent open RC and ileal conduit between January 1996 to December 2016 were split into developing (n=948) and validating (n=237) cohorts. The time to radical cystectomy (TTC) was defined as the interval between the onset of symptoms and RC. The regression coefficients of the independent predictors obtained by Cox regression were used to construct the nomogram. Discrimination, validation, and clinical usefulness in the validation cohort were assessed by the area under the curve, the calibration plot, and decision curve ***: In the developing dataset, the 1-, 5-, and 10-year RFS were 83.0%, 47.2%, and 44.4%, respectively. On multivariate analysis, independent predictors were TTC (hazards ratio [HR] 1.07, 95% confidence interval [CI] 1.05-1.08, p<0.001), PBT (one unit: HR 1.40, 95% CI 1.03-1.90, p=0.03;two or more units: HR 1.72, 95% CI 1.29-2.29, p<0.001), bilateral hydronephrosis (HR 1.54, 95% CI 1.21-1.97, p<0.001), squamous cell carcinoma (HR 0.60, 95% CI 0.45-0.81, p=0.001), pT3-T4 (HR 1.77, 95% CI 1.41-2.22, p<0.001), lymph node status (HR 1.53, 95% CI 1.21-1.95, p<0.001), and lymphovascular invasion (HR 1.28, 95% CI 1.01-1.62, p=0.044). The areas under the curve in the validation dataset were 79.3%, 69.6%, and 76.2%, for 1-, 5-, and 10-year RFS, respectively. Calibration plots showed considerable correspondence between predicted and actual survival probabilities. The decision curve analysis revealed a better net benefit of the ***: A nomogram with good discrimination, validation, and clinical utility was constructed utilizing TTC and PBT in addition to standard pathological criteria.

关键词： Radicalcystectomy Blood transfusion Time to radical cystectomy Survival Nomogram

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The role of transcriptional factor D-site-binding protein in circadian CCL2 gene expression in anti-Thy1 nephritis

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Cellular & Molecular Immunology 2019年第9期16卷 735-745页

作者： Yang Lu Yan Mei Lei Chen Lingling Wu Xu Wang Yingjie Zhang Bo Fu Xizhao Chen Yuansheng Xie Guangyan Cai Xueyuan Bai Qinggang Li Xiangmei Chen Department of nephrology Chinese PLA General HospitalChinese PLA Institute of NephrologyState Key Laboratory of Kidney DiseasesNational Clinical Research Center for Kidney DiseasesBeijingChina

Mesangial proliferative glomerulonephritis(MsPGN)is an inflammatory disease,but both the nature of disease progression and its regulation remain *** the present study,we monitored the course of anti-Thy1 nephritis from days 1 to 5 and established gene expression profiles at each time point using microarrays to explore the development of *** to the gene expression profiles,macrophage infiltration(triggered by CCL2 activation)was evident on day 1 and enhanced inflammation over the next few *** screened for genes with expression levels similar to CCL2 and found that the upregulation of the circadian gene albumin D-site-binding protein(DBP)was involved in CCL2 activation in mesangial *** importantly,CCL2 expression showed oscillatory changes similar to DBP,and DBP induced peak CCL2 expression at 16:00 a clock on day 1 in the anti-Thy1 nephritis *** knocked down DBP through transfection with a small interfering RNA(siRNA)and used RNA sequencing to identify the DBP-regulated TNF-α-CCL2 *** performed chromatin immunoprecipitation sequencing(ChIP-Seq)and the dual luciferase assay to show that DBP bound to the TRIM55 promoter,regulating gene expression and in turn controlling the TNF-α-CCL2 *** conclusion,DBP-regulated circadian CCL2 expression by the TRIM55-TNF pathway in injured mesangial cells at an early stage,which promoted macrophage recruitment and in turn triggered infiltration and inflammation in a model of anti-Thy1 nephritis.

关键词： Mesangial proliferative glomerulonephritis DBP CCL2 Trim 55 Macrophage

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Emerging approaches and technologies in transplantation:the potential game changers

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Cellular & Molecular Immunology 2019年第4期16卷 334-342页

作者： Anil Dangi Shuangjin Yu Xunrong Luo Division of nephrology Department of MedicineDuke University Medical CenterDurhamNCUSA Duke Transplant center Duke University Medical CenterDurhamNCUSA

Newly emerging technologies are rapidly changing conventional approaches to organ *** the modern era,the key challenges to transplantation include(1)how to best individualize and possibly eliminate the need for life-long immunosuppression and(2)how to expand the donor pool suitable for human *** article aims to provide readers with an updated review of three new technologies that address these ***,single-cell RNA sequencing technology is rapidly evolving and has recently been employed in settings related to *** new sequencing data indicate an unprecedented cellular heterogeneity within organ transplants,as well as exciting new molecular signatures involved in alloimmune ***,sophisticated nanotechnology platforms provide a means of therapeutically delivering immune modulating reagents to promote transplant *** nanoparticles with regulatory molecules and donor antigens are capable of targeting host immune responses with tremendous precision,which,in some cases,results in donor-specific ***,CRISPR/Cas9 gene editing technology has the potential to precisely remove immunogenic molecules while inserting desirable regulatory *** technology is particularly useful in generating genetically modified pigs for xenotransplantation to solve the issue of the shortage of human ***,these new technologies are positioning the transplant community for major breakthroughs that will significantly advance transplant medicine.

关键词： Transplantation Single cell sequencing Crisper Cas9 Nanotechnology

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Microplastic and nanoplastic exposure and risk of diabetes mellitus

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World Journal of Clinical Cases 2025年第3期13卷 24-29页

作者： Hui-Yi Hsiao Chung-Yi Nien Ruei-Feng Shiu Wei-Chun Chin Tzung-Hai Yen Department of Biomedical Sciences College of MedicineChang Gung UniversityTaoyuan 33302TaiwanChina center for Tissue Engineering Chang Gung Memorial HospitalLinkouTaoyuan 33305TaiwanChina Department of Life Sciences National Central UniversityZhongli 320317TaoyuanTaiwanChina center of Excellence for The Oceans Taiwan Ocean UniversityKeelung 20224TaiwanChina Institute of Marine Environment and Ecology Taiwan Ocean UniversityKeelung 20224TaiwanChina Department of Chemical and Materials Engineering University of California MercedMercedCA 95343United States Department of nephrology Clinical Poison CenterChang Gung Memorial HospitalLinkou 33305TaoyuanTaiwanChina School of Traditional Chinese Medicine College of MedicineChang Gung UniversityTaoyuan 33302TaiwanChina

The issue of plastic pollutants has become a growing *** microplastics(MPs)(particle size<5 mm)and nanoplastics(NPs)(particle size<1μm)can cause DNA damage,cytotoxicity,and oxidative stress in various *** primary known impacts of microplastic/nanoplastic are observed in the liver and respiratory system,leading to hepatotoxicity and chronic obstructive pulmonary *** research on the effects of MPs and NPs on diabetes is still in its early stages,there are potential *** editorial highlights the risk to diabetics from co-exposure to contaminants and MPs/NPs,supported by evidence from animal studies and the various chemical compositions of MPs/NPs.

关键词： Microplastics Nanoplastics Plastic pollution,Diabetes mellitus Insulin resistance

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A bioactive composite hydrogel dressing that promotes healing of both acute and chronic diabetic skin wounds

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Bioactive Materials 2024年第4期34卷 298-310页

作者： Shunlai Shang Kaiting Zhuang Jianwen Chen Ming Zhang Shimin Jiang Wenge Li Department of nephrology China-Japan Friendship HospitalBeijingChina Department of nephrology First Medical Center of Chinese PLA General HospitalNephrology Institute of the Chinese People’s Liberation ArmyNational Key Laboratory of Kidney DiseasesNational Clinical Research Center for Kidney DiseasesBeijing Key Laboratory of Kidney Disease ResearchBeijing100853China Department of nephrology Affiliated Beijing Chaoyang Hospital of Capital Medical UniversityBeijing100020China

Mesenchymal stem cell derived exosomes(MSC-Exos)demonstrate beneficial effects on wound healing via anti-inflammatory and angiogenic ***(CS)exhibits excellent biocompatibility and accelerates cellular migration,adhesion,and *** ions released from bioactive glass(BG)and titanium dioxide(TiO_(2))nanoparticles exhibit sustained angiogenic and antibacterial *** this study,CMCS-CEBT hydrogel was synthesized from exosomes encapsulated carboxymethyl chitosan(CMCS),chitosan nanoparticles(CS-NPs),BG,and TiO_(2)nanoparticles for a preliminary evaluation of its impacts on the treatment of full-thickness skin defects,diabetic wounds,and burn skin injury due to *** vitro analysis indicated that the hydrogel exhibits excellent cell compatibility,stimulates endothelial cell adhesion and proliferation,and presents anti-inflammatory,angiogenic,and antibacterial *** vivo,the composite hydrogel dressing accelerated a wound healing acceleration effect,stimulated angiogenesis,and increased collagen deposition and the expression of anti-inflammatory *** innovative composite hydrogel dressing as a potential clinical therapy,utilizing bioactive materials,holds promise as a potential clinical therapy that aims to facilitate the regeneration of acute and chronically damaged skin tissue.

关键词： Exosomes Bioactive glass Diabetic wound Anti-inflammatory Titanium dioxide

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Successful treatment of pyoderma gangrenosum with concomitant immunoglobulin A nephropathy: A case report and review of literature

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World Journal of Clinical Cases 2018年第13期6卷 703-706页

作者： Xiao-Li Li Zhi-Gang Ma Wen-Hui Huang Er-Qing Chai Yun-Fei Hao Department of nephrology Gansu Provincial Hospital Cerebrovascular Disease center Gansu Provincial Hospital

Pyoderma gangrenosum(PG)is an uncommon ulcerative cutaneous condition of an unknown etiology and is often associated with immune ***,PG rarely shows visceral involvement,especially in the kidney.A 20-year-old female presented with pedal edema and skin ulceration of both lower *** skin lesion began as an erythematous plaque and then became a *** also complained of abdominal distension and a decreasing urine *** data showed high proteinuria,hypoalbuminemia and *** skin and kidney were *** pathological results indicated PG and immunoglobulin A(IgA)*** patient was finally cured with prednisolone in combination with cyclosporine A(CsA).

关键词： Pyoderma gangrenosum Immunoglobulin A nephropathy Treatment

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Renal aspergillosis in a liver transplant patient: A case report and review of literature

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World Journal of Clinical Cases 2018年第16期6卷 1155-1159页

作者： Brigita Smolovic Batric Vukcevic Damir Muhovic Marina Ratkovic Faculty of Medicine University of Montenegro Department of Gastroenterohepatology Clinical Center of Montenegro Department of nephrology and Hemodialysis Clinical Center of Montenegro

BACKGROUND Aspergillosis is a frequent invasive fungal infection in liver recipients(affecting 1%-9.2% of all patients), second only to candidiasis. Significant risk factors for invasive aspergillosis in liver recipients include corticosteroid therapy, neutropenia, T-cell dysfunction, renal failure and requirement for renal replacement therapy. Aspergillus infection usually affects the lungs of liver recipients, with hematogenous dissemination occurring in 50%-60% of cases. Renal involvement is rare and is considered to occur in 0.4% of all cases of invasive *** SUMMARY This paper describes a case of a liver recipient presenting with a newly formed renal mass a year after liver transplantation. The patient underwent liver transplantation due to alcoholic liver cirrhosis, with preoperative corticosteroid therapy and postoperative immunosuppressants(tacrolimus and mycophenolate mofetil). His 1-year follow-up was uneventful, with a satisfying graft function and lack of any symptoms. During a routine follow-up abdominal ultrasound, he was diagnosed with a renal tumor. The renal ima-ging findings were inconclusive(with a differential diagnosis to renal cell carcinoma), while the computed tomography(CT) of the chest showed scar tissue in the lungs suggestive of previous inflammation. The patient underwent radical nephrectomy, with histopathological analysis showing renal aspergilloma, yielding postoperative treatment with voriconazole. His follow up was uneventful, and the chest CT did not show any change in pulmonary lesions. This case illustrates the possibility of aspergillosis affecting the lungs of liver recipients, subsequently affecting the kidney and forming an *** Clinicians should be aware of aspergilloma mimicking solid organ tumors in organ recipients.

关键词： Aspergillosis Immunosuppression Liver transplantation Nephrectomy Renal tumor Case report

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Harnessing endothelial cells and vascularization strategies for nerve regeneration

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Neural Regeneration Research 2024年第11期19卷 2337-2338页

作者： Papon Muangsanit Poppy Smith Virology and Cell Technology Research Team National Center for Genetic Engineering and Biotechnology(BIOTEC)National Science and Technology Development Agency(NSTDA)PathumthaniThailand ucl Centre for Nerve Engineering UCLLondonUK Department of Pharmacology UCL School of PharmacyUCLLondonUK

Peripheral nerves are essential components of the human body’s communication system,transmitting signals between the central nervous system and various body *** resulting from trauma or disease can result in debilitating sensory and motor *** injuries,particularly those resulting in significant gaps in the nerve tissue,pose a formidable challenge for clinicians and *** their limitations,including limited availability and donor site morbidity,nerve autografts remain the clinical gold standard for treating nerve injuries.

关键词： injuries nerves donor

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Acellular fish skin grafts in diabetic foot ulcer care:Advances and clinical insights

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World Journal of Diabetes 2025年第1期16卷 34-38页

作者： Yu Zhao Quan-Quan Shen Geriatric Medicine center Department of EndocrinologyZhejiang Provincial People's Hospital(Affiliated People's Hospital)Hangzhou Medical CollegeHangzhou 310014Zhejiang ProvinceChina Department of nephrology Zhejiang Provincial People’s Hospital Bijie HospitalBijie 551700Guizhou ProvinceChina Urology&nephrology center Department of NephrologyZhejiang Provincial People's Hospital(Affiliated People's HospitalHangzhou Medical College)Hangzhou 310014Zhejiang ProvinceChina

Diabetic foot ulcers(DFUs)represents a significant public health issue,with a rising global prevalence and severe potential complications including *** treatments often fall short due to various limitations such as high recurrence rates and extensive resource *** editorial explores the innovative use of acellular fish skin grafts as a transformative approach in DFU *** studies and a detailed case report highlight the efficacy of acellular fish skin grafts in accelerating wound closure,reducing dressing changes,and enhancing patient outcomes with a lower socio-economic *** their promise,challenges such as limited availability,patient acceptance,and the need for further research *** these through more extensive randomized controlled trials and fostering a multidisciplinary treatment approach may optimize DFU care and reduce the global health burden associated with these complex wounds.

关键词： Diabetic foot ulcer Acellular matrix tissues Acellular fish skin grafts Wound healing Bioengineered materials

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Can non-invasive measurements aid clinical assessment of volume in patients with cirrhosis?

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World Journal of Hepatology 2013年第8期5卷 433-438页

作者： Andrew Davenport Banwari Argawal Gavin Wright Konstantinos Mantzoukis Rumyana Dimitrova Joseph Davar Panayota Vasianopoulou Andrew K Burroughs ucl center for nephrology Royal Free Hospital Intensive care Unit Royal Free Hospital Sheila Sherlock centre for hepatic diseases Royal Free Hospital Department of Cardiology Royal Free Hospital

AIM:To evaluate the non-invasive assessments of volume status in patients with ***:Echocardiography and multifrequency bioimpedance analysis measurements and short synacthen tests were made in 20 stable and 25 acutely decompensated patients with ***:Both groups had similar clinical assessments,cortisol response and total body water(TBW),however the ratio of extracellular water(ECW)/TBW was significantly greater in the trunk(0.420±0.004 vs0.404±0.005),and limbs(R leg 0.41±0.003 vs 0.398±0.003,P<0.05,and L leg 0.412±0.003 vs 0.399±0.003)with decompensated cirrhosis compared to stable cirrhotics,P<0.05).Echocardiogram derived right atrial and ventricular filling and end diastolic pressures and presence of increased left ventricular end diastolic volume and diastolic dysfunction were similar in both *** decompensated group had lower systemic blood pressure,mean systolic 101.8±4.3 vs122.4±5.3 and diastolic 58.4±4.1 mmHg vs 68.8±3.1 mmHg respectively,P<0.01,and serum albumin30(27-33)vs 32(31-40.5)g/L,P<***:Decompensated cirrhotics had greater leg and truncal ECW expansion with lower serum albumin levels consistent with intravascular volume depletion and increased vascular permeability.

关键词： Cirrhosis Bioimpedance Echocardiography Extracellular water Ascites Cortisol

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