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Monogenic gene therapy for glaucoma and optic nerve injury

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Neural Regeneration Research 2025年第3期20卷 815-816页

作者： Chikako Harada Xiaoli Guo Takayuki Harada Visual Research Project Tokyo Metropolitan Institute of Medical ScienceTokyoJapan

The prevalence of glaucoma, the second leading cause of global blindness, is increasing due to aging populations. In glaucoma, degeneration of the optic nerve and retinal ganglion cells(RGCs) causes visual field defec... 详细信息

关键词： visual glaucoma degeneration

P2Y1 receptor in Alzheimer’s disease

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Neural Regeneration Research 2025年第2期20卷 440-453页

作者： Shan Luo Yifei Wang Tatsuhiro Hisatsune Department of Integrated Biosciences The University of TokyoKashiwaJapan

Alzheimer’s disease is the most frequent form of dementia characterized by the deposition of amyloid-beta plaques and neurofibrillary tangles consisting of hyperphosphorylated *** amyloid-beta plaques has been a primary direction for developing Alzheimer’s disease treatments in the last ***,existing drugs targeting amyloid-beta plaques have not fully yielded the expected results in the clinic,necessitating the exploration of alternative therapeutic *** evidence unravels that astrocyte morphology and function alter in the brain of Alzheimer’s disease patients,with dysregulated astrocytic purinergic receptors,particularly the P2Y1 receptor,all of which constitute the pathophysiology of Alzheimer’s *** receptors are not only crucial for maintaining normal astrocyte function but are also highly implicated in neuroinflammation in Alzheimer’s *** review delves into recent insights into the association between P2Y1 receptor and Alzheimer’s disease to underscore the potential neuroprotective role of P2Y1 receptor in Alzheimer’s disease by mitigating neuroinflammation,thus offering promising avenues for developing drugs for Alzheimer’s disease and potentially contributing to the development of more effective treatments.

关键词： astrocytes neuroinflammation P2Y1 receptor purinergic receptor

Role of resident memory T cells in neuroinflammatory and neurodegenerative diseases in the central nervous system

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Neural Regeneration Research 2025年第11期20卷 3227-3228页

作者： Kimitoshi Kimura Department of Neurology Kyoto University Graduate School of MedicineTokyoJapan Department of Immunology National Center of Neurology and PsychiatryTokyoJapan

The immune system has been attracting increasing attention in the field of chronic neurological disorders in the central nervous system(CNS).Autoreactive T cells targeting CNS antigens play a crucial role in the development of various autoimmune diseases,such as multiple sclerosis(MS)and neuromyelitis optica spectrum disorder(NMOSD).Moreover,T cells are now recognized as a pivotal contributor to the pathology of neurodegenerative disorders,including Alzheimer's disease(AD),Parkinson's disease(PD),and multiple system atrophy.

关键词： diseases degenerative pathology

Roles of N-cadherin in cerebral cortical development:cooperation with membrane trafficking and actin cytoskeletal regulation

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Neural Regeneration Research 2025年第1期20卷 188-190页

作者： Shiho Ito Takeshi Kawauchi Department of Adaptive and Maladaptive Responses in Health and Disease Graduate School of MedicineKyoto UniversityKyotoJapan Department of Physiology Keio University School of MedicineTokyoJapan

Cell adhesion plays pivotal roles in the morphogenesis of multicellular *** cells form several types of cell-to-cell adhesion,including zonula occludens(tight junctions),zonula adhaerens(adherens junctions),and macula adhaerens(desmosomes).Although these adhesion complexes are basically observed only in epithelial cells,cadherins,which are the major cell adhesion molecules of adherens junctions,are expressed in both epithelial and non-epithelial tissues,including neural tissues(Kawauchi,2012).The cadherin superfamily consists of more than 100 members,but classic cadherins.

关键词： cerebral skeletal cooperation

Spinal cord injury regenerative therapy development:integration of design of experiments

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Neural Regeneration Research 2025年第9期20卷 2571-2573页

作者： Yuji Okano Hideyuki Okano Yoshitaka Kase Division of CNS Regeneration and Drug Discovery International Center for Brain Science(ICBS)Fujita Health UniversityKutsukake-ChoToyoake-ShiAichiJapan Department of Extended Intelligence for Medicine The Ishii-Ishibashi LaboratoryKeio University School of MedicineShinanomachiShinjuku-KuTokyoJapan Keio University Regenerative Medicine Research Center Kawasaki-kuKawasaki-shiJapan

Spinal cord injury(SCI)can cause motor and sensory paralysis,and autonomic nervous system disorders including malfunction of urination and defecation,thereby significantly impairing the quality of *** continue to explo re new stem cell strategies for the treatment of paralysis by transpla nting human induced pluripotent stem cell-derived neural ste m/progenitor cells(hiPSCNS/PCs)into spinal cord injured tissues.

关键词： Spinal paralysis injury

How to get high-efficiency lead chalcogenide quantum dot solar cells?

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Science China(Physics,Mechanics & Astronomy) 2023年第1期66卷 34-59页

作者： Chao Ding Qing Shen Faculty of Informatics and Engineering The University of Electro-CommunicationsTokyo 182-8585Japan

Lead chalcogenide colloidal quantum dots(CQDs)are regarded as attractive absorption materials for novel solar cells(SCs).The cost of lead chalcogenide CQD has been decreased to a commercialization target of$5/g due to the direct production of CQD ***,the photoelectric conversion efficiency(PCE)of lead chalcogenide CQDSCs is presently close to 14%,well below the commercialization target(20%),which is only 41%of the theoretical Shockley-Queisser limit *** this study,the different losses of open-circuit voltage(V_(oc)),fill factor(FF),and short circuit current density(J_(sc))for current CQDSCs are systematically discussed,as well as the percentage and likely causes of each *** the primary reasons for the CQDSCs’performance constraints are *** that,we focus on the CQDSCs interfaces(i.e.,CQD/CQD,CQD/HTL,and ETL/CQD)and explore viable ways to reduce device performance ***,based on the discussion above,we propose many enhancements to significantly solve numerous major obstacles impeding device performance to boost the PCE of CQDSCs for future commercialization significantly.

关键词： lead chalcogenide colloidal quantum dots solar cell interface engineering non-radiative carrier recombination charge carrier transport losses

Recrystallization behaviour of fine-grained magnesium alloy after hot deformation

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中国有色金属学会会刊：英文版 2007年第6期17卷 1139-1142页

作者：杨续跃 H. Miura T. Sakai School of Materials Science and Engineering Central South University Department of Mechanical Engineering and Intell igent Systems UEC Tokyo Tokyo 182-8585 Japan Department of Mechanical Engineering and Intell igent Systems UEC Tokyo Tokyo 182-8585 JapanYANGXu-yue

Annealing behaviors of hot-deformed magnesium alloy AZ31 were studied at temperatures from 300 to 673 K by optical and SEM/EBSD metallographic observation. Temperature dependence of the average grain size(D) is categorized into three temperature regions, i.e. an incubation period for grain growth, rapid grain coarsening, and normal grain growth. The number of fine grains per unit area, however, is reduced remarkably even in incubation period. This leads to grain coarsening taking place continuously in the whole temperature regions. In contrast, the deformation texture scarcely changes even after full annealing at high temperatures. It is concluded that the annealing processes operating in hot-deformed magnesium alloy with continuous dynamic recrystallized grain structures can be mainly controlled by grain coarsening accompanied with no texture change, that is, continuous static recrystallization.

关键词：镁合金退火连续再结晶晶体生长纹理

Haptic interface using tendon electrical stimulation with consideration of multimodal presentation

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Virtual Reality & Intelligent Hardware 2019年第2期1卷 163-175页

作者： Akifumi TAKAHASHI Kenta TANABE Hiroyuki KAJIMOTO Department of Informatics University of Electro-CommunicationsChofuTokyo 182-8585Japan

Background Our previous studies have shown that electrical stimulation from the skin surface to the tendon region(Tendon Electrical Stimulation:TES)can elicit a force sensation,and adjusting the current parameters can control the amount of the *** is thought to present a proprioceptive force sensation by stimulating receptors or sensory nerves responsible for recognizing the magnitude of the muscle contraction existing inside the tendon,so it can be a proprioceptive module of a small-size,low-cost force feedback *** there is also suspect that TES presents only strong,noisy skin *** previous study,it was found that TES has some limitation on varying *** In this study,in addition to characterizing the proprioceptive sensation induced by TES,we constructed a multimodal presentation system reproducing a situation in which force is applied to the hand was offered,so as to investigate whether TES contributed to the reproduction of haptics cooperating with other modalities,rather than disturbing ***,we used vibration to present a cutaneous sensation and a visual head mounted display(HMD)system to present simultaneous *** this system,we also evaluated the efficacy of TES itself and that of the multimodal system involving *** We found that TES,along with visual and vibration stimulation,contributed to the perception of a certain *** Thus,TES appears to be an effective component of multimodal force sense presentation systems.

关键词： Tendon Electrical Stimulation Proprioception Multimodal Force sensation

Semantic segmentation-based semantic communication system for image transmission

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Digital Communications and Networks 2024年第3期10卷 519-527页

作者： Jiale Wu Celimuge Wu Yangfei Lin Tsutomu Yoshinaga Lei Zhong Xianfu Chen Yusheng Ji The University of Electro-Communication Tokyo182-8585Japan Toyota Motor Corporation Tokyo112-8701Japan VTT Technical Research Centre of Finland OuluFinland National Institute of Informatics(NII) Tokyo101-8430Japan

With the rapid development of artificial intelligence and the widespread use of the Internet of Things, semantic communication, as an emerging communication paradigm, has been attracting great interest. Taking image transmission as an example, from the semantic communication's view, not all pixels in the images are equally important for certain receivers. The existing semantic communication systems directly perform semantic encoding and decoding on the whole image, in which the region of interest cannot be identified. In this paper, we propose a novel semantic communication system for image transmission that can distinguish between Regions Of Interest (ROI) and Regions Of Non-Interest (RONI) based on semantic segmentation, where a semantic segmentation algorithm is used to classify each pixel of the image and distinguish ROI and RONI. The system also enables high-quality transmission of ROI with lower communication overheads by transmissions through different semantic communication networks with different bandwidth requirements. An improved metric θPSNR is proposed to evaluate the transmission accuracy of the novel semantic transmission network. Experimental results show that our proposed system achieves a significant performance improvement compared with existing approaches, namely, existing semantic communication approaches and the conventional approach without semantics.

关键词： Semantic Communication Semantic segmentation Image transmission Image compression Deep learning