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Needs and concerns of patients in isolation care units - learnings from COVID-19: A reflection

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World Journal of Clinical Cases 2020年第10期8卷 1763-1766页

作者： Peijin Esther Monica Fan Fazila Aloweni Shu Hui Lim Shin Yuh Ang Karen Perera Aik Huan Quek Hwee Koon Susan Quek tracy carol ayre tracy carol ayre Nursing DivisionSingapore General HospitalSingapore 169608Singapore Office of Patient Experience Singapore General HospitalSingapore 169608Singapore

With strict measures in place to contain the spread of coronavirus disease 2019,many have been isolated as suspected or confirmed *** isolated causes much inconvenience for the patients and ***'and next-of-kins’needs and concerns during isolation will be shared together with suggestions for key process *** hospital’s Senior Patient Experience Managers contact all patients admitted to the isolation wards on a daily basis to provide some form of *** issues raised were gathered and strategies to help with their needs and concerns were *** in isolation is a challenging period for both patients and ***,we can implement measures to mitigate against the adverse effects of *** education,effective and efficient means of communication,close monitoring for signs of distress and anxiety,and early intervention could help patients cope better with the whole isolation *** management may want to consider implementing the measures shared in the article to manage patient’s stress while not compromising on staff safety.

关键词： COVID-19 Anxiety Care delivery systems Communicable disease Isolation Infectious disease

Rocahepevirus ratti: An underrecognised cause of acute hepatitis

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World Journal of Hepatology 2024年第8期16卷 1084-1090页

作者： George S Gherlan Department of Infectious Diseases “Carol Davila”University of Medicine and PharmacyBucharest 050474Romania

Zoonoses are responsible for many of all emerging infectious diseases as well as for those already *** ratti is a rat-originated virus related to the hepatitis E virus(Paslahepevirus balayani)but highly divergent genetically from this,with a high cross-species infection potential and zoonotic *** can infect humans,leading to acute hepatitis,and is primarily transmitted through the consumption of contaminated *** ratti was first discovered in Germany in *** first human case was described in 2017 in Hong Kong in an immune-compromised *** first case of chronic infection with Rocahep-evirus ratti was described in 2023.A meta-analysis based on 38 studies published between 2000 and 2023 identified 21 cases in humans described up to this date and 489 infections in different *** awareness regarding this virus is essential,as there are probably many cases that remain undiagnosed,and the virus even has the ability to produce chronic infections in selected patients.

关键词： Hepatitis Rocahepevirus ratti Rats Zoonoses Hepeviridae Liver

Helium Plasma Effects on Polymer Surfaces:from Plasma Parameters and Surface Properties towards Bioengineering Applications

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Chinese Journal of Polymer Science 2024年第8期42卷 1156-1166页

作者： Andrei Vasile Nastuta Maria Butnaru Byron Cheatham Ramona Huzum Vasile Tiron Ionut Topala Physics and Biophysics Education Research Laboratory(P&B-EduResLab) Biomedical Science DepartmentFaculty of Medical Bioengineering‘Grigore T.Popa’University of Medicine and Pharmacy IasiM.Kogalniceanu 9-13Iasi 700454Romania Faculty of Medical Bioengineering ‘Grigore T.Popa’University of Medicine and Pharmacy IasiM.Kogalniceanu 9-13Iasi 700454Romania Cytoviva Inc.570 Devall Drive Suite 301Auburn 36832ALUSA Integrated Center of Environmental Science Studies in the North-Eastern Development Region(CERNESIM) Department of Exact and Natural SciencesInstitute of Interdisciplinary Research‘Alexandru Ioan Cuza’University of IasiBlvd.Carol I no.11Iasi 700506Romania Research Center on Advanced Materials and Technologies(RAMTECH) Department of Exact and Natural SciencesInstitute of Interdisciplinary Research‘Alexandru Ioan Cuza’University of IasiBlvd.Carol I no.11Iasi 700506Romania Iasi Plasma Advanced Research Center(IPARC) Faculty of Physics‘Alexandru Ioan Cuza’University of IasiBlvd.Carol I no.11Iasi 700506Romania

Plasma treatment is necessary to optimize the performance of biomaterial *** enhances and regulates the performance of biomaterial su rfaces,creating an effective interface with the human *** treatments have the ability to modify the chemical com position and physical structu re of a surface while leaving its properties *** possess the ability to modify material su rfaces,eliminate contaminants,conduct investigations on cancer therapy,and facilitate wound *** subject of study in question involves the integration of plasma science and technology with biology and *** a helium plasma jet source,applying up to 18 kV,with an average power of 10 W,polymer foils were treated for 60 *** treatment has the ability to alter the chemical composition and physical structure of a su rface while maintaining its *** investigation involved the application of helium plasma at atmospheric pressure to polyamide 6 and polyethylene terephthalate *** inquiry involves monitoring and assessing the plasma source and polymer materials,as well as analyzing the impacts of plasma *** the mean power of the discharge aids in assessing the economic efficacy of the plasma *** discharge in helium at atmospheric pressure has beneficial effects in technology,where it increases the surface free energy of polymer *** biomedicine,it is used to investigate cytotoxicity and cell survival,particularly in direct blood exposure situations that can expedite *** the specific parameters that influence the plasma source in the desired manner for the intended application is of utmost im portance.

关键词： Atmopheric pressure plasmas Plasma-polymer interaction Plasma Medicine Plasma diagnosis Polymer characterization

Solid pancreatic masses:What’s hidden beneath?Insights into rare pancreatic lesions

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World Journal of Clinical Cases 2024年第29期12卷 6255-6257页

作者： Daniel Vasile Balaban Department of Internal Medicine and Gastroenterology Carol Davila University of Medicine and PharmacyBucharest 020021Romania

The diagnostic approach to solid pancreatic masses has significantly evolved from the era when a focal pancreatic mass was almost synonymous to pancreatic ductal adenocarcinoma,to a wide spectrum of pancreatic lesions,some of which have good *** the advent of advanced diagnostic tools,particularly refined imaging and tissue acquisition techniques,a broader spectrum of differential diagnoses has been recognized,encompassing conditions ranging from neuroendocrine tumors or inflammatory masses,to rare entities like metastatic clear cell sarcoma or solitary fibrous *** herein discuss case reports of some rare pancreatic lesions,which were diagnosed by combining clinical and imaging features and endoscopic ultrasound-guided tissue sampling and confirmed on surgical *** reports on these rare pancreatic tumors will contribute to a better understanding of their pathogenesis and effective management.

关键词： Pancreatic mass Pancreas Metastasis Diagnosis Endoscopic ultrasound

Hypoglycaemia in screening oral glucose tolerance test in pregnancy with low birth weight fetus

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World Journal of Experimental Medicine 2024年第3期14卷 119-121页

作者： Nicoleta Gana Iulia Huluta Nicolae Gica Department of Obstetrics and Gynecology Filantropia Clinical Hospital BucharestBucharest 099098Romania Department of Obstetrics and Gynecology Carol Davila University of Medicine and PharmacyBucharest 098909Romania

Maternal hypoglycemia,a condition characterized by lower than normal blood glucose levels in pregnant women,has been increasingly associated with adverse pregnancy outcomes,including low birth weight(LBW)in ***,defined as a birth weight of less than 2500 g,can result from various factors,including maternal nutrition,health status,and metabolic conditions like *** hypoglycemia may affect fetal growth by altering the supply of essential nutrients and oxygen to the fetus,leading to restricted fetal development and *** condition poses significant risks not only during pregnancy but also for the long-term health of the child,increasing the likelihood of developmental delays,health issues,and chronic conditions later in *** in this area has focused on understanding the mechanisms through which maternal hypoglycemia influences fetal development,with studies suggesting that alterations in placental blood flow and nutrient transport,as well as direct effects on fetal insulin levels and metabolism,may play a *** the potential impact of maternal hypoglycemia on neonatal health outcomes,early detection and management are crucial to minimize risks for LBW and its associated *** investigations are needed to fully elucidate the complex interactions between maternal glucose levels and fetal growth,as well as to develop targeted interventions to support the health of both mother and *** these relationships is vital for improving prenatal care and outcomes for pregnancies complicated by hypoglycemia.

关键词： Glucose tolerance test Low birth weight Hypoglycaemia High-risk pregnancy Neonatal outcome

Pursuing meaningful end-points for stem cell therapy assessment in ischemic cardiac disease

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World Journal of Stem Cells 2017年第12期9卷 203-218页

作者： Maria Dorobantu Nicoleta-Monica Popa-Fotea Mihaela Popa Iulia Rusu Miruna Mihaela Micheu Department of Cardiology Clinical Emergency Hospital of Bucharest carol Davila University of Medicine 'Carol Davila' University of Medicine and Pharmacy Bucharest

Despite optimal interventional and medical therapy, ischemic heart disease is still an important cause of morbidity and mortality worldwide. Although not included in standard of care rehabilitation, stem cell therapy(SCT) could be a solution for prompting cardiac regeneration. Multiple studies have been published from the beginning of SCT until now, but overall no unanimous conclusion could be drawn in part due to the lack of appropriate endpoints. In order to appreciate the impact of SCT, multiple markers from different categories should be considered: Structural, biological, functional, physiological, but also major adverse cardiac events or quality of life. Imaging end-points are among the most used-especially left ventricle ejection fraction(LVEF) measured through different methods. Other imaging parameters are infarct size, myocardial viability and perfusion. The impact of SCT on all of the aforementioned end-points is controversial and debatable. 2 D-echocardiography is widely exploited, but new approaches such as tissue Doppler, strain/strain rate or 3 D-echocardiography are more accurate, especially since the latter one is comparable with the MRI gold standard estimation of LVEF. Apart from the objective parameters, there are also patient-centered evaluations to reveal the benefits of SCT, such as quality of life and performance status, the most valuable from the patient point of view. Emerging parameters investigating molecular pathways such as non-coding RNAs or inflammation cytokines have a high potential as prognostic factors. Due to the disadvantages of current techniques, new imaging methods with labelled cells tracked along their lifetime seem promising, but until now only pre-clinical trials have been conducted in humans. Overall, SCT is characterized by high heterogeneity not only in preparation, administration and type of cells, but also in quantification of therapy effects.

关键词： Stem cell therapy Cardiac imaging techniques Ischemic cardiac disease Cardiac regeneration Endpoints

Laparoscopic vs open complete mesocolic excision with central vascular ligation for colon cancer: A systematic review and meta-analysis

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World Journal of Gastrointestinal Oncology 2017年第12期9卷 475-491页

作者： Ionut Negoi Sorin Hostiuc Ruxandra Irina Negoi Mircea Beuran Department of General Surgery Emergency Hospital of Bucharest Carol Davila University of Medicine and Pharmacy Bucharest National Institute of Legal Medicine Mina Minovici Carol Davila University of Medicine and Pharmacy Bucharest Department of Anatomy Carol Davila University of Medicine and Pharmacy Bucharest Emergency Hospital of Bucharest Carol Davila University of Medicine and Pharmacy Bucharest

AIM To compare the effectiveness of laparoscopic complete mesocolic excision (CME) with central vascular ligation (L-CME) with its open (O-CME) counterpart. METHODS We conducted an electronic search of the PubMed/MEDLINE, Excerpta Medica Database, Web of Science Core Collection, Cochrane Center Register of Controlled Trails, Cochrane Database of Systematic Reviews, SciELO, and Korean Journal databases from their inception until May 2017. We considered randomized controlled trials (RCTs) and controlled clinical trials (CCTs) that included patients with colonic cancer comparing L-CME and O-CME. Primary outcomes included the quality of the resected specimen (lymph nodes retrieved, complete mesocolic plane excision, tumor to arterial high tie, resected mesocolon surface). Secondary outcomes included the three-year and five-year overall and disease-free survival rates, recurrence of the disease, surgical data, and postoperative morbidity and mortality. Two authors of the review screened the methodological quality of the eligible trials and independently extracted data from individual studies. RESULTS A total of one RCT and eleven CCTs (four from Europe and seven from Asia) met the inclusion criteria for the current meta-analysis. These studies involved 1619 patients in L-CME and 1477 patients in O-CME. The L-CME was associated with the same quality of the resected specimen, with no differences regarding the retrieved lymphnodes (MD = -1.06, 95%CI: -3.65 to 1.53, P = 0.42), and tumor to high tie distance (MD = 14.26 cm, 95%CI: -4.30 to 32.82, P = 0.13); the surface of the resected mesocolon was higher in the L-CME group (MD = 11.75 cm2, 95%CI: 9.50 to 13.99, P < 0.001). The L-CME was associated with a lower rate of blood transfusions (OR = 0.45, 95%CI: 0.27 to 0.75, P = 0.002), faster recovery of gastrointestinal function, and less postoperative overall complication rate. The L-CME approach was associated with a statistical significant better three-year overall

关键词： Colon cancer Complete mesocolic excision D3 lymphadenectomy Central vascular ligation

Mucinous appendiceal neoplasm:A case report

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World Journal of Clinical Cases 2021年第7期9卷 1728-1733页

作者： Alexandru Chirca Lucian Negreanu Andreea Iliesiu Radu Costea Surgery II Department University HospitalCarol Davila UniversityBucharestBucharest 050098Romania Gastroenterology II Department University HospitalCarol Davila UniversityBucharestBucharest 050098Romania Pathology Department University HospitalCarol Davila UniversityBucharestBucharest 050098Romania

BACKGROUND Primary appendiceal tumors are histologically diverse and have an insidious onset and few specific clinical *** the majority of cases,these tumors are discovered after appendectomy during pathological exam of the resected *** may include appendectomy(simple or radical)and right hemicolectomy depending on factors such as histological type,tumor size and lymph node/organ *** aim of this case study is to describe a rare case of a giant appendicular mucocele and raise awareness of this condition and its management options and follow-up *** SUMMARY We present the case of a 43-year-old patient who presented to our emergency department with mild right lower quadrant *** the initial check-up and imaging exams,he underwent surgery,where a giant 20 cm×13 cm appendicular tumor was found and *** mucocele was suspected due to the macroscopic appearance and was later confirmed by the pathological *** patient’s postoperative evolution was uneventful,and after discharge,he was included in our follow-up *** In conclusion,mucinous appendiceal neoplasms embody a rare pathology;they are asymptomatic or have few,unspecific clinical signs and in many cases are discovered after appendectomy.

关键词： Appendiceal tumors Appendicular mucocele Mucinous appendiceal neoplasms Case report

Cardiovascular involvement in inflammatory bowel disease: dangerous liaisons

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World Journal of Gastroenterology 2015年第33期21卷 9688-9692页

作者： Ana Maria Filimon Lucian Negreanu Michelle Doca Andreea Ciobanu Carmen Monica Preda Dragos Vinereanu Internal Medicine and Cardiology Department University Hospital Carol Davila University of Medicine Bucharest Internal Medicine 2 Gastroenterology Department University HospitalCarol Davila University of Medicine Bucharest Gastroenterology Department Fundeni Clinical InstituteCarol Davila Medicine University

Increasing evidence of a link between inflammatory bowel disease(IBD) and adverse cardiovascular events has emerged during the last *** 2014,an important number of meta-analyses and cohort studies clarified the subtle dangerous liaisons between gut inflammation and cardiovascular *** evidence suggests that patients with IBD have a significantly increased risk of myocardial infarction,stroke,and cardiovascular mortality,especially during periods of IBD *** populations(e.g.,women,young patients) may have an even greater *** effective treatment of IBD is aimed at disease remission and seems to reduce cardiovascular risk in these patients.A beneficial effect was demonstrated for salicylates,but not for steroids or *** necrosis factor-α antagonists,which are highly effective in the reduction of inflammation and in the restoration of the digestive mucosa,lead to conflicting cardiovascular effects,as they seem to reduce the risk for ischemic heart disease but increase the rate of cerebrovascular *** supplemental treatment strategies that may reduce the atherothrombotic risk during periods of IBD activity should be explored.

关键词： Inflammatory bowel disease Thrombotic events Activ