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Celecoxib enhances the response of tumor cells to cisplatin through upregulating PUMA in non–small cell lung cancer carrying wild-type p53

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Oncology and Translational Medicine 2024年第2期10卷 79-86页

作者： Yuxuan Xiao Ziyu Wang Meng Gu Jinjing Tan Weiying Li Cancer Research Center Beijing Chest HospitalCapital Medical UniversityBeijing Tuberculosis and Thoracic Tumor Research InstituteBeijingChina

Celecoxib,a cyclooxygenase-2 inhibitor,can enhance the efficacy of chemotherapy;however,its effect seems *** this study,we investigated whether celecoxib would increase the antiproliferative effects of cisplatin in human lung cancer *** data demonstrated the synergistic effects of celecoxib with cisplatin in wild-type p53 cells and their antagonistic effects inmutated or deleted p53 *** indices of 0.82 to 0.93 reflected a synergistic effect between celecoxib and cisplatin in lung cancer cells with wild-type *** indices of 1.63 to 3.00 reflected antagonism between celecoxib and cisplatin in lung cancer cells with mutated or deleted *** with that in cells with mutated or deleted p53,apoptosis significantly increased with the addition of celecoxib and cisplatin in wild-type p53 cells(Pstrategy for patients carrying wild-type p53,insensitive to cisplatin.

关键词： p53 Celecoxib Cisplatin Non-small cell lung cancer PUMA

Optimal confrontation position selecting games model and its application to one-on-one air combat

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Defence Technology（防务技术） 2024年第1期31卷 417-428页

作者： Zekun Duan Genjiu Xu Xin Liu Jiayuan Ma Liying Wang School of Mathematics and Statistics Northwestern Polytechnical UniversityXi'an 710072China International Joint Research Center on operations Research Optimization and Artificial IntelligenceXi'an 710129China AVIC Xi’an Aeronautics Computing Technique Research Institute Xi'an 710065China Unmanned System Research Institute Northwestern Polytechnical UniversityXi'an 710072China

In the air combat process,confrontation position is the critical factor to determine the confrontation situation,attack effect and escape probability of ***,selecting the optimal confrontation position becomes the primary goal of maneuver *** taking the position as the UAV’s maneuver strategy,this paper constructs the optimal confrontation position selecting games(OCPSGs)*** the OCPSGs model,the payoff function of each UAV is defined by the difference between the comprehensive advantages of both sides,and the strategy space of each UAV at every step is defined by its accessible space determined by the *** we design the limit approximation of mixed strategy Nash equilibrium(LAMSNQ)algorithm,which provides a method to determine the optimal probability distribution of positions in the strategy *** the simulation phase,we assume the motions on three directions are independent and the strategy space is a cuboid to simplify the *** simulations are performed to verify the feasibility,effectiveness and stability of the algorithm.

关键词： Unmanned aerial vehicles(UAVs) Air combat Continuous strategy space Mixed strategy Nash equilibrium

Integrated schedule of order picking and delivery for instant delivery

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Journal of Management Science and Engineering 2024年第1期9卷 88-100页

作者： Qiuchen Gu Tijun Fan Jingyi Chen School of Business East China University of Science and TechnologyShanghai200237China Research Center for operations and Supply Chain Management East China University of Science and TechnologyShanghai200237China Economics and Management School Minjiang UniversityFuzhou350108China

In this study,we introduce an integrated schedule of order picking and delivery for instant *** picking,including order batching and picking sequencing,is scheduled online under real-time order arrival,which integrates order delivery by depicting order location dispersion in an online order picking *** delivery,including delivery person assignment and route planning,is modeled to minimize the total duration of order fulfillment by considering the influence of the order picking completion time.A rule-based online order picking strategy is established,and a customized ant colony optimization(ACO)algorithm is proposed to optimize order *** on 16 simulated instances of different scales demonstrate that our online order picking schedule considering order delivery outperforms existing approaches and that the customized ACO algorithm for order delivery is effective.

关键词： Online scheduling Order picking Delivery routing Integrated order picking and delivery Instant delivery

Design,synthesis,and biological evaluation of 1,2,4-triazole derivatives as potent antitubercular agents

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Chinese Chemical Letters 2024年第3期35卷 326-331页

作者： Yu Wen Shichun Lun Yuxue Jiao Wei Zhang Tianyu Hu Ting Liu Fan Yang Jie Tang Bing Zhang William R.Bishai Li-Fang Yu Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development School of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai 200062China Center for tuberculosis Research Department of MedicineDivision of Infectious DiseaseJohns Hopkins School of MedicineBaltimoreMD21231-1044United States Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China Shanghai Key Laboratory of Green Chemistry and Chemical Process School of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai 200062China

Inhibition of mycobacterial membrane protein large 3(MmpL3)thereby affecting the mycolic acid biosynthetic pathway has been proven to be an effective strategy for developing antitubercular *** on the X-ray crystal structure of MmpL3 inhibitor complexes,a series of novel 1,2,4-triazole derivatives were designed,synthesized and evaluated antitubercular activity against Mtb strain *** structure–activity relationship exploration resulted in the identification of compounds 21 and 28,which possess potent antitubercular activity against Mtb strain H37Rv[minimum inhibitory concentration(MIC)=0.03–0.13μg/mL]and the clinical isolates of multidrug resistance(MDR)and extensive drug resistance(XDR)tuberculosis(MIC=0.06–1.0μg/mL).Moreover,compounds 21 and 28 showed neglectable cytotoxicity(IC_(50)≥32μg/mL)to the mammalian Vero cells and favorable physicochemical and pharmacokinetic properties according to the in silico absorption,distribution,metabolism and excretion(ADME)***,the potential target of representative 1,2,4-triazole 28 was identified to be MmpL3 using a microscale thermophoresis(MST)assay.

关键词： tuberculosis MDR and XDR-TB MmpL3 inhibitor 1 2 4-Triazole Structure-based drug design

An emerging terpolymeric nanoparticle pore former as an internal recrystallization inhibitor of celecoxib in controlled release amorphous solid dispersion beads:Experimental studies and molecular dynamics analysis

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2669-2684页

作者： Jamie Anne Lugtu-Pe Xuning Zhang Sako Mirzaie Hao Han R.Chang Nour AL-Mousawi Kuan Chen Yongqiang Li Anil Kane Daniel Bar-Shalom Xiao Yu Wu Advanced Pharmaceutics and Drug Delivery Laboratory Leslie Dan Faculty of PharmacyUniversity of TorontoToronto M5S 3M2Canada Candoo Pharmatech Company Inc. Mississauga L5N 5M1Canada Department of Pharmacy University of CopenhagenCopenhagen DK-2100Denmark Patheon by Thermo Fisher Scientific Toronto Region Operations(TRO)Mississauga L5N 3X4Canada

Solid oral controlled release formulations feature numerous clinical advantages for drug candidates with adequate solubility and dissolution ***,most new chemical entities exhibit poor water solubility,and hence are exempt from such *** combining drug amorphization with controlled release formulation is promising to elevate drug solubility,like other supersaturating systems,the problem of drug recrystallization has yet to be resolved,particularly within the dosage ***,we explored the potential of an emerging,non-leachable terpolymer nanoparticle(TPN)pore former as an internal recrystallization inhibitor within controlled release amorphous solid dispersion(CRASD)beads comprising a poorly soluble drug(celecoxib)reservoir and insoluble polymer(ethylcellulose)*** to conventional pore former,polyvinylpyrrolidone(PVP),TPN-containing membranes exhibited superior structural integrity,less crystal formation at the CRASD bead surface,and greater extent of celecoxib ***-atom molecular dynamics analyses revealed that in the presence of TPN,intra-molecular bonding,crystal formation tendency,diffusion coefficient,and molecular flexibility of celecoxib were reduced,while intermolecular H-bonding was increased as compared to *** work suggests that selection of a pore former that promotes prolonged molecular separation within a nanoporous controlled release membrane structure may serve as an effective strategy to enhance amorphicity preservation inside CRASD.

关键词： Controlled release amorphous solid dispersion Poorly soluble drug Internal recrystallization Membrane-reservoir coated beads Molecular dynamics simulation Effect of pore formers Terpolymer nanogel Drug-polymer interactions

Einstein Hybrid Structure of q-Rung Orthopair Fuzzy Soft Set and Its Application for Diagnosis of Waterborne Infectious Disease

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 1863-1892页

作者： Rana Muhammad Zulqarnain Hafiz Khalil ur Rehman Imran Siddique HijazAhmad Sameh Askar Shahid Hussain Gurmani School of Mathematical Sciences Zhejiang Normal UniversityJinhua321004China Department of Mathematics Government College UniversityFaisalabad38000Pakistan Department of Mathematics University of SargodhaSargodha40100Pakistan Section of Mathematics International Telematic University UninettunoCorso Vittorio Emanuele IIRoma3900186Italy Near East University Operational Research Center in HealthcareNear East BoulevardNicosia/Mersin 1099138Turkey Department of Statistics and operations Research College of ScienceKing Saud UniversityPO Box 2455Riyadh11451Saudi Arabia

This research is devoted to diagnosing water-borne infectious diseases caused by floods employing a novel diagnosis approach,the Einstein hybrid structure of q-rung orthopair fuzzy soft *** approach integrates parts of fuzzy logic and soft set theory to develop a robust alternative for disease detection in stressful situations,especially in areas affected by *** to the traditional intuitionistic fuzzy soft set and Pythagorean fuzzy soft set,the q-rung orthopair fuzzy soft set(q-ROFSS)adequately incorporates unclear and indeterminate *** major objective of this investigation is to formulate the q-rung orthopair fuzzy soft Einstein hybrid weighted average(q-ROFSEHWA)operator and its specific ***,our stated operator is implementing intelligentmulti-criteria group decision-making(MCGDM)*** are severe natural catastrophes that raise the risk of diseases and epidemics,particularly those caused by contaminants in the water,such as gastrointestinal diseases,respiratory infections,vector-borne diseases,skin infections,and water-borne *** designed MCGDM strategy tackles the prevalence of certain conditions in flood-affected patients.A comparative investigation determined that the suggested method for detecting water-borne infectious disease due to floods is more effective and productive than conventional methods because of its logical structure.

关键词： q-rung orthopair fuzzy soft set q-ROFSEHWA operator MCGDM environmental disaster water-born infection disease

Revealing Spatial Spillover Effect in High-Tech Industry Agglomeration from a High-Skilled Labor Flow Network Perspective

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Journal of Systems Science & Complexity 2022年第3期35卷 839-859页

作者： WANG Chen WANG Lu XUE Yanbo LI Ruiqi School of Economics and Management University of Science and Technology BeijingBeijing 100083China The Institute of Low Carbon operations strategy for Beijing Enterprises University of Science and Technology BeijingBeijing 100083China Career Science Lab Boss ZhipinBeijing 100028China UrbanNet Lab College of Information Science and TechnologyBeijing University of Chemical TechnologyBeijing 100029China

Understanding the high-tech industrial agglomeration from a spatial-spillover perspective is essential for cities to gain economic and technological competitive *** with rapid urbanization and the development of fast transportation networks,socioeconomic interactions between cities have been ever-increasing,traditional spatial metrics are not enough to describe actual inter-city ***-skilled labor flow between cities strongly influences the high-tech industrial agglomeration,yet receives less *** exploiting unique large-scale datasets and tools from complex network and data mining,the authors construct an inter-city high-skilled labor flow network,which was integrated into spatial econometric *** regression results indicate that spatial-spillover effects exist in the development of high-tech industries in the Yangtze River Delta Urban Agglomeration ***,the spatial-spillover effects are stronger among cities with a higher volume of high-skilled labor flows than among cities with just stronger geographic ***,the authors investigate the channels for the spillover effects and discover that inadequate local government expenses on science and technology likely hamper the high-tech industrial agglomeration,so does the inadequate local educational *** increasing foreign direct investments in one city likely encourages the high-tech industrial agglomeration in other cities because of the policy inertia toward traditional industries.

关键词： High-tech industry agglomeration labor flow network spatial econometrics topological space

Optimizing Decision-Making of A Smart Prosumer Microgrid Using Simulation

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Computers, Materials & Continua 2023年第7期76卷 151-173页

作者： Oussama Accouche Rajan Kumar Gangadhari College of Engineering and Technology American University of the Middle EastEgaila 54200Kuwait operations and IT ICFAI Business SchoolHyderabad501203India

Distributed renewable energy sources offer significant alternatives for Qatar and the Arab Gulf region’s future fuel supply and *** are essential for providing dependable power in difficult-to-reach areas while incorporating significant amounts of renewable energy *** energy-efficient data centers,distributed generation can be used to meet the facility’s overall power *** study primarily focuses on the best energy management practices for a smart microgrid in Qatar while taking demandside load management into *** article looked into a university microgrid in Qatar that primarily aimed to get all of its energy from the *** diesel generators are categorized as a dispatchable distributed generation with energy storage added to handle solar radiation from the sun and high grid power operating costs in the suggested scenario,wind turbines and solar Photovoltaic(PV)are classified as non-dispatchable distributed *** resulting linear math issues are assessed and displayed in MATLAB optimization software using a mixed-integer linear programming(MILP)*** to the simulation results,the suggested energy management strategy reduced the university microgrid’s grid power costs by 38.8%,making it an affordable solution which is somehow greater than the prior case scenario’s 23%*** installed solar system capacity’s effects on the economy,society,and finances were also assessed,and it became clear that the best option for the smart microgrid was determined that would be 325 kW of solar PV,25 kW of wind turbine,and 600 kW of diesel generators,*** the current situation,university administrators are urged to participate in distributed generators and adopt cutting-edge designs for energy storage technologies due to the significant environmental and financial benefits.

关键词： Energy management smart grid prosumer demand-side load management renewable resources wind turbines

Implementation Performance of tuberculosis Controlin China:2011-2020

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China CDC weekly 2021年第12期3卷 252-255页

作者： Tao Li Xin Du Xiaoqiu Liu Yuhong Li Yanlin Zhao National Center for tuberculosis Control and Prevention ChinaCDCBeijingChina.

Summary What is already known about this topic?World Health Organization(WHO)launched ENDTB strategy but performance of tuberculosis(TB)control in China hasn’t been systematically evaluatedafter *** is added by this report?All five key indicators monitorred in national TBprogram(NTP)have kept with high level or gotimpressively improved from 2011 to *** weresome differences in the performance of indicatorsamong different regions.

关键词： tuberculosis indicators tuberculosis