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Design and aligner-assisted fast fabrication of a microfluidic platform for quasi-3D cell studies on an elastic polymer

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Bioactive Materials 2022年第9期7卷 288-304页

作者： Yingning He Yue Yu Yuqian Yang Yexin Gu Tianjiao Mao Yang Shen Qiong Liu Ruili Liu Jiandong Ding State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai200438China Translational Research Institute of Brain and Brain-like Intelligence Shanghai Fourth People’s HospitalSchool of MedicineTongji UniversityShanghai200434China

While most studies of mechanical stimulation of cells are focused on two-dimensional(2D)and three-dimensional(3D)systems,it is rare to study the effects of cyclic stretching on cells under a quasi-3D microenvironment as a linkage between 2D and 3D.Herein,we report a new method to prepare an elastic membrane with topographic microstructures and integrate the membrane into a microfluidic chip.The fabrication difficulty lay not only in the preparation of microstructures but also in the alignment and bonding of the patterned membrane to other layers.To resolve the problem,we designed and assembled a fast aligner that is cost-effective and convenient to operate.To enable quasi-3D microenvironment of cells,we fabricated polydimethylsiloxane(PDMS)microwell arrays(formed by micropillars of a few microns in diameter)with the microwell diameters close to the cell sizes.An appropriate plasma treatment was found to afford a coating-free approach to enable cell adhesion on PDMS.We examined three types of cells in 2D,quasi-3D,and 3D microenvironments;the cell adhesion results showed that quasi-3D cells behaved between 2D and 3D cells.We also constructed transgenic human mesenchymal stem cells(hMSCs);under cyclic stretching,the visualizable live hMSCs in microwells were found to orientate differently from in a 3D Matrigel matrix and migrate differently from on a 2D flat plate.This study not only provides valuable tools for microfabrication of a microfluidic device for cell studies,but also inspires further studies of the topological effects of biomaterials on cells.

关键词： Microfluidic chip Biomaterials Cell-material interaction Polymer Cell stretching

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基于CsPbBr_(3)量子点/有机半导体/SnO_(2)异质结的自供电型探测器用于弱光检测

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Science China Materials 2023年第2期66卷 716-723页

作者：杨奔郭璞郝丹丹王言李立代世磊黄佳 Interdisciplinary Materials research Center School of Materials Science and EngineeringFrontiers Science Center for Intelligent Autonomous SystemsTongji UniversityShanghai 201804China Translational Research Institute of Brain and Brain-like Intelligence Shanghai Fourth People’s Hospital Affiliated to Tongji UniversityTongji UniversityShanghai 200434China

全无机卤化铅钙钛矿量子点由于其优异的光电性能在光电探测器的发展中展示出巨大的潜力.然而,基于纯钙钛矿量子点的光电探测器光响应性能通常受到钙钛矿量子点薄膜电荷传输效率差的限制.本工作报道了基于钙钛矿量子点和有机半导体PQT-12... 详细信息

全无机卤化铅钙钛矿量子点由于其优异的光电性能在光电探测器的发展中展示出巨大的潜力.然而,基于纯钙钛矿量子点的光电探测器光响应性能通常受到钙钛矿量子点薄膜电荷传输效率差的限制.本工作报道了基于钙钛矿量子点和有机半导体PQT-12(聚3,3′′′-二十二烷基四噻吩)的高性能自供电光电探测器.即使在自供电模式下,该器件仍然可以对光信号展示出稳定的光响应性质,并实现了优异的光探测性能,包括5.8×10^(12)Jones的探测率和高达105的光暗电流比.更重要的是,器件对于强度低至3 nW cm^(-2)的弱光具有明显的光响应.据我们所知,该器件的自供电弱光探测能力优于大多数报道的基于钙钛矿量子点的光电探测器.此外,器件还可以制备成柔性探测器,在不同的弯曲角度下器件的光电流几乎保持不变.相比于已报道的自供电光电探测器,我们的器件综合性能十分优异.本工作可以为基于钙钛矿量子点开发高性能弱光探测自供电光电探测器提供借鉴.

关键词：光电探测器有机半导体弱光探测探测率暗电流异质结器件自供电

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用于人工突触的染料敏化钙钛矿/有机半导体三元晶体管

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Science China Materials 2022年第9期65卷 2521-2528页

作者：王鑫郝丹丹黄佳 School of Materials Science and Engineering Interdisciplinary Materials Research CenterFrontiers Science Center for Intelligent Autonomous SystemsTongji UniversityShanghai 201804China Translational Research Institute of Brain and Brain-like Intelligence Shanghai Fourth People’s Hospital Affiliated to Tongji UniversitySchool of Materials Science and EngineeringTongji UniversityShanghai 200434China

人工智能因其类脑工作模式和高效任务处理能力而受到广泛关注.光刺激突触器件在神经形态计算领域应用潜力巨大.本文报道了具有三元光敏材料体系的光刺激突触器件,该体系由有机金属卤化物钙钛矿CHNHPbBr、有机染料罗丹明B和有机半导体并... 详细信息

人工智能因其类脑工作模式和高效任务处理能力而受到广泛关注.光刺激突触器件在神经形态计算领域应用潜力巨大.本文报道了具有三元光敏材料体系的光刺激突触器件,该体系由有机金属卤化物钙钛矿CHNHPbBr、有机染料罗丹明B和有机半导体并五苯组成.我们发现,通过引入罗丹明B,复合器件的光吸收和光响应性能得到显著提升.通过调整输入信号,复合器件表现出了良好的仿真学习行为.并且,这些器件可对强度低至1.1μW cm^(-2)的光信号响应,并能在低电压下进行工作.器件在-50μV的源漏电压下实现了1.25 fJ的超低功耗,这一能量损耗与单次生物突触活动的能耗相当.此外,复合突触器件还实现了自我学习过程,表现出了良好的学习效率.同时,它们可识别不同摩斯电码之间的细微差别,未来可应用于加密信息解码领域.本文所提出的三元突触器件拥有优异的光性能,在开发人工智能方面具有广泛的应用前景.

关键词： perovskites Rhodamine B organic semiconductors synapses artificial intelligence

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Air-stable synaptic devices based on bismuth triiodide and carbon nanotubes

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Nano research 2022年第6期15卷 5435-5442页

作者： Dandan Hao Junyao Zhang Li Li Ben Yang Pu Guo Shiqi Zhang Jia Huang Interdisciplinary Materials research Center School of Materials Science and EngineeringFrontiers Science Center for Intelligent Autonomous SystemsTongji UniversityShanghai 201804China Translational Research Institute of Brain and Brain-like Intelligence Shanghai Fourth People’s Hospital Affiliated to Tongji UniversitySchool of Materials Science and EngineeringTongji UniversityShanghai 200434China

Artificial synaptic devices with the functions of emulating important biological synaptic behaviors are playing an increasingly important role in the development of neuromorphic computing systems.Single-walled carbon nanotubes(SWCNTs)with excellent electrical properties and high stability have been studied as active materials for synaptic devices.However,the performance of optical synaptic devices(OSDs)based on pure SWCNTs is limited by the weak light absorption property.Herein,bismuth triiodide(BiI_(3)),an environmentally stable and friendly optoelectronic material,is firstly combined with SWCNTs to fabricate OSDs with decent properties of perceiving and memorizing optical information.The OSDs can exhibit typical synaptic behaviors including excitatory postsynaptic current,paired-pulse facilitation,and short/long-term memory.Distinctively,the photoresponse of the OSD is independent of pulse light wavelength in the range of 365 to 650 nm,different from most of the previously reported OSDs,which usually have wavelength-dependent photo-response.Temperature-dependent photo-response behaviors of the devices are investigated.Importantly,the OSD without encapsulation holds good excitatory post-synaptic current(EPSC)behavior after being stored in the ambient environment for 170 days,indicating reliable environmental stability.Furthermore,an OSD array with nine synaptic devices is employed to mimic the human visual perception and memory functions.These results suggest the feasibility of BiI3/SWCNTs-based OSDs for the simulation of human visual memory.

关键词： semiconducting single-walled carbon nanotubes bismuth triiodide optical synaptic devices stability human visual memory

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Itch perception is reflected by neuronal ignition in the primary somatosensory cortex

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National Science Review 2022年第6期9卷 90-99页

作者： Xiao-Jun Chen Yan-He Liu Ning-Long Xu Yan-Gang Sun institute of Neuroscience State Key Laboratory of Neuroscience Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of Sciences University of Chinese Academy of Sciences Shanghai Center for brain Science and brain-Inspired intelligence Technology

Multiple cortical areas including the primary somatosensory cortex(S1) are activated during itch signal processing, yet cortical representation of itch perception remains unknown. Using novel miniature two-photon microscopic imaging in free-moving mice, we investigated the coding of itch perception in S1.We found that pharmacological inactivation of S1 abolished itch-induced scratching behavior, and the itch-induced scratching behavior could be well predicted by the activity of a fraction of layer 2/3 pyramidal neurons, suggesting that a subpopulation of S1 pyramidal neurons encoded itch perception, as indicated by immediate subsequent scratching behaviors. With a newly established optogenetics-based paradigm that allows precisely controlled pruritic stimulation, we found that a small fraction of S1 neurons exhibited an ignition-like pattern at the detection threshold of itch perception. Our study revealed the neural mechanism underlying itch perceptual coding in S1, thus paving the way for the study of cortical representation of itch perception at the single-neuron level in freely moving animals.

关键词： itch perception primary somatosensory cortex miniature two-photon microscopic imaging

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基于CsPbBr量子点/有机半导体/SnO异质结的自供电型探测器用于弱光检测(英文)

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Science China Materials 2022年

作者：杨奔郭璞郝丹丹王言李立代世磊黄佳 Translational Research Institute of Brain and Brain-like Intelligence Shanghai Fourth People's Hospital Affiliated to Tongji University Tongji University Interdisciplinary Materials research Center School of Materials Science and Engineering Frontiers Science Center for Intelligent Autonomous SystemsTongji University

全无机卤化铅钙钛矿量子点由于其优异的光电性能在光电探测器的发展中展示出巨大的潜力.然而,基于纯钙钛矿量子点的光电探测器光响应性能通常受到钙钛矿量子点薄膜电荷传输效率差的限制.本工作报道了基于钙钛矿量子点和有机半导体PQT-12...

全无机卤化铅钙钛矿量子点由于其优异的光电性能在光电探测器的发展中展示出巨大的潜力.然而,基于纯钙钛矿量子点的光电探测器光响应性能通常受到钙钛矿量子点薄膜电荷传输效率差的限制.本工作报道了基于钙钛矿量子点和有机半导体PQT-12(聚3,3′′′-二十二烷基四噻吩)的高性能自供电光电探测器.即使在自供电模式下,该器件仍然可以对光信号展示出稳定的光响应性质,并实现了优异的光探测性能,包括5.8×10Jones的探测率和高达10~5的光暗电流比.更重要的是,器件对于强度低至3 nW cm的弱光具有明显的光响应.据我们所知,该器件的自供电弱光探测能力优于大多数报道的基于钙钛矿量子点的光电探测器.此外,器件还可以制备成柔性探测器,在不同的弯曲角度下器件的光电流几乎保持不变.相比于已报道的自供电光电探测器,我们的器件综合性能十分优异.本工作可以为基于钙钛矿量子点开发高性能弱光探测自供电光电探测器提供借鉴.

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COVID-19 and Alzheimer’s disease:how one crisis worsens the other

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translational Neurodegeneration 2021年第2期10卷 178-194页

作者： Xiaohuan Xia Yi Wang Jialin Zheng Center for translational Neurodegeneration and Regenerative Therapy Tenth People’s Hospital of Tongji UniversityShanghai 200072China Translational Research Institute of Brain and Brain-like Intelligence Shanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China Collaborative Innovation Center for brain Science Tongji UniversityShanghai 200092China Department of Pharmacology and Experimental Neuroscience University of Nebraska Medical CenterOmahaNE 68198-5930USA

Alzheimer’s disease(AD)has emerged as a key comorbidity of coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus-2(SARS-CoV-2).The morbidity and mortality of COVID-19 are elevated in AD due to multiple pathological changes in AD patients such as the excessive expression of viral receptor angiotensin converting enzyme 2 and pro-inflammatory molecules,various AD complications including diabetes,lifestyle alterations in AD,and drug-drug interactions.Meanwhile,COVID-19 has also been reported to cause various neurologic symptoms including cognitive impairment that may ultimately result in AD,probably through the invasion of SARS-CoV-2 into the central nervous system,COVID-19-induced inflammation,long-term hospitalization and delirium,and post-COVID-19 syndrome.In addition,the COVID-19 crisis also worsens behavioral symptoms in uninfected AD patients and poses new challenges for AD prevention.In this review,we first introduce the symptoms and pathogenesis of COVID-19 and AD.Next,we provide a comprehensive discussion on the aggravating effects of AD on COVID-19 and the underlying mechanisms from molecular to social levels.We also highlight the influence of COVID-19 on cognitive function,and propose possible routes of viral invasion into the brain and potential mechanisms underlying the COVID-19-induced cognitive impairment.Last,we summarize the negative impacts of COVID-19 pandemic on uninfected AD patients and dementia prevention.

关键词： COVID-19 SARS-CoV-2 Alzheimer’s disease Central nervous system Inflammation Cognitive impairment Angiotensin converting enzyme 2

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Retina-Inspired Organic Heterojunction-Based Optoelectronic Synapses for Artificial Visual Systems

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research 2021年第1期2021卷 442-451页

作者： Junyao Zhang Yang Lu Shilei Dai Ruizhi Wang Dandan Hao Shiqi Zhang Lize Xiong Jia Huang Interdisciplinary Materials research Center School of Materials Science and EngineeringShanghai Institute of Intelligent Science and TechnologyTongji UniversityShanghai 201804China Translational Research Institute of Brain and Brain-like Intelligence Shanghai Fourth People's Hospital Affiliated to Tongji UniversityTongji UniversityShanghai 200434China

For the realization of retina-inspired neuromorphic visual systems which simulate basic functions of human visual systems,optoelectronic synapses capable of combining perceiving,processing,and memorizing in a single device have attracted immense interests.Here,optoelectronic synaptic transistors based on tris(2-phenylpyridine)iridium(Ir(ppy)_(3))and poly(3,3-didodecylquarterthiophene)(PQT-12)heterojunction structure are presented.The organic heterojunction serves as a basis for distinctive synaptic characteristics under different wavelengths of light.Furthermore,synaptic transistor arrays are fabricated to demonstrate their optical perception efficiency and color recognition capability under multiple illuminating conditions.The wavelength-tunability of synaptic behaviors further enables the mimicry of mood-modulated visual learning and memorizing processes of humans.More significantly,the computational dynamics of neurons of synaptic outputs including associated learning and optical logic functions can be successfully demonstrated on the presented devices.This work may locate the stage for future studies on optoelectronic synaptic devices toward the implementation of artificial visual systems.

关键词： Visual artificial optoelectronic

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The brain Connectome for Chinese Reading

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Neuroscience Bulletin 2022年第9期38卷 1097-1113页

作者： Wanwan Guo Shujie Geng Miao Cao Jianfeng Feng institute of Science and Technology for brain-Inspired intelligence Fudan UniversityShanghai200433China Key Laboratory of Computational Neuroscience and brain-Inspired intelligence(Ministry of Education) Fudan UniversityShanghai200433China

Chinese,as a logographic language,fundamentally differs from alphabetic languages like English.Previous neuroimaging studies have mainly focused on alphabetic languages,while the exploration of Chinese reading is still an emerging and fast-growing research field.Recently,a growing number of neuroimaging studies have explored the neural circuit of Chinese reading.Here,we summarize previous research on Chinese reading from a connectomic perspective.Converging evidence indicates that the left middle frontal gyrus is a specialized hub region that connects the ventral with dorsal pathways for Chinese reading.Notably,the orthography-to-phonology and orthography-to-semantics mapping,mainly processed in the ventral pathway,are more specific during Chinese reading.Besides,in addition to the left-lateralized language-related regions,reading pathways in the right hemisphere also play an important role in Chinese reading.Throughout,we comprehensively review prior findings and emphasize several challenging issues to be explored in future work.

关键词： brain connectome Chinese reading Word recognition Reading comprehension Structural connectivity Functional connectivity

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Targeted regulation of neuroinflammation via nanobiosignaler for repairing the central nerve system injuries

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Nano research 2023年第2期16卷 2938-2948页

作者： Xiaoru Sun Huitong Ruan Qidong Liu Silu Cao Qi Jing Yaru Xu Lize Xiong Wenguo Cui Cheng Li Department of Anesthesiology and Perioperative Medicine Shanghai Fourth People’s HospitalSchool of MedicineTongji UniversityShanghai 200434China Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesShanghai Institute of Traumatology and OrthopaedicsRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Translational Research Institute of Brain and Brain-like Intelligence Shanghai Fourth People’s HospitalSchool of MedicineTongji UniversityShanghai 200434China Shanghai Key Laboratory of Anesthesiology and brain Functional Modulation Shanghai 200434China

Neuroinflammation,commonly associated with various central nervous system(CNS)diseases such as postoperative cognitive dysfunction(POCD),is primarily mediated by the disruption of biological signals in microglia.However,the effective treatment of CNS diseases remains an ongoing challenge as biological signals show limited microglia-targeting effect.In this study,taking advantage of the highly expressed lipoprotein receptor-related protein-1(LRP1)on the microglia,a nanobiosignal delivery system modified by LRP1 high-affinity peptide ligand RAP12(RAP:receptor-associated protein)was constructed to specifically regulate neuroinflammation via targeting microglia.The uptake of the RAP12 modified-nanobiosignaler by microglia increased significantly,indicating its microglia-targeting ability.Both in vitro/vivo studies proved that the“nanobiosignaler”significantly reduced the secretion of pro-inflammatory cytokines,induced specific M2(anti-inflammatory type)microglia differentiation,and remarkably alleviated cognitive function impairment in the mice model when compared with unmodified groups.It was indicated that the“nanobiosignaler”could target microglia to deliver the biological signal and inhibit the excessive activation of microglia.Overall,the cell-targeted biological signal transmission system inspired by“nanobiosignaler”has broad application prospects in the future.

关键词： biosignal nanoparticles microglia neuroinflammation targeted delivery

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