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Photobiomodulation:a novel approach to promote trans-differentiation of adipose-derived stem cells into neuronal-like cells

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Neural Regeneration Research 2025年第2期20卷 598-608页

作者： Daniella Da Silva Madeleen Jansen van Rensburg Anine Crous Heidi Abrahamse Laser Research centre Faculty of Health SciencesUniversity of JohannesburgDoornfonteinJohannesburgSouth Africa

Photobiomodulation,originally used red and near-infrared lasers,can alter cellular *** has been demonstrated that the visible spectrum at 451-540 nm does not necessarily increase cell proliferation,near-infrared light promotes adipose stem cell proliferation and affects adipose stem cell migration,which is necessary for the cells homing to the site of *** this in vitro study,we explored the potential of adipose-derived stem cells to differentiate into neurons for future translational regenerative treatments in neurodegenerative disorders and brain *** investigated the effects of various biological and chemical inducers on trans-differentiation and evaluated the impact of photobiomodulation using 825 nm near-infrared and 525 nm green laser light at 5 J/*** adipose-derived stem cells can be used in autologous grafting and photobiomodulation has been shown to have biostimulatory *** findings reveal that adipose-derived stem cells can indeed trans-differentiate into neuronal cells when exposed to inducers,with pre-induced cells exhibiting higher rates of proliferation and trans-differentiation compared with the control ***,green laser light stimulation led to notable morphological changes indicative of enhanced trans-differentiation,while near-infrared photobiomodulation notably increased the expression of neuronal *** biochemical analysis and enzyme-linked immunosorbent assays,we observed marked improvements in viability,proliferation,membrane permeability,and mitochondrial membrane potential,as well as increased protein levels of neuron-specific enolase and ciliary neurotrophic ***,our results demonstrate the efficacy of photobiomodulation in enhancing the trans-differentiation ability of adipose-derived stem cells,offering promising prospects for their use in regenerative medicine for neurodegenerative disorders and brain injuries.

关键词： differentiation inducers green photobiomodulation immortalized adipose-derived stem cell near-infrared photobiomodulation neurodegenerative disease neurogenesis photobiomodulation trans-differentiation

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Device-measured physical activity and sedentary time in the Nordic countries:A scoping review of population-based studies

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Journal of Sport and health Science 2024年第5期13卷 650-660页

作者： Ing-Mari Dohrn Jakob Tarp Jostein Steene-Johannessen Tommi Vasankari Maria Hagströmer Division of Physiotherapy Department of NeurobiologyCare Sciences and SocietyKarolinska Institutet14183 HuddingeSweden Department of Sports Medicine Norwegian School of Sports Sciences0806 OsloNorway UKK Institute for health Promotion Research 33500 TampereFinland Faculty of Medicine and health Technology Tampere University33100 TampereFinland Academic Primary health Care centre Region Stockholm13365 StockholmSweden

Purpose:The purpose of this scoping review was to summarize and describe the methodology and results from population-based studies of physical activity and sedentary time measured with devices in the Nordic countries(Denmark,Finland,Iceland,Norway,and Sweden)and published in 2000 or ***:A systematic search was carried out in PubMed and Web of Science in June 2023 using predefined search ***:Fourteen unique research projects or surveillance studies were ***,2 surveillance studies published by national agencies were included,resulting in a total of 16 studies for *** surveillance systems exist in Finland and Norway,with regular survey waves in school-aged children/adolescents and *** Denmark,recent nationally representative data have been collected in school children *** far,Sweden has no regular national surveillance system using device-based data *** studies were found from *** first study was conducted in 2001 and the most recent in 2022,with most data collected from 2016 to *** studies included children/adole scents 6-18 years,no study included *** total 11 studies included adults,of which 8 also covered older *** study focused specifically on older *** analytical sample size ranged from 205 to 27,*** methodology is presented,such as information on sampling strategy,device type and placement,wear protocols,and physical activity classification *** of physical activity and sedentary time in children/adolescents,adults,and older adults across the Nordic countries are ***:A growing implementation of device-based population surveillance of physical activity and sedentary behavior in the Nordic countries has been *** variety of devices,placement,and data procedures both within and between the Nordic countries highlights the challenges when it comes to comparing study outcomes as well as the need for more standa

关键词： Accelerometer Light intensity Moderate-vigorous intensity Surveillance Wearable devices

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Liposomal dual delivery systems in visceral leishmaniasis enhance the synergistic effects of combination therapy:A promise for the future

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Asian Pacific Journal of Tropical Medicine 2024年第2期17卷 47-60页

作者： Raghunath Hazra Amrita Kar Santanu Kar Mahapatra Department of Paramedical and Allied health sciences Biodiversity and Environmental Studies Research CentreMidnapore City CollegeKuturiyaBhadutalaPaschim Medinipur-721129West BengalIndia

Visceral leishmaniasis(VL)is a neglected tropical disease,and this review has summarized the current treatment scenario and its *** also highlights alternative approaches used by research groups in India and around the world to develop cutting-edge and potent anti-leishmanial *** though numerous medications could be utilized to treat VL,the limitations of current treatments including their toxicity,cost,route of administration,and duration of doses,have contributed to the emergence of *** therapy might be a better option due to its shorter duration,easier route of administration,and ability to extend the lifespan of individual ***,there is a risk of not delivering both the drugs to the target site together,which can be overcome by the liposomal entrapment of those drugs and at a time knock an opportunity to reduce the dosage of amphotericin B if the combination drug provides a synergistic effect with ***,this review presents a novel strategy to fight against VL by introducing dual drug-loaded liposomes.

关键词： Visceral leishmaniasis Liposomal anti-leishmanial drug Dual drug liposome

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The use of oral human immunodeficiency virus pre-exposure prophylaxis in pregnant and lactating women in sub-Saharan Africa:considerations,barriers,and recommendations

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Global health Journal 2024年第2期8卷 41-45页

作者： Enos Moyo Grant Murewanhema Perseverance Moyo Tafadzwa Dzinamarira Andrew Ross School of Nursing&Public health College of Health SciencesUniversity of Kwa-Zulu NatalDurbanSouth Africa Faculty of Medicine and health sciences University of ZimbabweHarareZimbabwe Medical centre Oshakati OshakatiNamibia School of health Systems and Public health University of PretoriaPretoriaSouth Africa

In sub-Saharan Africa(SSA),63%of new human immunodeficiency virus(HIV)infections in 2021 were among women,particularly adolescent girls,and young *** is a high incidence of HIV among pregnant and lactating women(PLW)in *** is estimated that the risk of HIV-acquisition during pregnancy and the postpartum period more than *** this article,we discuss the safety and effectiveness of drugs used for oral HIV pre-exposure prophylaxis(PrEP),considerations for initiating PrEP in PLW,the barriers to initiating and adhering to PrEP among them and suggest recommendations to address these ***/emtricitabine,the most widely used combination in SSA,is safe,clinically effective,and cost-effective among *** PLW who requests PrEP and has no medical contraindications should receive *** users who are pregnant or lactating may experience barriers to starting and adhering for a variety of reasons,including personal,pill-related,and healthcare facility-related *** address the barriers,we recommend an increased provision of information on PrEP to the women and the communities,increasing and/or facilitating access to PrEP among the PLW,and developing strategies to increase adherence.

关键词： Pre-exposure prophylaxis Pregnancy Lactation Safety Barriers Recommendations

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Countermeasures to reduce the risk of infections at the 2024 Olympic and Paralympic Games—A balancing act

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Journal of Sport and health Science 2024年第6期13卷 722-725页

作者： Marcel Jooste Martin Schwellnus Sport Exercise Medicine and Lifestyle Institute(SEMLI)Faculty of Health SciencesUniversity of PretoriaPretoria 0083South Africa Section Sports Medicine Faculty of Health SciencesUniversity of PretoriaPretoria 0083South Africa IOC Research centre of South Africa Pretoria 0083South Africa

The Olympic and Paralympic Games are a global celebration of athletic dedication and achievement,bringing together athletes and spectators from around the ***,such large gatherings present public health challenges for the Organizing Committees and local *** highlighted by the coronavirus disease 2019(COVID-19)pandemic,these events are associated with an increased risk of transmission of infections,which can significantly impact the health and well-being of athletes and *** the health and safety of athletes,officials and spectators is fundamental to ensure the successful hosting of the ***,it is essential to design and implement comprehensive countermeasures to mitigate the risk of an infectious disease outbreak among participants but also to the residents of the host city.

关键词： gathering bringing infections

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Depositional Environment, Petrophysical Evaluation and Electrical Properties of Zeit Formation, Northwestern Shore of Gulf of Suez, Egypt

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Journal of Earth Science 2024年第5期35卷 1720-1737页

作者： Mohamed M.Gomaa Emad A.Abd El Aziz Geophysical sciences Department National Research Centre

The Zeit sand reservoir is one of the most prolific formations at Northwestern side of the Gulf of Suez. In this research we will try to coordinate between electrical, petrophysical properties, depositional environment and facies discrimination in order to evaluate the hydrocarbon potentiality of studied Zeit Formation. The statistical parameters for potassium（K）, thorium（Th） and Th/U ratio contents have a general increase towards northwestern parts, whereas uranium（U） content has a general increase towards southeastern parts. The sandstone facies is distinguished from the other facies by its thorium content >4 ppm. U has high carbonate content（U ≥ 1 ppm）. Rocks' electrical properties vary greatly depending on a number of factors. Electrical measurements were taken at frequencies range of(5 × 10-4Hz–100 kHz) for fully saturated samples（clayey sandstone） with NaCl（20 gm/L）. As salinity, clay content, and frequency increase, consequently does the electrical properties. The continental condition are present in northwestern part（back-sea） which is distinguished by high K percent, high Th, high Th/U ratio, and low U contents. Low K, Th, and Th/U ratio contents, with high U contents, characterize the marine depositional environment that existed around the east and southeastern parts（foresea coincide with the dipping of strata）. Furthermore, the studied Zeit Formation has good petrophysical properties that coincide with marine conditions. The middle and eastern parts（around ISS-94 and CSS-288） is a good reservoir（porosity 36%–39%, shale content <15%, hydrocarbon saturation 71%–92%, and net pay thickness 17–63 feet）.

关键词： Zeit Formation petrophysical evaluation depositional environment Spectral Gamma Ray electrical properties gulf of Suez sedimentology

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The association of diet quality and physical activity with cardiovascular disease and mortality in 85,545 older Australians:A longitudinal study

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Journal of Sport and health Science 2024年第6期13卷 841-850页

作者： Ding Ding Joe Van Buskirk Stephanie Partridge Philip Clare Edward Giovannucci Adrian Bauman Nicole Freene Robyn Gallagher Binh Nguyen Sydney School of Public health Faculty of Medicine and Healththe University of SydneyCamperdownNSW 2006Australia Charles Perkins centre the University of SydneyCamperdownNSW 2006Australia Sydney Local health District CamperdownNSW 2050Australia School of health sciences Faculty of Medicine and Healththe University of SydneyCamperdownNSW 2006Australia National Drug and Alcohol Research centre UNSW SydneySydneyNSW 2052Australia Departments of Nutrition and Epidemiology Harvard T.H.Chan School of Public HealthBostonMA 02115USA Faculty of health University of CanberraCanberraACT 2617Australia Susan Wakil School of Nursing and Midwifery the University of SydneyCamperdownNSW 2050Australia

Background:A quality diet and an active lifestyle are both important cornerstones of cardiovascular disease(CVD)***,despite their interlinked effects on metabolic health,the 2 behaviors are rarely considered jointly,particularly within the context of CVD *** examined the independent,interactive,and joint associations of diet and physical activity with CVD hospitalization,CVD mortality,and all-cause ***:CVD-free Australian participants aged 4574 years(n=85,545)reported physical activity,diet,sociodemographic,and lifestyle characteristics at baseline(20062009)and follow-up(20122015),and data were linked to hospitalization and death registries(03/31/2019 for CVD hospitalization and all-cause mortality and 12/08/2017 for CVD mortality).Diet quality was categorized as low,medium,and high based on meeting dietary *** activity was operationalized as(a)total moderate-to-vigorous physical activity(MVPA)as per guidelines,and(b)the composition of MVPA as the ratio of vigorous-intensity physical activity(VPA)to total *** used a left-truncated cause-specific Cox proportional hazards model using time-varying ***:During a median of 10.7 years of follow-up,6576 participants were admitted to the hospital for CVD and 6581 died from all causes(876 from CVD during 9.3 years).A high-quality diet was associated with a 17%lower risk of all-cause mortality than a low-quality diet,and the highest MVPA category(compared with the lowest)was associated with a 44%and 48%lower risk of CVD and all-cause mortality,*** interactions between diet and physical activity were *** all outcomes,the lowest risk combinations involved a high-quality diet and the highest MVPA *** for total MVPA,some VPA was associated with further risk reduction of CVD hospitalization and all-cause ***:For CVD prevention and longevity,one should adhere to both a healthy d

关键词： Diet Physical activity Cardiovascular disease Mortality Cohort studies

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Sexual and Reproductive Service Interventions for Menstrual Regulation, Safe Abortion, and Post-abortion Care and Their Effectiveness During Disaster Response: A Global Systematic Review

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International Journal of Disaster Risk Science 2024年第3期15卷 359-373页

作者： Nibedita S.Ray-Bennett Winifred Ekezie Isha Biswas Nimra Iqbal Choudhary David Cowie Lasith Dissanayake Lauren Macleod Azukaeogo Nnaji Madhulika Sahoo School of Business University of Leicester Avoidable Deaths Network University of Leicester Diabetes Research centre Leicester General Hospital University of Leicester School of Social sciences and Humanities Aston University Lifespan and Population health School of Medicine University of Nottingham School of Public health and Interdisciplinary Studies Auckland University of Technology Faculty of Life sciences and Education University of South Wales West African Regional ECHO (WARE) APIN Public Health Initiatives Department of Anthropology Kalahandi University

Sexual and reproductive health(SRH) services are crucial for women especially during disasters, to reduce maternal mortality and morbidity from miscarriages, unsafe abortions, and post-abortion complications. This study explored the SRH interventions provided during disaster response. A systematic review was conducted to identify what menstrual regulation(MR), safe abortion(SA), and post-abortion care(PAC) approaches/interventions exist to promote resilience in the health system in disaster settings; what intervention components were most eff ective; and challenges and opportunities to meeting SRH rights. Five electronic databases were searched, resulting in 4194 records. Following the screening process, seven publications were included. The intervention-related information in each publication was assessed based on availability,accessibility, acceptability, and quality. Two SRH approaches/interventions were found. The eff ectiveness of intervention components could not be conducted due to the limited number of relevant studies. Challenges were found at facility and community levels, and opportunities included overcoming them, making MR, SA, and PAC integral to the mitigation phase,and policy change to overcome barriers related to unaff ordability and inaccessibility. Recommendations are provided to encourage research and policy towards improving neglected SRH in disaster settings to realize Sustainable Development Goal 3 and the Global Strategy and Sendai Framework's priority to promote disaster-resilient health systems.

关键词： Abortion Disasters Sendai framework Sexual and reproductive health Sustainable development goal

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Physical activity volume,frequency,and intensity:Associations with hypertension and obesity over 21 years in Australian women

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Journal of Sport and health Science 2024年第5期13卷 631-641页

作者： Gregore I.Mielke Ding Ding Shelley E.Keating Bruno P.Nunes Ruth Brady Wendy J.Brown School of Public health The University of QueenslandBrisbaneQLD 4006Australia Sydney School of Public health Faculty of Medicine and HealthThe University of SydneySydneyNSW 2006Australia The Charles Perkins centre The University of SydneySydneyNSW 2006Australia School of Human Movement and Nutrition sciences The University of QueenslandBrisbaneQLD 4072Australia School of Nursing Federal University of PelotasPelotasRio Grande do Sul 96010-610Brazil Faculty of health sciences and Medicine Bond UniversityGold CoastQLD 4226Australia

Background:Optimal patterns of accrual of recommended levels of physical activity(PA)for prevention of hypertension and obesity are not *** overall aim of this study was to investigate whether different patterns of accumulation of PA are differentially associated with hypertension and obesity in Australian women over 21 ***,we investigated whether,for the same weekly volume of PA,the number of sessions(frequency)and vigorousness of PA(intensity)were associated with a reduction in the occurrence of hypertension and obesity in ***:Data from the 1973-1978 and 1946-1951 cohorts of the Australian Longitudinal Study on Women's health were analyzed(n=20,588;12%-16%with a Bachelor's or higher degree).Self-reported PA,hypertension,height,and weight were collected using mail surveys every 3 years from 1998/2000 to 2019/*** Estimating Equation models with a 3-year lag model were used to investigate the association of PA volume(metabolic equivalent min/week)(none;33-499;500-999;≥1000,weekly frequency(none;1-2 times;3-4times;5-7 times;≥8 times),and the proportion of vigorous PA to total volume of PA(none;0%;1%-33%;34%-66%;67%-100%)with odds of hypertension and obesity from 2000 to ***:The cumulative incidence of hypertension was 6%in the 1973-1978 and 23%in the 1946-1951 cohort;27%of women in the 1973-1978;and 15%in the 1946-1951 cohort developed obesity over the ***,a higher volume of PA was associated with reduced odds of hypertension and *** the volume of PA was considered,the odds of hypertension did not vary according to the frequency or intensity of ***,increased proportion of vigorous PA to the total volume of PA was associated with a small additional reduction in the risk of obe ***:PA volume appears to be more important than the pattern of accumulation for the prevention of hypertension and *** more sessions,particularly of vigorous-intensity PA,may provide extr

关键词： Physical activity Frequency Intensity Incidences Epidemiology Women

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Stepping up after spinal cord injury:negotiating an obstacle during walking

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Neural Regeneration Research 2025年第7期20卷 1919-1929页

作者： Alain Frigon Charly G.Lecomte Department of Pharmacology-Physiology Faculty of Medicine and Health SciencesUniversitéde SherbrookeCentre de recherche du Centre Hospitalier Universitaire de SherbrookeSherbrookeQCCanada

Every day walking consists of frequent voluntary modifications in the gait pattern to negotiate *** spinal cord injury,stepping over an obstacle becomes *** over an obstacle requires sensorimotor transformations in several structures of the brain,including the parietal cortex,premotor cortex,and motor *** information and planning are transformed into motor commands,which are sent from the motor cortex to spinal neuronal circuits to alter limb trajectory,coordinate the limbs,and maintain *** spinal cord injury,bidirectional communication between the brain and spinal cord is disrupted and animals,including humans,fail to voluntarily modify limb trajectory to step over an ***,in this review,we discuss the neuromechanical control of stepping over an obstacle,why it fails after spinal cord injury,and how it recovers to a certain extent.

关键词： biomechanics locomotion neurophysiology obstacle negotiation spinal cord injury

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