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2022 Chinese expert consensus and guidelines on clinical management of toxicity in anti-CD19 chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma

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Cancer Biology & Medicine 2023年第2期20卷 129-146页

作者： Ping Li Yang Liu Yun Liang Jian Bo Sujun Gao Yongxian Hu Yu Hu He Huang Xiaojun Huang Hongmei Jing Xiaoyan Ke Jianyong Li Yuhua Li Qifa Liu Peihua Lu Heng Mei Ting Niu Yongping Song Yuqin Song Liping Su Sanfang Tu Jianxiang Wang Depei Wu Zhao Wang Kailin Xu Zhitao Ying Qingming Yang Yajing Zhang Fengxia Shi Bin Zhang Huilai Zhang Xi Zhang Mingfeng Zhao Weili Zhao Xiangyu Zhao Liang Huang Jun Zhu Wenbin Qian Weidong Han Aibin Liang Department of Hematology Shanghai Tongji HospitalTongji University School of MedicineShanghai 200065China Department of Bio-therapeutic Chinese PLA General HospitalBeijing 100853China Department of Hematology The Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310009China Department of Hematology Chinese PLA General HospitalBeijing 100853China Department of Hematology The First Hospital of Jilin UniversityChangchun 130012China Center for Bone Marrow Transplantation The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310058China Institute of Hematology Union Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Peking University People’s Hospital&Peking University Institute of Hematology Beijing Key Laboratory of Hematopoietic Stem Cell TransplantationBeijing 100044China Department of Hematology Lymphoma Research CenterPeking University Third HospitalBeijing 100191China Department of Hematology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Hematology Zhujiang HospitalSouthern Medical UniversityGuangzhou 510280China Department of Hematology Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Lu Daopei Institute of Hematology Beijing 101102China Department of Hematology West China HospitalSichuan UniversityChengdu 610041China The Affiliated Cancer Hospital of Zhengzhou University Zhengzhou 450008China Department of Lymphoma Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Peking University Cancer Hospital and InstituteBeijing 100142China Department of Hematology Shanxi Cancer HospitalTaiyuan 030013China State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood DiseasesDivision of Pediatric Blood Disease CenterInstitute of Hematology&Blood Disease HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianj

Adoptive cellular immunotherapy with chimeric antigen receptor(CAR)T cells has emerged as a novel modality for treating relapsed and/or refractory B-cell non-Hodgkin lymphoma(B-NHL).With increasing approval of CAR T-cell products and advances in CAR T cell therapy,CAR T cells are expected to be used in a growing number of ***,CAR T-cell-associated toxicities can be severe or even fatal,thus compromising the survival benefit from this *** and studying the clinical management of these toxicities are *** contrast to other hematological malignancies,such as acute lymphoblastic leukemia and multiple myeloma,anti-CD19 CAR T-cell-associated toxicities in B-NHL have several distinctive features,most notably local cytokine-release syndrome(CRS).However,previously published guidelines have provided few specific recommendations for the grading and management of toxicities associated with CAR T-cell treatment for ***,we developed this consensus for the prevention,recognition,and management of these toxicities,on the basis of published literature regarding the management of anti-CD19 CAR T-cell-associated toxicities and the clinical experience of multiple Chinese *** consensus refines a grading system and classification of CRS in B-NHL and corresponding measures for CRS management,and delineates comprehensive principles and exploratory recommendations for managing anti-CD19 CAR T-cell-associated toxicities in addition to CRS.

关键词： CAR T-cell therapy B-cell non-Hodgkin lymphoma toxicity cytokine-release syndrome clinical management

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第十七届全国烧伤救治专题研讨会2022年亚太烧伤高峰论坛暨2022年中国医疗保健国际交流促进会烧伤医学分会年会西南五省一市烧伤整形学会年会通知

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中华烧伤与创面修复杂志 2022年第6期38卷 557-557页

作者：无《中华烧伤与创面修复杂志》(原《中华烧伤杂志》)编辑委员会《Burns&trauma》杂志编辑委员会中国医疗保健国际交流促进会烧伤医学分会西南五省一市烧伤整形学会

鉴于目前全国的新冠疫情趋于平缓,经研究决定原定于2022年6月举行的“第十七届全国烧伤救治专题研讨会、2022年亚太烧伤高峰论坛暨2022年中国医疗保健国际交流促进会烧伤医学分会年会、西南五省--市烧伤整形学会年会”拟于2022年9月1-3... 详细信息

鉴于目前全国的新冠疫情趋于平缓,经研究决定原定于2022年6月举行的“第十七届全国烧伤救治专题研讨会、2022年亚太烧伤高峰论坛暨2022年中国医疗保健国际交流促进会烧伤医学分会年会、西南五省--市烧伤整形学会年会”拟于2022年9月1-3日在广西壮族自治区南宁市举办。

关键词：烧伤医学烧伤救治烧伤整形广西壮族自治区高峰论坛亚太

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Epidemiology and risk factors for mortality in critically ill patients with pancreatic infection

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Journal of Intensive Medicine 2024年第1期4卷 81-93页

作者： Marie Dejonckheere Massimo Antonelli Kostoula Arvaniti Koen Blot Ben CreaghBrown Dylan Wde Lange Jan De Waele Mieke Deschepper Yalim Dikmen George Dimopoulos Christian Eckmann Guy Francois Massimo Girardis Despoina Koulenti Sonia Labeau Jeffrey Lipman Fernando Lipovestky Emilio Maseda Philippe Montravers Adam Mikstacki JoseArtur Paiva Cecilia Pereyra Jordi Rello JeanFrancois Timsit Dirk Vogelaers Stijn Blot the Abdominal Sepsis Study(AbSeS)group on behalf of the Trials Group of the European Society of Intensive Care Medicine Department of Internal Medicine and Pediatrics Faculty of Medicine and Health SciencesGhent UniversityGhentBelgium Department of Anesthesiology Intensive Care and Emergency MedicineFondazione Policlinico Universitario A.Gemelli IRCCSRomeItaly UniversitàCattolica del Sacro Cuore RomeItaly Intensive Care Unit Papageorgiou University Affiliated HospitalThessaloníkiGreece Department of Epidemiology and Public Health SciensanoIxellesBelgium Surrey Perioperative Anaesthetic Critical Care Collaborative Research Group(SPACeR) Royal Surrey County HospitalGuildfordUK Department of Clinical and Experimental Medicine University of SurreyGuildfordUK Department of Intensive Care Medicine University Medical Center UtrechtUniversity UtrechtUtrechtthe Netherlands Department of Intensive Care Medicine Ghent University HospitalGhentBelgium Data Science Institute Ghent University HospitalGhentBelgium Department of Anesthesiology and Reanimation Cerrahpasa School of MedicineIstanbul University-CerrahpasaIstanbulTurkey rd Department of Critical Care “EVGENIDIO”HospitalNational and Kapodistrian University of AthensAthensGreece Department of General Visceral and Thoracic SurgeryKlinikum Hannoversch-MuendenGoettingen UniversityGöttingenGermany Division of Scientific Affairs-Research European Society of Intensive Care MedicineBrusselsBelgium Anesthesia and Intensive Care Department University Hospital of ModenaModenaItaly UQ Centre for Clinical Research Faculty of MedicineThe University of QueenslandBrisbaneQLDAustralia nd Critical Care Department Attikon University HospitalAthensGreece Department of Nursing Faculty of EducationHealth and Social WorkUniversity College GhentGhentBelgium Jamieson trauma Institute The University of QueenslandBrisbaneQLDAustralia Nimes University Hospital University of MontpellierNimesFrance Critical Care Department Hospital of the Interamerican Open University(UAI)Buenos AiresArgentina Surgical Critical Care Department of AnesthesiaHospital Universitario

Background:The AbSeS-classification defines specific phenotypes of patients with intra-abdominal infection based on the(1)setting of infection onset(community-acquired,early onset,or late-onset hospital-acquired),(2)presence or absence of either localized or diffuse peritonitis,and(3)severity of disease expression(infection,sepsis,or septic shock).This classification system demonstrated reliable risk stratification in intensive care unit(ICU)patients with intra-abdominal *** study aimed to describe the epidemiology of ICU patients with pancreatic infection and assess the relationship between the components of the AbSeS-classification and ***:This was a secondary analysis of an international observational study(“AbSeS”)investigating ICU patients with intra-abdominal *** patients with pancreatic infection were included in this analysis(n=165).Mortality was defined as ICU mortality within 28 days of observation for patients discharged earlier from the *** with mortality were assessed using logistic regression analysis and reported as odds ratio(OR)and 95%confidence interval(CI).Results:The overall mortality was 35.2%(n=58).The independent risk factors for mortality included older age(OR=1.03,95%CI:1.0 to 1.1 P=0.023),localized peritonitis(OR=4.4,95%CI:1.4 to 13.9 P=0.011),and persistent signs of inflammation at day 7(OR=9.5,95%CI:3.8 to 23.9,P<0.001)or after the implementation of additional source control interventions within the first week(OR=4.0,95%CI:1.3 to 12.2,P=0.013).Gramnegative bacteria were most frequently isolated(n=58,49.2%)without clinically relevant differences in microbial etiology between survivors and ***:In pancreatic infection,a challenging source/damage control and ongoing pancreatic inflammation appear to be the strongest contributors to an unfavorable short-term *** this limited series,essentials of the AbSeS-classification,such as the setting of infection onset,diffuse

关键词： Pancreatic infection Intensive care unit Mortality Intra-abdominal infection Sepsis

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美国眼成形与重建外科简介

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中华眼外伤职业眼病杂志 1990年第1期 66-66页

作者：王成业 Don Liu Henry Ford Hospital 湖南医科大学附一院眼科教研室 Director of Oculoplastic and Orbital surgery Detroit Department of Ophthal mology U.S.A. M. D.

眼成形外科是在现代内科与外科的基础上形成的,是现代外科的分支。作为一个独立的眼科专业存在为时尚短,而这种技术在临床上的应用都有很长的时间了。称为美国

关键词：成形外科美国美利坚合众国北美洲

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Review of global neurosurgery education: Horizon of Neurosurgery in the Developing Countries

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Chinese Neurosurgical Journal 2020年第3期6卷 178-190页

作者： Y.Kato B.S.Liew A.A.Sufianov L.Rasulic K.I.Arnautovic V.H.Dong I.S.Florian F.Olldashi Y.Makhambetov B.Isam M.Thu Ts.Enkhbayar N.Kumarasinghe A.H.Bajama S.Nair S.Sharif M.R.Sharma J.A.Landeiro C.G.Yampolsky N.M.F.El-Ghandour A.M.Hossain S.Sim S.Chemate Hira Burhan L.Feng H.Andrade Isabelle M.Germano Department of Neurosurgery Fujita Health University Bantane HospitalNagoyaJapan Department of Neurosurgery Hospital Sungai BulohSungai BulohSelangorMalaysia Federal State-Financed Institution“Federal Centre of Neurosurgery”of Ministry of Health of the Russian Federation TyumenRussia I.M.Sechenov First Moscow State Medical University MoscowRussia Faculty of Medicine University of BelgradeBelgradeSerbia Semmes-Murphey Clinic and Department of Neurosurgery University of TennesseeMemphisTNUSA Neurosurgery Center of Viet Duc university hospital HanoiVietnam Department of Neurosurgery University of Medicine and Pharmacy“Iuliu Hatieganu”Cluj-NapocaCluj CountyRomania Department of Neurosurgery University Hospital of TraumaTiranaAlbania National Center of Neurosurgery AstanaKazakhstan Neurosurgical Centre Yangon General HospitalYangoonMyanmar Mongolian Neurosurgical Society UlaabaatarMongolia National Hospital of Sri Lanka ColomboSri Lanka Department of Neurosurgery Dr Soetomo General HospitalAirlangga UniversitySurabayaIndonesia Department of Neurosurgery Sree Chitra Tirunal Institute for Medical Sciences and TechnologyThiruvananthapuramIndia Institute of Postgraduate Studies and Medical Sciences Liaquat National Hospital&Medical CollegeKarachiPakistan Department of Neurosurgery TU Teaching HospitalKathmanduNepal Department of Neurosurgery Universidade Federal FluminenseNiteróiBrazil Department of Neurosurgery Hospital Italiano de Buenos AiresBuenos AiresArgentina Department of Neurosurgery Faculty of MedicineCairo University81 Nasr RoadNasr CityCairoEgypt Bangladesh Society of Neurosurgeons DhakaBangladesh Khema Clinic 18 StreetPhnom Penh 528Cambodia DNB Neurosurgery Apollo HospitalChennaiIndia Institute of Neurosciences Nobel Medical College and Teaching HospitalBiratnagarNepal China International Neuroscience Institute BeijingChina Department of Neurosurgery University Medicine MannheimMannheimGermany Icahn School of Medicine Mount Sinai HospitalNew York CityUSA

Globally,the discipline of neurosurgery has evolved remarkably *** being one of the latest medical specialties,which appeared only around hundred years ago,it has witnessed innovations in the aspects of diagnostics methods,macro and micro surgical techniques,and treatment ***,this development is not evenly distributed between developed and developing *** same is the case with neurosurgical education and training,which developed from only traditional apprentice programs in the past to more structured,competencebased programs with various teaching methods being utilized,in recent times.A similar gap can be observed between developed and developing counties when it comes to neurosurgical ***,most of the scholars working in this field do understand the coherent relationship between neurosurgical education and neurosurgical *** context to this understanding,a symposium was organized during the World Federation of Neurological Surgeons(WFNS)Special World Congress Beijing *** symposium was the brain child of *** Kato-one of the eminent leaders in neurosurgery and an inspiration for female *** speakers from different continents presented the stages of development of neurosurgical education in their respective *** paper summarizes the outcome of these presentations,with particular emphasis on and the challenges faced by developing countries in terms of neurosurgical education and strategies to cope with these challenges.

关键词： Global neurosurgical education Developing countries

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近红外二区荧光导航手术在足踝外科中的应用初探（英文）

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Engineering 2024年第9期 19-27页

作者：樊潇霄杨杰倪沪桅夏启铭刘孝龙吴天翔李霖 Paras N.Prasad 刘超林辉钱骏 Department of General surgery Sir Run Run Shaw Hospital School of Medicine Zhejiang University Centre for Optical and Electromagnetic Research & International Research Center for Advanced Photonics College of Optical Science and Engineering Zhejiang University Department of Orthopedics Sir Run Run Shaw Hospital School of Medicine Zhejiang University Institute for Lasers Photonics and Biophotonics Department of Chemistry State University of New York Zhejiang Engineering Research Center of Cognitive Healthcare Sir Run Run Shaw Hospital School of Medicine Zhejiang University College of Biomedical Engineering and Instrument Science Zhejiang University

Optical imaging in the second near-infrared(NIR-Ⅱ; 900–1880 nm) window is currently a popular research topic in the field of biomedical imaging. This study aimed to explore the application value of NIR-Ⅱ fluorescence imaging in foot and ankle surgeries. A lab-established NIR-Ⅱ fluorescence surgical navigation system was developed and used to navigate foot and ankle surgeries which enabled obtaining more high-spatial-frequency information and a higher signal-to-background ratio(SBR) in NIR-Ⅱ fluorescence images compared to NIR-I fluorescence images; our result demonstrates that NIR-Ⅱ imaging could provide higher-contrast and larger-depth images to surgeons. Three types of clinical application scenarios(diabetic foot, calcaneal fracture, and lower extremity trauma) were included in this study. Using the NIR-Ⅱ fluorescence imaging technique, we observed the ischemic region in the diabetic foot before morphological alterations, accurately determined the boundary of the ischemic region in the surgical incision,and fully assessed the blood supply condition of the flap. NIR-Ⅱ fluorescence imaging can help surgeons precisely judge surgical margins, detect ischemic lesions early, and dynamically trace the perfusion process. We believe that portable and reliable NIR-Ⅱ fluorescence imaging equipment and additional functional fluorescent probes can play crucial roles in precision surgery.

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Expert consensus on the perioperative management of patients with sepsis

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World Journal of Emergency Medicine 2015年第4期6卷 245-260页

作者： Jun-ping Chen Xiang-ming Fang Xiao-ju Jin Rong-tian Kang Ke-xuan Liu Jin-bao Li Yan Luo Zhi-jie Lu Chang-hong Miao Han-xiang Ma Wei Mei Yang-wen Ou Si-hua Qi Zai-sheng Qin Guo-gang Tian An-shi Wu Dong-xin Wang Tian Yu Yong-hao Yu Jing Zhao Ming-zhang Zuo Shi-hai Zhang Department of Anesthesiology Ningbo Number 2 Hospital Department of Anesthesiology First Affiliated HospitalSchool of MedicineZhejiang University Department of Anesthesiology and Critical Care Medicine Yijishan HospitalWannan Medical College Department of Anesthesiology Second Hospital of Hebei Medical University Department of Anesthesiology First Affiliated HospitalSun Yat-sen University Department of Anesthesiology and Intensive Care Medicine Changhai HospitalSecond Military Medical University Department of Anesthesiology Ruijin HospitalSchool of MedicineShanghai Jiaotong University Department of Anesthesiology and Intensive Care Medicine Eastern Hepatobiliary Surgery HospitalSecond Military Medical University Department of Anesthesiology Fudan University Shanghai Cancer CenterShanghai Medical CollegeFudan University Department of Anesthesiology General Hospital of Ningxia Medical University Department of Anesthesiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and Technology Department of Anesthesiology Third Xiangya HospitalCentral South University Department of Anesthesiology Fourth Affiliated HospitalHarbin Medical University Department of Anesthesiology Nanfang HospitalSouthern Medical University Department of Anesthesiology People's Hospital of Sanya Department of Anesthesiology Beijing Chaoyang HospitalCapital Medical University Department of Anesthesiology and Surgical Intensive Care Peking University First Hospital Department of Anesthesiology Affiliated Hospital of Zunyi Medical College Department of Anesthesiology Tianjin Medical University General Hospitaland Tianjin Research Institute of Anesthesiology Department of Anesthesiology Peking Union Medical College HospitalChinese Academy of Medical Sciences Department of Anesthesiology Beijing Hospital Department of Anesthesiology Union HospitalTongji Medical CollegeHuazhong University of Science and Technology

INTRODUCTION Sepsis is defined as an infection associated with systemic manifestations of inflammation, which has become the most common complication in the perioperative period caused by severe burn/trauma and major surgical operation.[1,2] The incidence of sepsis in adults is estimated to be 149–240/100 000 per year, and that of severe sepsis and septic shock is 56–91/100 000 per year. In the last decade, the short-term mortality of sepsis has declined to around 20% in developed countries partly due to the international Surviving Sepsis Campaign （SSC）, while the mortality remains very high （50%–80%） in 1–5 years after discharge from hospitals.[3–7] Thus, sepsis and its subsequent severe sepsis and septic shock are currently major issues in the field of medical and health care.

关键词： Expert consensus perioperative management patients with sepsis

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