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Screening for metastasis-related genes in mouse melanoma cells through sequential tail vein injection

Biophysics Reports 2024年第1期10卷 15-21页

作者： Qinggang Hao Rui Dong Weiyu Bai Dong Chang Xinyi Yao Yingru Zhang Huangying Xu Huiyan Li Xiang Kui Feng Wang Yan Wang Chengqin Wang Yujie Lei Yan Chen Junling Shen Lei Sang Yan Bai Jianwei Sun Center for Life Sciences Yunnan Key Laboratory of Cell Metabolism and Diseases State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan School of Life Sciences Yunnan University Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan province Yan'an Hospital Affiliated to Kunming Medical University shandong Provincial Key Laboratory of Animal Resistance Biology Collaborative Innovation Center of Cell Biology in Universities of Shandong Center for Cell Structure and Function Institute of Biomedical Science College of Life Sciences Shandong Normal University Department of Pathology The Second Affiliated Hospital of Kunming Medical University State Key Laboratory of Bioactive Molecules and Druggability Assessment Institute of Genomic Medicine College of Pharmacy Jinan University Department of Pathology School of Basic Medicine Qingdao University Department of Thoracic Surgery Yunnan Cancer Hospital & The Third Affiliated Hospital of Kunming Medical University & Yunnan Cancer Center

Tumor metastasis, responsible for approximately 90% of cancer-associated mortality, remains poorly understood. Here in this study, we employed a melanoma lung metastasis model to screen for metastasis-related genes. By sequential tail vein injection of mouse melanoma B16F10 cells and the subsequently derived cells from lung metastasis into BALB/c mice, we successfully obtained highly metastatic B16F15 cells after five rounds of in vivo screening. RNA-sequencing analysis of B16F15 and B16F10 cells revealed a number of differentially expressed genes, some of these genes have previously been associated with tumor metastasis while others are novel discoveries. The identification of these metastasis-related genes not only improves our understanding of the metastasis mechanisms, but also provides potential diagnostic biomarkers and therapeutic targets for metastatic melanoma.

关键词： Melanoma Lung metastasis model Gene screening Tail vein injection

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Cellular zinc metabolism and zinc signaling:from biological functions to diseases and therapeutic targets

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Signal Transduction and Targeted Therapy 2024年第2期9卷 401-441页

作者： Bonan Chen Peiyao Yu Wai Nok Chan Fuda Xie Yigan Zhang Li Liang Kam Tong Leung Kwok Wai Lo Jun Yu Gary M.K.Tse Wei Kang Ka Fai To Department of Anatomical and Cellular Pathology State Key Laboratory of Translational OncologyPrince of Wales HospitalThe Chinese University of Hong KongHong KongChina State Key Laboratory of Digestive Disease Institute of Digestive DiseaseThe Chinese University of Hong KongHong KongChina CUHK-Shenzhen research institute The Chinese University of Hong KongShenzhenChina Department of Pathology Nanfang Hospital and Basic Medical CollegeSouthern Medical UniversityGuangdong Province Key Laboratory of Molecular Tumor PathologyGuangzhouChina institute of Biomedical research Taihe HospitalHubei University of MedicineShiyanChina Department of Pediatrics The Chinese University of Hong KongHong KongChina Department of Medicine and Therapeutics The Chinese University of Hong KongHong KongChina

Zinc metabolism at the cellular level is critical for many biological processes in the body.A key observation is the disruption of cellular homeostasis,often coinciding with disease *** an essential factor in maintaining cellular equilibrium,cellular zinc has been increasingly spotlighted in the context of disease *** research suggests zinc’s involvement in promoting malignancy and invasion in cancer cells,despite its low tissue *** has led to a growing body of literature investigating zinc’s cellular metabolism,particularly the functions of zinc transporters and storage mechanisms during cancer *** transportation is under the control of two major transporter families:SLC30(ZnT)for the excretion of zinc and SLC39(ZIP)for the zinc ***,the storage of this essential element is predominantly mediated by metallothioneins(MTs).This review consolidates knowledge on the critical functions of cellular zinc signaling and underscores potential molecular pathways linking zinc metabolism to disease progression,with a special focus on *** also compile a summary of clinical trials involving zinc *** the main localization of zinc transporters at the cell membrane,the potential for targeted therapies,including small molecules and monoclonal antibodies,offers promising avenues for future exploration.

关键词： metabolism invasion involvement

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Data-driven real-time prediction for attitude and position of super-large diameter shield using a hybrid deep learning approach

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Underground Space 2024年第2期15卷 275-297页

作者： Yanbin Fu Lei Chen Hao Xiong Xiangsheng Chen Andian Lu Yi Zeng Beiling Wang Key Laboratory of Coastal Urban Resilient Infrastructures(MOE) Shenzhen UniversityShenzhen 518060GuangdongChina College of Civil and transportation Engineering Shenzhen UniversityShenzhen 518060GuangdongChina Shenzhen Key Laboratory of Green Efficient and Intelligent Construction of Underground Metro StationShenzhen UniversityShenzhen 518060GuangdongChina Guangdong Yuehai Pearl River Delta Water Supply Limited Company Guangzhou 511458China Shanghai Tunnel Engineering and Rail Transit Design and research institute Shanghai 200235China

The presented research introduces a novel hybrid deep learning approach for the dynamic prediction of the attitude and position of super-large diameter shields-a critical consideration for construction safety and tunnel lining *** study proposes a hybrid deep learning approach for predicting dynamic attitude and position prediction of super-large diameter *** approach consists of principal component analysis(PCA)and temporal convolutional network(TCN).The former is used for employing feature level fusion based on features of the shield data to reduce uncertainty,improve accuracy and the data effect,and 9 sets of required principal component characteristic data are *** latter is adopted to process sequence data in predicting the dynamic attitude and position for the advantages and potential of convolution *** approach’s effectiveness is exemplified using data from a tunnel construction project in *** obtained results show remarkable accuracy in predicting the global attitude and position,with an average error ratio of less than 2 mm on four shield outputs in 97.30%of ***,the approach displays strong performance in accurately predicting sudden fluctuations in shield attitude and position,with an average prediction accuracy of 89.68%.The proposed hybrid model demonstrates superiority over TCN,long short-term memory(LSTM),and recurrent neural network(RNN)in multiple *** additive exPlanations(SHAP)analysis is also performed to investigate the significance of different data features in the prediction *** study provides a real-time warning for the shield driver to adjust the attitude and position of super-large diameter shields.

关键词： Shield attitude and position Super-large diameter shield PCA-TCN Deep learning Real-time warning

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Novel intelligent reasoning system for tool wear prediction and parameter optimization in intelligent milling

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Advances in Manufacturing 2024年第1期12卷 76-93页

作者： Long-Hua Xu Chuan-Zhen Huang Zhen Wang Han-Lian Liu Shui-Quan Huang Jun Wang School of Mechanical Engineering Yanshan UniversityQinhuangdao066004HebeiPeople’s Republic of China Center for Advanced Jet Engineering Technologies(CaJET) Key Laboratory of High-efficiency and Clean Mechanical Manufacture(Ministry of Education)National Experimental Teaching Demonstration Center for Mechanical Engineering(Shandong University)School of Mechanical EngineeringShandong UniversityJinan250061People’s Republic of China institute of Manufacturing Technology Guangdong University of TechnologyGuangzhou510006People’s Republic of China

Accurate intelligent reasoning systems are vital for intelligent *** this study,a new intelligent reasoning system was developed for milling processes to accurately predict tool wear and dynamically optimize machining *** developed system consists of a self-learning algorithm with an improved particle swarm optimization(IPSO)learning algorithm,prediction model determined by an improved case-based reasoning(ICBR)method,and optimization model containing an improved adaptive neural fuzzy inference system(IANFIS)and *** results showed that the IPSO algorithm exhibited the best global convergence *** ICBR method was observed to have a better performance in predicting tool wear than standard CBR *** IANFIS model,in combination with IPSO,enabled the optimization of multiple objectives,thus generating optimal milling *** paper offers a practical approach to developing accurate intelligent reasoning systems for sustainable and intelligent manufacturing.

关键词： Improved particle swarm optimization(IPSO)algorithm Improved case-based reasoning(ICBR)method Adaptive neural fuzzy inference system(ANFIS)model Tool wear prediction Intelligent manufacturing

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Early Triassic Legoupil Formation in Schmidt Peninsula,Antarctic Peninsula:Provenance and Depositional Settings

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Journal of Earth Science 2024年第2期35卷 317-331页

作者： Chao Zhang Ying-Chun Cui Chen-Guang Liu Fang-Hua Cui Lu-Yuan Wang Wei-Qiang Zhang School of Resources and Environmental Engineering Shandong University of TechnologyZibo255049China MNR Key Laboratory for Polar Science Polar Research Institute of ChinaShanghai201209China Key Laboratory of Marine Sedimentology and Environmental Geology First Institute of OceanographyState Oceanic AdministrationQingdao266061China Laboratory for Marine Geology Qingdao National Laboratory for Marine Science and TechnologyQingdao266061China Key Laboratory of Mineral Resources Evaluation in Northeast Asia Ministry of Land and ResourcesChangchun130061China

Geochemical compositions can be used to determine the tectonic setting of sedimentary basins,while where the link of source to sink is no longer preserved,detrital zircon age patterns can aid in resolving the original basin *** metasedimentary Legoupil Formation,located at Cape Legoupil and the Schmidt Peninsula,could give a hint for the tectonic evolution of Antarctic *** this contribution,we constrain the sedimentary provenance of the Legoupil Formation through geochemistry and detrital zircon U-Pb *** petrography and geochemical features indicate that the provenance of the Legoupil Formation could be felsic *** zircon grains record a steady supply of Permian and Ordovician material into the Legoupil *** youngest concordant zircon ages of 262 Ma suggest that the depositional time of Legoupil Formation is no older than Late *** detrital zircon age spectrum of Legoupil Formation suggests that the Legoupil Formation sediments should be derived from regional sources endemic to western Gondwana prior to its *** with the previous studies,geochemistry and detrital zircons reflect an active continental margin tectonic setting and the detrital zircon spectra of Legoupil Formation are similar to the ones deposited in forearc tectonic setting.

关键词： Schmidt Peninsula Legoupil Formation Trinity Peninsula Group detrital zircons Antarctic Peninsula geochemistry

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Composite structure Al_(2)O_(3)/Al_(2)O_(3)-YAG:Ce/YAG ceramics with high color spatial uniformity for white laser lighting

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Journal of Advanced Ceramics 2024年第2期13卷 189-197页

作者： Pengfei Sang Le Zhang Jian Kang Mingzhou Li Shiwei Chen Peng Yang Bingheng Sun Yang Li Wieslaw Strek Hao Chen Jiangsu Key Laboratory of Advanced Laser Materials and Devices School of Physics and Electronics EngineeringJiangsu Normal UniversityXuzhou 221116China Jiangsu Xiyi Advanced Materials research institute of Industrial Technology Xuzhou 221400China Xuzhou EAGLED Technology Co. Ltd.Xuzhou 221116China Xuzhou Kangna Advanced Materials Technology Co. Ltd.Xuzhou 221116China Xuzhou Fuchang Electronic Technology Co. Ltd.Xuzhou 221116China Shanghai institute of Optics Fine Mechanics Chinese Academy of SciencesShanghai 201800China School of Material Science and Engineering Shanghai Institute of TechnologyShanghai 201418China State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100China institute of Low Temperature and Structure research Polish Academy of SciencesWroclaw 50-422Poland

Composite ceramic phosphor(CCP)is a candidate light-conversion material to obtain the high-quality laser lighting *** based on the transmissive configuration model could not simultaneously meet the requirements of angular color uniformity and high thermal *** this study,a novel composite structure ceramic was designed,including Al_(2)O_(3)-YAG:Ce/YAG layered ceramic with a size of 1 mm×1 mm for lighting,and Al_(2)O_(3) ceramic(φ=16.0 mm)was used as the wrapping material due to its outstanding thermal *** prepared ceramics exhibited excellent thermal performance and no yellow ring *** this design,we achieved the match of the intensity distribution of the blue and yellow lights,resulting in a high angular color uniformity of 0.9 with a view angle of±80°.All ceramics showed no luminous saturation phenomenon,even the laser power density was increased up to 47.51 W/mm^(2).A high-brightness white-light source with a luminous flux of 618 lm,a luminous efficiency of 126 lm/W,a CCT of 6615 K,and a CRI of 69.9 was obtained in the transmissive *** particular,the surface temperature of the ceramic was as low as 74.1℃ under a high laser radiation(47.51 W/mm^(2)).These results indicate that Al_(2)O_(3)/Al_(2)O_(3)-YAG:Ce/YAG composite structure ceramic is a promising luminescent material in the high-power laser lighting applications.

关键词： Al_(2)O_(3)/Al_(2)O_(3)-YAG:Ce/YAG angular color uniformity high thermal stability high-power laser lighting

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Catalytic asymmetric dearomative azo-Diels–Alder reaction of 2-vinlyindoles

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Chinese Chemical Letters 2024年第4期35卷 357-362页

作者： Yu-Hang Miao Zheng-Xu Zhang Xu-Yi Huang Yuan-Zhao Hua Shi-Kun Jia Xiao Xiao Min-Can Wang Li-Ping Xu Guang-Jian Mei Green Catalysis Center and College of ChemistryZhengzhou UniversityZhengzhou 450052China School of Chemistry and Chemical Engineering Shandong University of TechnologyZibo 255000China institute of Pharmaceutical Science and Technology Zhejiang University of TechnologyHangzhou 310014China

Due to the high electrophilic nature of azo-dienophiles, azo-Diels–Alder proceeds rapidly even without the need of a catalyst and is therefore regarded as the “click reaction”. This spontaneity causes strong background reaction and poses a daunting challenge to chemists for developing the catalytic asymmetric version. Reported herein is the first catalytic asymmetric dearomative azo-Diels–Alder reaction between2-vinylindoles and triazoledione. This protocol makes use of the high energy barrier of dearomatization to avert the strong background reaction of azo-Diels–Alder reaction, allowing the implementation of the projected reaction at ambient temperature. Density functional theory calculations have been performed to gain insights into the reaction mechanism and the origins of the enantioselectivity. By using this method,a variety of tetracyclic indole derivatives have been readily prepared in good to excellent yields and with excellent diastereo-and enantio–selectivities(33 examples, up to 97% yield and >99% ee, >20:1 dr).

关键词： Catalytic asymmetric dearomatization Azo-Diels–Alder reaction 2-Vinylindoles Chiral phosphoric acid Tetracyclic indole derivatives

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An advanced machine learning method for simultaneous breast cancer risk prediction and risk ranking in Chinese population:A prospective cohort and modeling study

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Chinese Medical Journal 2024年第17期137卷 2084-2091页

作者： Liyuan Liu Yong He Chunyu Kao Yeye Fan Fu Yang Fei Wang Lixiang Yu Fei Zhou Yujuan Xiang Shuya Huang Chao Zheng Han Cai Heling Bao Liwen Fang Linhong Wang Zengjing Chen Zhigang Yu Department of Breast Surgery The Second HospitalCheeloo College of MedicineShandong UniversityJinanShandong 250033China School of Mathematics Shandong UniversityJinanShandong 250100China Zhongtai Securities institute for Financial Studies Shandong UniversityJinanShandong 250100China institute of Translational Medicine of Breast Disease Prevention and Treatment Shandong UniversityJinanShandong 250033China Department of Maternal and Child Health School of Public HealthPeking UniversityHaidian DistrictBeijing 100191China National Center for Chronic and Non-communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 100050China

Background:Breast cancer(BC)risk-stratification tools for Asian women that are highly accurate and can provide improved interpretation ability are *** aimed to develop risk-stratification models to predict long-and short-term BC risk among Chinese women and to simultaneously rank potential non-experimental risk ***:The Breast Cancer Cohort Study in Chinese Women,a large ongoing prospective dynamic cohort study,includes 122,058 women aged 25-70 years old from the eastern part of *** developed multiple machine-learning risk prediction models using parametric models(penalized logistic regression,bootstrap,and ensemble learning),which were the short-term ensemble penalized logistic regression(EPLR)risk prediction model and the ensemble penalized long-term(EPLT)risk prediction model to estimate BC *** models were assessed based on calibration and discrimination,and following this assessment,they were externally validated in new study participants from 2017 to ***:The AUC values of the short-term EPLR risk prediction model were 0.800 for the internal validation and 0.751 for the external validation *** the long-term EPLT risk prediction model,the area under the receiver operating characteristic curve was 0.692 and 0.760 in internal and external validations,*** net reclassification improvement index of the EPLT relative to the Gail and the Han Chinese Breast Cancer Prediction Model(HCBCP)models for external validation was 0.193 and 0.233,respectively,indicating that the EPLT model has higher classification ***:We developed the EPLR and EPLT models to screen populations with a high risk of developing *** can serve as useful tools to aid in risk-stratified screening and BC prevention.

关键词： Breast cancer Cancer prevention Models Women Risk assessment

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Influence of cutterhead opening ratio on soil arching effect and face stability during tunnelling through non-uniform soils

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Underground Space 2024年第4期17卷 45-59页

作者： Xue-Jian Chen Pei-Pei Fang Qiu-Nan Chen Jun Hu Kai Yao Yong Liu State Key Laboratory of Water Resources Engineering and Management Wuhan UniversityWuhan 430072China Hubei Technology Innovation Center for Smart Hydropower Wuhan 430000China College of Civil Engineering Anhui Jianzhu UniversityHefei 230601China School of Civil Engineering Hunan University of Science and TechnologyXiangtan 411201China School of Civil and Architectural Engineering Hainan UniversityHaikou 570228China School of Qilu transportation Shandong UniversityJinan 250002China

Tunnelling has increasingly become an essential tool in the exploration of underground space.A typical construction problem is the face instability during tunnelling,posing a great threat to associated *** face instability often occurs with the soil arching *** study investigates the combined effect of cutterhead opening ratio and soil non-uniformity on soil arching effect and face stability,via conducting random finite-element analysis coupled with Monte–Carlo *** results underscore that the face stability is strongly associated with the evolution of stress *** obtained stability factors in the uniform soils can serve as a reference for the design of support pressure in practical tunnelling *** addition,non-uniform soils exhibit a lower stability factor than uniform soils,which implies that the latter likely yields an underestimated probability of face *** tunnel face is found to have a probability of failure more than 50%if the spatial non-uniformity of soil is *** the end,a practical framework is established to determine factor of safety(FOS)corresponding to different levels of probability of face failure considering various opening ratios in non-uniform *** required FOS is 1.70 to limit the probability of face instability no more than 0.1%.Our findings can facilitate the prediction of probability of instability in the conventionally deterministic design of face pressure.

关键词： Tunnel Face stability Soil arching effect Cutterhead opening ratio Non-uniform soil Random field

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Abrogation of nuclear entry of TERT by fructose 1,6-bisphosphatase 1-mediated dephosphorylation

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Cancer Communications 2024年第10期44卷 1102-1105页

作者： Pengbo Yao Gaoxiang Zhao Min Li Wensheng Qiu Zhimin Lu Department of Oncology The Affiliated Hospital of Qingdao UniversityQingdao UniversityQingdao Cancer InstituteQingdaoShandongP.R.China Zhejiang Provincial Key Laboratory of Pancreatic Disease The First Affiliated Hospitaland Institute of Translational MedicineZhejiang University School of MedicineHangzhouZhejiangP.R.China Cancer Center Zhejiang UniversityHangzhouZhejiangP.R.China institute of Fundamental and Transdisciplinary research Zhejiang UniversityHangzhouZhejiangP.R.China

Telomeres maintain chromosome *** of telomere function,which is attributed to progressively shortened telomeres in each round of DNA replication,induces endto-end fusion of chromosomes,anaphase bridges with subsequent chromosome breakage,and eventually leads to senescence and apoptosis in normal cells[1].In cancer cells,highly activated telomerase synthesizes telomere repeats to promote telomere elongation.

关键词： eventually bridges maintain

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