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Hepatitis C virus enhances incidence of idiopathic pulmonary fibrosis

World Journal of Gastroenterology 2008年第38期14卷 5880-5886页

作者： Yasuji Arase Fumitaka Suzuki Yoshiyuki Suzuki Norio Akuta Masahiro Kobayashi Yusuke Kawamura Hiromi Yatsuji Hitomi Sezaki Tetsuya Hosaka Miharu Hirakawa Satoshi Saito Kenji Ikeda Hiromitsu Kumada Department of Hepatology Toranomon HospitalTokyo 105-8470 Japan

AIM： To investigate the cumulative development incidence and predictive factors for idiopathic pulmonary fibrosis in hepatitis C virus （HCV） positive patients. METHODS： We studied 6150 HCV infected patients who were between 40-70 years old （HCV-group）. Another 2050 patients with hepatitis B virus （HBV） were selected as control （HBV-group）. The mean observation period was 8.0 ± 5.9 years in HCV-group and 6.3 ± 5.5 years in HBV-group. The primary goal is the development of idiopathic pulmonary fibrosis （IPF） in both groups. The cumulative appearance rate of IPF and independent factors associated with the incidence rate of IPF were calculated using the Kaplan- Meier method and the Cox proportional hazard model. All of the studies were performed retrospectively by collecting and analyzing data from the patient records in our hospital. RESULTS： Fifteen patients in HCV-group developed IPF. On the other hand, none of the patients developed IPF in HBV-group. In HCV-group, the cumulative rates of IPF development were 0.3% at 10th year and 0.9% at 20th year. The IPF development rate in HCV-group was higher than that in HBV-group （P = 0.021）. The IPF development rate in patients with HCV or HBV was high with statistical significance in the following cases：（1） patients ≥ 55 years （P 〈 0.001）; （2） patients who had smoking index （package per day x year） of ≥20 （P = 0.002）; （3） patients with liver cirrhosis （P = 0.042）. CONCLUSION： Our results indicate that age, smoking and liver cirrhosis enhance the development of IPF in HCV positive patients.

关键词： Hepatitis B virus Hepatitis C virus Idiopathic pulmonary fibrosis A retrospective cohort study

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Phosphoglyceride crystal deposition disease requiring differential diagnosis from malignant tumors and confirmed by Raman spectroscopy: A case report

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World Journal of Clinical Cases 2022年第23期10卷 8304-8311页

作者： Yu Ohkura Hironori Uruga Masato Shiiba Shinji Ito Hayato Shimoyama Makiko Ishihara Masaki Ueno Harushi Udagawa Department of Gastroenterological Surgery Toranomon HospitalTokyo 105-8470Japan Department of Diagnostic Pathology Toranomon HospitalTokyo 105-8470Japan Department of Diagnostic Imaging Center Toranomon HospitalTokyo 105-8470Japan

BACKGROUND Phosphoglyceride crystal deposition disease(PCDD)is a rare acquired disease in which phospholipid crystals deposit in bone and soft tissue long after surgery,trauma,or repeated *** SUMMARY A 60-year-old-woman was referred to our department because of multiple abdominal masses after open splenectomy for idiopathic thrombocytopenic purpura 29 years *** the masses showed marked fluorodeoxyglucose(FDG)uptake on ^(18)F-fluorodeoxyglucose positron emission tomography(^(18)F-FDGPET)and were strongly suspected to be malignant *** biopsies were performed,and the abdominal masses were found to be aligned vertically,three in a row,along the tissue layers cut in the patient’s previous *** finding of the specimens showed foreign body granuloma consisting of histiocytes and multinucleated giant cells accumulating around needle-like *** crystals were confirmed as phosphoglyceride by Raman spectroscopy,and PCDD was *** our knowledge,this is the first report of PCDD diagnosed by Raman *** We made a definitive diagnosis of PCDD in a patient with multiple tumors showing marked FDG uptake on ^(18)F-FDG-PET by incisional biopsy and composition analysis using Raman spectroscopy,a method that has not previously been reported for the diagnosis of PCDD.

关键词： Phosphoglyceride crystal deposition disease Raman spectroscopy Positron emission tomography Foreign body granuloma with crystal deposition Surgical scar Case report

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Benign esophageal stricture after thermal injury treated with esophagectomy and ileocolon interposition

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World Journal of Gastroenterology 2014年第27期20卷 9205-9209页

作者： Toshihiro Kitajima Kota Momose Seigi Lee Shusuke Haruta Hisashi Shinohara Masaki Ueno Takeshi Fujii Harushi Udagawa Department of Digestive Surgery Toranomon Hospital 2-2-2 Toranomon Minato-ku Tokyo 105-8470 Japan Department of Pathology Toranomon Hospital 2-2-2 Toranomon Minato-ku Tokyo 105-8470 Japan

Thermal injuries of the esophagus are rare causes of benign esophageal stricture, and all published cases were successfully treated with conservative management. A 28-year-old Japanese man with a thermal esophageal injury caused by drinking a cup of hot coffee six months earlier was referred to our hospital. The hot coffee was consumed in a single gulp at a party. Although the patient had been treated conservatively at another hospital, his symptoms of dysphagia gradually worsened after discharge. An upper gastrointestinal endoscopy and computed tomography revealed a pinhole like area of stricture located 19 cm distally from the incisors to the esophagogastric junction, as well as circumferential stenosis with notable wall thickness at the same site. The patient underwent a thoracoscopic esophageal resection with reconstruction using ileocolon interposition. The pathological findings revealed wall thickening along the entire length of the esophagus, with massive fibrosis extending to the muscularis propria and adventitia at almost all levels. Treatment with balloon dilation for long areas of stricture is generally difficult, and stent placement in patients with benign esophageal stricture, particularly young patients, is not yet widely accepted due to the incidence of late adverse events. Considering the curability and qualityof-life associated with a long expected prognosis, we determined that surgery was the best treatment option for this young patient. In this case, we decided to perform an esophagectomy and reconstruction with ileocolon interposition in order to preserve the reservoir function of the stomach and to avoid any problems related to the reflux of gastric contents. In conclusion, resection of the esophagus is a treatment option in patients with benign esophageal injury, especially in cases involving young patients with refractory esophageal stricture. In addition, ileocolon interposition may help to improve the quality-of-life of patients.

关键词： Thermal injury Benign esophageal stricture Esophageal resection Ileocolon interposition Video-assisted thoracic surgery

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Solid pseudopapillary neoplasm of the pancreas in a young male with main pancreatic duct dilatation: A case report

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World Journal of Clinical Cases 2021年第36期9卷 11382-11391页

作者： Saki Nakashima Yoshiki Sato Tsunao Imamura Daisuke Hattori Tetsuo Tamura Rikako Koyama Junichiro Sato Yuta Kobayashi Masaji Hashimoto Department of Neurology The University of Tokyo HospitalBunkyo-ku 113-8655TokyoJapan Department of Gastroenterology Toranomon HospitalTokyo 105-0001Japan Department of Pathology Toranomon HospitalTokyo 105-0001Japan Department of Gastrointestinal Surgery Toranomon HospitalTokyo 105-0001Japan

BACKGROUND Solid pseudopapillary neoplasms(SPNs)are rare tumors of the ***,they occur in young females,often have characteristic imaging features,such as cystic components and calcification,and have few effects on the pancreatic *** SUMMARY A 31-year-old man was admitted to our hospital with the chief complaint of epigastric *** was only mild tenderness in his upper abdomen,and blood tests showed only a slight increase in alkaline ***-enhanced computed tomography showed a 40-mm-diameter,hypovascular mass in the head of the pancreas,and the main pancreatic duct upstream of the mass was severely *** resonance imaging showed low intensity on T1-weighted images,with high intensity on T2-weighted image in some *** ductal adenocarcinoma was the primary differential *** vein infiltration could not be ruled out,so this case was a candidate for neoadjuvant ***,endoscopic ultrasound-guided fine needle aspiration was performed,and pathological evaluation and immunostaining suggested a diagnosis of ***,pancreatoduodenectomy was *** year after the operation,the patient is alive with no *** Main pancreatic duct dilatation is usually a finding of suspected pancreatic ***,pancreatic duct dilatation can occur in SPN depending on the location and growth ***,SPN should be considered in the differential diagnosis of tumors with pancreatic duct dilatation,and pathological evaluation by endoscopic ultrasound-guided fine needle aspiration should be actively performed.

关键词： Solid pseudopapillary neoplasm Endoscopic ultrasound-guided fine-needle aspiration Main pancreatic duct dilatation Male Case report

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Original single-incision laparoscopic cholecystectomy for acute inflammation of the gallbladder

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World Journal of Gastroenterology 2012年第9期18卷 944-951页

作者： Kazunari Sasaki Goro Watanabe Masamichi Matsuda Masaji Hashimoto Department of Digestive Surgery Hepato Pancreato Biliary Surgery UnitToranomon Hospital

AIM： To investigate the safety and feasibility of our original single-incision laparoscopic cholecystectomy （SII_C） for acute inflamed gallbladder （AIG）.

关键词： Single-incision laparoscopic cholecystectomy Acute cholecystitis Acute cholangitis

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Primary hepatic neuroendocrine neoplasm diagnosed by somatostatin receptor scintigraphy:A case report

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World Journal of Clinical Cases 2022年第7期10卷 2222-2228页

作者： Miho Akabane Yuta Kobayashi Keiichi Kinowaki Satoshi Okubo Junichi Shindoh Masaji Hashimoto Division of Hepatobiliary-pancreatic Surgery Department of Gastroenterological SurgeryToranomon HospitalTokyo 105-8470Japan Department of Diagnostic Pathology Toranomon HospitalTokyo 105-8470Japan

BACKGROUND Primary hepatic neuroendocrine neoplasm(NEN)is a rare condition,and it is difficult to differentiate between primary and metastatic hepatic ***,we report a case of primary hepatic NEN that initially mimicked a hemangioma but showed a gradual increase in size on long-term careful *** SUMMARY A 47-year-old woman was incidentally diagnosed with a 12-mm liver mass,suspected to be a *** then,regular follow-up had been carried *** years later,she was referred to our institute due to the tumor(located in segment 4)having increased to 20 *** imaging studies depicted no apparent extrahepatic *** emission tomography(PET)/computed tomography exhibited significant accumulation in the mass lesion,which made us consider the possibility of *** hepatectomy was *** histopathological diagnosis was neuroendocrine tumor grade 2,with somatostatin receptor 2 a/5 *** somatostatin receptor scintigraphy(SRS)showed no other site,leading to the diagnosis of NEN of primary hepatic *** gradual growth of the hepatic NEN over 10 years suggested that it was likely to be a primary liver *** In this case,positivity on PET and postoperative SRS may have helped determine whether the tumor was primary or metastatic.

关键词： Hepatic neoplasm Scintigraphy Surgery Positron-emission tomography Clinical decision-making Case report

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Stratification of risk of recurrence after curative-intent treatment for small hepatocellular carcinoma

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Hepatobiliary Surgery and Nutrition 2019年第6期8卷 649-650页

作者： Junichi Shindoh Hepatobiliary-Pancreatic Surgery Division Department of Gastroenterological SurgeryToranomon HospitalTokyoJapan

For patients with preserved liver function,tumor number and size have conventionally been main criteria for selecting optimal treatment for hepatocellular carcinoma(HCC)(1,2).Particularly for the group of patients with small(≤3 cm)HCC,there have been aggressive discussions regarding the superiority of surgery *** therapies(3)because this group of patients may enjoy long-term survival with an adequate curative-intent treatment.

关键词： treatment. treatment discussions

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Right hepatectomy for giant cavernous hemangioma with diffuse hemangiomatosis around Glisson's capsule

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World Journal of Gastroenterology 2014年第25期20卷 8312-8316页

作者： Yu Ohkura Masaji Hashimoto Seigi Lee Kazunari Sasaki Masamichi Matsuda Goro Watanabe Department of Digestive Surgery Hepato Pancreato Billiary Surgery UnitToranomon HospitalTokyo 105-8470Japan

Diffuse liver hemangiomatosis with giant cavernous hemangioma in adult is extremely rare. A 35 year-old woman presented to hospital with main complaint of epigastric pain and abdominal fullness. An enhanced computed tomography scan revealed a massive liver tumor in right lobe about 150 mm in size. There was contrast enhancement at the periphery of the mass consistent with a cavernous hemangioma. She underwent right hepatectomy. Histologically, it was diagnosed as a cavernous hemangioma. And also, hemangiomatous lesions were scattered around the Glisson’s capsule on the back ground liver. These hemangiomatous lesions were not recognized preoperatively. Even if we couldn’t diagnose hemangiomatosis around the main giant hemangioma preoperatively, we need to take enough surgical margins because the giant hemangioma has the potential to have small hemangiomatous lesions around the tumor. We reported right hepatectomy for giant cavernous hemangioma with diffuse hepatic hemangiomatosis without an extrahepatic lesion in an adult.

关键词： Giant cavernous hemangioma Hemangiomatosis Right hepatectomy Around Glisson’ s capsule Surgery

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Bronchial bleeding caused by recurrent pneumonia after radical esophagectomy for esophageal cancer

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World Journal of Gastroenterology 2015年第11期21卷 3394-3401页

作者： Toshihiro Kitajima Kota Momose Seigi Lee Shusuke Haruta Masaki Ueno Hisashi Shinohara Sakashi Fujimori Takeshi Fujii Ryoji Takei Tadasu Kohno Harushi Udagawa Department of Gastroenterological Surgery Toranomon Hospital Department of Thoracic Surgery Toranomon Hospital Department of Pathology Toranomon Hospital Department of Radiology Toranomon Hospital

We herein report a case of bronchial bleeding afterradical esophagectomy that was treated with lobectomy.A 65-year-old male who underwent subtotal esophagectomy with three-field lymph node dissection for esophageal carcinoma was referred to our hospital because of sudden *** the esophagectomy,bilateral vocal cord paralysis was observed,and the patient suffered from repeated episodes of aspiration *** revealed hemosputum in the right middle lobe bronchus,and contrast-enhanced computed tomography showed tortuous arteries arising from the right inferior phrenic artery and left subclavian artery toward the right middle lobe *** bronchial arterial embolization was performed twice to control the recurrent hemoptysis,the procedures were *** middle lobectomy was therefore performed via video-assisted thoracic *** bronchial arterys with medial hypertrophy and overgrowth of the small branches were noted near the bronchus in the resected *** patient recovered uneventfully and was discharged on postoperative day 14.

关键词： Hemoptysis Esophagectomy Recurrent laryngeal nerve

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Impairment of secondary peristalsis in Barrett's esophagus by transnasal endoscopy-based testing

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World Journal of Gastroenterology 2014年第3期20卷 822-828页

作者： Go Kobayashi Mitsuru Kaise Hiroshi Arakawa Hisao Tajiri Department of Gastroenterology and Hepatology Jikei University Daisan Hospital Department of Gastroenterology Toranomon Hospital Department of Endoscopy Jikei University Kashiwa Hospital Department of Gastroenterology and Hepatology Jikei University School of Medicine

AIM: To investigate dysfunctions in esophageal peristalsis and sensation in patients with Barrett’s esophagus following acid infusion using endoscopy-based testing.

关键词： Barrett’ s esophagus, Transnasal endoscopy, Acid infusion test, Esophageal sensation, Secondary peristalsis

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