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Nano Research 2024年第3期17卷 2145-2153页

作者： Tandra Ghoshal Michael A.Morris School of Chemistry AMBER and CRANNTrinity College DublinDublinIrelandD02 AK60

Herein,we demonstrate the fabrication of sub-20 nm MoS_(2) horizontal nanowire arrays on silicon substrates using a self-assembled block copolymer assisted in situ inclusion *** separated long-range ordered polystyrene-b-polyethylene oxide(PS-b-PEO)block copolymer(BCP)line-space nanopatterns were achieved through thermo-solvent *** patterns produced had long-range order and domain sizes>1μ*** BCP structures were lightly etched and modified by anhydrous ethanol to facilitate insertion of molybdenum precursor within the film maintaining the parent BCP *** ordered molybdenum oxide nanowire arrays were then fabricated by ultraviolet(UV)/ozone treatment at room *** oxides were converted to sulphides by thermal evaporation at different temperatures in Ar/H_(2) environment.X-ray photoelectron spectroscopy revealed the composition and phases of the molybdenum oxide and sulphide *** mapping was performed to investigate the interfaces between the oxide and sulphide nanowires with the substrate *** formation and stability of the sulphide nanowires were studied at different *** photoluminescence and Raman properties were studied at different formation temperatures to investigate defects and estimate the number of layers.

关键词： MoS_(2) block copolymer nanowires inclusion X-ray photoelectron spectroscopy(XPS) mapping photoluminescence

Primary lateral sclerosis:more than just an upper motor neuron disease

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Neural Regeneration Research 2024年第9期19卷 1881-1882页

作者： Ee Ling Tan Jasmin Lope Peter Bede Computational Neuroimaging Group(CNG) School of MedicineTrinity College DublinIreland Department of Neurology St James’s HospitalDublinIreland

Advances in clinical care and recent research achievements:Primary lateral sclerosis(PLS)has traditionally been regarded as a pure upper motor neuron condition,a view perpetuated by most medical textbooks.

关键词： sclerosis clinical traditionally

Effect of linear friction welding process on microstructure evolution,mechanical properties and corrosion behavior of GH4169 superalloy

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Chinese Journal of Aeronautics 2024年第6期37卷 504-520页

作者： Yu SU Xiawei YANG Tingxi MENG Dong WU Rui XU Haiyu XU Wenya LI Shuo YIN State Key Laboratory of Solidification Processing School of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Department of Mechanical Manufacturing&Biomedical EngineeringParsons BuildingTrinity College DublinThe University of DublinDublin 2Ireland

Linear Friction Welding(LFW)technology was used to realize the welding of GH4169 superalloy,and the effect of welding parameters on the microstructure,mechanical properties and corrosion behavior of the joint was *** results show that there is a positive correlation between the weld hardness and the tensile *** the gradual increase of heat input and welding pressure,the joint quality is gradually improved,but the heat affected zone is not significantly *** smaller the grain size of the weld,the higher the strength and plasticity of the *** the increase of the joint shortening amount,the corrosion resistance of the weld first gradually ***,when the shortening reaches a certain level,the corrosion resistance of the joint becomes little *** the increase of solution temperature,the corrosion current density increases and the polarization impedance *** higher the corrosion temperature,the worse the corrosion resistance of the *** is no significant correlation between the joint strength and the corrosion *** corrosion resistance of the joint can be enhanced without changing the joint mechanical properties by reducing the welding frequency and amplitude or increasing the welding pressure.

关键词： Linear Friction Welding(LFW) GH4169 superalloy Microstructure Mechanical properties Corrosion behavior

Non-linear dynamic state-space network modeling for decoding neurodegeneration

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Neural Regeneration Research 2024年第9期19卷 1879-1880页

作者： Venkata C.Chirumamilla Chi Wang Ip Martin Reich Robert Peach Jens Volkmann Bahman Nasseroleslami Muthuraman Muthuraman Prenatal Pediatrics Institute Children’s National HospitalWashingtonDCUSA Neural Engineering with Signal Analytics and Artificial Intelligence Department of NeurologyUniversity of WürzburgWürzburgGermany Academic Unit of Neurology Trinity Biomedical Sciences InstituteTrinity College DublinUniversity of DublinDublinIreland

Neurodegenerative disorders represent a pervasive global health challenge,yet therapeutic options remain conspicuously *** disorders are inherently dynamic processes within the central nervous system,unfolding across distinct sub-stages:initial structural neuronal alterations(sub-stage 1),functional impairment(sub-stage 2),and culminating in neuronal death(sub-stage 3).

关键词： alterations impairment dynamic

Neurogenic potential of NG2 in neurotrauma:a systematic review

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Neural Regeneration Research 2024年第12期19卷 2673-2683页

作者： Yuri R.Rigo Radharani Benvenutti Luis V.Portela Nathan R.Strogulski Departamento de Bioquímica Instituto de Ciências Básicas da SaúdeUniversidade Federal do Rio Grande do Sul(UFRGS)Porto AlegreBrazil School of Pharmacy and Biomolecular Sciences RCSI University of Medicine and Health SciencesDublinIreland School of Biochemistry and Immunology Trinity Biomedical Sciences InstituteTrinity College DublinUniversity of DublinDublinIreland

Regenerative approaches towards neuronal loss following traumatic brain or spinal cord injury have long been considered a dogma in neuroscience and remain a cutting-edge area of *** is reflected in a large disparity between the number of studies investigating primary and secondary injury as therapeutic to rgets in spinal co rd and traumatic brain *** advances in biotechnology may have the potential to reshape the current state-of-the-art and bring focus to primary injury neurotrauma *** studies using neural-glial factor/antigen 2(NG2)cells indicate that they may differentiate into neurons even in the developed *** these cells show great potential to play a regenerative role,studies have been conducted to test various manipulations in neurotrauma models aimed at eliciting a neurogenic response from *** the present study,we systematically reviewed the experimental protocols and findings described in the scientific literature,which were peer-reviewed original research articles(1)describing preclinical experimental studies,(2)investigating NG2 cells,(3)associated with neurogenesis and neurotrauma,and(4)in vitro and/or in vivo,available in PubMed/MEDLINE,Web of Science or SCOPUS,from 1998 to ***,we have reviewed a total of 1504 papers,and summarized findings that ultimately suggest that NG2 cells possess an inducible neurogenic potential in animal models and in *** also discriminate findings of NG2 neurogenesis promoted by different pharmacological and genetic approaches over functional and biochemical outcomes of traumatic brain injury and spinal co rd injury models,and provide mounting evidence for the potential benefits of manipulated NG2 cell ex vivo transplantation in primary injury *** findings indicate the feasibility of NG2 cell neurogenesis strategies and add new players in the development of therapeutic alternatives for neurotrauma.

关键词： neural-glial antigen 2 neural-glial factor 2 neuron differentiation NG2 cell regeneration spinal cord injury(SCI) traumatic brain injury(TBI)

Microscale shaping and rounding of ridge arrays and star pattern features on nickel mould via electrochemical polishing

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Advances in Manufacturing 2024年第2期12卷 207-226页

作者： Sana Zaki Nan Zhang Michael D.Gilchrist School of Mechanical and Materials Engineering University College DublinBelfieldDublin 4Ireland

High quality micro mould tools are critical for ensuring defect-free production of micro injection moulded *** demoulding stage of the micro injection moulding can adversely affect the surface integrity due to friction,adhesion and thermal stresses between the metallic mould and polymeric replicated *** the present work,we propose the use of precision electropolishing(EP)as a shaping and polishing process to control the draft angle and fillet radius of micro features in order to ease *** defects that occur in replicated polymer parts include cracks,burrs and distorted features.A nickel mould having multiple linear ridges and star shape patterns was designed for the present investigation to have characteristic dimensions ranging from 10μm to 150μm and with various aspect ratios to study the effect of electropolishing on modifying the shape of micro features and surface morphology.A transient 2D computational analysis has been conducted to anticipate the effect of shaping on the Ni mould after electrochemical polishing with non-uniform material removal rates,based on the distribution of current *** experimental results indicate that after shaping using EP,the draft angle of star-patterns and linear patterns can be effectively increased by approximately 3.6°,while the fillet radius increases by up to 5.0μ*** controlling the electropolishing process,the surface roughness can be maintained under 50 *** work uses a green and environmental friendly nickel sulfamate electrolyte which can be effective for shaping of nickel micro features without causing any surface deposition.

关键词： Micro feature shaping and electropolishing Micro mould tools Green electrolyte Demoulding micro patterns

Blood biomarkers of Alzheimer’s disease:important considerations for use in clinical practice

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Neural Regeneration Research 2025年第1期20卷 205-206页

作者： Sarah Fullam Sean O’Dowd Antoinette O’Connor Department of Neurology Tallaght University HospitalDublinIreland Academic Unit of Neurology Trinity College DublinIreland

Introduction:Fluid and positron emission tomography(PET)biomarkers that enable the detection of the hallmark proteins of Alzheimer’s disease(AD)(amyloid and tau)have revolutionized our approach to the diagnosis of *** evolution of AD diagnostic criteria to include biological characterization(Alzheimer’s Association Working Group,2023)provides an appropriate framework to reduce levels of clinico-pathologic mismatch and improve in-vivo diagnostic *** the therapeutic landscape for neurodegenerative disease evolves,it is increasingly incumbent on clinicians to provide timely,and pathologically precise diagnoses for ***,the expensive and invasive nature of these tests limits their scalability.

关键词： Blood Alzheimer diagnosis

Direct ink writing of multifunctional gratings with gel-like MXene/norepinephrine ink for dynamic electromagnetic interference shielding and patterned Joule heating

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Nano Research 2024年第3期17卷 1585-1594页

作者： Pei-Zhu Jiang Zhiming Deng Peng Min Lvxuan Ye Cheng-Zhang Qi Hao-Yu Zhao Ji Liu Hao-Bin Zhang Zhong-Zhen Yu Beijing Key Laboratory of Advanced Functional Polymer Composites Beijing University of Chemical TechnologyBeijing 100029China State Key Laboratory of Organic-Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China School of Chemistry CRANN and AMBERTrinity College DublinDublin D02PN40Ireland

Intelligent electromagnetic interference(EMI)shielding modulators with a wide tuning range and cyclic stability are urgently needed but their fabrication remains challenging.A gel-like MXene/norepinephrine ink is developed and multifunctional MXene gratings with wide EMI shielding effectiveness(SE)tuning range,superior reversibility,and high mechanical flexibility are constructed by direct ink writing approach for dynamic EMI shielding and patterned Joule heating *** modulable MXene/norepinephrine grating with a high conductivity of 3510 S·cm-1 can conveniently realize the seamless modulation of the EMI SE by adjusting the angle between the MXene grating filaments and the electric field of the incident electromagnetic waves,offering highly reversible switching between shielding“On”(28.0 dB)and“Off”(0.5 dB)***,due to the optimized integration of the MXene ink and the rationally designed pattern,a superior specific EMI SE of 95,688.2 dB·cm^(2)·g^(-1) is achieved in the“On”***,the MXene/norepinephrine ink can be used to fabricate many complex patterned gratings with superior stability,instant responsibility,and superb mechanical flexibility,exhibiting a unique patterned Joule heating *** writing of multifunctional gratings paves a means for developing intelligent EMI shielding materials,wearable electronic devices,and advanced thermal management materials.

关键词： MXene ink direct ink writing electromagnetic interference shielding multifunctional gratings Joule heating

Strengthening mechanism and forming control of linear friction welded GH4169 alloy joints

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Chinese Journal of Aeronautics 2024年第4期37卷 609-626页

作者： Yu SU Xiawei YANG Tingxi MENG Xinyuan HE Dong WU Wenya LI Shuo YIN State Key Laboratory of Solidification Processing School of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Shaanxi Key Laboratory of Friction Welding Technologies School of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Department of Mechanical Manufacturing and Biomedical EngineeringParsons BuildingTrinity College DublinThe University of DublinDublin 2Ireland

Numerical simulation and experimental research on Linear Friction Welding(LFW) for GH4169 superalloy were carried out. Based on the joint microstructure and mechanical properties,a suitable welding process was determined, which provided an important theoretical basis for the manufacture and repair of aeroengine components such as the superalloy blisk. The results show that the joint strain rate gradually increases with the increase of welding frequency, and the deformation resistance of the thermoplastic metal increases in the welding process, resulting in the interface thermoplastic metal not being extruded in time to form a flash, so the joint shortening amount gradually decreases. The thermoplastic metal in the center of the welding surface is kept at high welding temperature for a long time, resulting in the decrease of the joint strength. The microhardness of the joint shows a “W” distribution perpendicular to the weld, and most of the joints break in the Thermo-Mechanically Affected Zone(TMAZ) with high tensile strength and low *** the welding area is increased without changing the aspect ratio of the welding surface, the interface peak temperature increases gradually, and the joint shortening amount decreases with the increase of the welding interface size.

关键词： Linear Friction Welding(LFW) Microstructure Mechanical properties Numerical simulation Joint shortening amount

Proposition of atomic and close-to-atomic scale manufacturing

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Advances in Manufacturing 2024年第1期12卷 1-5页

作者： Ju‑Fan Zhang Jens Ducree School of Mechanical and Materials Engineering University College DublinDublin 4Ireland School of Physical Sciences Dublin City UniversityDublinIreland

Atomic and close-to-atomic scale manufacturing(ACSM)is the core competence of Manufacturing *** other conceptions or terminologies that only focus on the atomic level precision,ACSM defnes a new realm of manufacturing where quantum mechanics plays the dominant role in the atom/molecule addition,migration and removal,considering the uncertainty principle and the discrete nature of *** ACSM is still in its infant stage,only little has been systematically elaborated at the core proposition of ACSM by now,hence there is a need to understand its concept and *** article elucidates the development of ACSM and clarifes its proposition,which aims to achieve a clearer understanding on ACSM and direct more efective eforts toward this promising area.

关键词： Atomic and close-to-atomic scale manufacturing(ACSM) Atomic Precision Manufacturing Paradigm Manufacturing III