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中国饲料 2002年第9期 23-25页

作者：常碧影宋荣丁永胜廖志勇国家饲料质量监督检验中心中国科学院生态环境研究中心 ucb

氯化胆碱（Choline Choride）化学名称为2-羟乙基-三甲基胺盐酸盐,是动物生长不可缺少的一种水溶性维生素,在动物体内起着极其重要的作用。它是构成卵磷脂和鞘磷脂（构成体内磷脂的70％-80％）以及乙酰胆碱的主要成分。

关键词：饲料添加剂氯化胆碱测定国家标准中国

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Facile Synthesis of 7-epi-Taxane and Its Derivatives and Preliminary Evaluation of Anticancer Activity

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Chinese Journal of Chemistry 2016年第11期34卷 1165-1176页

作者： Zhao Li Jia Feng Kun Zou Zhuo Yang Yong Zhang Zhijian Xu Bo Li Jiye Shi Yiming Li Weiliang Zhu Kaixian Chen School of Pharmacy Shanghai University of Traditional Chinese Medicine Shanghai 201203 China CAS Key Laboratory of Receptor Research Drug Discovery and Design Centre Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 China Nano Science and Technology Institute University of Science and Technology of China Suzhou Jiangsu 215123 China ucb Biopharma SPRL Chemin du Foriest Braine-l'Alleud Belgium Kellogg College University of Oxford 60-62 Banbury Road Oxford OX2 6PN United Kingdom

7-epi-Taxane has been achieved efficiently in gram scale from natural taxane via inversion of the 7-hydroxyl group simply using Ag20 as catalyst and DMF as solvent. The catalyst could he quantitatively recovered by filtra- tion without loss of catalytic activity. This condition is also applicable to the direct epimerization of taxane derivatives （e.g., docetaxel and paclitaxel） to 7-epi-taxane derivatives （e.g., 7-epi-docetaxel and 7-epi-paclitaxel）. Furthermore, 33 ester derivatives of 7-epi-taxane with different amino acid moieties at the position of C-13 were successfully synthesized via esterification without protecting C-7-OH. Bioassay results revealed that compounds 13 and 18 have good selectivity against prostatic cancer cell line DU145, with ICs0 value as low as 15.9 nmol/L for 18.

关键词： taxane 7-epi-taxane silver oxide amino acid C-13 derivative of taxane anticancer activity

Comparison of clinical outcomes between unrelated single umbilical cord blood and"ex-vivo"T-cell depleted haploidentical transplantation in children with hematological malignancies

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World Journal of Pediatrics 2021年第6期17卷 609-618页

作者： Carmen Gomez-Santos Marta Gonzalez-Vicent Blanca Molina Natalia Deltoro Blanca Herrero Julia Ruiz Antonio Perez-Martinez Miguel A Diaz Department of Pediatrics Hematopoietic Stem Cell Transplantation UnitHospital Infantil Universitario"Nino Jesus"Menedez Pelayo 6528009 MadridSpain Hospital Infantil Universitario"La Pa"Madrid MadridSpain

Background Over the last two decades,umbilical cord blood(ucb)and haploidentical transplantation(HaploHSCT)have emerged as alternative sources of hematopoietic stem cell for allogeneic *** are few retrospective studies and no prospective studies comparing both types of alternative transplantation in pediatric *** We analyzed the data of 134 children with hematological malignancies who received a hematopoietic stem cell transplantation from a single umbilical cord blood(ucb)(n=42)or an"tex-vivo"T-cell depleted transplant from a haploi-dentical-related donor(HaploHSCT)(n=92)between 1996 and *** recovery was faster after HaploHSCT than the ucb transplant group(median times to neutrophil and platelet recovery:13 vs.16 days,10 vs.57 days,respectively)(Pucb ***,after the first year *** had a lower number of CD4+ T and B lymphocytes compared with the ucb transplant *** cumulative incidence of TRM was 29±8%in the HaploHSCT group versus 40±5%in the ucb *** incidence was 21±7%in the HaploHSCT group and 19±8%in the ucb *** of DFS was 58±8%in the HaploHSCT group versus 40±9%in the ucb group(P=0.051).Conclusions TCD haploidentical transplant is associated with advantages in terms of engraftment and early immune reconstitution *** haploidentical transplant was associated with lower incidence of infectious and non-infectious complications,especially in the early phases of the transplant compared with ucb transplant ***,there are no advantages in transplant outcomes compared with ucb transplant.

关键词： Children Cord blood transplant Hematologic malignancies Immune reconstitution TCD haploidentical transplant

在中国使用左乙拉西坦和卡马西平单药治疗部分性癫痫发作的比较:一项开放性、非劣效性试验的主要结果

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临床神经病学杂志 2020年第5期33卷 321-327页

作者：廖卫平周东 Toru Osakabe Christian Loesch 杜新鲁 Frank Tennigkeit 王学峰广州医科大学附属第二医院神经内科 510260 四川大学华西医院神经内科日本东京ucb Pharma 德国蒙海姆ucb Pharma 中国香港ucb Pharma 重庆医科大学附属第一医院神经内科

目的针对≥16岁、新诊断或最近诊断为部分性癫痫发作的中国患者,比较左乙拉西坦和速释卡马西平(CBZ-IR)单药治疗的疗效。方法在Ⅲ期、随机分配、开放性试验N01364(NCT01954121)中,患者按1∶1的比例随机分配接受左乙拉西坦1 000 mg/d或CB... 详细信息

目的针对≥16岁、新诊断或最近诊断为部分性癫痫发作的中国患者,比较左乙拉西坦和速释卡马西平(CBZ-IR)单药治疗的疗效。方法在Ⅲ期、随机分配、开放性试验N01364(NCT01954121)中,患者按1∶1的比例随机分配接受左乙拉西坦1 000 mg/d或CBZ-IR 400 mg/d,记录6个月无癫痫发作的患者比例及患者保留率、首次癫痫发作的时间、因不良事件或缺乏疗效导致首次癫痫发作/中止试验的时间、安全性和耐受性。结果在对符合方案集进行的分析中,接受左乙拉西坦治疗的186例患者中有88例(47.3%),接受CBZ-IR治疗的171例患者中有117例(68.4%)达到6个月无癫痫发作;校正后绝对差值为-22.9%(95%CI:-33.1%,-12.6%),其下限低于非劣效性界值-20%。左乙拉西坦组的患者保留率为48.4%,CBZ-IR组为70.2%。对于评估期首次癫痫发作时间,左乙拉西坦与CBZ-IR的风险比为2.686(95%CI:1.838,3.927);对于因不良事件或缺乏疗效导致首次癫痫发作/中止试验的时间,风险比为2.338(95%CI:1.629, 3.356)。使用左乙拉西坦在治疗中出现的不良事件(61.9%)略低于CBZ-IR(67.9%)。结论在低剂量单药治疗下,无法确定左乙拉西坦的疗效不低于CBZ-IR。左乙拉西坦的安全性/耐受性情况优于CBZ-IR。

关键词：卡马西平疗效部分性癫痫发作左乙拉西坦安全性/耐受性

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情绪与高低温复合应激中细胞乳酸脱氢酶和肌酸磷酸激酶的释放

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基础医学与临床 1984年第Z1期 105-106页

作者：刘克嘉,B.W.Grunbaum 航天医学工程研究所 Environmental Physiolgy Laboratory ucb USA

本实验目的:研究情绪引起的血浆酶的升高的组织来源;用高温低温与情绪结合加大刺激后是否会涉及更多组织的酶的释放。第一步实验用灵长类动物——8只猪尾猴(macaca memestrina)分别束缚在椅上8小时,动物表现强烈的紧张与挣扎。在实验中... 详细信息

本实验目的:研究情绪引起的血浆酶的升高的组织来源;用高温低温与情绪结合加大刺激后是否会涉及更多组织的酶的释放。第一步实验用灵长类动物——8只猪尾猴(macaca memestrina)分别束缚在椅上8小时,动物表现强烈的紧张与挣扎。在实验中及实验后的3日内间断地取血测定LDH同功

关键词： LDH CPK 实验结果情绪动物

超重和肥胖者的血管内皮NAD(P)H氧化酶-p47^(phox)表达增加并有内皮氧化应激的证据

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世界核心医学期刊文摘（心脏病学分册） 2007年第7期3卷 36-37页

作者： Silver A.E. Beske S.D. Christou D.D. D.R. Seals 徐永城 Department of Integrative Physiology University of Colorado at Boulder UCB 354 Boulder CO 80309 United States Dr.

背景：肥胖可改变一些分子的血管内皮细胞蛋白表达（VECPE），从而影响对动脉粥样硬化的易感性。方法和结果：研究对象为无其他临床疾病、肥胖程度不同的108例男女性受试者（体重指数18．4～36．7kg／m^2；总体脂肪5．8～55．0kg；腰围6... 详细信息

背景：肥胖可改变一些分子的血管内皮细胞蛋白表达（VECPE），从而影响对动脉粥样硬化的易感性。方法和结果：研究对象为无其他临床疾病、肥胖程度不同的108例男女性受试者（体重指数18．4～36．7kg／m^2；总体脂肪5．8～55．0kg；腰围63．0～122．9em），用定量免疫荧光法检测其血管内皮细胞。所有3种肥胖状况的表达方式均与氧化酶亚单位NAD（P）H氧化酶-p47[部分相关系数（rpart）=0．22～0．24，所有P〈0．05]和抗氧化酶过氧化氢酶（rpart=0．71～0．75，所有P〈0．001）的VECPE呈正相关。

关键词： NAD(P)H氧化酶血管内皮细胞肥胖者氧化应激证据超重动脉粥样硬化部分相关系数

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Rare Primary Diffuse Large B-Cell Lymphoma of a Male Breast

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Case Reports in Clinical Medicine 2021年第4期10卷 99-107页

作者： Hani Alothaid Umama Yezdani Mahmoud M. Habibullah Saad Saeed Alamri Mazen M. Ghaith Mohammad Gayoor Khan Department of Basic Medical Sciences Faculty of Applied Medical Sciences Al-Baha University Al-Baha Saudi Arabia Department of Pharmacy Practice MRM College of Pharmacy Hyderabad India Medical Laboratory Technology Department Faculty of Applied Medical Sciences Jazan University Jazan Saudi Arabia Research Center King Fahad Medical City Riyadh Saudi Arabia Laboratory Medicine Department Faculty of Applied Medical Science Umm Al-Qura University Makkah Saudi Arabia ucb unit Department of Pharmacovigilance Bioclinica Mysore India

Background: Breast lymphomas are typical extranodal types of lymphoma, also known as Extranodal-lymphoma (ENL), which occur extremely infrequently, aggregating into a very small proportion of malignant breast tumors. The rarity of breast lymphomas is attributed to the scant lymphoid tissue content of the chest wall. Aims of Study: This case report is aimed at providing an up-to-date review of the literature on breast lymphomas for clinicians to, therefore, consider the possibility of this disease entity while treating a breast mass. Case Presentation: A case was reported of a 52-year man with chief mammary non-Hodgkin breast ENL when fine-needle aspiration cytology (FNAC) was not leading to a firm conclusion or result. Following an incisional biopsy, he was found to have a primary breast lymphoma. Later, the patient was diagnosed with the diffuse large B-cell type of lymphoma also known as non-Hodgkin’s Lymphoma (NHL). He had a complete reduction and disappearances of all the signs and symptoms of the disease after a course of neoadjuvant chemotherapy: Cyclophosphamide, Doxorubicin, Vincristine and Prednisolone (CHOP). CONCLUSION: Based on the above case presentation, it is vital for health care professionals and oncologists to recognize the disease by assessing the breast mass accurately with more entities so that proper diagnosis via core biopsy (incisional biopsy) can eliminate the PBL before further treatment is required.

关键词： Non-Hodgkin’s Lymphoma PBL B-Cell Lymphoma Breast Cancer CHOP ENL

Dimensions of Access to Antihypertensive Medications in Ceilandia,Distrito Federal,Brazil

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Health 2015年第11期7卷 1517-1526页

作者： Fabiana Xavier Cartaxo Salgado Dayani Galato Gislane Ferreira de Melo Marileusa Dosolina Chiarello Aline Gomes de Oliveira Letícia Farias Gerlack Micheline Marie Milward de Azevedo Meiners Margo Gomes de Oliveira Karnikowski Graduate Program in Health Sciences and Technology Campus of CeilandiaUniversity of Brasília(FCE/UnB)BrasíliaBrazil Graduate Program in Gerontology Catholic University of Brasília(UCB)BrasíliaBrazil Graduate Program in Public Health University of Brasília(UnB)BrasíliaBrazil

Access can be understood as the sum of a number of elements of the interface between patients and the health care system. This study took a comprehensive approach to the dimensions of access to medications, employing indicators to evaluate the dimensions of access to antihypertensive medications in Ceilandia, DF, Brazil. This was a cross-sectional epidemiological study, administering questionnaires during home visits. The survey covered epidemiological and socioeconomic profiles, behavioral habits and the dimensions of access to antihypertensive medications comprising physical, financial, and geographic availability and accept ability according to the hypertensive population of Ceilandia. The total sample comprised 400 individuals and the hypertensive subset numbered 140 (35%). Indicators of physical availability of medications revealed that users found it difficult to acquire their drugs on almost one third of occasions and in some cases were unable to access any of these products. The greatest barriers to access were reported by users of pharmacies belonging to the Brazilian National Health Service (SUS) and on the “People’s Pharmacies” network. More than one third of the hypertensive sample spent their own money on medications they could not find at these pharmacies. The majority of the hypertensive subsets were overweight/obese, a minority engaged in physical activity and 40% were smokers/ex-smokers. More women reduced their salt intake. Men had higher incomes, educational level, and socioeconomic status. Failure to keep the public health care system supplied has prejudiced access to essential medications for hypertension treatment, transferring the costs onto users. This population has lifestyle habits that increase the risk of exacerbation of hypertension. These results reveal a need for effective public policies to ensure access to antihypertensive medications and involve users of the health care system in changing their habits and behaviors in order to achie

关键词： Health Care Access Systemic Arterial Hypertension Drug Treatments

Vadose Zone Heterogeneity Effect on Unsaturated Water Flow Modeling at Meso-Scale

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Journal of Water Resource and Protection 2015年第4期7卷 353-368页

作者： Artur Paiva Coutinho Laurent Lassabatere Thierry Winiarski Jaime Joaquim da Silva Pereira Cabral Antonio Celso Dantas Antonino Rafael Angulo-Jaramillo LEHNA UMR 5023 CNRS ENTPE UCB-Lyon-1 Vaulx-en-Velin France Universidade Federal de Pernambuco Centro de Tecnologia e Geociências Programa de Pós Graduacao em Engenharia Civil/Tecnologia Ambiental e Recursos Hídricos Recife Brasil

The understanding of unsaturated flow in heterogeneous formations is a prerequisite to the understanding of pollutant transfer in the vadose zone and the proper management of infiltration basins settled over such heterogeneous formations. This study addresses the effect of lithological heterogeneity of a glaciofluvial deposit on flow in the vadose zone underneath an infiltration basin settled in the Lyon suburbs. The basin had already been the subject of several previous studies, some of which demonstrated the impact of soil heterogeneity. But all of them were only based on the sedimentological study of a trench and no study addressed the potential spatial variability of results due to the spatial variability of soil heterogeneity. In this study, we model flow in the vadose zone for several case studies, including drainage, water infiltration during a rainfall event, and a complete meteorological chronic. These calculations were conducted for several sections, previously characterized in the basin using GPR and sedimentological study and compared with a blank (homogeneous section). The results clearly show that heterogeneity impacts unsaturated flow and that these impacts depend upon the section considered. Some geometrical architectural and textural parameters were proposed to explain the spatial variability and effect of the soil heterogeneity on unsaturated flow, thus establishing the first step towards modeling unsaturated flow in the basin at the meso-scale.

关键词： Architectural and Structural Indicators Ground Penetration Radar Numerical Modeling Preferential Flow Structural Heterogeneity Unsaturated Flow