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RNA-protein interactions in the core domain of spliceosomal u4 snRNP

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RNA-protein interactions in the core domain of spliceosomal ...

Hyperspectral Evaluation of <i>Venturia inaequalis</i>Management using the Disease Predictive Model RIMpro in the Northeastern u.S.

亚洲晶体学联合大会

作者： Adelaine K.W.Leung Jade Li Kiyoshi Nagai Medical Research Council Laboratory of Molecular Biology Hills RoadCambridgeCB2 0QHU.K. Department of Neurobiology Harvard Medical School220 Longwood AvenueBostonMA02115USA

＜正＞The spliceosome responsible for processing pre-mRNA to mRNA is assembled from u1, u2, and u4/u6-u5 snRNPs （small nuclear ribonucleoprotein particles）. The core domain of the u1, u2, u4 and u5 snRNPs is formed ...

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Agricultural Sciences 2017年第12期8卷 1358-1371页

作者： Matthew Wallhead Heping Zhu Kirk Broders Department of Biological Sciences University of New Hampshire Durham USA u.S. Department of Agriculture-Agriculture Research Service Application Technology Research Unit Wooster USA Department of Bioagricultural Sciences and Pest Management Colorado State University Fort Collins USA

use of hyperspectral spectroradiometers allows for information on different light bands to be captured, allowing for identification of plant health status. Apple scab is the most important disease in the production of apples. RIMpro is a web-based decision support system (DDS) for orchardists that has the capacity to improve optimal fungicide application for the control of apple scab and has the potential to reduce the number of applications and thereby reduce input expenses. The objective of this study was to complete a hyperspectral assessment of apple leaves in order to evaluate the spectral characteristics of trees sprayed according to forecasted infection events from the DDS. No significant differences in visual assessments or vegetation indices were observed between conventionally treated leaves and leaves treated according to the DSS. In the first year of this study two fungicide treatments were eliminated, in the second one fungicide treatment was eliminated. This finding is important because it provides evidence that plant health status is similar between conventionally sprayed trees and trees on a DSS-guided reduced spray program. In addition, the use of spectroradiometers for assessing the efficacy of different fungicide programs was demonstrated. Finally, potassium bicarbonate tank-mixed with sulfur was confirmed to be an effective spray material for managing apple scab. By integrating the precise information provided by DSSs and the use of biorational pesticides, agricultural producers, service providers and educators are able to adapt climate change considerations and action-oriented decisions into pest management plans.

关键词： Integrated Pest Management Decision Support System Pathogens Fungicide Remote Sensing

Self-Powered Absorptive Reconfigurable Intelligent Surfaces for Securing Satellite-Terrestrial Integrated Networks

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China Communications 2024年第9期21卷 276-291页

作者： Lin Zhi Niu Hehao He Yuanzhi An Kang Zhong Xudong Chu Zheng Xiao Pei College of Electronic Engineering National University of Defense TechnologyHefei 230037China Sixty-Third Research Institute National University of Defense TechnologyNanjing 210007China Institute of Systems Engineering Academy of Military ScienceBeijing 100141China Department of Electrical and Electronic Engineering University of Nottingham Ningbo ChinaNingbo 315100China Institute for Communication Systems University of SurreyGuildford GU27XHU.K.

Satellite communications have attracted significant interests due to its advantages of large footprint and massive ***,the commonly used onboard beamforming is hard to achieve reliable security because of the highly correlated legitimate and wiretap downlink *** exploit the benefits of satellite-terrestrial integrated network(STIN)and a novel absorptive reconfigurable intelligent surface(RIS)for improving the security of satellite downlink communications(SDC)in the presence of eavesdroppers(Eves).This paper aims to maximize the achievable secrecy rate of the earth station(ES)while satisfying the signal reception constraints,harvested power threshold at the RIS,and total transmit power *** solve this nonconvex problem,we propose a penalty-function based dual decomposition scheme,which firstly transforms the original problem into a two-layer optimization ***,the outer layer and inner problems are solved by utilizing the successive convex approximation,Lagrange-dual and Rayleigh quotient methods to obtain the beamforming weight vectors and the reflective coefficient ***,simulation results verify the effectiveness of the proposed scheme for enhancing the SDC security.

关键词： absorptive RIS beamforming design secure communications STIN

Initial constraints on the timing of granitic magmatism in North Korea using u-Pb zircon geochronology

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Initial constraints on the timing of granitic magmatism in N...

New Rotative Radiofrequency Technology: A Multicenter Retrospective Study on Efficacy and Safety

中国科学院地质与地球物理研究所2007学术年会

作者： Ryong-Hyon Han Simon A.Wilde Song-Chol Park Institute of Geology State Academy of Sciences Kwahak-1 dongUnjongPyongyangDemocratic People’s Republic of Korea Department of Applied Geology Curtin university of Technology P O Box U1987PerthWestern Australia 6845Australia

The geology of North Korea is very poorly *** this paper,twenty-seven granitic samples from the Tumangang belt and the Rangnim massif,including diorite,granodiorite and monzogranite,were selected for in situ zircon u-Pb isotopic *** the Tumangang belt,granites formed mainly in the Jurassic,with one sample giving a Triassic *** is contrary to previous views that considered the granites to be Permian to Triassic in *** the Rangnim massif,Precambrian granitic magmatism mainly took place at～2.1 and 1.9-1.8 Ga;no Archean emplacement ages have been documented in this study,although some inherited discordant zircon may be of this *** magmatism in this area can be divided into three stages with ages of 234-213,～173 and 114-109 *** Triassic granites are mostly exposed in the north and the Early Cretaceous ones in the *** distribution of Jurassic granites is less well documented and only one sample was identified in this ***,previous data indicate they are more widely distributed in the ***～2.1 and 1.9-1.8 Ga Precambrian ages are comparable to Paleoproterozoic magmatism in northeastern China,indicating that the Rangnim massif was most likely part of the North China Craton during that ***,the absence of 2.5 Ga granites and the occurrence of 1.2 Ga granites,indicate that the Rangnim massif was probably at the margin of the North China Craton and affected by Mesoproterozoic *** similarity in age patterns of the Mesozoic granites in North Korea to surrounding areas of South Korea and the Liaodong Peninsula of northeastern China indicate that they were controlled by subduction of the Pacific Ocean under eastern ***,roll-back or retreat of the subduction zone resulted in a younging trend from northwest to southeast during the Cretaceous.

关键词： North Korea u-Pb dating Zircon Granite

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Journal of Cosmetics, Dermatological Sciences and Applications 2024年第1期14卷 69-83页

作者： José Antonio Ferrández Martínez Gregorio Viera Mármol Fabrizio Vignoli Joanet Perera Agustin Blanch Mara Suárez Alicia Robledo Jorge Reyna Vargas Lamas Sinclair Barcelona Spain Studio Vignoli Bologna Italy Clinica Perla Medic Alicante Spain Dr. Agustin Blanch Clinica Barcelona Spain Intek Medical Technology S.L.u. Barcelona Spain

Background: Non-ablative radiofrequency (RF) technology is widely used for the treatment of signs of aging, skin laxity, localized fat and cellulite. However, many RF devices suffer from technical limitations that make the results highly dependent on the user’s experience or clinical limitations that compromise safety, efficacy and comfort. Objective: To evaluate the efficacy and safety of a novel semi-automatic non-ablative RF device for skin tightening, body shaping and cellulite reduction. Materials and methods: A retrospective multicenter study was performed using a novel rotative RF device with temperature and impedance control (Sculpt&Shapeup>®up>, Sinclair, Spain). 58 subjects underwent a minimum of 4 treatments every 1-2 weeks. A total of 120 treatments (56.7% body and 43.3% facial) and 1034 sessions were performed. Efficacy was evaluated by 3 researchers using the Global Aesthetic Improvement Scale (GAIS) and anthropometric measurements were collected. Subject and practitioner satisfaction were recorded. Safety was evaluated by analyzing the perception of pain during the treatment and the side and adverse effects immediately after treatment and over the next 48 hours. Results: Between 25% and 50% improvement was achieved according to the GAIS. Statistically significant (p uction of 5.1 mm and circumference reduction of 32.0 mm, 16.4 mm and 13.9 mm were recorded for the abdomen, legs and arms, respectively. 77.5% of subjects and 94.9% of practitioners were either satisfied or very satisfied. Minor adverse effects were found in 0.97% of the sessions. Conclusion: This novel semi-automatic rotative RF device has been found to provide treatments that are effective, safe and comfortable for both practitioners and subjects. .

关键词： Rotative Radiofrequency RF Cellulite Skin Tightening Body Shaping

Adult neurogenesis:a real hope or a delusion?

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Neural Regeneration Research 2024年第1期19卷 6-15页

作者： Ghulam Hussain Rabia Akram Haseeb Anwar Faiqa Sajid Tehreem Iman Hyung Soo Han Chand Raza Jose-Luis Gonzalez De Aguilar Neurochemicalbiology and Genetics Laboratory(NGL) Department of PhysiologyFaculty of Life SciencesGovernment College UniversityFaisalabadPunjabPakistan Department of Physiology School of MedicineClinical Omics InstituteKyungpook National UniversityDaeguKorea Department of Zoology Faculty of Chemistry and Life SciencesGovernment College UniversityLahorePakistan INSERM U1118Mécanismes Centraux et Péripheriques de la NeurodégénérescenceStrasbourgFranceUniversitéde StrasbourgStrasbourgFrance

Adult neurogenesis,the process of creating new neurons,involves the coordinated division,migration,and differentiation of neural stem *** process is restricted to neurogenic niches located in two distinct areas of the brain:the subgranular zone of the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricle,where new neurons are generated and then migrate to the olfactory *** has been thought to occur only during the embryonic and early postnatal stages and to decline with age due to a continuous depletion of neural stem ***,recent years have seen tremendous progress in our understanding of adult brain neurogenesis,bridging the knowledge gap between embryonic and adult ***,we discuss the current status of adult brain neurogenesis in light of what we know about neural stem *** this notion,we talk about the importance of intra cellular signaling molecules in mobilizing endogenous neural stem cell prolife *** on the current understanding,we can declare that these molecules play a role in targeting neurogenesis in the mature ***,to achieve this goal,we need to avoid the undesired proliferation of neural stem cells by controlling the necessary checkpoints,which can lead to tumorigenesis and prove to be a curse instead of a blessing or hope.

关键词： adult neurogenesis aging brain-derived neurotrophic factor dentate gyrus hippocampus neural stem cells neurotrophic factors Notch oxidative stress stem cells subgranular zone

FRET-based two-photon benzo[a]phenothiazinium photosensitizer for fluorescence imaging-guided photodynamic therapy

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Chinese Chemical Letters 2024年第7期35卷 325-328页

作者： Yiling Li Zekun Gao Xiuxiu Yue Minhuan Lan Xiuli Zheng Benhua Wang Shuang Zhao Xiangzhi Song College of Chemistry&Chemical Engineering Central South UniversityChangsha 410083China Key Laboratory of Photochemical Conversion and Optoelectronic Materials and City u-CAS Joint Laboratory of Functional Materials and Devices Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China Department of Dermatology Xiangya HospitalCentral South UniversityChangsha 410083China

To overcome the conflict between the long-wavelength excitation and high singlet oxygen quantum yield of photosensitizers,we conjugated a two-photon fluorophore,tetrahydroquinoxaline coumarin(TQ),and an efficient photodynamic therapeutic agent,benzo[a]phenothiazinium(NBS-NH_(2)),through a hexamethylene linker to build a two-photon photosensitizer,*** TQ-NBS,TQ served as an energy donor and NBS-NH_(2) acted as an energy acceptor;and TQ-NBS was a F?rster resonance energy transfer(FRET)cassette with a 92.8%*** large two-photon absorption cross-section of TQ allowed photosensitizer TQ-NBS to work in a 900 nm two-photon excitation(TPE)mode,which greatly benefited the deep tissue penetration in PDT ***,the excellent phototoxicity and near-infrared fluorescence of NBS-NH2was kept in TQ-NBS under a TPE mode via a FRET *** TQ-NBS exhibited a high phototoxic efficacy in living cells and tumor-bearing mice.

关键词： Photodynamic therapy Two-photon excitation FRET-based photosensitizer Singlet oxygen Near-infrared fluorescence

中国自由式滑雪u型场地运动员体能训练年度计划制定的诊断及评价研究

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北京体育大学学报 2019年第3期42卷 32-43页

作者：王耀东杨卓刘树明任四维中国矿业大学北京100083 北京城市学院北京100083 沈阳体育学院竞技体校辽宁沈阳110102 自由式滑雪u型场地国家队北京100044

以我国自由式滑雪u型场地国家队12名运动员为测试对象,主要运用专家访谈法、测试法、实证法、数理统计法等研究方法,对该项目运动员的体能训练进行实证研究。主要结论:自由式滑雪u型场地运动员体能训练的内容主要包括力量、协调、灵敏... 详细信息

以我国自由式滑雪u型场地国家队12名运动员为测试对象,主要运用专家访谈法、测试法、实证法、数理统计法等研究方法,对该项目运动员的体能训练进行实证研究。主要结论:自由式滑雪u型场地运动员体能训练的内容主要包括力量、协调、灵敏、无氧及有氧代谢等能力的训练,力量训练是最主要的训练内容。根据专项技术结构的4个环节——助滑、起跳、空中动作和落地设计出了具有针对性的专项性体能训练内容。年度训练阶段可划分为春季体能集训期、夏季雪上专项训练期、秋季体能集训期、赛季前雪上专项训练期和赛季比赛期5个周期。体能训练在不同阶段的训练目的、任务、内容以及负荷安排存在一定的差异。通过对快速力量、上肢力量、下肢力量、灵敏能力、无氧及有氧能力6个方面12个测试指标进行诊断与评价,证明训练取得了明显效果,在此基础上初步构建了中国该项目运动员体能训练方法与手段体系。

关键词：自由式滑雪 u型场地体能训练训练计划诊断与评价

Intraplaque injections of hyaluronic acid for the treatment of stable-phase Peyronie’s disease:a retrospective single-center experience

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Asian Journal of Andrology 2024年第3期26卷 268-271页

作者： Simone Cilio Roberto La Rocca Giuseppe Celentano Claudio Marino Massimiliano Creta Gianluigi Califano Celeste Manfredi Giorgio Ivan Russo Afonso Morgado Marco Falcone Marco Capece YAu Working Group Sexual and Reproductive Health Department of Neurosciences Reproductive Sciences and OdontostomatologyUrology UnitUniversity of Naples“Federico II”Naples 80131Italy urology unit Department of WomenChild and General and Specialized Surgery“Luigi Vanvitelli”UniversityNaples 80131Italy urology Section Department of SurgeryUniversityof CataniaCatania 95131Italy Department of urology Centro Hospitalar Universitário São JoãoPorto 4200-319Portugal urology Clinic-A.O.u.“Cittàdella Salute edella Scienza”-Molinette Hospital University of TurinTurin 10100Italy 不详

Peyronie’s disease(PD)is a condition of penile connective tissue affecting up to 10%of men *** the complexity ofits management,nonsurgical treatments,such as intraplaque injections,are gaining *** current literature shows dataon the efficacy of intraplaque injections of hyaluronic acid(HA)mainly in acute-phase ***,data on injections of HA instable-phase PD are *** for this retrospective study were derived from a prospectively maintained database of privatepatients presenting at a private medical practice affiliated to the university of Naples“Federico II”(Naples,Italy)with stable-phasePD between January 2020 and March *** underwent a standard protocol of three injections,each administered at atwo-week *** the intervals,patients performed vacuum device therapy,penile stretching,and modeling *** compiled the Peyronie’s Disease Questionnaire(PDQ)and Global Assessment of Peyronie’s Disease(GAPD)at baselineand 2 weeks after the third injection.A penile Doppler ultrasound was performed 2 weeks after the last injection to record thefinal ***,we recruited 62 patients with stable-phase PD and a mean(±standard deviation[s.d.])curvature of52.7°(±9.7°).After 6 weeks,eight(12.9%)patients did not experience any curvature *** remaining 54 patientshad a final mean(±s.d.)curvature of 40.3°(±9.1°)with Pund improvement inall PDQ domains(all P≤0.01),and 50(80.6%)patients reported subjective improvement of the penile curvature according to *** conclusion,we demonstrated that after three injections of HA administered according to the adopted protocol,patientswith stable-phase PD could experience significant improvements in penile curvature,and physical and psychological consequencesof the disease without significantly relevant side effects.

关键词： hyaluronic acid intraplaque injection Peyronie’s disease stable-phase therapy