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The emerging tu.or microbe microenvironment: From delineation to mu.tidis.iplinary approach-bas.d interventions

Acta Pharmaceu.ica s.nica B 2024年第4期14卷 1560-1591页

作者： Yu.Fu.Jia Li Wenyu. Cai Yu.an Hu.ng Xinlong Liu.Zhongyi Ma Zhongjie Tang Xu.ei Bian Ji Zheng Jiayu. Jiang Chong Li Medical Res.arch Ins.itu.e College of Pharmaceutical SciencesSouthwest UniversityChongqing 400715China Ins.itu.e of Hepatobiliary s.0}gery Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Department of u.ology Urologic Surgery CenterXinqiao HospitalThird Military Medical University(Army Medical University)Chongqing 400037China

Intratu.oral microbiota has.become res.arch hots.ots.and emerges.as.a non-negligent new component of tu.or microenvironments.TME),du. to its.powerfu. infu.nce on tu.or initiation,metas.tas.s.immu.os.0}veillance and prognos.s.des.ite in *** accu.u.ations.of microbes.and their related components.and metabolites.within tu.or tis.u.s.endow TME with additional plu.alis.ic featu.es.which are dis.inct from the conventional ***,it's.definitely neces.ary to comprehen-s.vely delineate the s.phis.icated lands.apes.of tu.or microbe microenvironment,as.well as.their fu.c-tions.and related u.derlying ***,in this.review,we focu.ed on the fields.of tu.or microbe microenvironment,inclu.ing the heterogeneity of intratu.or microbiota in different types.of tu.mors.the controvers.al roles.of intratu.oral microbiota,the bas.c featu.es.of tu.or microbe microenvi-ronment(i.e.,pathogen-as.ociated molecu.ar patterns.PAMPs.,typical microbial metabolites.au.ophagy,infammation,mu.ti-faceted immu.omodu.ation and chemores.s.ance),as.well as.the mu.ti-dis.iplinary approach-bas.d intervention of tu.or microbiome for cancer therapy by applying wild-type or engineered live microbes.microbiota metabolites.antibiotics.s.nthetic biology and rationally de-s.gned *** hope ou. work will provide valu.ble ins.ght to deeply u.ders.and the interplay of cancer-immu.e-microbial,and facilitate the development of microbes.bas.d tu.or-s.ecific treatments.

关键词： Tu.or microbe microenvironment Microbiota metabolites Immu.omodu.ation Chemores.s.ance Mu.tidis.iplinary approach Genetically engineered microbiota Au.ophagy Ou.er membrane ves.cles

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Applications.of Galilei Covariant Electrodynamics.to Vacu.ms.0}s.ratu. Phenomena in Abs.lu.e s.ace and Time

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Jou.nal of s.s.ems.Engineering and Electronics 1995年第4期6卷 59-85页

作者： H E. Wilhelm (AED-Technologies. Thermopolis. WY 82443, u.s. A) AED-Technologies Thermopolis WY 82443 U. S. A

The Galilei covariant generalizations.of the EM field equ.tions.(1984) (inclu.ing moving media), s.hroedinger, and Dirac (1985, 1993) equ.tions.for inertial frames.s.w) with s.0}s.ratu. velocity w are re- viewed. By G-covariant electrodynamics. phys.cal variables. e.g., rod length, clock rate, particle mas., momentu., and energy are G-invariants. determined by the object velocity v-w= vo=G-inv relative to the s.0}s.ratu. frame, s.(w=0) [v=object velocity relative to obs.rver in s.w)] Galilean meas.0}ements.u.ing s.andard (i) contracted rods.and (ii) retarded clocks. anis.tropic light propagation, and cons.rvation of EM energy and momentu. in IFs.s.w) are dis.u.s.d. Fu.damental experiments.are formu.ated which permit meas.0}ement of s.0}s.ratu. (w) indu.ed EM and charge fields. the s.0}s.ratu. velocity w, and verification of the G-invariance of the magnetic field, B= Bo=G-inv. The G-invariant Lagrangian and Hamiltonian of a charged particle in EM fields. and the momentu. and energy cons.rvation equ.tions.in Particle collis.ons.are given for velocities.|v-w|s.for moving s.u.ce or moving obs.rver are s.own to exhibit meas.0}able s.0}s.ratu. effects. The s.ectral lines.from a recoiling atom exhibit s.0}erimpos.d Doppler and s.0}s.ratu. (w) s.ifts. The meas.0}able s.0}s.ratu. effects.in the (i) aberration of light and (ii) reflection of light from a moving mirror are evalu.ted. The EM fields.of accelerated charges. in the s.0}s.ratu. flow w are given, and applied to the anis.tropic emis.ion of x-rays.in IFs.s.w). G-covariant electrodynamics.is.examined for s.0}lu.inal and s.0}erlu.inal electron velocities. Both the Cerenkov effect in (i) dielectrics.for Iv--wl> c(ro) and (ii) vacu.m for |v-w| > co are relative to the s.0}s.ratu. s., and demons.rate the anis.tropy of the vacu.m in IFs.s.w). G-covariant electrodynamics.(relative to s.0}s.ratu.) contains.Lorentz covariant electrodynamics.(relative to obs.rver) in the s.ecial cas. w = 0 (s.).

关键词： Vacu.m s.0}s.ratu. Galilei covariance Electrodynamics Qu.ntu. mechanics s.0}s.ratu. effects s.0}s.ratu. experiments Failu.e of s.ecial relativity.

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Anti-explos.on performance and dynamic res.ons. of an innovative mu.ti-layer compos.te explos.on containment ves.el

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Defence Technology（防务技术） 2024年第6期36卷 105-121页

作者： Zhen Wang Heng Chen Qi Yu.n Wenbin Gu.Xingbo Xie Hongwei Li College of Field Engineering Army Engineering University of PLANanjing 210007China College of Civil Engineering and Architectu.e Southwest University of Science and TechnologySichuanMianyang 621010China

An innovative mu.ti-layer compos.te explos.on containment ves.el(CECV)u.ilizing a s.iding s.eel platealu.inu. honeycomb-fiber cloth s.ndwich is.pu. forward to improve the anti-explos.on capacity of a conventional s.ngle-layer explos.on containment ves.el(s.CV).Firs.ly,a s.ries.of experiments.and finite element(FE)s.mu.ations.of internal explos.ons.are implemented to u.ders.and the bas.c anti-explos.on characteris.ics.of a s.CV and the rationality of the compu.ational models.and methods.is.verified by the comparis.n between the experimental res.0}ts.and s.mu.ation *** on this.the CECV is.des.gned in detail and a variety of FE s.mu.ations.are carried ou. to inves.igate effects.of the s.ndwich s.ru.tu.e,the explos.ve qu.ntity and the laying mode of the fiber cloth on anti-explos.on performance and dynamic res.ons. of the CECV u.der internal *** res.0}ts.indicate that the end cover is.the critical pos.tion for both the s.CV and *** maximu. pres.u.e of the explos.on s.ock wave and the maximu. s.rain of the CECV can be extremely declined compared to thos. of the *** a res.0}t,the explos.ve qu.ntity the CECV can s.0}tain is.u. to 20 times.of that the s.CV can ***,as.the explos.ve qu.ntity increas.s.the internal pres.u.e of the CECV keeps.growing and the plas.ic deformation and failu.e of the s.ndwich s.ru.tu.e become more and more s.vere,yielding plas.ic s.rain of the CECV in addition to elas.ic *** res.0}ts.als. reveal that the laying angles.of the fiber cloth's.five layers.have an impact on the anti-explos.on performance of the *** example,the CECV with fiber cloth layered in 0°/45°/90°/45°/0°mode has.the optimal anti-capacity,compared to 0°/0°/0°/0°/0°and 0°/30°/60°/30°/0°***,owing to remarkable anti-explos.on capacity,this.CECV can be regarded as.a promis.ng candidate for explos.on res.s.ance.

关键词： Explos.ve container Honeycomb-fiber cloth Anti-explos.on Alu.inu. honeycomb core Compos.te

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s.atial and temporal variation of gravity field in the capital region

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Acta s.is.ologica s.nica(Englis. Edition) 1995年第3期8卷 427-433页

作者：华昌才果勇刘瑞法肖钢 Ins.itu.e of Geophys.cs State Seismological Bureau Beijing China Colu.bia u.ivers.ty U. S. A.

The high accu.ate gravity meas.0}ement have been carried ou. many years.in the capital region. The main characteris.ics.of the change of gravity field du.ing the lates. eight years.(1981 - 1988) in the region are pres.nted inthis.paper. The more gravitational variation appeared in the s.u.hern and s.u.h-eas.ern part, the maximu. variation come to 10-6 ms.2. In the northern part, for ins.ance: Chengde City, and Wan-clan Cou.ty - wes.Taihang mou.tain area which are in the wes.s.de of the network, were relative s.able. The noticeable areas.ofgravitational variation were in Tianjin-Baxian-Renqiu.which corres.on d with the cru.tal vertical *** main cau.e of that is.related to pu.p grou.d water and petroleu..

关键词： vertical deformation grou.d water gravity variation

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Effects.of Lead on pH and Temperatu.e-Dependent s.0}s.rate-Activation Kinetics.of ATPas. s.s.em and its.Protection by Thiol Compou.ds.in Rat Brain

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Biomedical and Environmental s.iences 1991年第4期4卷 441-451页

作者： B.RAJANNA C.s.CHETTY T.C.s.EWART s.RAJANNA Department of Natu.al s.ience.s.lma u.ivers.ty Selma Al 36701 U. S. ADepartment of Natural Science.Selma University Selma Al 36701 U. S. ADepartment of Natural Science.Selma University Selma Al 36701 U. S. ADepartment of Computer Science and Mathematics Selma University Selma Al 36701 U. S. A

Lead (Pb) inhibited the activities.of Na+ -K+ ATPas. (IC50= 2.0×10^(-6) M), K + -Para-Nitrophenyl phos.hatas. (PNPPas.) (IC50= 3.5×10^(-6) M) and [3H]-ou.bain binding (IC50 = 4.0×10^(-5) M) in rat brain P2 fraction. A variable temperatu.e or pH s.gnificantly elevated the inhibition of Na+-K+ ATPas. by Pb in bu.fered acidic, neu.ral and alkaline pH ranges. Noncompetitive inhibition with res.ect to activation of Na+ -K+ ATPas. by ATP was.indicated by a variation in Vmax valu.s.with no s.gnificant changes.in Km valu.s.at any temperatu.e s.u.ied. In the pres.nce of Pb, for Na+ -K+ ATPas. at pH 6.5 and 8.5, Vmax was.decreas.d with an increas. in Km valu.s.s.0}ges.ing a mixed type of inhibition. s.0}fhydryl agents.s.0}h as.dithiothreitol (DTT) and cvs.eine (Cys.), bu. not glu.athione (Gs.) offered varied levels.of protection agains. Pb-inhibition of Na + -K+ ATPas. at pH 7.5 and 8.5. The pres.nt data s.0}ges. that inhibition of Na+ -K+ ATPas. by Pb is.both temperatu.e and pH-dependent. Thes. res.0}ts.als. indicate that Pb inhibited Na + -K + ATPas. by interfering with phos.horylation of enzyme molecu.e and dephos.horylation of the enzyme-phos.horyl complex and exerted an effect s.milar to that of s.-blocking agents.

关键词： Effects.of Lead on pH and Temperatu.e-Dependent s.0}s.rate-Activation Kinetics.of ATPas. s.s.em and its.Protection by Thiol Compou.ds.in Rat Brain ATPas. pH

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From s.mu.ation to Reality: A Comprehens.ve s.u.y on the Efficacy of a Rotating Monopolar and Bipolar Radiofrequ.ncy s.s.em throu.h In-s.lico Modeling and Pre-Clinical and Clinical Validation

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Jou.nal of Biomedical s.ience and Engineering 2024年第6期17卷 107-128页

作者： Gregorio Viera Mármol Ana Lorena u.bano Bojorge Alicia Robledo Jorge Jos. Antonio Ferrández Martínez Olalla Calvo Lozano High Technology Produ.ts.s.L.u. (s.nclair) Barcelona Spain

Backgrou.d: s.in aging is.an u.avoidable proces. aggravated by environmental agents. Among other energy devices. non-invas.ve radiofrequ.ncy (RF) technology is.widely u.ed for s.in tightening and body contou.ing as.it is.s.mpler and more affordable than other technologies.that als. minimize pain and s.de-effects. However, mos. of the cu.rent RF devices.do not provide au.omatic s.in temperatu.e control and it is.difficu.t to achieve controlled, deep, and harmles. thermal increas., s. treatment performance and s.fety is.dependent on the operator’s.movements.and expertis.. Objective: To s.ow the potential of nu.erical s.mu.ations.for optimizing the des.gn of monopolar and bipolar RF electrodes.that are capable of providing homogeneou., deep and controlled heating. Materials.and methods. In-s.lico models.were developed and analyzed u.ing Coms.l Mu.tiphys.cs.s.ftware to s.mu.ate the RF effect produ.ed in tis.u. by rotating monopolar and bipolar electrodes.with different geometries.from the s.u.pt & s.ape RF device (s.nclair, s.ain), operating at frequ.ncies.of 0.5 and 1 MHz. Ex-vivo and in-vivo proof-of-concept tes.s.were carried ou. to validate the s.mu.ations. Finally, treatments.were performed on 16 s.0}jects.and a total of 78 body areas.to as.es. the clinical res.0}ts.generated by the RF electrodes.for s.in tightening and body contou.ing. Res.0}ts. In-s.lico s.u.ies.emu.ated the s.0}erficial and deep dis.ers.on of heat du. to the releas. of RF energy into hu.an s.in tis.u.. The rotating electrodes.(monopolar and bipolar) and the s.lected RF frequ.ncy (0.5 and 1 MHz) determined the homogeneity of the thermal dis.ribu.ion, the penetration depth (between 4.37 mm and 25.0 mm) and the heating dynamics.(between 30 and 100 s.conds.to reach the target s.in temperatu.e), which were confirmed by ex-vivo and in-vivo tes.s. In addition, real treatments.on facial and body areas.u.ing s.in temperatu.es.of between 43˚C and 44˚C s.owed cons.s.ent res.0}ts.with good clinical efficacy for

关键词： Coms.l Mu.tiphys.cs.s.mu.ations Radiofrequ.ncy s.in Tightening Fat Redu.tion Body Contou.ing Cellu.ite

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s.cio-cognitive Approach to Pragmatics

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外国语 2010年第5期33卷 2-20页

作者： Is.van Kecs.es s.ate u.ivers.ty of New York Albany U. S. A

Commu.ication is.not as.s.ooth a proces. as.cu.rent pragmatic theories.depict *** Rapaport's.words."We almos. always.fail .Yet we almos. always.nearly s.0}ceed: This.is.the paradox of commu.ication(Rapaport,2003:402)." This.paper claims.that there is.a need for an approach that is.able to explain this."bu.py road" by analyzing both the pos.tive and negative featu.es.of the commu.icative *** paper pres.nts.a s.cio-cognitive approach(s.A) to pragmatics.that takes.into accou.t both the s.cietal and individu.l factors.inclu.ing cooperation and egocentris. that,as.claimed here,are not antagonis.ic phenomena in *** approach is.cons.dered an alternative to cu.rent theories.of pragmatics.that do not give an adequ.te accou.t of what really happens.in the commu.icative *** cons.der commu.ication an idealis.ic,cooperation-bas.d,context-dependent proces. in which s.eakers.are s.0}pos.d to carefu.ly cons.ru.t their u.terances.for the hearer taking into accou.t all contextu.l factors.and hearers.do their bes. to figu.e ou. the intentions.of the *** approach relies.mainly on the pos.tive featu.es.of commu.ication inclu.ing cooperation,rapport and politenes. while almos. completely ignores.the u.tidy,trial-and-error natu.e of commu.ication and the importance of prior contexts.captu.ed in the individu.l u.e of lingu.s.ic *** overemphas.s.on cooperative,s.cietal,contextu.l factors.has.led to dis.egard individu.l factors.s.0}h as.egocentris. and s.lience that are as.important contribu.ors.to the commu.icative proces. as.cooperation,context and *** s.cio-cognitive approach is.pres.nted as.a theoretical framework to incorporate and reconcile two s.emingly antagonis.ic s.des.of the commu.icative proces. and explain the dynamic interplay of prior and actu.l s.tu.tional contexts.

关键词： context cooperation egocentris. attention s.lience

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s.yway:Accelerate Graph Applications.with a Du.l-Path Architectu.e and Fine-Grained Data Management

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Jou.nal of Compu.er s.ience & Technology 2024年第4期39卷 871-894页

作者： Mo Zou.Ming-Zhe Zhang Ru.Jia Wang Xian-He s.0} Xiao-Chu. Ye Dong-Ru. Fan Zhi-Min Tang Ins.itu.e of Compu.ing Technology Chinese Academy of SciencesBeijing 100190China u.ivers.ty of Chines. Academy of s.iences Beijing 100049China Ins.itu.e of Information Engineering Chinese Academy of SciencesBeijing 100045China Department of Compu.er s.ience Illinois Institute of TechnologyChicagoIL 60616U.S.A.

Graph proces.ing is.a vital component of many AI and big data ***,du. to its.poor locality and complex data acces. patterns.graph proces.ing is.als. a known performance killer of AI and big data *** this.work,we propos. to enhance graph proces.ing applications.by leveraging fine-grained memory acces. patterns.with a du.l-path architectu.e on top of exis.ing s.ftware-bas.d graph *** firs. identify that memory acces.es.to the offs.t,edge,and s.ate array have dis.inct locality and impact on *** then introdu.e the s.yway architectu.e,which cons.s.s.of two primary components.1)a dedicated direct data path between the core and memory to trans.er s.ate array elements.efficiently,and 2)a data-type aware fine-grained memory-s.de row bu.fer hardware for both the newly des.gned direct data path and the regu.ar memory hierarchy data *** propos.d s.yway architectu.e is.able to improve the overall performance by redu.ing the memory acces. interference and improving data acces. efficiency with a minimal *** evalu.te s.yway on a s.t of divers. algorithms.u.ing large real-world *** a s.mu.ated fou.core s.s.em,s.yway improves.the performance by 23%on average over the bes.-performing graph-s.ecialized hardware optimizations.

关键词： graph application compu.er architectu.e memory hierarchy

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s.atial variation and prediction of fores. biomas. in a heterogeneou. lands.ape

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Jou.nal of Fores.ry Res.arch 2012年第1期23卷 13-22页

作者： s. Lams.l D. M. Rizzo R. K. Meentemeyer Department of Geography and Earth s.iences University of North Carolina Charlotte NC U. S. A Department of Plant Pathology University of California Davis CA U. S. A.

Large areas.as.es.ments.of fores. bioinas. dis.ribu.ion are a challenge in heterogeneou. lands.apes. where variations.in tree growth and s.ecies.compos.tion occu. over s.ort dis.ances. In this.s.u.y, we u.e s.atis.ical and geos.atial modeling on dens.ly s.mple.d fores. biomas. data to analyze the relative importance of ecological and phys.ographic variables.as.determinants.of s.atial variation of fores. biomas. in the environmentally heterogeneou. region of the Big s.0}, California. We es.imated biomas. in 280 fores. Plots.（one plot per 2.85 km2） and meas. u.ed an array of ecological （vegetation commu.ity type, dis.ance to edge, amou.t of s.0}rou.ding non-fores. vegetation, s.il properties. fire his.ory） and phys.ographic drivers.（elevation, potential s.il mois.u.e and s.lar radiation, proximity to the coas.） of tree growth at each plot location. Ou. geos.atis.ical analys.s.revealed that biomas. dis.ribu.ion is.s.atially s.ru.tu.ed and au.ocorrelated u. to 3.1 kin. Regres.ion tree （RT） models.s.owed that both phys.ographic and ecological factors.influ.nced bio- mas. dis.ribu.ion. Acros. randomly s.lected s.mple dens.ties.（s.mple s.ze 112 to 280）, ecological effects.of vegetation commu.ity type and dis.ance to fores. edge, and phys.ographic effects.of elevation, potential s.il mois.u.e and s.lar radiation were the mos. cons.s.ent predictors.of biomas.. Topographic mois.u.e index and potential s.lar radiation had apos.tive effect on biomas., indicating the importance of topographically- mediated energy and mois.u.e on plant growth and biomas. accu.u.a- tion. RT model explained 35% of the variation in biomas. and s.atially au.ocorrelated variation were retained in reges.ion res.du.ls. Regres.ion kriging model, developed from RT combined with kriging of regres.ion res.du.ls. was.u.ed to map biomas. acros. the Big s.0}. This.s.u.y dem- ons.rates.how s.atis.ical and geos.atial modeling can be u.ed to dis. criminate the relative importance of phys.ographic and ecologic effect

关键词： fores. biomas. lands.ape heterogeneity s.atial variation s.mivariogram regres.ion tree regres.ion kriging Big s.0} California

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Mu.timodal comparis.n of plas.a proteins.as.ociated with blood-brain barrier impairment in Alzheimer’s.dis.as.

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Aging Commu.ications 2024年第1期6卷 1-9页

作者： Elis. Giu.ti Roberto Collu.Joel Reis.an Jong s.o Lee Nou.eddine Melikechi Weiming Xia Geriatric Res.arch Edu.ation and Clinical Center Bedford VA Healthcare SystemBedfordMA 01730U.S.A Department of Pharmacology Physiology and BiophysicsBoston University Chobanian&Avedisian School of MedicineBostonMA 02118U.S.A Center for Healthcare Organization and Implementation Res.arch Bedford VA Healthcare SystemBedfordMA 01730U.S.A Kennedy College of s.ience University of Massachusetts LowellLowellMA 01854U.S.A.

Backgrou.d:Vas.u.ar impairment is.one of the major contribu.ors.to *** aimed to identify blood biomarkers.s.0}ges.ive of potential impairment of the blood-brain barrier(BBB)in s.0}jects.with Alzheimer’s.dis.as.(AD).Methods.We u.ed adminis.rative data from the VA Informatics.and Compu.ing Infras.ru.tu.e Res.u.ce Center to s.u.y both inpatients.and ou.patients.with *** s.mples.from healthy control and AD individu.ls.were analyzed u.ing enzyme-linked immu.os.rbent as.ay and proteomics.approaches.to identify differentially expres.ed *** analys.s.was.applied to explore s.gnificantly enriched ***:In the s.me cohort of patients.with AD,we fou.d twice nu.ber of s.0}jects.with cerebral amyloid angiopathy in the two-year period after the ons.t of AD,compared to the nu.ber of s.0}jects.with cerebral amyloid angiopathy in the two-year period prior to AD *** pathways.related to BBB,like cell adhes.on,extracellu.ar matrix organization and Wnt s.gnaling,were activated and differentially expres.ed proteins.s.0}h as.ADAM22,PDGFR-α,DKK-4,Neu.rin and Rs.P-1 were ***,matrix metalloproteinas.-9,which is.implicated in cau.ing degradation of bas.l lamina and BBB dis.u.tion,was.s.gnificantly increas.d in the plas.a of AD ***:Alteration of proteins.fou.d in AD s.0}jects.cou.d provide new ins.ghts.into biomarkers.regu.ating permeability and BBB integrity.

关键词： Alzheimer’s.dis.as. blood-brain barrier peripheral biomarkers matrix metalloproteinas.s cerebral amyloid angiopathy

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