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Bidirectional regulation of the brain-gut-microbiota axis following traumatic brain injury

Neural Regeneration Research 2025年第8期20卷 2153-2168页

作者： Xinyu You Lin Niu Jiafeng Fu Shining Ge Jiangwei Shi Yanjun Zhang Pengwei Zhuang National Key Laboratory of chinese medicine Modernization Tianjin University of Traditional Chinese MedicineTianjinChina Haihe Laboratory of Modern chinese medicine Tianjin University of Traditional Chinese MedicineTianjinChina First Teaching Hospital of Tianjin University of traditional chinese medicine TianjinChina National Clinical Research center for chinese medicine Acupuncture and Moxibustion TianjinChina

Traumatic brain injury is a prevalent disorder of the central nervous *** addition to primary brain parenchymal damage,the enduring biological consequences of traumatic brain injury pose long-term risks for patients with traumatic brain injury;however,the underlying pathogenesis remains unclear,and effective intervention methods are *** dysfunction is a significant consequence of traumatic brain *** the most densely innervated peripheral tissue in the body,the gut possesses multiple pathways for the establishment of a bidirectional“brain-gut axis”with the central nervous *** gut harbors a vast microbial community,and alterations of the gut niche contribute to the progression of traumatic brain injury and its unfavorable prognosis through neuronal,hormonal,and immune pathways.A comprehensive understanding of microbiota-mediated peripheral neuroimmunomodulation mechanisms is needed to enhance treatment strategies for traumatic brain injury and its associated *** comprehensively reviewed alterations in the gut microecological environment following traumatic brain injury,with a specific focus on the complex biological processes of peripheral nerves,immunity,and microbes triggered by traumatic brain injury,encompassing autonomic dysfunction,neuroendocrine disturbances,peripheral immunosuppression,increased intestinal barrier permeability,compromised responses of sensory nerves to microorganisms,and potential effector nuclei in the central nervous system influenced by gut ***,we reviewed the mechanisms underlying secondary biological injury and the dynamic pathological responses that occur following injury to enhance our current understanding of how peripheral pathways impact the outcome of patients with traumatic brain *** review aimed to propose a conceptual model for future risk assessment of central nervous system-related diseases while elucidating novel insights into the bidirectional effec

关键词： traumatic brain injury brain-gut-microbiome axis gut microbiota neuroimmune immunosuppression host defense vagal afferents bacterial infection dorsal root ganglia nociception neural circuitry

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Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

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Science China Life Sciences 2025年第1期 300-302页

作者： Ze-Min Lin Mai Xiang Wen-Hui Wei Shu-Hui Fan Li Chen Jie Wang Xiao-Qian Yang Chun-Hao Yang Shi-Jun He Jian-Ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of traditional chinese medicine Shanghai University of Traditional Chinese Medicine Experiment center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

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C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway as a therapeutic target and regulatory mechanism for spinal cord injury

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Neural Regeneration Research 2025年第8期20卷 2231-2244页

作者： Xiangzi Wang Xiaofei Niu Yingkai Wang Yang Liu Cheng Yang Xuyi Chen Zhongquan Qi School of medicine Guangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Graduate School of Tianjin University of traditional chinese medicine TianjinChina Characteristic Medical center of People’s Armed Police Forces TianjinChina Fujian Maternity and Child Health Hospital FuzhouFujian ProvinceChina

Spinal cord injury involves non-reversible damage to the central nervous system that is characterized by limited regenerative capacity and secondary inflammatory *** expression of the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis exhibits significant differences before and after *** studies have revealed that the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis is closely associated with secondary inflammatory responses and the recruitment of immune cells following spinal cord injury,suggesting that this axis is a novel target and regulatory control point for *** review comprehensively examines the therapeutic strategies targeting the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis,along with the regenerative and repair mechanisms linking the axis to spinal cord ***,we summarize the upstream and downstream inflammatory signaling pathways associated with spinal cord injury and the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review primarily elaborates on therapeutic strategies that target the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the latest progress of research on antagonistic drugs,along with the approaches used to exploit new therapeutic targets within the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the development of targeted ***,there are presently no clinical studies relating to spinal cord injury that are focusing on the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review aims to provide new ideas and therapeutic strategies for the future treatment of spinal cord injury.

关键词： apoptosis C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway C-C motif chemokine receptor 2 antagonists chemokine ligand 2 chemokine receptor 2 inflammation macrophage microglia spinal cord injury therapeutic method

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Practices,challenges,and opportunities:HIV/aids treatment with traditional chinese medicine in China

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Frontiers of medicine 2011年第2期5卷 123-126页

作者： Jian Wang Wen Zou traditional chinese medicine center for aids prevention and treatment China Academy of Chinese Medicine SciencesBeijing 100700China

traditional chinese medicine(TCM)has become widely used in the treatment of acquired immune deficiency syndrome(aids)in China in recent *** this article,we summarize the recent major developments in human immunodeficiency virus/aids(HIV/aids)treatment with *** use of TCM is associated with preventing or alleviating HIV-related symptoms,reducing treatment side effects,and improving the quality of *** potential beneficial effects of TCM should be confirmed through extensive and rigorous trials.

关键词： HIV/aids traditional chinese medicine

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Prevalence of liver injury among patients with acquired immunodeficiency syndrome treated with highly active antiretroviral therapy in China

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Journal of traditional chinese medicine 2019年第2期39卷 275-280页

作者： Yuan Jun Xu Qianlei Chen Xiumin Meng Pengfei Li Qingya Xu Liran Meng Xiangle Jin Yantao Guo Huijun Department of aids treatment and Research center the First Affiliated Hospital of Henan University of Traditional Chinese Medicine

OBJECTIVE: To estimate the prevalence of liver injury among patients with acquired immunodeficiency syndrome(aids) who received highly active antiretroviral therapy(HAART) in rural Henan Province in China, and to explore whether traditional chinese medicine(TCM) treatment based on HAART would increase this ***: This was a retrospective cross-sectional study. We collected medical information on patients with aids from two treatment databases in2014. Criteria established by the aids Clinical Trials Group in 1996 were used for grading liver injury,classified based on the limit of normal(ULN) for alanine transaminase and aspartate aminotransferase:grade 1(1.25-2.5 × ULN); grade 2(2.6-5 × ULN);grade 3(5.1-10 × ULN); and grade 4(> 10 × ULN).Factors associated with liver injury were evaluated using a logistic regression ***: A total 6953 patients with aids(3324 male and 3629 female patients) were enrolled into this study. The prevalence of liver injury was 22.0%(18.0% grade 1, 3.1% grade 2, 0.9% grade 3). In multivariate analysis, patients aged 34-45 years were more likely to have liver injury than patients in other age groups [adjusted odds ratio(AOR), 1.39; 95%CI, 1.01-1.91)]. Other factors associated with liver injury included male sex(AOR, 1.64; 95% CI,1.46-1.85), HIV infection via blood(AOR, 1.47; 95%CI, 1.19-1.82), hepatitis B virus antibody positive(AOR, 1.07; 95% CI, 0.85-1.36), and hepatitis C virus(HCV) antibody positive(AOR, 2.76; 95% CI,2.28-3.34).CONCLUSION: The prevalence of liver injury was relatively high among HAART-experienced patients. Several factors associated with liver injury included male sex, age 35-45 years old, HIV infection through blood, and concurrent HCV infection. TCM had no relationship with liver injury in patients receiving HAART.

关键词： Acquired immunodeficiency syndrome Chemical and drug induced liver injury Prevalence Antiretroviral therapy,highly active medicine,chinese traditional

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Advantages of chinese medicine for Patients with Acquired Immunodeficiency Syndrome in Rural Central China

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chinese Journal of Integrative medicine 2018年第12期24卷 891-896页

作者： XU Qian-lei GUO Hui-jun JIN Yan-tao WANG Jian JIANG Zi-qiang LI Zheng-wei CHEN Xiu-min LIU Ying XU Li-ran Department of Acquired Immune Deficiency Syndrome treatment and Research center the First Affiliated Hospital of Henan University of Traditional Chinese MedicineZhengzhou 450000China Henan Key Laboratory of Viral Diseases Control with traditional chinese medicine Zhengzhou 450000China traditional chinese medicine center for Acquired Immune Deficiency Syndrome prevention and treatment China Academy of Traditional Chinese MedicineBeijing 100700China

Objective： To analyze the effect of chinese medicine （CM） on mortality and quality of life （QOL） of acquired immunodeficiency syndrome （aids） patients treated with combined antiretroviral therapy （cART）. Methods： A random sample of aids patients enrolled in the National chinese medicine treatment Trial Program （NCMTP） that met the inclusion criteria was included in this study. NCMTP patients were included as the CM＋cART group, and those not in the NCMTP were included as the cART group. Survival from September 2004 to September 2012 was analyzed by retrospective cohort study. QOL was analyzed by cross-sectional study. Results： The retrospective cohort study included 528 aids patients, 322 in the CM＋cART group and 206 in the cART group. After 8 years, the mortality in the CM＋cART group was 3.3/100 person-years, which was lower than the cART group of 5.3/100 person-years （P〈0.05）. The hazard ratio （HR） for mortality in the cART group was 1.6 times that of the CM＋cART group by Cox proportional hazard model analysis. After controlling for gender, age, marital status, education, and CD4＋ T-cell count, the HR was 1.9 times higher in the cART group compared with the CM＋cART group （P〈0.05）. The cross-sectional study investigated 275 aids patients. The mean scores of all QOL domains except spirituality/personal beliefs were higher in the CM＋cART group than in the cART group （P〈0.05）. Conclusions： For aids patients, CM could help to prolong life, decrease mortality, and improve QOL. However, there were limitations in the study, so prospective studies should be carded out to confirm our primary results.

关键词： acquired immunodeficiency syndrome mortality quality of life chinese medicine

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Recent Advances of HIV/aids treatment with traditional chinese medicine in China

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Journal of traditional chinese medicine 2010年第4期30卷 305-308页

作者：王健邹雯 traditional chinese medicine center for aids prevention and treatment China Academy of Chinese Medical Sciences

Since the early 1980's over 40 million individuals have infected with HIV worldwide and over 12 million have died. In China by 2009 there had been 319,877

关键词：艾滋病毒中国中医药传统治疗

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Anti-inflammatory mechanism of the non-volatile ingredients performance liquid chromatography-heated electron spray ionization-high resolution mass spectroscope and cell metabolomics

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Journal of traditional chinese medicine 2024年第2期44卷 260-267页

作者： JING Wenguang LIN Xiaoyu LI Chu ZHAO Xiaoliang CHENG Xianlong WANG Penglong WEI Feng MA Shuangcheng Institute of Control of chinese traditional medicine and Ethnic medicine National Institutes for Food and Drug ControlBeijing 102629China School of traditional chinese medicine Beijing University of Chinese MedicineBeijing 102488China Beijing Key Laboratory of traditional chinese medicine Basic Research on prevention and treatment of Major Diseases Experimental Research CenterChina Academy of Chinese Medical SciencesBeijing 100700China

OBJECTIVE:To explore the anti-inflammatory components and mechanism of the non-volatile ingredients of ***:High performance liquid chromatographyheated electron spray ionization-high resolution mass spectroscope(HPLC-HESI-HRMS)was used to analyze the chemical constituents of the non-volatile ingredients of *** anti-inflammatory activity of ingredients was evaluated using lipopolysaccharide(LPS)induced RAW264.7 cell inflammation model,and the antiinflammatory mechanism was investigated using multivariate statistical analysis of cell ***:The non-volatile ingredients of patchouli were characterized by HPLC-HESI-HRMS,and 36 flavonoids and 18 other components were *** ingredients of patchouli not only had a good protective effect on the LPS-induced inflammation model of RAW264.7 cells,but also regulated the expression levels of arginine,L-leucine,cholesterol,fructose and sorbitol by down-regulating arginine metabolism,aminoacyl-tRNA biosynthesis,polyol/sorbitol pathway,so as to reduce inflammation and reduce cell ***:The non-volatile ingredients of patchouli had good anti-inflammatory effect and exerted its curative effect by regulating endogenous metabolic pathway to reduce inflammatory response.

关键词： Pogostemon non-volatile ingredients anti-inflammatory cell metabolomics

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Survival of people living with HIV after treatment with traditional chinese medicine in Henan province of China: a retrospective cohortstudy

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Journal of traditional chinese medicine 2014年第4期34卷 430-436页

作者： Yantao Jin Zhibin Liu Xiumin Chen Xin Wang Dan Wang Ziqiang Jiang Ying Liu Jian Wang Wen Zou Huijun Guo Liran Xu Department of Acquired Immune Deficiency Syndrome treatment and Research center the First Affiliated Hospital of Henan University of Traditional Chinese Medicine National center for aids/STD Control and prevention Chinese Center for Disease ControlandPrevention Key Laboratory of Viral Diseases prevention and treatment of traditional chinese medicine of Henan Province School of International Education Zhengzhou Railway Vocational and Technical College traditional chinese medicine center for Acquired Immune Deficiency Syndrome prevention and treatment China Academy of Traditional Chinese Medicine National center for aids/STD Control and prevention Chinese Center for Disease Control and Prevention traditional chinese medicine center for Acquired Immune Deficiency Syndrome prevention and treatment China Academy of Traditional Chinese Medicine

OBJECTIVE: To provide survival estimates of people living with human immunodeficiency virus(PLHIV) after treatment with traditional chinese medicine(TCM) in rural China, to identify the prognostic factors at enrollment, and to explore the effectiveness of TCM intreating ***: PLHIV who enrolled in national TCM HIV treatment trial program in October 2004 were analyzed in this study and followed up to October 2010. Survival time was estimated by the Kaplan-Meier curve and hazard ratios, and identifying prognostic factors were computed through Cox proportional hazard ***:A total of 1666 PLHIV were included with 102 591 person-months of follow-up. Overall, 312(18.7%) patients died. The total mortality rate over the study period was 3.6 per 100 person-years,which was lower than the worldwide rate. The cumulative survival rate was 95.9% at 1 year[95% confidence interval(CI)(94.8-96.8)] and 80.4% at 6years [95% CI(78.4-82.3)]. Elevated death risks emerged among males, older individuals, and thosewithlowerCD4+***: TCM could increase survival and lengthen the life span of PLHIV in Henan province of China, as shown by our retrospective cohort study. Factors such as sex, age, education, and CD4+ T-cell counts correlated to survival. However,retrospective cohorts bias the data, so more prospective studies should be performed to confirm our primary results.

关键词： Retrospective studies HIV Acquired immunodeficiency syndrome Survival medicine chinese traditional

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Investigation on Prescription Screening of a Polyherbal Preparation Based on Splenocyte Proliferation Activity and its Preparation Method

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World Journal of traditional chinese medicine 2017年第4期3卷 7-14页

作者： Ahmed Attia Ahmed Abdelmoaty Yu-Ling Ma Ruibin Bai Xiao-Ping Zheng Fang-Di Hu Ying-Dong Li traditional chinese medicine and Natural medicine Research Institute School of PharmacyLanzhou University Institute of Integrated traditional chinese and Western medicine Gansu University of Traditional Chinese Medicine Gansu Key Laboratory of traditional chinese medicine for prevention and treatment of Chronic Diseases Gansu Clinical Medical center of Integrated traditional chinese and Western medicine treatment of Cardiovascular and Cerebrovascular

Objective: The present study aims to optimize the extraction conditions of polysaccharides and flavonoids from a polyherbal preparation consisting of three kinds of chinese medicinal herbs, Codonopsis pilosula, Crataegus pinnatifida, and Lycium barbarum, and evaluation of its immunomodulatory activity in immunosuppressed mice. Materials and Methods: An orthogonal design(L_9 [3]~4) was constructed to achieve the optimal extraction conditions. The immunomodulatory action of the polyherbal preparation was studied at three doses of 10, 20, and 40 mL/kg/day orally by measuring splenocyte proliferation in mice model of cyclophosphamide-induced immunosuppression. Results: The chosen parameters, including the ratio of solvent-to-raw material, duration of extraction, and extraction times, were the fundamental variables that influenced the extract yields. The highest yield of total polysaccharides content was 54.3 mg/mL when the ratio of solvent-to-raw material,duration of extraction, and number of extractions were 12:1, 1.5 h, and 3, respectively. The maximum extraction yield of the flavonoids was 3.5 mg/mL when the ratio of solvent-to-raw material was 12:1, the extraction time was 2 h, and the number of extractions was 3. The prescription screening showed that the impact of the polyherbal preparation on the splenocyte proliferation capacity was more pronounced than its disassembled components. Oral administration of the polyherbal preparation could significantly increase the concanavalin A-stimulated mouse spleen cells proliferation in a dose-dependent manner. Conclusion: These findings suggested that the polyherbal preparation possesses potential for augmenting the immune activity due to the polysaccharide and flavonoid content in these herbal medicines.

关键词： Codonopsis pilosula Crataegus pinnatifida flavonoids Lycium barbarum polysaccharides

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