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Genetic mechanisms of critical illness in Covid-19

四川生理科学杂志 2020年第4期42卷 455-455页

作者： Erola Pairo-Castineira Roslin institute University of Edinburgh Edinburgh UK MRC Human Genetics unit Institute of Genetics and Molecular Medicine University of Edinburgh Western General Hospital Edinburgh UK Genomics England London UK Centre for Inflammation research The Queen’s Medical Research Institute University of Edinburgh Edinburgh UK Centre for Genomic and Experimental Medicine Institute of Genetics and Molecular Medicine University of Edinburgh Western General Hospital Edinburgh UK Edinburgh Clinical research Facility Western General Hospital University of Edinburgh Edinburgh UK Intensive Care National Audit & research Centre London UK institute for Molecular Bioscience The University of Queensland Brisbane Queensland Australia Biostatistics Group School of Life Sciences Sun Yat-sen University Guangzhou China The Crick institute London UK Intensive Care unit Royal Infirmary of Edinburgh Edinburgh UK school of Life sciences Westlake University Hangzhou China Westlake Laboratory of Life sciences and Biomedicine Hangzhou China Wellcome Centre for Human Genetics University of Oxford Oxford UK Department of Medicine University of Cambridge Cambridge UK Department of Intensive Care Medicine Guy’s and St Thomas’ NHS Foundation Trust London UK school of Immunology and Microbial sciences King’s College London London UK NIHR Health Protection research unit for Emerging and Zoonotic Infections Institute of Infection Veterinary and Ecological Sciences University of Liverpool Liverpool UK MRC-university of Glasgow Centre for Virus research Institute of Infection Immunity and Inflammation College of Medical Veterinary and Life Sciences University of Glasgow Glasgow UK William Harvey research institute Barts and the London School of Medicine and Dentistry Queen Mary University of London London UK Centre for Tropical Medicine and Global Health Nuffield Department of Medicine University of Oxford Oxford UK Clinical research Centre at st Vincent’s university Hospital Un

Host-mediated lung inflammation is present,1 and drives mortality,2 in critical illness caused by *** genetic variants associated with critical illness may identify mechanistic targets for therapeutic development.3 Here we report the results of the GenOMICC(Genetics Of Mortality In Critical Care)genome-wide association study(GWAs)in 2244 critically ill Covid-19 patients from 208 uK intensive care units(ICus).We identify and replicate novel genome-wide significant associations,on chr12q24.13(rs10735079,p=1.65[Formula:see text]10-8)in a gene cluster encoding antiviral restriction enzyme activators(OAs1,OAs2,OAs3),on chr19p13.2(rs2109069,p=2.3[Formula:see text]10-12)near the gene encoding tyrosine kinase 2(TYK2),on chr19p13.3(rs2109069,p=3.98[Formula:see text]10-12)within the gene encoding dipeptidyl peptidase 9(DPP9),and on chr21q22.1(rs2236757,p=4.99[Formula:see text]10-8)in the interferon receptor gene *** identify potential targets for repurposing of licensed medications:using Mendelian randomisation we found evidence in support of a causal link from low expression of IFNAR2,and high expression of TYK2,to life-threatening disease;transcriptome-wide association in lung tissue revealed that high expression of the monocyte/macrophage chemotactic receptor CCR2 is associated with severe *** results identify robust genetic signals relating to key host antiviral defence mechanisms,and mediators of inflammatory organ damage in *** mechanisms may be amenable to targeted treatment with existing ***-scale randomised clinical trials will be essential before any change to clinical practice.

关键词： lung drugs critical

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Neuronal photoactivation through secondharmonic near-infrared absorption by gold nanoparticles

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Light(science & Applications) 2018年第1期7卷 79-91页

作者： Wieteke D.A.M.de Boer Jan J.Hirtz Antonio Capretti Tom Gregorkiewicz Mercè Izquierdo-serra shuting Han Christophe Dupre Yuriy shymkiv Rafael Yuste NeuroTechnology Center Department of Biological SciencesColumbia UniversityNew YorkNY 10027USA Van der Waals–Zeeman institute University of Amsterdam1098 XH AmsterdamNetherlands Present address:Laboratori de Fisiologia Molecular Departament de Ciències Experimentals i de la SalutUniversitat Pompeu FabraBarcelonaSpain

Optical activation of neurons requires genetic manipulation or the use of chemical photoactivators with undesirable side *** a solution to these disadvantages,here,we demonstrate optically evoked neuronal activity in mouse cortical neurons in acute slices and in vivo by nonlinear excitation of gold *** addition,we use this approach to stimulate individual epitheliomuscular cells and evoke body contractions in Hydra *** achieve this,we use a low-power pu.s.d near-infrared excitation at the double-wavelength of the plasmon resonance of gold nanoparticles,which enables optical sectioning and allows for high spatial precision and large penetration *** effect is explained by second-harmonic Mie scattering,demonstrating light absorption by a second-order nonlinear process,which enables photothermal stimulation of the *** approach also minimizes photodamage,demonstrating a major advancement towards precise and harmless photoactivation for neuroscience and human therapeutics.

关键词： activation harmonic absorption

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Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)

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Hepatobiliary surgery and Nutrition 2022年第2期11卷 227-252,I0011-I0014页

作者： Hui-Chuan sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu.s.ichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang shao Yinghong shi Tianqiang song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu.s.ukui Qin Feng shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang shusen Zheng Jia Fan 无 Department of Liver surgery and Transplantation Liver Cancer InstituteZhongshan HospitalFudan UniversityShanghaiChina Department of Medical Oncology of PLA Cancer Center Jinling HospitalNanjingChina Department of Infectious Disease Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Liver surgery The First Affiliated Hospital of USTCHefeiChina Minimally Invasive Interventional Division Sun Yat-sen University Cancer CenterGuangzhouChina Department of Hepatobiliary surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Radiation Oncology Beijing Tsinghua Changgung HospitalBeijingChina Department of Hepatobiliary and Pancreatic surgery the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouChina Department of Pathology Fudan University Shanghai Cancer CentreShanghaiChina Department of Liver surgery Sun Yat-sen University Cancer CentreGuangzhouChina Department of Hepatobiliary surgery Clinical Medical CollegeYangzhou UniversityYangzhouChina Department of Hepatobiliopancreatic surgery Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouChina Division of Hepatobiliary surgery Department of General SurgeryRuijin HospitalShanghai Jiaotong University School of MedicineShanghaiChina Department of Hepatobiliary and splenic surgery Shengjing Hospital Affiliated to China Medical UniversityShenyangChina The Department of Hepatobiliary Oncology of sun Yat-sen university Cancer Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouChina Department of Hepatobiliary and Pancreatic surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouChina Key Laboratory of Carcinogenesis and Translational research(Ministry of Education) Sarcoma CenterPeking University Cancer Hospital and InstituteBeijingChina Department of Hepatobili

Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response *** has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’***,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being *** the evidence for conversion therapy in HCC and develop consensus statements to guide clinical *** review:Many research centers in China have accumulated significant experience implementing HCC conversion *** findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related *** order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical *** consensus statements on the implementation of conversion therapy for HCC were *** statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC.

关键词： Hepatocellular carcinoma(HCC) conversion therapy surgical resection systematic treatment locoregional treatment consensus China

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Nanoscale fluctuation of stacking fault energy strengthens multi-principal element alloys

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Journal of Materials science & Technology 2023年第27期158卷 218-225页

作者： Zongrui Pei Markus Eisenbach Peter K.Liaw Mingwei Chen New York university New York 10012USA Oak Ridge National Laboratory Oak RidgeTennessee 37831USA Department of Materials science and Engineering The University of TennesseeKnoxvilleTN 37996USA Department of Materials science and Engineering Johns Hopkins UniversityBaltimoreMaryland 21218USA Engineering and Hopkins Extreme Materials institute Johns Hopkins UniversityBaltimoreMaryland 21218USA

Chemical randomness and the associated energy fluctuation are essential features of multi-principal ele-ment alloys(MPEAs).Due to these features,nanoscale stacking fault energy(sFE)fluctuation is a natural and independent contribution to strengthening ***,existing models for conventional alloys(i.e.,alloys with one principal element)cannot be applied to *** extreme valu.s.of sFEs required by such models are unknown for MPEAs,which need to calculate the nanoscale volume relevant to the sFE *** the present work,we developed an analytic model to evaluate the strengthening ef-fect through the sFE fluctuation,profuse in *** model has no adjustable parameters,and all parameters can be determined from experiments and ab initio *** model explains available experimental observations and provides insightful guidance for designing new MPEAs based on the sFE *** generally applies to MPEAs in random states and with chemical short-range order.

关键词： Nanoscale energy fluctuation staking fault energy Chemical short-range order Multi-principal element alloy Mechanism

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Extension of Noether's theorem in PT-symmetry systems and its experimental demonstration in an optical setup

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science China(Physics,Mechanics & Astronomy) 2023年第4期66卷 13-27页

作者： Qi-Cheng Wu Jun-Long Zhao Yu-Liang Fang Yu Zhang Dong-Xu Chen Chui-Ping Yang Franco Nori Quantum Information research Center Shangrao Normal UniversityShangrao 334001China school of Physics Nanjing UniversityNanjing 210093China Department of Physics Hangzhou Normal UniversityHangzhou 311121China Theoretical Quantum Physics Laboratory RIKENWako-shiSaitama 351-0198Japan RIKEN Center for Quantum Computing RIKENWako-shiSaitama 351-0198Japan Physics Department The University of MichiganAnn Arbor 48109-1040USA

Noether’s theorem is one of the fundamental laws in physics,relating the symmetry of a physical system to its constant of motion and conservation *** the other hand,there exist a variety of non-Hermitian parity-time(PT)-symmetric systems,which exhibit novel quantum properties and have attracted increasing *** this work,we extend Noether’s theorem to a class of significant PT-symmetry systems for which the eigenvalu.s.of the PT-symmetry Hamiltonian HPTchange from purely real numbers to purely imaginary numbers,and introduce a generalized expectation value of an operator based on biorthogonal quantum *** find that the generalized expectation value of a time-independent operator is a constant of motion when the operator presents a standard symmetry in the PT-symmetry unbroken regime,or a chiral symmetry in the PT-symmetry broken *** addition,we experimentally investigate the extended Noether’s theorem in PT-symmetry single-qubit and two-qubit systems using an optical *** experiment demonstrates the existence of the constant of motion and reveals how this constant of motion can be used to judge whether the PT-symmetry of a system is ***,a novel phenomenon of masking quantum information is first observed in a PT-symmetry two-qubit *** study not only contributes to full understanding of the relation between symmetry and conservation law in PT-symmetry physics,but also has potential applications in quantum information theory and quantum communication protocols.

关键词： Noether’s theorem PT-symmetry systems chiral symmetry optical setup

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A physics informed bayesian optimization approach for material design: application to NiTi shape memory alloys

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npj Computational Materials 2023年第1期9卷 85-95页

作者： Danial Khatamsaz Raymond Neuberger Arunabha M.Roy sina Hossein Zadeh Richard Otis Raymundo Arróyave Materials science and Engineering Department Texas A&M UniversityCollege StationTX 77843USA Engineering and science Directorate Jet Propulsion LaboratoryCalifornia Institute of TechnologyPasadenaCA 91109USA Mechanical Engineering Department Texas A&M UniversityCollege StationTX 77843USA Department of Industrial&systems Engineering Texas A&M UniversityCollege StationTX 77843USA

The design of materials and identification of optimal processing parameters constitute a complex and challenging task,necessitating efficient utilization of available *** Optimization(BO)has gained popularity in materials design due to its ability to work with minimal ***,many BO-based frameworks predominantly rely on statistical information,in the form of input-output data,and assume black-box objective *** practice,designers often possess knowledge of the underlying physical laws governing a material system,rendering the objective function not entirely black-box,as some information is partially *** this study,we propose a physics-informed BO approach that integrates physics-infused kernels to effectively leverage both statistical and physical information in the decision-making *** demonstrate that this method significantly improves decision-making efficiency and enables more data-efficient *** applicability of this approach is showcased through the design of NiTi shape memory alloys,where the optimal processing parameters are identified to maximize the transformation temperature.

关键词： alloys shape approach

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声波超材料中D类拓扑的观测

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science Bulletin 2024年第7期69卷 893-900页

作者：吴世巧程文婷刘啸宇吴柄权 Emil Prodan Camelia Prodan 蒋建华 school of Physical science and Technology&Collaborative Innovation Center of suzhou Nano science and Technology Soochow UniversitySuzhou 215006China school of Physics and Optoelectronic Engineering Foshan UniversityFoshan 528000China Guangdong-Hong Kong-Macao Joint Laboratory for Intelligent Micro-Nano Optoelectronic Technology Foshan UniversityFoshan 528000China Department of Physics University of MichiganAnn Arbor MI 48109USA Department of Physics Yeshiva UniversityNew York NY 10033USA Department of Physics and Engineering Physics Fordham UniversityNew York NY 10023USA suzhou institute for Advanced research University of Science and Technology of ChinaSuzhou 215123China

Topological materials and metamaterials opened new paradigms to create and manipulate phases of matter with unconventional *** D-class phases(TDPs)are archetypes of the ten-fold classification of topological phases with particle-hole *** two dimensions,TDPs support propagating topological edge modes that simulate the elusive Majorana elementary ***,a piercing ofπ-flux Dirac-solenoids in TDPs stabilizes localized Majorana excitations that can be braided for the purpose of topological quantum *** two-dimensional(2D)TDPs have been a focus in the research frontier,but their experimental realizations are still under ***,with a novel design scheme,we realize 2D TDPs in an acoustic crystal by synthesizing both the particle-hole and fermion-like time reversal symmetries for a wide range of *** design scheme leverages an enriched unit cell structure with real-valued couplings that emulate the targeted Hamiltonian of TDPs with complex hoppings:A technique that could unlock the realization of all topological classes with passive *** our experiments,we realize a pair of TDPs with opposite Chern numbers in two independent sectors that are connected by an intrinsic fermion-like timereversal symmetry built in the *** measure the acoustic Majorana-like helical edge modes and visualize their robust topological transport,thus revealing the unprecedented D and DIII class topologies with direct *** study opens up a new pathway for the experimental realization of two fundamental classes of topological phases and may offer new insights in fundamental physics,materials science,and phononic information processing.

关键词： D-class topology Chiral symmetry Time-reversal symmetry Particle-hole symmetry Gapless edge states

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short-term and oncological outcomes of natural orifice specimen extraction surgery(NOsEs)for colorectal cancer in China:a national database study of 5055 patients

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science Bulletin 2022年第13期67卷 1331-1334,M0003页

作者： Xu Guan Xiyue Hu Zheng Jiang Ye Wei Donghui sun Miao Wu Haitao Zhou Hongliang Yao Junmin song Guiyu Wang Junhong Hu Mingyang Ren Qing Xu Jianchun Cai Jian Peng Dan Ma Yangchun Zheng Qingsi He Bo Jiang Zejun Wang Taiyuan Li su Yan Luchuan Chen Tiegang Li Zhiguo Xiong Pan Chi Liang Kang Gang Yu Xiaodong Deng Hong Zhang Ming Xie Jianbao Wei Hongyan Gong Xuejun sun Weidong Zang Yongmao song Peng He Zhengqi Wen Chunxu Zhang Yusheng Wang Yinggang Chen Guangwei Xie Mingzhang Li shaojun Yu Haiying Liu Min Pu Chuangang Fu Xishan Wang on behalf of China NOsEs Alliance Department of Colorectal surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of General surgery Zhongshan HospitalFudan UniversityShanghai 200032China Department of Gastrointestinal and Anal surgery Jilin University First HospitalChangchun 130021China Department of Gastrointestinal surgery The Second People’s Hospital of YibinYibin 644000China Department of Gastrointestinal surgery The Second Xiangya HospitalCentral South UniversityChangsha 410011China Department of Anorectal surgery First Affiliated HospitalZhengzhou UniversityZhengzhou 450052China Department of Colorectal Cancer surgery The Second Affiliated Hospital of Harbin Medical UniversityHarbin 150081China Department of Gastrointestinal surgery Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000China Department of Gastrointestinal surgery Renji HospitalShanghai JiaoTong University School of MedicineShanghai 200240China Department of Gastrointestinal surgery Zhongshan Hospital of Xiamen UniversityXiamen 361004China Department of General surgery Xiangya HospitalCentral South UniversityChangsha 410008China Department of General surgery Xinqiao HospitalThird Military Medical UniversityChongqing 400037China Department of Gastrointestinal surgery Sichuan Cancer HospitalChengdu 610041China Department of General surgery Shandong University Qilu HospitalJinan 250012China Department of Colorectal and Anal surgery Shanxi Cancer HospitalTaiyuan 030013China Department of Gastrointestinal surgery The Affiliated Cancer Hospital of Guizhou Medical UniversityGuiyang 550008China Department of General surgery The First Affiliated Hospital of Nanchang UniversityNanchang 330006China Department of Gastrointestinal surgery Qinghai University Affiliated HospitalXining 810012China Department of Gastrointestinal surgery Fujian Medical University Cancer HospitalFuzhou 350014China Depar

经自然腔道取标本手术(NOsEs)通过无切口理念与常规手术器械的结合,表现出极佳的微创效果,并带给患者全新的就医感受.目前,尽管NOsEs已广泛用于结直肠肿瘤治疗,大量研究也表明相比常规腹腔镜手术,NOsEs具有恢复快、创伤小、疼痛轻等优势... 详细信息

经自然腔道取标本手术(NOsEs)通过无切口理念与常规手术器械的结合,表现出极佳的微创效果,并带给患者全新的就医感受.目前,尽管NOsEs已广泛用于结直肠肿瘤治疗,大量研究也表明相比常规腹腔镜手术,NOsEs具有恢复快、创伤小、疼痛轻等优势,但绝大多数研究均为小样本、单中心回顾性研究.本研究旨在通过分析我国5055例结直肠肿瘤NOsEs患者数据,进一步探讨NOsEs的短期疗效与预后.研究对象中,经直肠NOsEs占整体比例的90.3%,经阴道NOsEs占9.7%.NOsEs术后短期并发症发生率为14.1%,吻合口瘘发生率为4.9%,腹盆腔感染率为1.9%.患者3年总生存率为93.2%,无病生存率为82.2%,局部复发率为3.6%.研究结果提示NOsEs具有较好的安全性与可行性,为其应用于结直肠肿瘤治疗提供了证据.

关键词：结直肠肿瘤肿瘤学并发症发生率无病生存率吻合口瘘回顾性研究总生存率经直肠

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Non-invasive photoacoustic computed tomography of rat heart anatomy and function

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Light(science & Applications) 2023年第1期12卷 109-117页

作者： Li Lin Xin Tong susana Cavallero Yide Zhang shuai Na Rui Cao Tzung K.Hsiai Lihong V.Wang Caltech Optical Imaging Laboratory Andrew and Peggy Cherng Department of Medical EngineeringDepartment of Electrical EngineeringCalifornia Institute of TechnologyPasadenaCAUSA Department of Bioengineering UCLALos AngelesCAUSA Division of Cardiology Department of MedicineUCLALos AngelesCAUSA Present address:College of Biomedical Engineering and Instrument science Zhejiang UniversityHangzhouChina Present address:The First Affiliated Hospital Zhejiang University School of MedicineHangzhouChina

Complementary to mainstream cardiac imaging modalities for preclinical research,photoacoustic computed tomography(PACT)can provide functional optical contrast with high imaging speed and ***,PACT has not been demonstrated to reveal the dynamics of whole cardiac anatomy or vascular system without surgical procedure(thoracotomy)for tissue ***,we achieved non-invasive imaging of rat hearts using the recently developed three-dimensional PACT(3D-PACT)platform,demonstrating the regulated illumination and detection schemes to reduce the effects of optical attenuation and acoustic distortion through the chest wall;thereby,enabling unimpeded visualization of the cardiac anatomy and intracardiac hemodynamics following rapidly scanning the heart within 10 *** further applied 3D-PACT to reveal distinct cardiac structural and functional changes among the healthy,hypertensive,and obese rats,with optical contrast to uncover differences in cardiac chamber size,wall thickness,and ***,3D-PACT provides high imaging speed and nonionizing penetration to capture the whole heart for diagnosing the animal models,holding promises for clinical translation to cardiac imaging of human neonates.

关键词： anatomy hypertensive illumination

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Endogenous electric field as a bridge for antibacterial ion transport from implant to bacteria

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science China Materials 2020年第9期63卷 1831-1841页

作者： Jinxia Zhai Yahong Zhou Zhengao Wang Lei Fan Cairong Xiao Xiaolan Wang Yangfan Li Zhengnan Zhou Yian Luo Changhao Li suijian Qi Guoxin Tan Lei Zhou Peng Yu Chengyun Ning school of Materials science and Engineering South China University of TechnologyGuangzhou 510640China school of Biomedical sciences and Engineering National Engineering Research Center for Tissue Restoration and ReconstructionKey Laboratory of Biomedical Engineering of Guangdong ProvinceKey Laboratory of Biomedical Materials and Engineering of the Ministry of EducationInnovation Center for Tissue Restoration and Reconstruction.South China University of TechnologyGuangzhou 510006China CAs Key Laboratory of Bio-inspired Materials and Interfacial science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China school of Chemical Engineering and Light Industry Guangdong University of TechnologyGuangzhou 510006China school of Food science and Engineering South China University of TechnologyGuangzhou 510640China

Tissue implant-related infections are among the most serious complications after surgical implantation,including orthopedics and *** with antibacterial ion release systems are efficient and economical antibiotic su.s.itutes to fight against bacterial ***,the excessive amount of released antibacterial ions may cause biological toxicity while killing *** raises a fundamental issue on how to properly control the amounts of ions and their ***,we develop low-dose antibacterial ions-incorporated ferroelectric implants(copper-doped potassium sodium niobate,K0.5Na0.5NbO3-Cu,KNNCu)whose surface potential can be tuned via external *** released Cu2+ions can be targeted to bacteria via endogenous electric field(EEF)between KNNCu implants and negatively charged ***,the antibacterial efficacy of the implants is determined by the amount of Cu^2+ions that reaches bacteria,instead of the total amount of released Cu2+*** amount of Cu2+ions reaching bacteria from the high-surface-potential implant is 2.4 times that from the lowsurface-potential implant within 12 h,resulting in the increased antibacterial ratio from about 65%to 100%,while remaining low cell *** work provides insights into the specific role of the EEF in guiding mass transport between charged materials and living organisms,and a new perspective for the design of high-performance antibacterial biomaterials.

关键词： bacterial infection endogenous electric field ion transport ferroelectric implant

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