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Double Penalized Semi-Parametric Signed-Rank Regression with Adaptive LASSO

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Journal of Systems Science & Complexity 2021年第1期34卷 381-401页

作者： KWESSI Eddy trinity Place Trinity UniversitySan AntonioTX 78258USA

In this paper, a semi-parametric regression model with an adaptive LASSO penalty imposed on both the linear and the nonlinear components of the mode is considered. The model is rewritten so that a signed-rank technique can be used for estimation. The nonlinear part consists of a covariate that enters the model nonlinearly via an unknown function that is estimated using Bsplines. The author shows that the resulting estimator is consistent under heavy-tailed distributions and asymptotic normality results are given. Monte Carlo simulations as well as practical applications are studied to assess the validity of the proposed estimation method.

关键词： Adaptive-LASSO B-splines penalty rank regression semi-parametric

Integrating NIR light photocage enables in vivo dual-channel tracking of drug release

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Science China Chemistry 2018年第11期61卷 1347-1348页

作者： Thorfinnur Gunnlaugsson School of Chemistry and trinity Biomedical Sciences Institute (TBSI) Trinity College Dublin The University of Dublin

On-demand drug release at the right place and time becomes a central challenge in disease diagnosis and therapy. Light is a uniquely powerful tool to manipulate a biological process in space or time. Light-triggered drug delivery systems （DDSs） have proven to be an effective strategy for improving therapeutics. These caged prodrugs are functional lightsensitive probes that make the drug in an inactive form by covalent conjugation. Light irradiation liberates the caged drugs, permitting facile control intact and activate prodrugs in soace and time. It is limited, however.

关键词： vivo 版本 NIR 集成追踪隧道用药疾病诊断

Convergent evolution of brain morphology and communication modalities in lizards

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Current Zoology 2015年第2期61卷 281-291页

作者： Christopher D. ROBIN.SON Michael S. PATTON Britmey M. ANDRE Michele A. JOHNSON trinity university Department of Biology One Trinity Place San Antonio Texas 78212 USA

Animals communicate information within their environments via visual, chemical, auditory, and/or tactile modalities. The use of each modalityis generally linked to particular brain regions, but it is not yet known whether the cellular morphology of neurons in these regions has evolved in association with the relative use of a *** investigated relationships between the behavioral use of communication modalities and neural morphologies in six lizard species. Two of these species （Anolis carol# nensis and Leiocephalus carinatus） primarily use visual signals to communicate with conspecifics and detect potential prey, and two （Aspidoscelis gularis and Scincella lateralis） communicate and forage primarily using chemical signals. Two other species （Hemidactylus turcicus and Sceloporus olivaceus） use both visual and chemical signals. For each species, we performed beha- vioral observations and quantified rates of visual and chemical behaviors. We then cryosectioned brain tissues from 9-10 males of each species and measured the soma size and density of neurons in two brain regions associated with visual behaviors （the lat- eral geniculate nucleus and the nucleus rotundus） and one region associated with chemical behaviors （the nucleus sphericus）. With analyses conducted in a phylogenetic context, we found that species that performed higher rates of visual displays had a denser lateral geniculate nucleus, and species that used a higher proportion of chemical displays had larger somas in the nucleus sphericus. These relationships suggest that neural morphologies in the brain have evolved convergently in species with similar communication behaviors .

关键词： Brain Communication modality Lizards Pheromones Social behavior Vision

Self-assembled bright luminescent hierarchical materials from a tripodal benzoate antenna and heptadentate Eu(III) and Tb(III) cyclen complexes

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Frontiers of Chemical Science and Engineering 2019年第1期13卷 171-184页

作者： Aramballi J.Savyasachi David F.Caffrey Kevin Byrne Gerard Tobin Bruno D'Agostino Wolfgang Schmitt Thorfinnur Gunnlaugsson School of Chemistry and trinity Biomedical Sciences Institute (TBSI) University of Dublin Trinity College Dublin Dublin 2 Ireland School of Chemistry and Centre for Research on Adaptive Nanostructures and Nanodevices (CRANN) University of Dublin Trinity College Dublin Dublin 2 Ireland

The europium heptadentate coordinatively unsaturated (Eu(III)) and the terbium (Tb(III)) 1,4,7,10-tetraazacyclododecane (cyclen) complexes 1 and 2 were used in conjunction with ligand 3 (1,3,5-benzene-trisethynylbenzoate) to form the supramolecular self-assembly structures 4 and 5;this being investigated in both the solid and the solution state. The resulting self-assemblies gave rise to metal centered emission (both in the solid and solution) upon excitation of 3, confirming its role as a sensitizing antenna. Drop-cased examples of ligand 3, and the solid forms of 4 and 5, formed from both organic and mixture of organic-aqueous solutions, were analyzed using Scanning Electron Microscopy, which showed significant changes in morphology;the ligand giving rise to one dimensional structures, while both 4 and 5 formed amorphous materials that were highly dense solid networks containing nanoporous features. The surface area (216 and 119 m2·g^-1 for 4 and 5 respectively) and the ability of these porous materials to capture and store gases such as N2 investigated at 77 K. The self-assembly formation was also investigated in diluted solution by monitoring the various photophysical properties of 3–5. This demonstrated that the most stable structures were that consisting of a single antennae 3 and three complexes of 1 or 2 (e.g., 4 and 5) in solution. By monitoring the excited state lifetimes of the Eu(III) and Tb(III) ions in H2O and D2O respectively, we showed that their hydration states (the q-value) changed from -2 to 0, upon formation of the assemblies, indicating that the three benzoates of 3 coordinated directly to the each of the three lanthanide centers. Finally we demonstrate that this hierarchically porous materials can be used for the sensing of organic solvents as the emission is highly depended on the solvent environment;the lanthanide emission being quenched in the presence of acetonitrile and THF, but greatly enhanced in the presence of methanol.

关键词： self-assembly supramolecular chemistry lanthanides Eu(III) and Tb(III) complexes luminescence metallostars

New insights into the in-process densification mechanism of cold spray Al coatings: Low deposition efficiency induced densification

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Journal of Materials Science & Technology 2019年第3期35卷 427-431页

作者： Richard Jenkins Shuo Yin Barry Aldwell Morten Meyer Rocco Lupoi trinity College Dublin The University of Dublin Department of Mechanical and Manufacturing Engineering

This work details new insights into the in-process densification mechanism of cold spray Al coatings. The results show a trend counter to common observations: coating plastic deformation levels and coating density decreases with an increase in particle impact velocity. A lower particle impact velocity and the consequent lower deposition efficiency(DE) results in greater tamping energy per unit volume of deposit,which is the primary reason for the observed trend. This is the first time that DE has been shown to have a non-linear impact on the density of a cold spray coating, with particle in-process tamping being the primary mechanism for coating densification.

关键词： Coating Hardness test Plastic deformation Tamping

MULTIPLE POSITIVE SOLUTIONS FOR SUPERLINEAR SECOND ORDER SINGULAR BOUNDARY VALUE PROBLEMS WITH DERIVATIVE DEPENDENCE

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Acta Mathematica Scientia 2008年第4期28卷 851-864页

作者：闫宝强 Department of Mathematics Shandong Normal University School of Mathematics Trinity College

The existence of at least two positive solutions is presented for the singular second-order boundary value problem{1/p（t）（ p（t）x′（t））′＋Φ（t）f（t,x（t）,p（t）x′（t））=0,0〈t〈1, limt→0 p（t）x′（t）=... 详细信息

关键词： Boundary value problems singularity fixed point index

Asian Urban Environment and Climate Change: Preface

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Journal of Environmental Sciences 2017年第9期29卷 1-5页

作者： Julian Hunt Jianping Wu university College London and trinity College university of Cambridge School of Civil Engineering Tsinghua University

The Asian Network on Climate Science and Technology （***）, in collaboration with Tsinghua university, held a conference on environmental and climate science, air pollution, urban planning and transportation in July 2015, with over 40 Asian experts participating and presentation. This was followed by a meeting with local government and community experts on the practical conclusions of the conference. Of the papers presented at the conference a selection are included in this special issue of ]ournal of Environmental Science, which also reflects the conclusions of the Paris Climate meeting in Dec 2015, when the major nations of the world agreed about the compelling need to reduce the upward trend of adverse impacts associated with global climate change. Now is the time for urban areas to work out the serious consequences for their populations, but also how they should work together to take action to reduce global wanning to benefit their own communities and also the whole planet!

关键词： Air pollution Local government Climate change Paris Agreement (2016) Prevention of global warming

4-Amino-1,8-naphthalimide based fluorescent photoinduced electron transfer (PET) pH sensors as liposomal cellular imaging agents: The effect of substituent patterns on PET directional quenching

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Frontiers of Chemical Science and Engineering 2020年第1期14卷 61-75页

作者： Miguel Martinez-Calvo Sandra A.Bright Emma B.Veale Adam F.Henwood D.Clive Williams Thorfinnur Gunnlaugsson School of Chemistry and trinity Biomedical Sciences Institute(TBSI) Trinity College DublinThe University of DublinDublin 2Ireland School of Biochemistry and Immunology and trinity Biomedical Sciences Institute(TBSI) Trinity College DublinThe University of DublinDublin 2Ireland Centro Singular de Investigacion en Quimica Bioloxica e Materiais Moleculares(CIQUS)and Departamento de Quimica Organica Universidade de Santiago de Compostela Rua Jenaro de la Fuente s/n15782Santiago de CompostelaSpain

Four new fluorescent sensors(1-4)based on the 4-amino-1,8-naphthalimide fluorophores(Naps)have been synthesized based on the classical fluorophore-spacer-receptor *** four compounds all gave rise to emission bands centred at ca.535 nm,which were found to be highly pH dependent,the emission being‘switched on’in acidic media,while being quenched due to PET from the amino moieties to the excited state of the Nap at more alkaline *** luminescent pH dependence for these probes was found to be highly dependent on the substitution on the imide site,as well as the polyamine chain attached to the position 4-amino *** the case of sensor 2 the presence of the 4-amino-aniline dominated the pH dependent ***,at higher pH,PET quenching was also found to occur from the polyamine ***,2 is better described as a receptor1-spacer1-fluorophore-spacer2-receptor2 system,where the dominant PET process is due to(normally less favourable)‘directional’PET quenching from the 4-amino-aniline unit to the Nap *** trends and pH fluorescence dependences were also seen for 3 and *** compounds were also tested for their imaging potential and toxicity against HeLa cells(using DRAQ5 as nuclear stain which does now show pH dependent changes in acidic and neutral pH)and the results demonstrated that these compounds have reduced cellular viability at moderately high concentrations(with IC50 values between ca.8-30μmol?L^?1),but were found to be suitable for intracellular pH determination at 1μmol?L^?1 concentrations,where no real toxicity was *** allowed us to employ these as lysosomal probes at sub-toxic concentrations,where the Nap based emission was found to be pH depended,mirroring that seen in aqueous solution for 1-4,with the main fluorescence changes occurring within acidic to neutral pH.

关键词： sensors pH photoinduced electron transfer cellular imaging confocal microscopy

Is a mirror necessary for mirror therapy?

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Neural Regeneration Research 2023年第12期18卷 2703-2704页

作者： Richard G.Carson Alannah Morley trinity College Institute of Neuroscience and School of Psychology Trinity College DublinDublinIreland Dublin Ireland(Carson RG)School of PsychologyQueen’s University BelfastBelfastNorthern IrelandUK(Carson RG)School of MedicineTrinity College DublinDublinIreland

Since it was first described as a method to treat phantom limb pain, mirror therapy(MT) has been applied in many areas of rehabilitation. Its seminal application with the aim of restoring motor function following stro... 详细信息

关键词： mirror al. therapy