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Recent progress on the pretreatment and fractionation of lignocelluloses for biorefinery at QIBEBT

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Journal of Bioresources and Bioproducts 2017年第1期2卷 4-9页

作者： Bin Li Chao Liu Guang Yu Yuedong Zhang Haisong Wang Xindong Mu Hui Peng CAS Key Laboratory of Bio-based Material Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesQingdao 266101China Liaoning Key Laboratory of Pulp and Papermaking Engineering Dalian Polytechnic UniversityDalian 116034China

Pretreatment and fractionation are amongst the key steps for the conversion of lignocelluloses to sustainable biofuels,biomaterials or biochemicals,as pretreatment/fractionation can break the natural recalcitrance of lignocelluloses,improving the conversion efficiency of downstream *** paper reviews the recent progress on the pretreatment and fractionation of lignocelluloses for biorefinery at the Chinese Academy of Sciences-Qingdao institute of Bioenergy and Bioprocess Technology(QIBEBT).The main technologies developed at the QIBEBT in recent years include alkaline twin-screw extrusion pretreatment,modified alkali pretreatment,hydrogen peroxide-assisted sodium carbonate pretreatment,fractionation with formic acid,as well as the two-step fractionation by hot water treatment coupling ammonium sulfite *** the development of these technologies,a pilot scale platform for the pretreatment and saccharification of biomass has been established in the pilot plant of QIBEBT.

关键词： Biomass Pretreatment Fractionation Sustainable biofuels Value added products

Novel coumarone-derived(S,E)-4-(4-fluorobenzylidene)-3-phenylchroman-3-ol inhibits muscle-invasive bladder cancer cells by repressing the S and G2 cell cycle phases

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Precision Medicine research 2023年第2期5卷 8-15页

作者： Xin-Yi Han A-Dan Li Fa-Ying Zhou Chao Li Guo-Du Liu Yong Xia College of Basic Medicine Jining Medical UniversityJining 272067China College of Chemistry and Chemical Engineering Inner Mongolia University(South Campus)Hohhot 010030China institute of Precision Medicine Jining Medical UniversityJining 272067China

Background:This study aimed to select compounds with unique inhibitory effects on muscle-invasive bladder cancer(MIBC)from coumarone derivatives with similar parent nuclear structures and to reveal their tumor-suppressive effects using various ***:Bladder cancer cell lines SW780 and T24,as well as human normal bladder epithelial cell line SV-HUC-1 were selected as the study model,and these urinary system cells were co-incubated with various concentrations of(S,E)-4-(4-methylbenzylidene)-3-phenylchroman-3-ol,(S,E)-4-(4-isocyanobenzylidene)-3-phenylchroman-3-ol,(S,E)-4-(4-fluorobenzylidene)-3-phenylchroman-3-ol(FPO),and(S,E)-3-phenyl-4-(4-(trifluoromethoxy)benzylidene)*** activity was detected using cell counting *** showed the strongest inhibitory effect on MIBC cells;therefore,it was selected for further *** monitored the FPO-induced T24 cell morphological changes with an inverted *** FPO-inhibited migration of T24 cells was examined using a cell scratch *** detected the clonogenic ability of T24 cells through a clone formation test and evaluated their proliferative ability using a 5-ethynyl-2’-deoxyuridine fluorescence staining *** inhibitory effect of FPO against the cell cycle was monitored using flow cytometry,and its suppressive effect on the DNA replication ability of T24 cells was detected using double fluorescence staining(Ki67 and phalloidin).Results:Among the four candidate coumarone derivatives,FPO showed the most significant inhibitory effect on MIBC cells and was less toxic to normal urothelial *** inhibited T24 cell growth in time and dose-dependent manners(the half-inhibitory concentration is 8μM).FPO significantly repressed the proliferation,migration,and clonogenic ability of bladder cancer T24 *** mobility was significantly inhibited by FPO:30μM FPO almost completely repressed migration occurred at after 24 h ***,FPO significantly suppressed the clonogenic

关键词： muscle-invasive bladder cancer cell proliferation cell cycle DNA replication coumarone derivate

Natural selection bet ween two games with environmentai feedback

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International Journal of Biomathematics 2021年第7期14卷 123-143页

作者： Hairui Yuan Xinzhu Meng Zhenqing Li College of Mathematics and Systems Scienceshandong University of Science and Technology Qingdao 266590 P.R.China State Key Laboratory of Vegetation and Environmental Change institute of Botangy Chinese Academy of Sciences Beijing 100093P.R.China

Evolutionary game theory has extensively investigated situations in which several gamesare competing against each other at the same time,but the model only assumes sym-metric interactions in homogeneous ***,the population is consideredin heterogeneous environments,individuals in the population occupy a different qualityof patches,and individual fitness depends not only on the interaction between individ-uals,but also on the quality of the ***,by establishing a mathemati-cal framework,we analyze the natural selection between two strategies and two gamesin heterogeneous ***,we analyze the natural selection of Pris-oner's Dilemma and Hawk-Dove games theoretically to demonstrate the dynamics ofcooperators and defectors in their choice of environment and their respective ***,the distribution of games and strategies changes with *** on differentinitial population compositions,we also discuss the invasion problem of games from dif-ferent *** one's surprise,we can find that good quality patches attract allindividuals;the long-term dynamics in invariant rich environments is the same as thedynamics of symmetric interactions in homogeneous environments.

关键词： Evolutionary game theory Heterogencous environment HKV method Hawk-Dove Prisoner's dilemma

Organochlorine pesticides in eco-geochemical survey, China

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Chinese Journal Of Geochemistry 2006年第B8期25卷 213-213页

作者： Shihua QI Gan ZHANG Xiangdong LI Qiuke SU Xianyi GONG Chunling LU Jun LI Julia Burnet E Key Laboratory of Biogeology and Environmental Geology of Ministry of Education China University of Geosciences Wuhan 430074 China State Key Laboratory of Organic Geochemistry Guangzhou Institute of Geochemistry Guangzhou 510640 China Department of Civil and Structural Engineering The Hong Kong Polytechnic University Hung Horn Hong Kong

山东省沂源县西部地区恙虫病东方体、地方性斑疹伤寒和斑点热立克次体血清流行病学的初步研究

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山东大学学报（医学版） 2013年第10期51卷 98-100,104页

作者：迟媛媛翟慎勇温红玲崔峰王玲杜俊王谦张寿锋 Kandace Schneider 徐文斌赵丽于学杰山东大学公共卫生学院微生物检验室济南250012 淄博市疾病预防控制中心山东淄博255026 沂源县疾病预防控制中心山东沂源256100 Biocell Diagnostics Inc.BaltimoreMD 21224USA Department of Pathology and Microbiology Center for Biodefense and Emerging Infectious DiseasesInstitute for Human Infections and ImmunityUniversity of Texas Medical BranchGalvestonTexas 77555-0609USA

目的了解近年山东省沂源县西部地区农村人口恙虫病东方体、地方性斑疹伤寒立克次体和斑点热立克次体的感染情况,为自然疫源性疾病的预防和控制提供依据。方法 2011年从山东省沂源县西部乡镇的农村人口中随机收集192份血清,采用间接免疫... 详细信息

目的了解近年山东省沂源县西部地区农村人口恙虫病东方体、地方性斑疹伤寒立克次体和斑点热立克次体的感染情况,为自然疫源性疾病的预防和控制提供依据。方法 2011年从山东省沂源县西部乡镇的农村人口中随机收集192份血清,采用间接免疫荧光法检测血清中恙虫病东方体、地方性斑疹伤寒立克次体和斑点热立克次体抗体。结果恙虫病东方体、地方性斑疹伤寒立克次体和斑点热立克次体抗体血清阳性率分别为56.77%(109/192)、79.69%(153/192)和69.79%(134/192)。结论山东省沂源县西部农村人口中恙虫病东方体、地方性斑疹伤寒立克次体和斑点热立克次体的感染率较高。

关键词：恙虫病地方性斑疹伤寒斑点热血清抗体阳性率

Sustainable preparation and characterization of thermally stable and functional cellulose nanocrystals and nanofibrils via formic acid hydrolysis

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Journal of Bioresources and Bioproducts 2017年第1期2卷 10-15页

作者： Haishun Du Chao Liu Dong Wang Yuedong Zhang Guang Yu Chuanling Si Bin Li Xindong Mu Hui Peng CAS Key Laboratory of Bio-based Material Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesQingdao 266101China Tianjin Key Laboratory of Pulp and Paper College of Papermaking Science and TechnologyTianjin University of Science and TechnologyTianjin 300457China CHTC Helon Co.Ltd. Weifang 261100China

In this work,a sustainable method to prepare functional cellulose nanocrystals(CNCs)and cellulose nanofibrils(CNFs)using formic acid(FA)(a recoverable organic acid)was *** FA hydrolysis,the obtained CNCs could be well dispersed in ***,the CNC products and fibrous cellulosic solid residue(FCSR)in DMAC could be easily separated by a conventional centrifugal process,and the collected FCSR could be further fibrillated to CNFs with relatively low-intensity mechanical fibrillation *** isolated CNC products showed high crystallinity index(about 75%)and excellent thermal stability(with onset thermal degradation temperature of 325℃).Both the resultant CNCs and CNFs showed better dispersibility in DMSO,DMF and DMAC respectively because of the introduction of ester groups on the surface of the *** presence of surface ester groups could increase the interface compatibility of nanocelluloses with polymeric matrices and enable their applications in reinforcing polymeric matrix materials(*** composite films like PHVB+CNFs).

关键词： Cellulose nanocrystals Cellulose nanofibrils Formic acid hydrolysis Sustainable process CNF/PHBV nanocomposites

把握机会窗口期减缓气候变化对中国居民健康影响

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科学通报 2023年第15期68卷 1899-1905页

作者：蔡闻佳张弛张诗卉艾思奇白玉琪鲍俊哲常楠陈彬陈慧琪程亮亮崔学勤戴瀚程 Bawuerjiang Danna 底骞董伟董文轩窦德景范维澄范星房小怡高仝高源耿阳关大博郭亚菲 Ian Hamilton 胡艺馨华峻翊黄存瑞黄弘黄建斌蒋俏蕾姜晓朋柯丕煜 Gregor Kiesewetter Pete Lampard 李传玺李瑞奇李双利梁璐林波荣林华亮刘欢刘起勇刘小波刘心远刘昱甫刘钊刘竹楼书含鲁晨曦罗勇罗震宇马伟 Alice McGushin 牛彦麟任超阮增良 Wolfgang Schöpp 单钰理苏婧孙韬淳王灿王琼文三妹谢杨熊辉徐冰徐朦颜钰杨军杨廉平杨秀俞乐岳玉娟曾仪娉张镜张少辉张曜张仲宸赵继尧赵亮赵梦真赵琦赵哲周景博朱征宏陈冯富珍宫鹏清华大学地球系统科学系北京100084 北京理工大学管理与经济学院北京100081 中山大学公共卫生学院广州510080 郑州大学公共卫生学院郑州450001 南京医科大学公共卫生学院南京211166 北京师范大学环境学院北京100875 北京大学环境工程学院北京100871 清华大学新闻与传播学院北京100084 清华大学万科公共卫生学院北京100084 浙江大学地球科学学院杭州310058 清华大学公共安全研究所北京100084 清华大学工程物理系北京100084 百度研究院北京100091 山东师范大学环境与生态研究院济南250013 中国气象科学研究院气象影响与风险研究中心北京100086 山东师范大学商学院济南250013 中国疾病预防控制中心传染病预防控制所传染病预防控制国家重点实验室北京102206 清华大学建筑学院北京100084 中国疾病预防控制中心环境与人群健康重点实验室环境与健康相关产品安全所北京102206 Energy institute University College LondonLondon WC1E 6BTUK 南方科技大学统计与数据科学系深圳518055 香港大学建筑学院中国香港999077 世界卫生组织驻华代表处北京100600 Pollution Management research Group EnergyClimateand Environment ProgramInternational Institute for Applied Systems Analysis(IIASA)Schlossplatz 1-A-2361 LaxenburgAustria Department of Health Sciences University of YorkYork YO105DDCanada 山东大学齐鲁医学院公共卫生学院流行病学系济南250002 中国科学技术大学计算机科学与技术学院合肥230027 Department of Geography and the Environment University of North TexasDenton TX 76203-5017USA 清华大学环境学院北京100084 Geography College of Life and Environmental SciencesUniversity of ExeterExeter EX12LUUK 山东大学气候变化与健康研究中心济南250002 institute for Global Health University College LondonLondon WC1H 0ALUK School of Geography Earth and Environmental SciencesUniversity of BirminghamBirmingham B152TTUK 清华大学人文学院北京100084 北京航空航天大学经济与管理学院北京100083 香港科技大学(广州)信息枢纽人工智能学域广州511443 暨南大学环境与气候研究所广州510632 清华大学气候变化与可持续发展研究院北京100084 清华大学苏世民学院北京100084 清华大学体育学部北京100084 中国科学院大气物理研究所大气科学和地球流体力学数值模拟国家重点实验室北京100029 香港大学地球科学系和地理系中国香港999077

随着中国总人口的不断增加以及改革开放以来经济的飞速发展,中国面临来自气候变化的健康威胁也在不断上升.与此同时,中国也处于一个独特的机遇窗口期,如果能够有效应对气候变化带来的健康风险,将造福今后几代人的健康.反之,如果没有及... 详细信息

随着中国总人口的不断增加以及改革开放以来经济的飞速发展,中国面临来自气候变化的健康威胁也在不断上升.与此同时,中国也处于一个独特的机遇窗口期,如果能够有效应对气候变化带来的健康风险,将造福今后几代人的健康.反之,如果没有及时、充分的应对措施,气候变化对中国居民健康和生命的威胁将与日俱增.为了推动更及时且有利于改善人群健康的气候应对行动,由清华大学牵头建立的柳叶刀倒计时亚洲中心在全球柳叶刀倒计时工作的基础上[1,2],从2020年开始,聚焦气候变化对中国人群健康的影响进行全面且系统的评估[3,4].

关键词：减缓气候变化人群健康柳叶刀居民健康窗口期倒计时应对措施把握机会

Synergistic combination of a Co-doped𝜎σ-MnO_(2)cathode with an electrolyte additive for a high-performance aqueous zinc-ion battery

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ChemPhysMater 2023年第1期2卷 77-82页

作者： Shuhua Yang Le Zhang Mengjiao Luo Yanwei Cui Jieqiang Wang Degang Zhao Chao Yang Xiutong Wang Bingqiang Cao Materials Center for Energy and Photoelectrochemical Conversion School of Material Science and EngineeringUniversity of JinanJinan 250022China School of Physics and Physical Engineering Qufu Normal UniversityQufu 273165China Key Laboratory of Marine Environmental Corrosion and Bio-fouling Institute of Oceanology and Center for Ocean Mega-ScienceChinese Academy of SciencesQingdao 266071China

The key challenges in aqueous zinc-manganese dioxide batteries(MnO_(2)//Zn)are their poor electrochemical kinetics and stability,which are mainly due to low conductivity and the inevitable dissolution of MnO_(2).A syn-ergistic combination of a Co-doped𝜎σ-MnO_(2)electrode(Co-MnO_(2))and a Co(CH_(3)COO)_(2)•4H_(2)O(CoAc)electrolyte additive is here developed to design a high-performance aqueous MnO_(2)//Zn battery(denoted as a Co-MnO_(2)//Zn battery with CoAc).The introduction of Co ions(Co^(3+)/Co^(2+))into the𝜎σ-MnO_(2)electrode is achieved via a facile one-step electrodeposition *** from the synergistic coupling effect of the Co-MnO_(2)electrode and the CoAc electrolyte additive,the fabricated Co-MnO_(2)//Zn battery with CoAc shows a commendable dis-charge capacity of 313.8 mAh g^(−1)at 0.5 A g^(−1),excellent rate performance,excellent durability over 1000 cycles(∼92%capacity retention at 1.0 A g^(−1))and admirable energy density(439.3 Wh kg^(−1)),which is a significant improvement compared with an un-doped𝜎σ-MnO_(2)//Zn battery.

关键词： Co-dopedσ-MnO_(2) CoAc electrolyte additive Synergistic coupling effect MnO_(2)//Zn battery