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Serum cystatin C,monocyte/high-density lipoprotein-C ratio,and uric acid for the diagnosis of coronary heart disease and heart failure

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World Journal of Clinical Cases 2024年第18期12卷 3461-3467页

作者： Ming Li Da-Hao Yuan Zhi Yang Teng-Xiang Luw Xiao-Biao Zou Clinical Laboratory Linquan County People's HospitalLinquan 236400Anhui ProvinceChina Hemodialysis Center Linquan County People's HospitalLinquan 236400Anhui ProvinceChina cardiovascular Medicine Linquan Country People’s HospitalLinquan 236400Anhui ProvinceChina

BACKGROUND Coronary heart disease(CHD)and heart failure(HF)are the major causes of morbidity and mortality *** and accurate diagnoses of CHD and HF are essential for optimal management and ***,conventional diagnostic methods such as electrocardiography,echocardiography,and cardiac biomarkers have certain limitations,such as low sensitivity,specificity,availability,and ***,there is a need for simple,noninvasive,and reliable biomarkers to diagnose CHD and *** To investigate serum cystatin C(Cys-C),monocyte/high-density lipoprotein cholesterol ratio(MHR),and uric acid(UA)diagnostic values for CHD and *** We enrolled 80 patients with suspected CHD or HF who were admitted to our hospital between July 2022 and July *** patients were divided into CHD(n=20),HF(n=20),CHD+HF(n=20),and control groups(n=20).The serum levels of Cys-C,MHR,and UA were measured using immunonephelometry and an enzymatic method,respectively,and the diagnostic values for CHD and HF were evaluated using receiver operating characteristic(ROC)curve *** Serum levels of Cys-C,MHR,and UA were significantly higher in the CHD,HF,and CHD+HF groups than those in the control *** serum levels of Cys-C,MHR,and UA were significantly higher in the CHD+HF group than those in the CHD or HF *** ROC curve analysis showed that serum Cys-C,MHR,and UA had good diagnostic performance for CHD and HF,with areas under the curve ranging from 0.78 to *** optimal cutoff values of serum Cys-C,MHR,and UA for diagnosing CHD,HF,and CHD+HF were 1.2 mg/L,0.9×10^(9),and 389μmol/L;1.4 mg/L,1.0×10^(9),and 449μmol/L;and 1.6 mg/L,1.1×10^(9),and 508μmol/L,*** Serum Cys-C,MHR,and UA are useful biomarkers for diagnosing CHD and HF,and CHD+*** can provide information for decision-making and risk stratification in patients with CHD and HF.

关键词： Serum cystatin C Monocyte/high-density lipoprotein-C ratio Uric acid Coronary heart disease Heart failure Risk stratification

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Stress Echocardiography for Chronic Coronary Syndrome:Clinical Practice Guidelines(2023)

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Journal of Geriatric Cardiology 2024年第5期21卷 475-505页

作者： Peng-Fei ZHANG Jia-Wei TIAN Tian-Gang ZHU Jue-Fei WU Xiao-Ping LENG Yi WANG Meng-Meng LI Xin-Hao LI Qian-Qian WANG Xiao-Peng FENG Jia-Yan LV Li-Xue YIN Yun ZHANG Mei ZHANG Chinese Society of Echocardiography,Superficial Tissue and Vascular group of Chinese Society of Ultrasound in Medicine,Ultrasound Professional Committee of Chinese Medicine Education Association State Key Laboratory for Innovation and Transformation of Luobing Theory Key Laboratory of Cardiovascular Remodeling and Function ResearchChinese Ministry of EducationChinese National Health Commission and Chinese Academy of Medical SciencesDepartment of CardiologyQilu Hospital of Shandong UniversityJinanChina The Second Affiliated Hospital of Harbin Medical University HaerbinChina Peking University People's Hospital BeijingChina Sichuan Province People's Hospital ChengduChina Nanfang Hospital Southern Medical UniversityGuangzhouChina Peking Union Medical College Hospital Chinese Academy of Medical SciencesBeijingChina 不详

In the context of the People's Republic of China,coronary artery disease(CAD)presents a sig-nificant clinical challenge,with over 11.3 mil-lion patients ***,the diagnos-is of CAD has predominantly relied on invasive coronary angiography.[1]However,recent advances in clinical research have revealed a notable trend:a substantial 82% of patients subjected to such invas-ive diagnostics do not necessitate interventional therapy.

关键词： coronary clinical patients

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Association of creatine kinase with Alzheimer’s disease pathology:A cross-sectional study

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Chinese Medical Journal 2024年第1期137卷 117-119页

作者： Yutong Wang Peiyang Gao Hongman Liu Tingyu Wang Jiaming Fan Tingbo Jiang Alzheimer’s Disease Neuroimaging Initiative(ADNI) Beijing Hospital National Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100005China Department of Cardiology The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215000China Institute for cardiovascular Science of Soochow University SuzhouJiangsu 215000China Department of Neurology Qingdao Municipal HospitalQingdao UniversityQingdaoShandong 266071China Cardiac Function Department the Affiliated Taian City Central Hospital of Qingdao UniversityTaianShandong 271000China Department of Cardiac Surgery The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215000China 不详

To the Editor:Creatine kinase(CK),also called creatine phosphokinase,is primarily located in the cytoplasm and *** can be used to diagnose cardiac diseases such as myocardial infarction,viral myocarditis,and pericarditis because it is a vital kinase directly related to intracellular energy operation,muscle contraction,and adenosine triphosphate(ATP)*** studies have confirmed in recent years that serum biomarkers such as elevated CK are associated with Alzheimer’s disease(AD)and its related pathological protein.[1]Previous research indicated that systemic conditions,particularly cardiovascular and cerebrovascular diseases,are significant risk factors for cognitive impairment,and dysfunction of peripheral organs may also contribute to cognitive decline and AD.[2]However,the connection between CK and AD remains ***,to investigate the association between CK and cerebrospinal fluid(CSF)AD pathology biomarkers,we analyzed data from the Alzheimer’s Disease Neuroimaging Initiative(ADNI),a global multi-centered database.

关键词： Alzheimer pathology organs

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Analysis of acupoint massage combined with touch on relieving anxiety and pain in patients with oral implant surgery

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World Journal of Psychiatry 2024年第4期14卷 533-540页

作者： Jin-Hong Qu Cheng-Cheng Shou Xin He Qin Wang Yue-Xia Fang Department of Stomatology Hangzhou Lin'an Traditional Chinese Medicine HospitalHangzhou 311300Zhejiang ProvinceChina Department of Software R&D Hangzhou Broadlink Technology CoLtd.Hangzhou 311300Zhejiang ProvinceChina Department of Stomatology Hangzhou Red Cross HospitalHangzhou 310003Zhejiang ProvinceChina Department of cardiovascular Hangzhou Lin'an Traditional Chinese Medicine HospitalHangzhou 311300Zhejiang ProvinceChina Department of Traditional Chinese Medicine Development Hangzhou Lin'an Traditional Chinese Medicine HospitalHangzhou 311300Zhejiang ProvinceChina

BACKGROUND Oral implant surgery is an effective procedure for artificial implants in missing tooth areas under local *** patients under local anesthesia are conscious during this procedure,compared with general anesthesia-related operations,they are more likely to experience negative emotions,such as anxiety and *** emotional reactions result in shivering and chills in the limbs,leading to poor doctor-patient cooperation and even avoidance of *** traditional Chinese medicine,it is believed that acupoint massage regulates blood and Qi,dredge menstruation,and relieve pain,which is beneficial for patients’emotional adjustment;however,there are few related clinical *** To observe the changes in anxiety and pain in patients with oral implant after acupoint massage combined with touch *** One hundred patients undergoing oral implantation in our hospital between May 2020 and May 2023 were randomly divided into control and study groups,according to a random number table,with 50 patients in each *** control group received routine intervention,and the study group received acupoint massage combined with touch on the basis of the control ***[assessed using the Modified Dental Anxiety Scale(MDAS)],pain severity,blood pressure,heart rate,and satisfaction were compared between the two *** Before intervention,the difference in MDAS score between the two groups was not significant(P>0.05),while after the intervention,the MDAS scores decreased in both groups compared with those before the intervention(Pstudy group was lower than that of the control group,with a statistically significant difference(Pgroup was significantly lower than that in the control group(Pgroups(P>0.05).The systolic and d

关键词： Oral implant Acupoint massage Touch Anxiety Degree of pain

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Comparison of the early curative effect in patients undergoing mechanical vs. bioprosthetic aortic valve replacement with concomitant annuloplasty by the Nicks procedure

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South China Journal of Cardiology 2024年第1期25卷 29-37页

作者：吴浩向鸿谟王露朱平 Guangdong cardiovascular Institute Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong 510100China Guangdong Provincial Key Laboratory of Pathogenesis Targeted Prevention and Treatment of Heart DiseaseGuangzhou Key Laboratory of Cardiac Pathogenesis and PreventionGuangzhouGuangdong 510100China

Background The probability of prosthesis-patient mismatch(PPM)is high in aortic valve replacement surgery for small aortic valve annulus,which increases the postoperative prosthetic valve transvalvular pressure *** aortic annuloplasty is a commonly applied surgical procedure,but there is currently no uniform standard or guideline on the type of prosthetic valve that should be used during ***,this study aimed to analyze whether there was any difference in the short-term prognosis between the choice of mechanical valves and bioprosthetic valves during aortic valve replacement surgery with concomitant aortic annuloplasty by the Nicks *** A retrospective analysis was conducted based on the clinical data from 55 patients undergoing aortic valve replacement surgery with concomitant annuloplasty by the Nicks procedure at the Cardiac Surgery Department of Guangdong Provincial People’s Hospital from November 2021 to December *** this study,all patients received aortic annuloplasty by the Nicks *** these patients,30 were in the mechanical valve group,while the other 25 were in the bioprosthetic valve *** including left ventricular end-diastolic/endsystolic diameters,left ventricular ejection fraction,interventricular septal thickness,left ventricular posterior wall thickness,transvalvular pressure gradient,left ventricular fractional shortening,and left ventricular mass index were collected 1 week preoperatively and 1 week and 3 months *** on gender,age,body surface area,types of perioperative complications,operation time,complication rates,and outcomes was also *** Among the 55 patients enrolled in this study,4 *** main causes of death included postoperative low cardiac output syndrome,severe pulmonary infection,and multi-organ ***,there was a statistically significant difference in left ventricular end-diastolic diameter between the mechanical valv

关键词： Valve replacement Small aortic annulus Nicks procedure Prosthesis-patient mismatch Mechani-cal valve Bioprosthetic valve

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Prognostic Role of Preoperative Tricuspid Annular Plane Systolic Excursion (TAPSE) in Mitral Valve Replacement (MVR) for Rheumatic Mitral Stenosis Patients

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World Journal of cardiovascular Surgery 2024年第8期14卷 115-130页

作者： Satyajit Sharma Muhit Abdullah Md. Noor-E-Elahi Mozumder Munjerin Refat Synthee Md. Zafar-Al-Nimari Anowarul Azim Saikat Das Gupta Dewan Iftakher Raza Chowdhury Siddhartha Shankar Howlader Noel Crypian Gomes Saleh Ahmed Samir Kumar Biswas Department of Cardiac Surgery National Heart Foundation Hospital & Research Institute (NHFH & RI) Dhaka Bangladesh Department of Cardiac Surgery National Institute of Cardiovascular Diseases & Hospital Dhaka Bangladesh Department of Cardiothoracic and Vascular Surgery Square Hospital Dhaka Bangladesh Department of Cardiothoracic and Vascular Surgery Evercare Hospital Chattogram Bangladesh

Tricuspid annular plane systolic excursion has been proposed as a simple and reproducible parameter for quantitative assessment of the right ventricular ejection fraction. The prognostic importance of preoperative TAPSE in patients with mitral valve replacement for rheumatic mitral stenosis patients is still under focused. Therefore, the objective of the study was to predict the outcome after MVR in rheumatic mitral stenosis patients in relation to preoperative TAPSE. This comparative cross-sectional study was conducted at the Department of Cardiac Surgery, National Heart Foundation Hospital and Research Institute. A total of 72 patients of rheumatic mitral stenosis patients who underwent mitral valve replacement were included in the study. They were divided into two groups: group A and B. group A included 36 patients with TAPSE 0.05) except for the preoperative TAPSE. Mean TAPSE of group A was 13.17 (±1.40) and group B was 18.61 (±1.57), the difference was statistically significant (p 0.05). Among the postoperative complications, including postoperative atrial fibrillation was higher in group A (30.56%) than group B (11.11%), mean ventilation time was higher in group A (27.78%) than group B (5.56%), length of intensive care was higher in group A (33.33%) than group B (11.12%), and hospital stay was higher in group A (25.0%) than group B (5.56%), (p < 0.05). Higher preoperative TASPE could be used as a prognostic tool for MVR in rheumatic mitral stenosis patients in our settings.

关键词： Tricuspid Annular Plane Systolic Excursion Mitral Valve Replacement Rheumatic Heart Disease Mitral Stenosis Right Ventricular Ejection Fraction Postoperative Complications

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Impact of baseline blood pressure on all-cause mortality in patients with atrial fibrillation:results from a multicenter registry study

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Chinese Medical Journal 2023年第6期136卷 683-689页

作者： Wei Xu Qirui Song Han Zhang Juan Wang Xinghui Shao Shuang Wu Jun Zhu Jun Cai Yanmin Yang Emergency Center Fuwai HospitalState Key Laboratory of Cardiovascular Disease of ChinaNational Center for Cardiovascular DiseasesNational Clinical Research Center of Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Hypertension Center Fuwai HospitalState Key Laboratory of Cardiovascular Disease of ChinaNational Center for Cardiovascular Diseases of ChinaNational Clinical Research Center of Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China

Background:The ideal blood pressure(BP)target for patients with atrial fibrillation(AF)is still *** present study aimed to assess the effect of the baseline BP on all-cause mortality in patients with ***:This registry study included 20 emergency centers across China and consecutively enrolled patients with AF from 2008 to *** participants were followed for 1 year±1 *** primary endpoint was all-cause ***:During the follow-up,276(13.9%)all-cause deaths ***-Meier curves showed that a systolic blood pressure(SBP)110 mmHg or>160 mmHg was associated with a higher risk of all-cause mortality(log-rank test,P=0.014),and a diastolic blood pressure(DBP)group with SBP110 mmHg(hazard ratio[HR],1.963;95%confidence interval[CI],1.306-2.951),and DBP<70 mmHg(HR,1.628;95%CI,1.163-2.281).In the restricted cubic splines,relations between baseline SBP or DBP and all-cause mortality showed J-shaped associations(non-linear P<0.001 and P=0.010,respectively).The risk of all-cause mortality notably increased at a lower baseline SBP and ***:Having a baseline SBP110 mmHg or DBP<70 mmHg was associated with a significantly higher risk of all-cause mortality in patients with *** excessively low BP may not be an optimal target for patients with AF.

关键词： All-cause death All-cause mortality Atrial fibrillation Blood pressure Diastolic blood pressure Hypertension Systolic blood pressure

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Malware incident response(IR) informed by cyber threat intelligence(CTI)

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Science China(Information Sciences) 2022年第7期65卷 256-258页

作者： Ying HE Ellis INGLUT Cunjin LUO School of Computer Science and Informatics De Montfort University Key Lab of Medical Electrophysiology Ministry of Education The Health Informatics group Institute of Cardiovascular Research Southwest Medical University School of Computer Science and Engineering Northeastern University

Dear editor, Security experts have been fighting against cybercriminals for many years and existing research shows that this battle will continue. Malicious software has no remorse when it targets different organizations, regardless of its forms [1]. Ransomware [2] has caused serious issues in different industries, especially in healthcare. The existing report shows that 34% of ransomware is targeting healthcare organizations. Nowadays, criminals prefer crypto-jacking over ransomware (which also relies on cryptocurrency for anonymous ransom payments).

关键词： Malware Analysis Cyber Threat Intelligence Crypto Jacking Incident Response Malware Incident Response

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Operation room nursing based on humanized nursing mode combined with nitric oxide on rehabilitation effect after lung surgery

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World Journal of Clinical Cases 2024年第18期12卷 3368-3377页

作者： Qiao-Li Wang Zhi-Bo Wang Jin-Fu Zhu Department of Anesthesiology and Perioperative Medicine The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina Department of Thoracic Surgery Jiangsu Provincial People’s HospitalNanjing 210029Jiangsu ProvinceChina Department of cardiovascular Surgery The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina

BACKGROUND With advancements in the diagnosis and treatment of lung diseases,lung segment surgery has become increasingly *** rehabilitation is critical for patient recovery,yet challenges such as complications and adverse outcomes *** humanized nursing modes and novel treatments like nitric oxide inhalation may enhance recovery and reduce postoperative *** To evaluate the effects of a humanized nursing mode combined with nitric oxide inhalation on the rehabilitation outcomes of patients undergoing lung surgery,focusing on pulmonary function,recovery speed,and overall treatment *** A total of 79 patients who underwent lung surgery at a tertiary hospital from March 2021 to December 2021 were divided into a control group(n=39)receiving a routine nursing program and an experimental group(n=40)receiving additional humanized nursing interventions and atomized inhalation of nitric *** indicators were compared between the two groups alongside an analysis of treatment *** The experimental group demonstrated significant improvements in pulmonary function,reduced average recovery time,and lower total treatment costs compared to the control ***,the quality of life in the experimental group was significantly better in the 3 months post-surgery,indicating a more effective rehabilitation *** The combination of humanized nursing mode and nitric oxide inhalation in postoperative care for lung surgery patients significantly enhances pulmonary rehabilitation outcomes,accelerates recovery,and reduces economic *** approach offers a promising reference for improving patient care and rehabilitation efficiency following lung surgery.

关键词： Humanized nursing Nitric oxide Lung segment surgery Rehabilitation Pulmonary function

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Long-term outcome of percutaneous or surgical revascularization with and without prior stroke in patients with threevessel disease

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Journal of Geriatric Cardiology 2022年第8期19卷 583-593页

作者： Na XU Ce ZHANG Lin JIANG Jing-Jing XU Ru LIU Ying SONG Xue-Yan ZHAO Lian-Jun XU Run-Lin GAO Bo XU Jin-Qing YUAN Lei SONG Center for Coronary Heart Disease National Clinical Research Center for Cardiovascular DiseasesNational Center for Cardiovascular DiseasesState Key Laboratory of Cardiovascular DiseaseFuwai HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

OBJECTIVE To determine whether high-risk patients with three-vessel disease(TVD)with and without prior stroke preferen-tially benefit from three strategies[percutaneous coronary intervention(PCI),coronary artery bypass grafting(CABG)and medical therapy(MT)].METHODS A total of 8943 patients with TVD were included in the *** enrolled were stratified into two categories according to the presence or absence of prior stroke *** primary endpoint was all-cause *** endpoints in-cluded stroke and major adverse cardiac and cerebrovascular event(MACCE),a composite of death,myocardial infarction(MI),unplanned revascularization and *** Prior stroke was present in 888 patients(9.9%).These patients were older and had higher rates of ***-ring a median follow-up of 7.5 years,patients with prior stroke were strongly associated with increased risks of all-cause death,cardiac death,stroke and MACCE,even after adjusting for confounding variables and results been consistent across either treat-ment subgroup(PCI,CABG and MT)(all adjusted Pgroup compared with the PCI group,but with similar rate of all-cause death regardless of prior stroke *** prevalence of stroke was significantly higher after CABG when compared with PCI or MT in no prior stroke patients[hazard ratio(HR)=1.429,95%CI:1.132-1.805 for CABG ***;HR=1.703,95%CI:1.371-2.116 for CABG ***].CONCLUSIONS Patients with TVD and prior stroke have poor clinical *** is essential to balance benefit and risk when determining the optimal treatment strategy for TVD with and without prior stroke.

关键词： patients prior founding

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