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Neural Regeneration Research 2025年第9期20卷 2581-2582页

作者： Marianne Bardy-Lagarde Narimène Asbelaoui Abdel Mouman Ghoumari uMR1195 “Diseases and Hormones of the Nervous System”Inserm and University Paris-SaclayKremlin-BicêtreFrance

Multiple sclerosis(MS)is the most common chronic disease of the central nervous system(CNS)in young adults and represents the first cause of severe handicap,originally non-traumatic(Oh et al.,2018).MS is chara cterized by the infiltration of auto reactive lymphocytes specific to myelin through the blood-brain barrier,which results in the appearance of inflammatory demyelinating lesions caused by the death of the central nervous system myelinating cells,oligodendrocytes(Oh et al.,2018).There is a prevalence sexual with a ratio of three times more affected women than men.

关键词： myelin CXCR4

Activity-dependent mechanisms of neuroprotection:promising avenues against dementia

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Neural Regeneration Research 2024年第7期19卷 1409-1410页

作者： Davide Tampellini u1195 INSERM-universitéParis-Saclay Le Kremlin-BicêtreFrance Institut Professeur Baulieu Le Kremlin-BicêtreFrance

The study of the brain and its complex functions is highly fascinating and,at the same time,extremely ***,furthering our understanding of the biology of neurons and synapses is a prerequisite to uncover the mechanisms involved in memory formation and the coordination of movement as well as their alterations occurring in several neurological disorders.

关键词： alterations mechanisms neurological

Comparison of the Nerve Regeneration Capacity and Characteristics between Sciatic Nerve Crush and Transection Injury Models in Rats

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Biomedical and Environmental Sciences 2023年第2期36卷 160-173页

作者： WANG Bin Bin GuO Chao SuN Sheng Qiao ZHANG Xing Nan LI Zhen LI Wei Jie LI De Zhi SCHuMACHER Michael LIu Song Beijing Neurosurgical Institute Capital Medical UniversityBeijing 100070China Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China u1195 Inserm et Universite Paris-SaclayLe Kremlin-Bicetre 94276France

Objective To provide useful information for selecting the most appropriate peripheral nerve injury model for different research purposes in nerve injury and repair studies,and to compare nerve regeneration capacity and characteristics between *** Sixty adult SD rats were randomly divided into two groups and underwent crush injury alone(group A,n=30)or transection injury followed by surgical repair(group B,n=30)of the right hind *** group was subjected to the CatWalk test,gastrocnemius muscle evaluation,pain threshold measurement,electrophysiological examination,retrograde neuronal labeling,and quantification of nerve regeneration before and 7,14,21,and 28 days after *** Gait analysis showed that the recovery speed in group A was significantly faster than that in group B at 14 *** 21 days,the compound muscle action potential of the gastrocnemius muscle in group A was significantly higher than that in group B,and the number of labeled motor neurons in group B was lower than that in group *** number of new myelin sheaths and the g-ratio were higher in group A than in group *** was a 7-day time difference in the regeneration rate between the two injury *** The regeneration of nerve fibers was rapid after crush nerve injury,whereas the transection injury was relatively slow,which provides some ideas for the selection of clinical research models.

关键词： Sciatic nerve injury Degeneration Regeneration Myelination

Light-controlled phosphorylation in the TrkA-Y785 site by photosensitive uAAs activates the MAPK/ERK signaling pathway

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BIOCELL 2023年第6期47卷 1377-1388页

作者： SHu ZHAO SHIXIN YE School of Life Sciences Nantong UniversityNantong226019China Institute National de la Sante et de la Recherche Medicale(INSERM)u1195 Bicetre HospitalParis-Saclay UniversityLe Kremlin-Bicêtre94276France

Background:This paper aims to establish a light-controlled phosphorylation detection method at the Y785 site of tropomyosin receptor kinase A(TrkA)receptor in mammalian cells by using genetic code expansion technology and detecting the effects of optical activation of this site on the downstream MAPK/ERK *** study is based on the current situation that the regulatory mechanism of TrkA phosphorylation has not been fully ***:Two photosensitive unnatural amino acids,p-azido-L-phenylalanine(AzF)and photo-caged tyrosine(ONB)were introduced into the TrkA-Y785 site by genetic code expansion technology and site-directed *** blotting and laser confocal imaging were conducted to analyze the effects of this site on activating the MAPK/ERK pathway and nerve cell differentiation before and after ***:Our results supplemented the light-controlled results of the TrkA-Y785 site based on our previous research and verified that Y785 also makes important contributions in regulating the MAPK/ERK ***:This study demonstrated the significant contributions of the TrkAY785 site in regulating the ERK pathway by precisely controlling the phosphorylation state of a single tyrosine site.

关键词： Tropomyosin receptor kinase A Genetic code expansion Y785 P-azido-L-phenylalanine Photo-caged tyrosine

Translational machinery and translation regulation in axon regeneration

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Neural Regeneration Research 2025年第5期20卷 1392-1394页

作者： Homaira Nawabi Stephane Belin univ.Grenoble Alpes InsermU1216Grenoble Institut NeurosciencesGrenobleFrance

Over the centuries,the regeneration field has been puzzled by the dual response of the central nervous system(CNS-brain,spinal cord,cranial nervesⅠandⅡ)and the peripheral nervous system(PNS that refers to all the nerves that innervate muscles,skin,organs,bones among others).Even Ramon y Cajal had noticed that an injury to the PNS often leads to axon regrowth,in contrast to the CNS.

关键词： nerves organs muscles

Central role of altered phosphodiesterase 2-dependent signaling in the pathophysiology of cognition-based brain disorders

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Neural Regeneration Research 2025年第8期20卷 2302-2303页

作者： Asma Boulksibat Alessandra Tempio Barbara Bardoni Institut de Pharmacologie Moléculaire et Cellulaire CNRS UMR7275Inserm U1323ValbonneFrance

The second messengers 3',5'-cyclic adenosine monophosphate(cAMP)and 3',5'-cyclic guanosine monophosphate(cGMP)modulate molecular pathways that are involved in a large variety of cellular *** the brain,these processes include neurogenesis,neuronal differentiation,activation and function of microglia,and synaptic plasticity,finally resulting in memory formation.

关键词： formation processes finally

Multi-quasiparticle excitations in ^(145)Tb

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Science China(Physics,Mechanics & Astronomy) 2004年第5期47卷 561-570页

作者： T. Hayakawa M. Oshima T. Toh T. Shizuma J. Katakura Y. Hatsukawa M. Matsuda H. Kusakari M. Sugawara Japan Atomic Energy Research Institute Tokai Ibaraki 319-1195 JapanJapan Atomic Energy Research Institute Tokai Ibaraki 319-1195 JapanJapan Atomic Energy Research Institute Tokai Ibaraki 319-1195 JapanJapan Atomic Energy Research Institute Tokai Ibaraki 319-1195 JapanJapan Atomic Energy Research Institute Tokai Ibaraki 319-1195 JapanJapan Atomic Energy Research Institute Tokai Ibaraki 319-1195 JapanJapan Atomic Energy Research Institute Tokai Ibaraki 319-1195 JapanChiba University Inage-ku Chiba 263-8512 JapanChiba Institute of Technology Narashino Chiba 275-0023 Japan

High-spin states in 145Tb have been populated using the 118Sn (32S, 1p4n) reaction at beam energy of 165 MeV. The level scheme of 145Tb has been established up to Ex ≈7.4 MeV. The level scheme shows characteristics of a spherical or slightly oblate nucleus. Based on the systematic trends of the level structure in the neighboring N = 80 isotones, the level structure in 145Tb below 2 MeV excitation is well explained by coupling an h11/2valence proton to the even-even 144Gd core. Above 2 MeV excitation, most of the yrast levels are interpreted with multi-quasiparticle shell-model configurations.

关键词： high-spin states, level scheme, multi-quasiparticle excitations.

Climate Change:No Going Back

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China Today 2025年第1期74卷 42-44页

作者： ROBERT WALKER Beijing Normal university Royal Society of Arts Academy of Social Sciences in the u.K

With a commitment to reduce emissions,and its investment in green technology bringing down global costs,China is emerging as the leader in fighting climate *** knows that our world is getting *** also know *** out po... 详细信息

关键词： investment bringing fighting

Advancing healthcare through laboratory on a chip technology:Transforming microorganism identification and diagnostics

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World Journal of Clinical Cases 2025年第3期13卷 9-19页

作者： Carlos M Ardila Department of Basic Sciences Biomedical Stomatology Research GroupUniversidad de Antioquia U de AMedellín 0057Colombia

In a recent case report in the World Journal of Clinical Cases,emphasized the crucial role of rapidly and accurately identifying pathogens to optimize patient treatment ***-on-a-chip(LOC)technology has emerged as a transformative tool in health care,offering rapid,sensitive,and specific identification of *** editorial provides a comprehensive overview of LOC technology,highlighting its principles,advantages,applications,challenges,and future *** studies from the field have demonstrated the practical benefits of LOC devices in clinical diagnostics,epidemiology,and food *** studies have underscored the superiority of LOC technology over traditional methods,showcasing improvements in speed,accuracy,and *** future integration of LOC with biosensors,artificial intelligence,and data analytics promises further innovation and *** call to action emphasizes the importance of continued research,investment,and adoption to realize the full potential of LOC technology in improving healthcare outcomes worldwide.

关键词： Laboratory-on-a-chip Microorganism identification Diagnostics Point-ofcare testing Biosensors

Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès Sylvain Gabriele univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage