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Reprodu.ible large-scale synthesis of su.face silanized nanoparticles as an enabling nanoproteomics platform: Enrichment of the hu.an heart phosphoproteome

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Nano Research 2019年第6期12卷 1473-1481页

作者： David S.Roberts Bifan Chen Timothy N.Tiambeng Zhijie Wu.Ying Ge Song Jin Department of Chemistry University of Wisconsin-MadisonMadisonWisconsin 53706USA Department of Cell and Regenerative Biology University of Wisconsin-MadisonMadisonWisconsin 53705USA

A reprodu.ible synthetic strategy was developed for facile large-scale (200 mg) synthesis of su.face silanized magnetite (Fe3O4) nanoparticles (NPs) for biological *** fu.ther cou.ling a phosphate-specific affinity ligand,these fu.ctionalized magnetic NPs were u.ed for the highly specific enrichment of phosphoproteins from a complex biological ***,correlating the su.face silane density of the silanized magnetite NPs to their resu.tant enrichment performance established a simple and reliable qu.lity assu.ance control to ensu.e reprodu.ible synthesis of these NPs rou.inely in large scale and optimal phosphoprotein enrichment performance from ***,by su.cessfu. exploitation of a top-down phosphoproteomics strategy that integrates this high throu.hpu. nanoproteomics platform with online liqu.d chromatography (LC) and tandem mass spectrometry (MS/MS),we were able to specifically enrich,identify,and characterize endogenou. phosphoproteins from highly complex hu.an cardiac tissu. *** nanoproteomics platform possesses a u.iqu. combination of scalability,specificity,reprodu.ibility,and efficiency for the captu.e and enrichment of low abu.dance proteins in general,thereby enabling downstream proteomics applications.

关键词： nanoparticles nanoproteomics su.face fu.ctionalization large-scale phosphoprotein enrichment top-down proteomics mass spectrometry

In vitro stu.y of enhanced photodynamic cancer cell killing effect by nanometer-thick gold nanosheets

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Nano Research 2020年第12期13卷 3217-3223页

作者： Ziyi Zhang Dalong Ni Fei Wang Xin Yin Shreya Goel Lazaru. NGerman Yizhan Wang Ju. Li Weibo Cai Xu.ong Wang Department of Materials Science and Engineering University of Wisconsin-MadisonMadisonWisconsin53706USA Department of Radiology University of Wisconsin-MadisonMadisonWisconsin53705USA u.iversity of wisconsin Carbone Cancer Center MadisonWisconsin53705USA

Photodynamic therapy(PDT)by near-infrared(NIR)irradiation is a promising techniqu. for treating variou. ***,we reported the development of free-standing wafer-scale Au.nanosheets(NSs)that exhibited an impressive PDT *** Au.NSs were synthesized by ionic layer epitaxy at the air-water interface with a u.iform thickness in the range from 2 to 8.5 *** Au.NSs were fou.d very effective in generating singlet oxygen u.der NIR *** vitro cellu.ar stu.y showed that the Au.NSs had very low cytotoxicity and high PDT efficiency du. to their u.iform 2D *** NSs cou.d kill cancer cells after 5 min NIR irradiation with little heat *** performance is comparable to u.ing 10 times mass loading of Au.nanoparticles(NPs).This work su.gests that two-dimensional(2D)Au.NSs cou.d be a new type of biocompatible nanomaterial for PDT of cancer with an extraordinary photon conversion and cancer cell killing efficiency.

关键词： gold nanosheet ionic layer epitaxy su.face plasmon photodynamic effect cancer therapy

Materials advancements for the safety and patency of implantable cardiovascu.ar devices

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Nano Research 2024年第10期17卷 8977-8989页

作者： Zu.mari Silva Pedraza Bo Liu.Xu.ong Wang Department of Materials Science and Engineering University of Wisconsin−MadisonMadisonWisconsin 53706USA Departments of Cell and Regenerative Biology University of Wisconsin-MadisonMadisonWisconsin 53705USA

Implantable cardiovascu.ar devices have revolu.ionized the management of cardiovascu.ar diseases,significantly enhancing patients’qu.lity of *** the increasing demand of cardiac implantable electronic devices,the imperative for novel device development is *** review article first elaborates the mechanisms u.derlying foreign body response and infection,elu.idating the complex interplay between implanted constru.ts and host *** discu.sion then focu.es on cu.rent advancements in materials science and engineering aimed at mitigating these *** innovations,su.h as dru.elu.ing materials,su.face modifications,and biomimetic materials,are explored as strategies to modu.ate these responses and to prevent fibrotic or thrombotic complications and ***,fu.u.e directions in materials development for implantable cardiovascu.ar devices are *** addressing safety and patency concerns throu.h innovative material strategies,this article aims to gu.de the research and development of advanced materials for both cu.rent and fu.u.e cardiovascu.ar implantable devices,u.timately improving patient ou.comes and advancing cardiovascu.ar disease treatment.

关键词： biomaterials implantable devices cardiovascu.ar diseases implantable materials

Diabetic peripheral neu.opathy and neu.omodu.ation techniqu.s:a systematic review of progress and prospects

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Neu.al Regeneration Research 2025年第8期20卷 2218-2230页

作者： Rahu. Mittal Keelin McKenna Grant Keith Evan McKenna Joana R.N.Lemos Jeenu.Mittal Khemraj Hirani Diabetes Research Institu.e University of Miami Miller School of MedicineMiamiFLUSA Department of Otolaryngology University of Miami Miller School of MedicineMiamiFLUSA Herbert Wertheim College of Medicine Florida International UniversityMiamiFLUSA School of Medicine and Pu.lic Health University of WisconsinMadisonWIUSA

Neu.omodu.ation for diabetic peripheral neu.opathy represents a significant area of interest in the management of chronic pain associated with this *** peripheral neu.opathy,a common complication of diabetes,is characterized by nerve damage du. to high blood su.ar levels that lead to symptoms,su.h as pain,tingling,and nu.bness,primarily in the hands and *** aim of this systematic review was to evalu.te the efficacy of neu.omodu.atory techniqu.s as potential therapeu.ic interventions for patients with diabetic peripheral neu.opathy,while also examining recent developments in this *** investigation encompassed an array of neu.omodu.ation methods,inclu.ing frequ.ncy rhythmic electrical modu.ated systems,dorsal root ganglion stimu.ation,and spinal cord *** systematic review su.gests that neu.omodu.atory techniqu.s may be u.efu. in the treatment of diabetic peripheral *** the advantages of these treatments will enable physicians and other healthcare providers to offer additional options for patients with symptoms refractory to standard pharmacologic *** these efforts,we may improve qu.lity of life and increase fu.ctional capacity in patients su.fering from complications related to diabetic neu.opathy.

关键词： diabetes mellitu. diabetic peripheral neu.opathy neu.omodu.ation neu.ostimu.ation therapy non-pharmacological treatment pain management

Nanofabricated high tu.n-density spiral coils for on-chip electromagneto-optical conversion

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Microsystems & Nanoengineering 2024年第2期10卷 181-192页

作者： Ilhan Bok Alireza Ashtiani Yash Gokhale Jack Phillips Tianxiang Zhu.Aviad Hai Department of Biomedical Engineering University of Wisconsin–MadisonMadisonWIUSA Department of Electrical and Compu.er Engineering University of Wisconsin–MadisonMadisonWIUSA wisconsin Institu.e for Translational Neu.oengineering(WITNe) University of Wisconsin–MadisonMadisonWIUSA

Circu.t-integrated electromagnets are fu.damental bu.lding blocks for on-chip signal transdu.tion,modu.ation,and tu.ability,with specific applications in environmental and biomedical micromagnetometry.A primary challenge for improving performance is pu.hing qu.lity limitations while minimizing size and fabrication complexity and retaining spatial *** efforts have exploited highly involved three-dimensional synthesis,advanced insu.ation,and exotic material ***,we present a rapid nanofabrication process that employs electron beam dose control for high-tu.n-density diamond-embedded flat spiral coils;these coils achieve efficient on-chip electromagnetic-to-optical signal *** fabrication process relies on fast 12.3 s direct writing on standard poly(methyl methacrylate)as a basis for the metal lift-off *** with 70 micrometer overall diameters and 49–470 nm intertu.n spacings with corresponding indu.tances of 12.3–12.8 nH are *** u.ilize optical micromagnetometry to demonstrate that magnetic field generation at the center of the stru.tu.e effectively correlates with finite element modeling *** designs based on ou. process can be integrated with photolithography to broadly enable optical magnetic sensing and spin-based compu.ation.

关键词： u.ilize retaining high

Thickness-Dependent Piezoelectric Property from Qu.si-Two-Dimensional Zinc Oxide Nanosheets with u.it Cell Resolu.ion

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Research 2021年第1期2021卷 1-7页

作者： Corey Carlos Yizhan Wang Jingyu.Wang Ju. Li Xu.ong Wang Department of Materials Science and Engineering University of Wisconsin–MadisonMadisonWisconsin 53706USA

A qu.ntitative u.derstanding of the nanoscale piezoelectric property will u.lock many application potentials of the electromechanical cou.ling phenomenon u.der qu.ntu. *** this work,we present an atomic force microscopy-(AFM-)based approach to the qu.ntification of the nanometer-scale piezoelectric property from single-crystalline zinc oxide nanosheets(NSs)with thicknesses ranging from 1 to 4 *** identifying the appropriate driving potential,we minimized the influ.nces from electrostatic interactions and tip-sample cou.ling,and extrapolated the thickness-dependent piezoelectric coefficient(d_(33)).By averaging the measu.ed d_(33) from NSs with the same nu.ber of u.it cells in thickness,an intrigu.ng tri-u.it-cell relationship was *** NSs with 3n u.it cell thickness(n=1,2,3),a bu.k-like d_(33) at a valu. of~9 pm/V was obtained,whereas NSs with other thickness showed a~30%higher d_(33) of~12 pm/*** of d_(33) as a fu.ction of ZnO u.it cell nu.bers offers a new experimental discovery toward nanoscale piezoelectricity from nonlayered materials that are piezoelectric in bu.k.

关键词： piezoelectric cou.ling driving

Calibration after bootstrap for accu.ate u.certainty qu.ntification in regression models

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npj Compu.ational Materials 2022年第1期8卷 1092-1100页

作者： Glenn Palmer Siqi Du.Alexander Politowicz Joshu. Pau. Emory Xiyu.Yang Anu.raas Gau.am Grishma Gu.ta Zhelong Li Ryan Jacobs Dane Morgan Department of Compu.er Sciences University of Wisconsin-MadisonMadisonWIUSA Department of Materials Science and Engineering University of Wisconsin-MadisonMadisonWIUSA

Obtaining accu.ate estimates of machine learning model u.certainties on newly predicted data is essential for u.derstanding the accu.acy of the model and whether its predictions can be tru.ted.A common approach to su.h u.certainty qu.ntification is to estimate the variance from an ensemble of models,which are often generated by the generally applicable bootstrap *** this work,we demonstrate that the direct bootstrap ensemble standard deviation is not an accu.ate estimate of u.certainty bu. that it can be simply calibrated to dramatically improve its *** demonstrate the effectiveness of this calibration method for both synthetic data and nu.erou. physical datasets from the field of Materials Science and *** approach is motivated by applications in physical and biological science bu. is qu.te general and shou.d be applicable for u.certainty qu.ntification in a wide range of machine learning regression models.

关键词： ensemble applicable u.certainty

INFLu.NCE OF THE ANTARCTIC SEA-ICE ON THE NORTH-WEST PACIFIC Su.TROPICAL HIGH AND ITS BACKGROu.D OF OCEANATMOSPHERIC CIRCu.ATION

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Chinese Science Bu.letin 1989年第17期34卷 1463-1465页

作者：彭公炳 PAO K.WANG Department of Climatology Institute of Geography Academia Sinica Beijing Department of Meteorology University of Wisconsin Madison U. S. A.

In view of the importance of the North-west Pacific su.tropical high to weather-climate conditions in large areas of the Chinese territory, we have devoted ou. attention mainly to analyzing the relationship between the su.tropical high and the Antarctic sea-ice. We have fou.d that the high and the sea-ice are closely related to each other in ou.

关键词： Antarctic sea-ice su.tropical high influ.nce model

Graph neu.al networks for an accu.ate and interpretable prediction of the properties of polycrystalline materials

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npj Compu.ational Materials 2021年第1期7卷 925-933页

作者： Minyi Dai Mehmet F.Demirel Yingyu.Liang Jia-Mian Hu Department of Materials Science and Engineering University of Wisconsin-MadisonMadisonWIUSA Department of Compu.er Sciences University of Wisconsin-MadisonMadisonWIUSA

Variou. machine learning models have been u.ed to predict the properties of polycrystalline materials,bu. none of them directly consider the physical interactions among neighboring grains despite su.h microscopic interactions critically determining macroscopic material ***,we develop a graph neu.al network(GNN)model for obtaining an embedding of polycrystalline microstru.tu.e which incorporates not only the physical featu.es of individu.l grains bu. also their *** embedding is then linked to the target property u.ing a feed-forward neu.al *** the magnetostriction of polycrystalline Tb_(0.3)Dy_(0.7)Fe_(2) alloys as an example,we show that a single GNN model with fixed network architectu.e and hyperparameters allows for a low prediction error of~10%over a grou. of remarkably different microstru.tu.es as well as qu.ntifying the importance of each featu.e in each grain of a microstru.tu.e to its *** a microstru.tu.e-graph-based GNN model,therefore,enables an accu.ate and interpretable prediction of the properties of polycrystalline materials.

关键词： microstru.tu.e polycrystalline prediction