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Biomedical and Environmental Sciences 2017年第2期30卷 150-155页

作者： YU Fang Fang PING Zhi Guang YAO Chong WANG Zhi Wen WANG Fu Qi GUO Xiong Institute of Endemic Diseases School of Public Health of Health Science CenterXi'an Jiaotong UniversityKey Laboratory of Trace Elements and Endemic DiseasesNational Health and Family Planning CommissionXi'an 710061ShaanxiChina Department of Health Statistics College of Public HealthZhengzhou UniversityZhengzhou 45001HenanChina The Centers for Disease Control of Linyou country Linyou 721500ShaanxiChina

This study aimed to evaluate the sensitivity and specificity of the new clinical diagnostic and classification criteria for Kashin-Beck disease （KBD） using six clinical markers： flexion of the distal part of fingers, deformed fingers, enlarged finger joints, shortened fingers, squat down, and dwarfism. One-third of the total population in Linyou County was sampled by stratified random sampling.

关键词： KBD in China Evaluation of the Sensitivity and Specificity of the New Clinical Diagnostic and Classification Criteria for Kashin-Beck Disease

Exploring Genome-wide DNA Methylation Profiles Altered in Kashin-Beck Disease Using Infinium Human Methylation 450 Bead Chips

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Biomedical and Environmental Sciences 2016年第7期29卷 539-543页

作者： SHI Xiao Wei SHI Bo Hui LYU Ai Li ZHANG Feng ZHOU Tian Tian GUO Xiong Department of Pediatrics The First Affiliated Hospital of the Medical College of Xi’an Jiaotong University Department of Oncosurgery The First Affiliated Hospital of the Medical College of Xi’an Jiaotong University School of Public Health Health Science CenterXi’an Jiaotong UniversityKey Laboratory of Environment and Gene Related Diseases of Ministry of EducationKey Laboratory of Trace Elements and Endemic Diseases of Ministry of Health

To understand how differentially methylated genes（DMGs）might affect the pathogenesis of Kashin-Beck disease（KBD）.Genome-wide methylation profiling of whole blood from 12matched KBD and controls pairs was performed... 详细信息

关键词： KBD Exploring Genome-wide DNA Methylation Profiles Altered in Kashin-Beck Disease Using Infinium Human Methylation 450 Bead Chips DNA

Polymorphism in rs2229783 of the Alpha 1(XI) Collagen Gene Is Associated with Susceptibility to but not Severity of Kashin-Beck Disease in a Northwest Chinese Han Population

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Biomedical and Environmental Sciences 2018年第4期31卷 322-326页

作者： SHI Xiao Wei ZHANG Feng LI Zhi Yan LYU Ai Li GUO Xiong Department of Pediatrics The First Affiliated Hospital of Medical Collage of Xi'an Jiaotong University School of Public Health Health Science Center Xi'an Jiaotong University Key Laboratory of Environment and Gene Related Diseases of Ministry of Education Key Laboratory of Trace Elements and Endemic Diseases of Ministry of Health Department of Emergency The First Affiliated Hospital of Medical Collage of Xi'an Jiaotong University

The purpose of this study was to explore whether genomic polymorphisms in the alpha 1（XI）collagen gene（COL11A1）were associated with the risk and severity of Kashin-Beck disease（KBD）.

关键词： KBD Polymorphism in rs2229783 of the Alpha 1 XI

Psychosocial Stress Modifies the Acute Cardiac Health Effects of Traffic-Related Air Pollution

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Environment & Health 2024年第1期2卷 11-22页

作者： Tongjun Guo Wanzhou Wang Xi Chen Huaqi Guo Kai Wang Yating Ma Hongyan Deng Xianggui Li Anqi Shan Qian Wu Yaoyan Li Hongyu Li Qisijing Liu Juan Chen Yang Lan Jian Lei Furong Deng Zhiwei Sun Xinbiao Guo Shaowei Wu Yan Wang Naijun Tang Department of Occupational and Environmental Health Sciences School of Public HealthPeking UniversityBeijing 100191China Department of Occupational and Environmental Health Tianjin Key Laboratory of EnvironmentNutrition and Public HealthSchool of Public HealthTianjin Medical UniversityTianjin 300070China Department of Respiratory and Critical Care Medicine The Ninth People’s Hospital of Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of Occupational and Environmental Health School of Public HealthXi’an Jiaotong University Health Science CenterXi’anShaanxi 710049China Key Laboratory of trace elements and Endemic Diseases in Ministry of Health Xi’anShaanxi 710049China Key Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province Xi’anShaanxi 710049China Institute of Social Psychology School of Humanities and Social SciencesXi’an Jiaotong UniversityXi’anShaanxi 710049China Qinglongqiao Community Health Service Centre Beijing 100091China Key Laboratory of Environment and Genes Related to Diseases(Xi’an Jiaotong University) Ministry of EducationXi’an 710061China School of Public Health Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of HAI Management Tianjin Huanhu HospitalTianjin 300060China Office for National Clinical Research Center for Geriatric Diseases Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100005China Research Institute of Public Health School of MedicineNankai University300071 TianjinChina Department of Toxicology and Sanitary Chemistry School of Public HealthCapital Medical UniversityBeijing 100069China Beijing Key Laboratory of Environmental Toxicology Capital Medical UniversityBeijing 100069China The Ninth People’s Hospital of Shanghai Jiao Tong University School of Medicine Shanghai 200011China

Previous studies have shown that exposure to black carbon(BC,a tracer of traffic-related air pollution)and psychosocial stress are both associated with adverse cardiac effects,but whether psychosocial stress could modify the cardiac effects of BC is *** investigate the potential modifying effect of psychosocial stress on the associations between acute exposure to BC and typical cardiac health variables,real-time personal 24 h measurements were conducted in a repeated-measure study among adults with elevated blood pressure(high-risk group)and a panel study among normal adults(low-risk group)in *** cardiac health variables included ST-segment depression events,heart rate,and heart rate variability(HRV)*** Stress Scale,State Anxiety Inventory and Self-rating Depression Scale were used to assess the recent psychosocial stress status of the participants,and a composite stress index was established based on these *** linear mixed-effects model was used to analyze the associations between BC exposure and cardiac health variables and potential effect modification by psychosocial stress.A total of 9724 h measurements among 97 participants in the repeated-measure study and 20224 h measurements among 87 participants in the panel study were included in the final *** BC exposure was significantly associated with increased ST-segment depression events and heart rate and decreases in HRV in both *** marginal effects of acute BC exposure on most cardiac health variables generally tended to be amplified under higher vs low levels of psychosocial stress in both studies,with the composite stress index apparently modifying the associations of BC exposure with most ST-segment depression events and HRV *** findings suggest that psychosocial stress may increase the participants’cardiac susceptibility to BC exposure,which could be helpful for the identification of susceptible individuals in the context of traff

关键词： Air pollution Black carbon Cardiac health Effect modification Psychosocial stress

Increased Chondrocyte Apoptosis in Kashin-Beck Disease and Rats Induced by T-2 Toxin and Selenium Deficiency

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Biomedical and Environmental Sciences 2017年第5期30卷 351-362页

作者： YANG Hao Jie ZHANG Ying WANG Zhi Lun XUE Sen Hai LI Si Yuan ZHOU Xiao Rong ZHANG Meng FANG Qian WANG Wen Jun CHEN Chen DENG Xiang Hua CHEN Jing Hong Institute of Endemic Diseases School of Public HealthXi'an Jiaotong University Health Science CenterKey Laboratory of Trace Elements and Endemic DiseasesNational Health and Family Planning CommissionXi'an 710061ShaanxL China Xi'an Jiaotong University Hospital Xi'an 710049ShaanxL China School of Biomedical Sciences the University of QueenslandBrisbane 4072Australia Laboratory for Soft Tissue Research Hospital for Special SurgeryNew York 10021USA

Objective To investigate chondrocyte apoptosis and the expression of biochemical markers associated with apoptosis in Kashin-Beck disease（KBD） and in an established T-2 toxin-and selenium（Se） deficiency-induced rat model. Methods Cartilages were collected from the hand phalanges of five patients with KBD and five healthy children. Sprague-Dawley rats were administered a selenium-deficient diet for 4 weeks prior to T-2 toxin exposure. The apoptotic chondrocytes were observed by terminal deoxynucleotidyl transferase d UTP nick end labeling staining. Caspase-3, p53, Bcl-2, and Bax proteins in the cartilages were visualized by immunohistochemistry, their protein levels were determined by Western blotting, and m RNA levels were determined by real-time reverse transcription polymerase chain reaction. Results Increased chondrocyte apoptosis was observed in the cartilages of children with KBD. Increased apoptotic and caspase-3-stained cells were observed in the cartilages of rats fed with normal and Se-deficient diets plus T-2 toxin exposure compared to those in rats fed with normal and Se-deficient diets. Caspase-3, p53, and Bax proteins and m RNA levels were higher, whereas Bcl-2 levels were lower in rats fed with normal or Se-deficiency diets supplemented with T-2 toxin than the corresponding levels in rats fed with normal diet. Conclusion T-2 toxin under a selenium-deficient nutritional status induces chondrocyte death, which emphasizes the role of chondrocyte apoptosis in cartilage damage and progression of KBD.

关键词： KBD Chondrocyte Apoptosis T-2 toxin Selenium-deficiency

Difference in apoptosis-associated genes expression profiling and immunohistology analysis between Kashin-Beck disease and primary osteoarthritis

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Chinese Science Bulletin 2014年第9期59卷 833-839页

作者： Shixun Wu Chen Duan Feng Zhang Robert Pierce McKenzie Jingjing Zheng Umer Farooq Yidong Bai Xiong Guo School of Public Health College of Medicine Key Laboratory of Environment and Gene Related Diseases of Ministry Education Key Laboratory of Trace Elements and Endemic Diseases Ministry of Health Xi’an Jiaotong University Department of Orthopedics Surgery The First Affiliated Hospital College of Medicine Xi’an Jiaotong University Department of Cellular and Structural Biology University of Texas Health Sciences Center at San Antonio Department of Community Medicine Ayub Medical College

Kashin-Beck disease(KBD)is a chronic and deformed endemic osteoarthritis,without fully known *** compared to primary osteoarthritis(POA),its pathogenesis still exists *** performed this study to discriminate the difference in genes expression involved in apoptosis from KBD cartilages and POA *** analysis and Ingenuity Pathway Analysis(IPA)were used to identify the molecular mechanisms/canonical pathways implicated in KBD *** staining was carried out to detect tissue distribution of PDCD5 and EGR1 in the knee cartilages from KBD and *** 23 up-regulated apoptosis-related genes with[2-fold change were identified.‘‘Role of Macrophages,Fibroblasts,and Endothelial Cells in Rheumatoid Arthritis’’signaling was screened as the most relevant pathway through *** 8 differentially regulated genes were verified by qRT-PCR *** cell death 5 in middle and deeper zones and early growth response 1 in superficial and middle zones showed protein overexpressed in KBD cartilage samples comparing to those in POA cartilage *** indicates a higher expression level of apoptosis-related functional genes in KBD articular cartilage compared with POA articular cartilage.

关键词：细胞凋亡相关基因大骨节病骨关节炎原发性免疫组化表达谱 RT-PCR分析程序性细胞死亡

Comparing gene expression profiles of Kashin-Beck and Keshan diseases occurring within the same endemic areas of China

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Science China(Life Sciences) 2013年第8期56卷 797-803页

作者： WANG Xi WANG Shuang HE ShuLan ZHANG Feng TAN WuHong LEI YanXia YU HanJie LI Zheng NING YuJie XIANG YouZhang GUO Xiong Faculty of Public Health Medical College of Xi'an Jiaotong University Key Laboratory of Environment and Gene Related Diseases of Ministry of Education Key Laboratory of Trace Elements and Endemic Diseases of Ministry of Health National Engineering Research Center for Miniaturized Detection Systems Northwest University Shandong Institute for Prevention & Treatment of Endemic Disease

In this study, differentially expressed genes in peripheral blood from patients with Kashin-Beck disease and Keshan disease were compared to further investigate the etiology and pathogenesis of both diseases, which occur in a common endemic area of China. Twenty Kashin-Beck disease patients and 12 healthy controls, and 16 Keshan disease patients and 16 healthy controls, were grouped into four pairs. Patients and controls were selected from common endemic areas for the two diseases. Total RNA was isolated from peripheral blood mononuclear cells from all patients and controls, and gene expression profiles analyzed by oligonucleotide microarrays. Sixteen genes differentially expressed in both Kashin-Beck disease and Keshan disease (versus controls) were identified, and comprised nine genes showing synchronous and seven asynchronous expression. The Comparative Toxicogenomics Database shows that expression and biological function of these genes can be affected by multiple environmental factors, including mycotoxin and selenium content, potential environmental risk factors for the two diseases. Thus, these shared differentially expressed genes may contribute to the distinct organ lesions, caused by common environmental risk factors of Kashin-Beck disease and Keshan disease.

关键词： Kashin-Beck disease Keshan disease microarray peripheral blood mononuclear cells common environmental factors differential gene expression

The importance of glutathione and phytochelatins on the selenite and arsenate detoxification in Arabidopsis thaliana

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Journal of Environmental Sciences 2016年第11期28卷 150-161页

作者： Fatai Adigun Aborode Andrea Raab Matthias Voigt Leticia Malta Costa Eva M.Krupp Joerg Feldmann trace Element Spedation Laboratory Department of Chemistry University of Aberdeen Aberdeen AB24 3UE Scotland UK Departamento de Quimica Uniuersidade Federal de Minas Gerais Belo Horizonte MG CEP： 31270-901 Brazil

We investigated the role of glutathione（GSH） and phytochelatins（PCs） on the detoxification of selenite using Arabidopsis thaliana. The wild-type（WT） of Arabidopsis thaliana and its mutants（glutathione deficient Cad 2–1 and phytochelatins deficient Cad 1–3） were separately exposed to varying concentrations of selenite and arsenate and jointly to both toxicants to determine their sensitivities. The results of the study revealed that, the mutants were about 20-fold more sensitive to arsenate than the WT, an indication that the GSH and PCs affect arsenate detoxification. On the contrary, the WT and both mutants showed a similar level of sensitivity to selenite, an indication that the GSH and PCs do not significantly affect selenite detoxification. However, the WT is about 8 times more sensitive to selenite than to arsenate, and the mutants were more resistant to selenite than arsenate by a factor of 2. This could not be explained by the accumulation of both elements in roots and shoots in exposure experiments. The co-exposure of the WT indicates a synergistic effect with regards to toxicity since selenite did not induce PCs but arsenic and selenium compete in their PC binding as revealed by speciation analysis of the root extracts using HPLC–ICP–MS/ESI–MS. In the absence of PCs an antagonistic effect has been detected which might suggest indirectly that the formation of Se glutathione complex prevent the formation of detrimental selenopeptides. This study, therefore, revealed that PC and GSH have only a subordinate role in the detoxification of selenite.

关键词： Toxicity Phytochelatins Glutathione Selenopeptides ICP–MS ESI–MS Arabidopsis thaliana

Crosstalk between CpG Methylation and Polymorphisms (CpG-SNPs) in the Promotor Region of DIO2 in Kashin-Beck Disease

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Chinese Medical Sciences Journal 2022年第1期37卷 52-59页

作者： Rongqiang Zhang Dandan Zhang Di Zhang Xiaoli Yang Qiang Li Chen Wang Xuena Yang Yongmin Xiong School of Public Health Shaanxi University of Chinese MedicineXianyangShaanxi712046China Institute of Endemic Diseases and Key Laboratory of trace elements and Endemic Diseases National Health Commission of the People’s Republic of ChinaSchool of Public HealthXi′an Jiaotong University Health Science CenterXi′an 710061China

Objective This study was designed to determine the methylation profile of four CpGs and the genotypes of two CpG-SNPs located in promoter region of DIO2 in patients with Kashin-Beck disease(KBD).We also analyzed the interaction between the CpGs methylations and *** Whole blood specimens were collected from 16 KBD patients and 16 healthy *** CpGs and two CpG-SNPs in the promoter regions of DIO2 were detected using matrix-assisted laser desorption ionization time of flight mass spectrometry(MALDI-TOF-MS).The CpGs methylation levels were compared between samples from KBD patients and healthy *** methylation levels were also analyzed in KBD patients with different CpG-SNP *** The mRNA expression of DIO2 in whole blood of KBD patients was significnatly lower than in healthy controls(P<0.05).The methylation levels of DIO2-1_CpG_3 in KBD patients were significantly higher than those in healthy controls(P<0.05).The methylation levels of four CpGs were not significantly different between KBD patients and healthy *** methylation level of DIO2-1_CpG_3 in the promoter region of DIO2 in KBD patients with GA/AA genotype was significantly higher than that of KBD patients with GG genotype(P<0.05).Conclusion The methylation level of DIO2 increases in KBD *** trends exist in KBD carriers of variant genotypes of CpG-SNPs DIO2 rs955849187.

关键词： Kashin-Beck disease DNA methylation CpG CpG-SNP

APPLICATION OF CHEMO-PATTERN RECOGNITION TO RESEARCH ON BIOtrace ELEMENT SPECTRUM

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Chinese Science Bulletin 1986年第4期31卷 239-241页

作者：徐辉碧朱治良余明书吴燮和李德华黄开勋 Huazhong University of Seience and Technology Wuhan Huazhong University of Seience and Technology Wuhaniotrace element is a developing frontier of which the main object concerns the relationship between the trace element and health. Because of the antagonistic and synergetic effects it is always necessary to take the different kinds of elements not only one into account in the research work. At present the statistic remarkable test is used popularly which shows whether there is any relationship between a trace element and the disease and if there is then how close the relationship is. Unfortunately

Biotrace element is a developing frontier, of which the main object concerns the relationship between the trace element, and health. Because of the antagonistic and synergetic effects, it is always necessary to take the different kinds of elements, not only one, into account in the research work. At present, the statistic remarkable test is used popularly, which shows whether there is any relationship between a trace element and the disease and, if there is, then how close the relationship is. Unfortunately,

关键词： frontier remarkable statistic stores varia inverse remaining format deter mines