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中华烧伤杂志 2021年第6期37卷 581-581页

作者：曾茁(译) 彭毅志(审校) Zhou B Liu J Zeng L The Third Affiliated Hospital Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation Guangzhou Medical University Guangzhou China State Key Laboratory of trauma Burns and Combined Injury Institute of Surgery Research Daping Hospital Army Medical University Chongqing China Department of Pediatrics The Third Xiangya Hospital Central South University Changsha China Laboratory of Emergency Medicine North Shore University Hospital and the Feinstein Institute for Medical Research Manhasset USA Department of Surgery University of Pittsburgh Pittsburgh USA Equipe Labellisée par la Ligue Contre le Cancer Université de Paris Sorbonne Université Institut National de la Santé et de la Recherche Médicale U1138 Centre de Recherche des Cordeliers Paris France Metabolomics and Cell Biology Platforms Gustave Roussy Cancer Campus Villejuif France Pôle de Biologie Hôpital Européen Georges Pompidou Assistance Publique-Hôpitaux de Paris Paris France Suzhou Institute for Systems Medicine Chinese Academy of Sciences Suzhou China Department of Women’s and Children’s Health Karolinska University Hospital Stockholm Sweden Life Sciences Institute and Department of Molecular Cellular and Developmental Biology University of Michigan Ann Arbor USA Department of Surgery UT Southwestern Medical Center Dallas USA

宿主对感染的反应失调导致脓毒症成为全世界ICU最常见的死亡原因。本文研究了脓毒症中SQSTM1/p62——一种自噬受体,其可作为先天性免疫调节剂的作用。作者指出LPS引起gasdermin D依赖性焦亡,使巨噬细胞和单核细胞被动释放SQSTM1;而跨膜... 详细信息

宿主对感染的反应失调导致脓毒症成为全世界ICU最常见的死亡原因。本文研究了脓毒症中SQSTM1/p62——一种自噬受体,其可作为先天性免疫调节剂的作用。作者指出LPS引起gasdermin D依赖性焦亡,使巨噬细胞和单核细胞被动释放SQSTM1;而跨膜蛋白173依赖的TANK结合激酶1激活导致SQSTM1丝氨酸403磷酸化,随后巨噬细胞和单核细胞分泌SQSTM1。此外,细胞外SQSTM1与胰岛素受体结合.

关键词：胰岛素受体巨噬细胞免疫调节剂脓毒症 SQS 单核细胞死亡原因跨膜蛋白

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Erratum to:Double-edged effects caused by magnesium ions and alkaline environment regulate bioactivities of magnesiumincorporated silicocarnotite in vitro

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Regenerative Biomaterials 2021年第6期8卷 318-318页

作者： Qiang Wu Shunxiang Xu Fei Wang Bo He Xin Wang Ye Sun Congqin Ning Kerong Dai Shanghai Key Laboratory of Orthopedic Implant Department of Orthopaedic SurgeryShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineNo.639Zhizaoju RoadShanghaiHuangpu District 200011China The Education Ministry Key Lab of Resource Chemistry and Shanghai Key Laboratory of Rare Earth Functional Materials Shanghai Normal UniversityNo.100Guilin RoadShanghaiXuhui District 200234China Department of Orthopedics trauma and Microsurgery Zhongnan Hospital of Wuhan UniversityNo.169East Lake RoadWuchang DistrictWuhan 430071China Department of Orthopaedics The First Affiliated Hospital of Nanjing Medical UniversityNo.300Guangzhou RoadDrum-tower DistrictNanjing210029China State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesNo.1295Dingxi RoadChangning DistrictShanghai 200050China

[This corrects the article DOI: 10.1093/rb/rbab016.].

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Use of video-assisted thoracoscope in 121 cases of cardiac surgery

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Journal of Medical Colleges of PLA(China) 2003年第5期18卷 321-324页

作者：徐学增俞世强程云阁蔡振杰段大为王红兵陈文生 Department of Cardiovascular Surgery Xijing HospitalFourth Military Medical UniversityXi'an 710033China Department of Cardiovascular Surgery Xijing HospitalFourth Military Medical UniversityXi'an 710033Chinabjective: To sum up 121 cases of heart disease operations with the help of thoracoscope from May to August in 2000. Among these cases 48 cases were atrial septal defect (ASD) the average age of patients is 20±10 years old average weight is (43±16) kg. 67 patients with ventricular septal defects (VSD) average age13±9 years old one male patient 44 years old with Ebstein malformation one female patient (21 years old) partial atrioventricu-lar canal combined with cor triatriatum one male (21 years old) with ruptared aneuryem of aortic sinus. 3 cases(all females ) with mitral stenosis combined with mitral valve incompetence. One male patient (aged 16) with pericardiun effusion after trauma. Methods: During operations a patient with supine position and his/her right shoulder was padded 30°higher. Tracheal cannula was inserted and air was piped in with high frequency jet ventilation. Three mini tho-racotomies with a diameter of 2 to 3 cm were made in the 4th intercostals space of the right par sternum and the 4th and 7th intercostals spaces of the right middle axillary line respectively. An periphera extra corporeal circulation was made. the aortic clamp was clamped cannula for cold perfusion. After the heart was sliced and a reformative operation was performed. The process of the operation of defects repairs was finished under the thoracoscope. The other operations were performed with the help of thoracoscope. 3 rheumatic heart disease patients got 25# mechanical mitral valve prosthesis. A 30# tricuspid plasty ring was applied to The Ebstein malformation patient. Results: all 121 patients were successfully operated on without death. Two VSD cases appeared transient third degree atrialventricular block. Because 4 cases had more chest drainage so they were stanched bleeding twice. After the operation he

Objective: To sum up 121 cases of heart disease operations with the help of thoracoscope from May to August in 2000. Among these cases, 48 cases were atrial septal defect (ASD); the average age of patients is 20±10 years old; average weight is (43±16) kg. 67 patients with ventricular septal defects (VSD), average age13±9 years old; one male patient, 44 years old with Ebstein malformation; one female patient (21 years old) partial atrioventricular canal combined with cor triatriatum; one male (21 years old) with ruptared aneuryem of aortic sinus. 3 cases(all females ) with mitral stenosis combined with mitral valve incompetence. One male patient(aged 16)with pericardiun effusion after trauma. Methods: During operations, a patient with supine position, and his/her right shoulder was padded 30°higher. Tracheal cannula was inserted and air was piped in with high frequency jet ventilation. Three mini thoracotomies with a diameter of 2 to 3 cm were made in the 4th intercostals space of the right par sternum and the 4th and 7th intercostals spaces of the right middle axillary line respectively. An periphera extra corporeal circulation was made. the aortic clamp was clamped, cannula for cold perfusion. After the heart was sliced and a reformative operation was performed. The process of the operation of defects repairs was finished under the thoracoscope. The other operations were performed with the help of thoracoscope. 3 rheumatic heart disease patients got 25# mechanical mitral valve prosthesis. A 30# tricuspid plasty ring was applied to The Ebstein malformation patient. Results: all 121 patients were successfully operated on without death. Two VSD cases appeared transient third degree atrialventricular *** 4 cases had more chest drainage, so they were stanched bleeding twice. After the operation, heart murmur vanished, and ultrasonic inspection showed no diffluence inside the heart. Conclusion: Our experience showed that all atrium, ventricular septal defects c

关键词：心脏手术电视胸腔镜手术方法疗效

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Ventilation practices in burn patients—an international prospective observational cohort study

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Burns & trauma 2021年第1期9卷 47-57页

作者： Gerie J.Glas Janneke Horn Markus W.Hollmann Benedikt Preckel Kirsten Colpaert Manu Malbrain Ary Serpa Neto Karim Asehnoune Marcello Gamma de Abreu Ignacio Martin-Loeches Paolo Pelosi Folke Sjoerg Jan M.Binnekade Berry Cleffken Nicole P.Juffermans Paul Knape Bert G.Loef David P.Mackie Perenlei Enkhbaatar Nadia Depetris Anders Perner Eva Herrero Lucia Cachafeiro Marc Jeschke Jeffrey Lipman Matthieu Legrand Johannes Horter Athina Lavrentieva Alex Kazemi Anne Berit Guttormsen Frederik Huss Mark Kol Helen Wong Therese Starr Luc De Crop Wilson de Oliveira Filho Joa Manoel Silva Junior Cintia M.C.Grion Marjorie Burnett Frederik Mondrup Francois Ravat Mathieu Fontaine Renan Le Floch Mathieu Jeanne Morgane Bacus Maite Chaussard Marcus Lehnhardt Bassem Daniel Mikhail Jochen Gille Aidan Sharkey Nicole Trommel Auke C.Reidinga Nadine Vieleers Anna Tilsley Henning Onarheim Maria Teresa Bouza Alexander Agrifoglio Filip Fredén Tina Palmieri Lynda E.Painting Marcus J.Schultz LAMiNAR investigators Academic Medical Center University of AmsterdamAmsterdamAZ 1105The Netherlands Department of Anaesthesia and Intensive Therapy Medical University of Lublin Aleje Racklawickie 1–20-059 Lublin–Poland AZ JAN PALFIJN GENT Watersportlaan 5–9000 Gent–Belgium ABC Medical School SaPauloBangúSP 5001Brazil Service d’Anesthésie Réanimation Chirurgicale Nantes 44093France University Hospital Carl Gustav Carus Dresden 01307Germany St James University Hospital Dublin D08 NHY1Ireland University of Genoa GenoaGE 16128Italy Linkoing University Hospital Linkoing 58185Sweden Maasstad Hospital RotterdamDZ 3079The Netherlands Red Cross Hospital BeverwijkLE 1942The Netherlands Martini Hospital GroningenNT 9728The Netherlands University of Texas Medical Branch GalvestonTX 77555USA Turin CTO Burn Center TurinTO 10126Italy Rigshospitalet Copenhagen 2100Denmark La Paz University Hospital Madrid 28046Spain Ross Tilley Burn Centre Sunnybrook Health Sciences CentreToronto M4N 3M5Canada Royal Brisbane and Women’s Hospital Queensland UniversityHerstonQLD 4029Australia Australian and New Zealand Intensive care Research Centre.Monash University MelbourneVIC 3004Australia GH St-Louis-Lariboisière APHPParis 75010France BG Klinik Ludwigshafen Ludwigshafen 67071Germany Papanikoalou Hospital Thessaloniki 54621Greece Middlemore Hospital OtahuhuAuckland 2025New Zealand Haukeland University Hospital Bergen 5021Norway Uppsala University Hospital Uppsala 75185Sweden Concord Repatriation General Hospital NSW University of SydneyConcord 2139Australia Ziekenhuis Netwerk Antwerpen-Stuivenberg Antwerpen 2060Belgium Universidade de Sao Paulo Sao Paulo 01246-903Brazil Universidade Estadual de Londrina Londrina 86057-970Brazil Sunnybrook Health Sciences Centre Toronto M4N 3M5Canada CHU Lyon St Luc Lyon 69007France CHU Nantes Service dánesthesie reanimation chirugicale Nantes 44093France Hopital Roger Salengro CHRU LilleLille 59037France Saint-Louis Hospital Paris 75010France BG University Hospital Bergmannsheil Bo

Background:It is unknown whether lung-protective ventilation is applied in burn patients and whether they benefit from *** study aimed to determine ventilation practices in burn intensive care units(ICUs)and investigate the association between lung-protective ventilation and the number of ventilator-free days and alive at day 28(VFD-28).Methods:This is an international prospective observational cohort study including adult burn patients requiring mechanical *** tidal volume(V_(T))was defined as V_(T)≤8 mL/kg predicted body weight(PBW).Levels of positive end-expiratory pressure(PEEP)and maximum airway pressures were *** association between V_(T) and VFD-28 was analyzed using a competing risk *** settings were presented for all patients,focusing on the first day of *** also compared ventilation settings between patients with and without inhalation ***:A total of 160 patients from 28 ICUs in 16 countries were *** V_(T) was used in 74%of patients,median V_(T) size was 7.3[interquartile range(IQR)6.2–8.3]mL/kg PBW and did not differ between patients with and without inhalation trauma(p=0.58).Median VFD-28 was 17(IQR 0–26),without a difference between ventilation with low or high V_(T)(p=0.98).All patients were ventilated with PEEP levels≥5 cmH_(2)O;80%of patients had maximum airway pressures<30 cmH_(2)***:In this international cohort study we found that lung-protective ventilation is used in the majority of burn patients,irrespective of the presence of inhalation *** of low V_(T) was not associated with a reduction in *** registration:*** *** of registration:9 December 2014.

关键词： Mechanical ventilation Inhalation trauma Lung-protective Critical care

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