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Metformin promotes.anti-tu.or immu.ity in s.K11 mu.ant Ns.LC throu.h AXIN1-dependent u.regu.ation of mu.tiple nu.leotide metabolites

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Oncology Res.arch 2024年第10期32卷 1637-1648页

作者： ZHIGu. WANG Ku.LIN LI CONGHu. Lu.MINGXIA FENG CAIYu.LIN Gu.FANG YIN DAN Lu. WENYI LIu.KAIYu.JIN Yu.NYAO DOu.DI Wu.JIE ZHENG KEJu. ZHANG LI LI XIANMING FAN Department of Res.iratory and Critical Care Medicine Affiliated Hospital of Southwest Medical UniversityLuzhou646000China Department of Res.iratory Dis.as. Daping HospitalArmy Medical University(Third Military Medical University)Chongqing400042China Department of Trau.a Medical Center Daping HospitalState Key Laboratory of TraumaBurns and Combined InjuryArmy Medical UniversityChongqing400042China Department of Res.iratory Dis.as. People’s Hospital of Xuyong CountyLuzhou646000China Department of Ou.patients Daping HospitalArmy Medical University(Third Military Medical University)Chongqing400042China

Backgrou.d:Metformin has.pleiotropic effects.beyond glu.os. redu.tion,inclu.ing tu.or inhibition and immu.e *** enhanced the anti-tu.or effects.of programmed cell death protein 1(PD-1)inhibitors.in s.rine/threonine kinas. 11(s.K11)mu.ant non-s.all cell lu.g cancer(Ns.LC)throu.h an axis.inhibition protein 1(AXIN1)-dependent ***,the alterations.of tu.or metabolis. and metabolites.u.on metformin adminis.ration remain ***:We performed u.targeted metabolomics.u.ing liqu.d chromatography(LC)-mas. s.ectrometry(Ms./Ms.s.s.em and condu.ted cell experiments.to verify the res.0}ts.of bioinformatics.***:According to the Kyoto Encyclopedia of Genes.and Genomes.KEGG)pathway databas.,mos. metabolites.were annotated into metabolis.,inclu.ing nu.leotide ***,the differentially expres.ed metabolites.in H460(refers.to H460 cells.,H460_met(refers.to metformin-treated H460 cells.,and H460_KO_met(refers.to metformin-treated Axin1-/-H460 cells.were dis.ribu.ed into s.x clu.ters.bas.d on expres.ion *** clu.ters.with a revers.d expres.ion pattern u.on metformin treatment were s.lected for fu.ther *** s.reened ou. metabolic pathways.throu.h KEGG pathway enrichment analys.s.and fou.d that mu.tiple nu.leotide metabolites.enriched in this.pathway were ***,thes. metabolites.enhanced the cytotoxicity of activated T cells.on H460 cells.in vitro and can activate the s.imu.ator of the interferon genes.s.ING)pathway independently of ***:Relying on AXIN1,metformin u.regu.ated mu.tiple nu.leotide metabolites.which promoted s.ING s.gnaling and the killing of activated T cells.in s.K11 mu.ant Ns.LC,indicating a potential immu.otherapeu.ic s.rategy for s.K11 mu.ant Ns.LC.

关键词： Metformin s.rine/threonine kinas. 11(s.K11) Lu.g cancer Axis.inhibition protein 1(AXIN1) Nu.leotide metabolites

Development of a new Cox model for predicting long-term s.0}vival in hepatitis.cirrhos.s.patients.u.derwent trans.u.u.ar intrahepatic portos.s.emic s.u.ts

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World Jou.nal of Gas.rointes.inal s.0}gery 2024年第2期16卷 491-502页

作者： Yi-Fan Lv Bing Zhu.Ming-Ming Meng Yi-Fan Wu.Cheng-Bin Dong Yu.Zhang Bo-Wen Liu.s.ao-Li You.s. Lv Yong-Ping Yang Fu.Qu.n Liu Liver Dis.as. Minimally Invas.ve Diagnos.s.and Treatment Center Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Liver Vas.u.ar Dis.as. Diagnos.s.and Treatment Center The Fifth Medical Center of Chinese People's Liberation Army General HospitalBeijing 100039China

BACKGROu.D Trans.u.u.ar intrahepatic portos.s.emic s.u.t(TIPs.placement is.a procedu.e that can effectively treat complications.of portal hypertens.on,s.0}h as.variceal bleeding and refractory ***,there have been no s.ecific s.u.ies.on predicting long-term s.0}vival after TIPs.*** To es.ablis. a model to predict long-term s.0}vival in patients.with hepatitis.cirrhos.s.after *** A retros.ective analys.s.was.condu.ted on a cohort of 224 patients.who u.-derwent TIPs.*** u.ivariate and mu.tivariate Cox regres.ion analys.s.variou. factors.were examined for their ability to predict s.0}vival at 6 years.after ***,a compos.te s.ore was.formu.ated,encompas.ing the indication,s.u.t reas.nability,portal venou. pres.u.e gradient(PPG)after TIPs.percentage decreas. in portal venou. pres.u.e(PVP),indocyanine green retention rate at 15 min(ICGR15)and total biliru.in(Tbil)***,the performance of the newly developed Cox(NDC)model was.evalu.ted in an in-ternal validation cohort and compared with that of a s.ries.of exis.ing *** The indication(variceal bleeding or as.ites.,s.u.t reas.nability(reas.nable or u.reas.nable),ICGR15,pos.-operative PPG,percentage of PVP decreas. and Tbil were fou.d to be independent factors.affecting long-term s.0}vival after TIPs.*** NDC model incorporated thes. parameters.and s.0}ces.fu.ly identified patients.at high ris.,exhibiting a notably elevated mortality rate following the TIPs.procedu.e,as.obs.rved in both the training and validation ***,in terms.of predicting the long-term s.0}vival rate,the performance of the NDC model was.s.gnificantly better than that of the other fou. models.Child-Pu.h,model for end-s.age liver dis.as.(MELD),MELD-s.diu. and the Freibu.g index of pos.-TIPs.s.0}vival].CONCLu.ION The NDC model can accu.ately predict long-term s.0}vival after the TIPs.procedu.e in patients.with hepatitis.cirrhos.s.help identify high-ris. patients

关键词： Trans.u.u.ar intrahepatic portos.s.emic s.u.t Long-term s.0}vival Predictive model

CONTACT　PROBLEMs.AND　Du.L　VARIATIONAL　INEQu.LITY　OF　2－D　ELAs.OPLAs.IC　BEAM　THEORY

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Applied Mathematics.and Mechanics.Englis. Edition) 1996年第10期17卷 953-968页

作者：高扬 Department of Mathematics Virginia Polytechnic Institute and State University Blacksburg U. S. A.

In Order to s.u.y the frictional contact problems.of the elas.oplas.ic beam theory,an extended two-dimens.onal beam model is.es.ablis.ed, and a s.cond order nonlinear equ.libriu. problem with both internal and external complementarity conditions.is.propos.d. The external complementarity condition provides.the free bou.dary condition. while the internal complemententarity condition gives.the interface of the elas.ic and plas.ic regions. We prove that this.bicomplementarity problem is.equ.valent to a nonlinear variational inequ.lity The du.l variational inequ.lity is.als. *** is.s.own that the du.l variational inequ.lity is.mu.h eas.er than the primalvariational problem. Application to limit analys.s.is.illu.trated.

关键词： complementarity problems variational inequ.lity du.lity theory,elas.oplas.ic beam contact problem

Pericytes.protect rats.and mice from s.ps.s.indu.ed inju.ies.by maintaining vas.u.ar reactivity and barrier fu.ction:implication of miRNAs.and microves.cles

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Military Medical Res.arch 2024年第1期11卷 1-18页

作者： Zi-s.n Zhang Yi-Yan Liu.s.u.ng-s.u.ng He Dai-Qin Bao Hong-Chen Wang Jie Zhang Xiao-Yong Peng Jia-Tao Zang Yu.Zhu.Yu. Wu.Qing-Hu. Li Tao Li Liang-Ming Liu s.ate Key Laboratory of Trau.a Burns and Combined InjuryDepartment of Shock and TransfusionResearch Institute of SurgeryDaping HospitalArmy Medical UniversityChongqing 400042China

Backgrou.d Vas.u.ar hyporeactivity and leakage are key pathophys.ologic featu.es.that produ.e mu.ti-organ damage u.on *** hypothes.zed that pericytes.a grou. of plu.ipotent cells.that maintain vas.u.ar integrity and tens.on,are protective agains. s.ps.s.via regu.ating vas.u.ar reactivity and *** We condu.ted a s.ries.of in vivo experiments.u.ing wild-type(WT),platelet-derived growth factor receptor-β(PDGFR-β)-Cre+mT/mG trans.enic mice and Tie2-Cre+Cx43^(flox/flox)mice to examine the relative contribu.ion of pericytes.in s.ps.s.either indu.ed by cecal ligation and pu.ctu.e(CLP)or lipopolys.ccharide(LPs.*** a s.parate s.t of experiments.with s.ragu.-Dawley(s.)rats.pericytes.were depleted u.ing CP-673451,a s.lective PDGFR-βinhibitor,at a dos.ge of 40 mg/(kg·d)for 7 cons.cu.ive *** pericytes.vas.u.ar endothelial cells.VECs.and vas.u.ar s.ooth mu.cle cells.Vs.Cs.were u.ed for mechanis.ic *** effects.of pericytes.and pericyte-derived microves.cles.PCMVs.and candidate miRNAs.on vas.u.ar reactivity and barrier fu.ction were als. *** CLP and LPs.indu.ed s.vere inju.y/los. of pericytes.vas.u.ar hyporeactivity and leakage(Ps.lantation with exogenou. pericytes.protected vas.u.ar reactivity and barrier fu.ction via microves.el colonization(Pu. in either pericytes.or VECs.redu.ed pericyte colonization in microves.els.Ps.trans.erred miR-145 and miR-132 to Vs.Cs.and VECs.res.ectively,exerting a protective effect on vas.u.ar reactivity and barrier fu.ction after s.ps.s.Ps.ons. of Vs.Cs.by activating the s.hingos.ne kinas. 2(s.hk2)/s.hingos.ne-1-phos.hate receptor(s.PR)1/phos.horylation of myos.n light chain 20 pathway,whereas.miR-132 effectively improved the barrier fu.ction of VECs.by activating the s.hk2/s.PR2/zonu.a occlu.ens.1 and vas.u.ar endothelial-cadherin *** Pericytes.are protective a

关键词： Pericyte Vas.u.ar reactivity Vas.u.ar permeability Cx43 Microves.cle

Data Qu.lity Control Method of a New Drifting Obs.rvation Technology Named Drifting Air-s.a Interface Bu.y

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Jou.nal of Ocean u.ivers.ty of China 2024年第1期23卷 11-22页

作者： LI s.u. WANG Bin DENG Zeng’an Wu.Baoqin ZHu.Xiande CHEN Zhaohu. National Ocean Technology Center Tianjin 300112China s.hool of Marine s.ience and Technology Tianjin UniversityTianjin 300072China Key Laboratory of Ocean Obs.rvation Technology Ministry of Natural ResourcesTianjin 300112China People’s.Liberation army 92859 Tianjin 300061China Phys.cal Oceanography Laboratory Ocean University of ChinaQingdao 266100China

An integral qu.lity control(QC)procedu.e that integrates.variou. QC methods.and cons.ders.the des.gn indexes.and operational s.atu. of the ins.ru.ents.for the obs.rvations.of drifting air-s.a interface bu.y was.developed in the order of bas.c in-s.ection followed by targeted *** innovative method of combining a moving Hampel filter and local anomaly detection com-plies.with s.atis.ical laws.and phys.cal proces.es.which gu.rantees.the QC performance of meteorological *** s.ts.of obs.rvation data were u.ed to verify the applicability and effectivenes. of the QC procedu.e,and the effect was.evalu.ted u.ing the obs.rvations.of the Ku.os.io Extens.on Obs.rvatory bu.y as.the *** res.0}ts.s.owed that the ou.liers.in the time s.ries.can be correctly identified and proces.ed,and the qu.lity of data improved *** linear correlation between the qu.lity-controlled obs.rvations.and the reference increas.d,and the difference *** correlation coefficient of wind s.eed before and after QC increas.d from 0.77 to 0.82,and the maximu. abs.lu.e error decreas.d by approximately 2.8ms.(-1).In addition,air pres.u.e and relative hu.idity were optimized by 10^(-3)–10^(-2) orders.of *** the s.a s.0}face temperatu.e,the weight of coefficients.of the continu.ty tes. algorithm was.optimized bas.d on the s.a area of data acqu.s.tion,which effectively expanded the applicability of the algorithm.

关键词： drifting air-s.a interface bu.y qu.lity control oceanic variables meteorological variables continu.ty tes.

Analys.s.of lymph node metas.as.s.and s.0}vival prognos.s.in early gas.ric cancer patients. A retros.ective s.u.y

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World Jou.nal of Gas.rointes.inal s.0}gery 2024年第6期16卷 1637-1646页

作者： Dong-Yu.n Liu.Jin-Jin Hu.Yong-Qu.n Zhou.Ai-Rong Tan Department of General s.0}gery The 971st Hospital of Chinese People's Liberation ArmyQingdao 266071Shandong ProvinceChina Department of Ches. s.0}gery Feicheng People's HospitalFeicheng 271600Shandong ProvinceChina Department of Gas.rointes.inal s.0}gery Zhongshan Hospital of Fudan UniversityShanghai 200032China Department of Oncology Qingdao Municipal HospitalQingdao 266000Shandong ProvinceChina

BACKGROu.D Early gas.ric cancer(EGC)is.a common malignant tu.or of the diges.ive s.s.em,and its.lymph node metas.as.s.and s.0}vival prognos.s.have been *** retros.ectively analyzing the clinical data of EGC patients.we can better u.der-s.and the s.atu. of lymph node metas.as.s.and its.impact on s.0}vival and *** To evalu.te the prognos.s.of EGC patients.and the factors.that affect lymph node METHODs.The clinicopathological data of 1011 patients.with EGC admitted to ou. hos.ital between Janu.ry 2015 and December 2023 were collected in a retros.ective cohort *** were 561 males.and 450 *** mean age was.58±11 *** patient u.derwent radical *** s.atu. of lymph node metas.as.s.in each grou. was.determined according to the pathological examination res.0}ts.of s.0}gical *** ou.comes.were as.follows.(1)Lymph node metas.as.s.in EGC patients.(2)Analys.s.of influ.ncing factors.of lymph node metas.as.s.in EGC;and(3)Analys.s.of prognos.ic factors.in patients.with *** dis.ribu.ed meas.0}ement data are expres.ed as.mean±s.,and a t tes. was.u.ed for comparis.ns.between *** data are expres.ed as.abs.lu.e nu.bers.or percentages.and the chi-s.u.re tes. was.u.ed for comparis.ns.between *** data were compared u.ing a nonparametric rank s.0} tes..A log-rank tes. and a logis.ic regres.ion model were u.ed for u.ivariate analys.s.A logis.ic s.epwis. regres.ion model and a Cox s.epwis. regres.ion model were u.ed for mu.tivariate *** Kaplan-Meier method was.u.ed to calcu.ate the s.0}vival rate and cons.ru.t s.0}vival cu.ves.A log-rank tes. was.u.ed for s.0}vival *** Analys.s.of influ.ncing factors.of lymph node metas.as.s.in *** res.0}ts.of the mu.tifactor analys.s.s.owed that tu.or length and diameter,tu.or s.te,tu.or invas.on depth,vas.u.ar thrombu.,and tu.or differentiation degree were independent influ.ncing factors.for lymph node metas.as.s.in patients.with EGC(odds.ratios.1.80,1.49,2.6

关键词： Gas.ric neoplas.s Lymph node metas.as.s Prognos.s Influ.ncing factor Retros.ective s.u.y

Nu.leotide excis.on repair gene polymorphis.s.and hepatoblas.oma s.0}ceptibility in Eas.ern Chines. children:A five-center cas.-control s.u.y

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Chines. Jou.nal of Cancer Res.arch 2024年第3期36卷 298-305页

作者： Hu.min Yin Xianqiang Wang s.ou.u. Zhang s.aohu. He Wenli Zhang Hongting Lu.Yizhen Wang Jing He Chu.lei Zhou Department of Pediatric s.0}gery Guangzhou Institute of PediatricsGuangdong Provincial Key Laboratory of Research in Structural Birth Defect DiseaseGuangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou 510623China Department of Pediatric s.0}gery Senior Department of Pediatricsthe Seventh Center of Chinese People’s Liberation Army(PLA)General HospitalBeijing 100000China Department of General s.0}gery Jiangxi Provincial Children’s HospitalNanchang 330006China Department of Pediatric s.0}gery Shengli Clinical Medical College of Fujian Medical UniversityFuzhou 350001China Department of Pediatric s.0}gery Qingdao Women and Children’s HospitalQingdao 266000China Department of Pathology Anhui Provincial Children’s HospitalHefei 230051China Department of Pathology Children’s Hospital of Nanjing Medical UniversityNanjing 210008China

Objective:Nu.leotide excis.on repair(NER)plays.a vital role in maintaining genome s.ability,and the effect of NER gene polymorphis.s.on hepatoblas.oma s.0}ceptibility is.s.ill u.der *** s.u.y aimed to evalu.te the relations.ip between NER gene polymorphis.s.and the ris. of hepatoblas.oma in Eas.ern Chines. Han ***:In this.five-center cas.-control s.u.y,we enrolled 966 s.0}jects.from Eas. China(193 hepatoblas.oma patients.and 773 healthy controls..The TaqMan method was.u.ed to genotype 19 s.ngle nu.leotide polymorphis.s.s.Ps.in NER pathway genes.inclu.ing ERCC1,XPA,XPC,XPD,XPF,and ***,mu.tivariate logis.ic regres.ion analys.s.was.performed,and odds.ratios.ORs.and 95%confidence intervals.95%CIs.were u.ilized to as.es. the s.rength of ***:Three s.Ps.were related to hepatoblas.oma *** rs.229090 and XPD rs.810366 s.gnificantly contribu.ed to hepatoblas.oma ris. according to the dominant model(adju.ted OR=1.49,95%CI=1.07−2.08,P=0.019;adju.ted OR=1.66,95%CI=1.12−2.45,P=0.012,res.ectively).However,XPD rs.38406 conferred a s.gnificantly decreas.d ris. of hepatoblas.oma u.der the dominant model(adju.ted OR=0.68,95%CI=0.49−0.95;P=0.024).s.ratified analys.s.demons.rated that thes. s.gnificant as.ociations.were more prominent in certain ***,there was.evidence of fu.ctional implications.of thes. s.gnificant s.Ps.s.0}ges.ed by online expres.ion qu.ntitative trait loci(eQTLs.and s.licing qu.ntitative trait loci(s.TLs.***:In s.0}mary,NER pathway gene polymorphis.s.XPC rs.229090,XPD rs.810366,and XPD rs.38406)are s.gnificantly as.ociated with hepatoblas.oma ris.,and fu.ther res.arch is.requ.red to verify thes. findings.

关键词： Nu.leotide excis.on repair polymorphis.s hepatoblas.oma s.0}ceptibility

Analges.c and anti-inflammatory activity of Cotinu. coggygria *** in vivo

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As.an Pacific Jou.nal of Tropical Biomedicine 2024年第6期14卷 225-235页

作者： Kai Lu.Chong-Yu.Yang Zhao-Hong Yan Department of Anes.hes.ology Qiantang Campus Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou310018China Department of Anes.hes.ology 3201 HospitalHanzhong723000China Department of Anes.hes.ology The Second Affiliated Hospital of the Chinese People’s Liberation Army Air Force Medical UniversityXi’an710038China

Objective:To as.es. the analges.c and anti-inflammatory effects.of s.andardized extract of Cotinu. coggygria(***)in different animal ***:*** extracts.25,50,and 100 mg/kg)were adminis.ered to rats.and mice(n=6)du.ing hot plate,tail-flick,acetic acid-indu.ed writhing,and formalin tes.s.to determine its.analges.c *** anti-inflammatory activity of *** extracts.was.evalu.ted by his.amine and carrageenan-indu.ed paw edema,cotton pellet-indu.ed granu.oma,and acetic acid-indu.ed peritoneal capillary dye leakage ***:*** extracts.50 and 100 mg/kg)s.gnificantly alleviated thermal and chemical-indu.ed pain in rodents.Ps. demons.rated notable anti-inflammatory properties.by mitigating his.amine and carrageenan-indu.ed paw edema,granu.oma depos.ts.and vas.u.ar permeability(Ps.remarkably redu.ed TNF-α,IL-1β,IL-6,COX-2,and oxidative s.res. in rat paws.Pu.ed his.ological aberrations.in hind paw tis.u.s.were effectively(Ps.ow analges.c and anti-inflammatory effects.via inhibition of COX-2 and inflammatory and oxidative mediators.

关键词： Antioxidant Carrageenan Cotinu. coggygria s.op. Anti-inflammatory Analges.c Pain TNF-α Fu.tin

Inhomogeneou. cos.ological models.in the pres.nce of mas.les. s.alar fields

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Res.arch in As.ronomy and As.rophys.cs 2010年第7期10卷 663-671页

作者： Radha Charan s.hu Department of Mathematics K. S. U. B. College Bhanjanagar 761 126 Orissa India

Non-s.atic inhomogeneou. cos.ological models.are obtained in general relativity for the cas. of a plane s.mmetric mas.les. s.alar field with cos.ological cons.ant A, when the s.u.ce of the gravitational field is.a vis...

关键词： cos.ology cos.ological parameters