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Expression of β-catenin in hepatocellular carcinoma

World Journal of Gastroenterology 2005年第16期11卷 2398-2401页

作者： Liem Thanh Tien Masahiro Ito Mikiko Nakao Daisuke Niino Meirmanov Serik Masahiro Nakashima Chun-Yang Wen Hiroshi Yatsuhashi Hiromi Ishibashi Department of Pathology National Nagasaki Medical Center 2-1001-1 KubaraOmuraNagasaki 856-8562Japan Department of Molecular Pathology Atomic Bomb Disease Institute Nagasaki University Graduate School of Biomedical Science1-12-4 SakamotoNagasaki 852-8523Japan tissue and histopathology section division of scientific data registry Atomic Bomb Disease Institute Nagasaki University Graduate School of Biomedical Science1-12-4 SakamotoNagasaki 852-8523Japan Department of Digestive Disease Nanjing Drum Tower Hospital Medical School of Nanjing UniversityNanjing 210008Jiangsu ProvinceChina Clinical Research Center National Nagasaki Medical Center 2-1001-1 KubaraOmuraNagasaki 856-8562Japan

AIM: The beta-catenin has been recognized as a critical member of the Wnt signaling pathway and plays an important role in the generation/differentiation of many tissues. Inappropriate activation of this pathway has been implicated in carcinogenesis. The mechanism underlying the development as well as its prognosis of hepatocellular carcinoma (HCC) has remained unclear. The purpose of this study is to analyze the expression of beta-catenin in HCC in relation to histological grades and viral hepatitis backgrounds. METHODS: Thirty-two sections were selected at random from autopsy and surgical cases of HCC. Immuohistologically, the location and positivity of beta-catenin expression in HCC was examined. RESULTS: Normal hepatocytes did not express beta-catenin. In 78% of HCC beta-catenin was expressed at the membrane of the cells, with or without cytoplasmic and/or nuclear expression. The tumor cells with well-and moderately-differentiated grades expressed frequently at the membrane and cytoplasm compared with poorly-differentiated type. Nuclear expression of beta-catenin was prone to occur in the tumor cells of poorly-differentiated grade. There were 15% of hepatitis C virus (HCV) backgrounds with nuclear expression. In contrast, there was 38% with nuclear expression in hepatitis B virus (HBV) backgrounds. In nonB-nonC hepatitis, no case expressed nuclear beta-catenin. CONCLUSION: The beta-catenin expression in HCC cells was heterogenous among types of hepatitis viral infection. Wnt signaling pathway might be deeply involved in less-differentiated HCC and HBV background. (C) 2005 The WJG Press and Elsevier Inc. All rights reserved.

关键词： Hepatocellular carcinoma beta-Catenin Immunohistochemistry

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Comprehensive analysis of uncertainty quantification for the 58Ni（n,p）58Co reaction cross section

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Chinese Physics C 2024年第9期48卷 174-179页

作者： Mahesh Choudhary Aman Sharma Namrata Singh Mahima Upadhyay Punit Dubey A.Gandhi Akash Hingu G Mishra Sukanya De L.S.Danu Ajay Kumar R.G.Thomas Saurav Sood Sajin Prasad S.Mukherjee I.N.Ruskov Yu.N.Kopatch A.Kumar Department of Physics Banaras Hindu University Horia Hulubei National Institute of Physics and Nuclear Engineering-IFIN-HH Department of Physics The Maharaja Sayajirao University of Baroda Nuclear Physics division Bhabha Atomic Research Centre Health Physics division Bhabha Atomic Research Centre Department of Electrical Power Engineering Brno University of Technology Institute for Nuclear Research and Nuclear Energy Bulgarian Academy of Sciences Joint Institute for Nuclear Research (JINR)

In this study,we measured the58Ni（n,p）58Co reaction cross section with neutron energies of 1.06,1.86,and 2.85 *** cross section was measured using neutron activation techniques and γ-ray spectroscopy,and it was compared with cross section data available in the ***,we calculated the covariance matrix of the measured cross section for the aforementioned nuclear *** uncertainties of the theoretical calculation for58Ni（n,p）58Co reaction cross section were calculated via Monte Carlo *** this study,we used uncertainties in the optical model and level density parameters to calculate uncertainties in the theoretical cross *** theoretical calculations were performed by using *** this study,we aim to analyze the effect of uncertainties of the nuclear model input as well as different experimental variables used to obtain the values of reaction cross section.

关键词： 58Ni(n, p)58Co reaction covariance analysis uncertainty quantification of cross section γ-ray spectroscopy

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Comparative dissolution study on counterfeit medicines of PDE-5 inhibitors

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Journal of Pharmaceutical Analysis 2014年第4期4卷 250-257页

作者： E.Deconinck S.Andriessens J.L.Bothy P.Courselle J.O.De Beer division of Food Medicines and Consumer SafetySection Medicinal ProductsScientific Institute of Public Health(WIV-ISP)J.Wytmansstraat 14B-1050 BrusselsBelgium

Counterfeit medicines are a growing problem in both developing and industrialised countries. In general the evaluation of these medicines is limited to the identification and the dosage of the active ingredients. In this study in vitro dissolution tests were conducted on two sets of counterfeit medicines containing PDE-5 inhibitors （sildenafil citrate and tadalafil）. The dissolution profiles were statistically compared to the ones of the genuine products using the f2-method and a comparison at each time point using the Cochran test. The results showed low equivalences between counterfeit and genuine products as well as higher variations around the mean dissolution value at the different time points for the counterfeit products.

关键词： Counterfeit PDE-5 inhibitors In vitro dissolution f2-Method Cochran test

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A novel expressed prostatic secretion(EPS)-urine metabolomic signature for the diagnosis of clinically significant prostate cancer

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Cancer Biology & Medicine 2021年第2期18卷 604-615页

作者： Denise Drago Annapaola Andolfo Ettore Mosca Alessandro Orro Luigi Nocera Vito Cucchiara MatteoBellone Francesco Montorsi Alberto Briganti ProMeFa Proteomics and Metabolomics FacilityCenter for Omics Sciences(COSR)IRCCS San Raffaele Scientific InstituteMilan 20132Italy Institute of Biomedical Technologies National Research Council(CNR)Milan 20090Italy Department of Urology and division of Experimental Oncology Urological Research Institute(URI)IRCCS San Raffaele Scientific InstituteMilan 20132Italy division of Immunology Transplantation and Infectious DiseasesIRCCS San Raffaele Scientific InstituteMilan 20132Italy

Objective:Significant efforts are currently being made to identify novel biomarkers for the diagnosis and risk stratification of prostate cancer(PCa).Metabolomics can be a very useful approach in biomarker discovery because metabolites are an important read-out of the disease when characterized in biological *** aimed to determine a metabolomic signature which can accurately distinguish men with clinically significant PCa from those affected by benign prostatic hyperplasia(BPH).Methods:We first performed untargeted metabolomics using ultrahigh-performance liquid chromatography tandem mass spectrometry on expressed prostatic secretion urine(EPS-urine)from 25 patients affected by BPH and 25 men with clinically significant PCa(defined as Gleason score≥3+4).Diagnosis was histologically confirmed after surgical *** EPS-urine metabolomic approach was then applied to a larger,prospective cohort of 92 consecutive patients undergoing multiparametric magnetic resonance imaging for clinical suspicion of PCa prior to ***:We established a novel metabolomic signature capable of accurately distinguishing PCa from benign tissue.A metabolomic signature was associated with clinically significant PCa in all subgroups of the Prostate Imaging Reporting and data System(PI-RADS)classification(100%and 89.13%of accuracy when the PI-RADS was in range of 1–2 and 4–5,respectively,and 87.50%in the more critical cases when the PI-RADS was 3).Conclusions:A combination of metabolites and clinical variables can effectively help in identifying PCa patients that might be overlooked by current imaging *** from EPS-urine should help in defining the diagnostic pathway of PCa,thus improving PCa detection and decreasing the number of unnecessary prostate biopsies.

关键词： Prostate cancer EPS-urine metabolomics prediction diagnosis

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The phenotypic convergence between microglia and peripheral macrophages during development and neuroinflammation paves the way for new therapeutic perspectives

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Neural Regeneration Research 2021年第4期16卷 635-637页

作者： Francesca Grassivaro Gianvito Martino Cinthia Farina Institute of Experimental Neurology Division of NeuroscienceSan Raffaele Scientific InstituteMilanItaly Vita-Salute San Raffaele University MilanItaly

Microglia,the tissue resident macrophages of the brain,are increasingly recognized as key players for central nervous system development and *** are long-lived cells deriving from a transient wave of yolk-sac derived erythro-myeloid progenitors early in *** unique ontology has prompted the search for specific markers to be used for their selective investigation and *** first generation of genomewide expression studies has provided a bundle of transcripts(such as Olfml3,Fcrls,Tmem119,P2ry12,Gpr34,and Siglech)useful to distinguish microglia from peripheral ***,more recent reports have revealed that microglial phenotype is constantly shaped by the microenvironment in a time-,and context-dependent *** this article,we review data that provide additional pieces to this complex scenario and show the existence of unexpected phenotypic convergence between microglia and peripheral macrophages at certain developmental stages and under pathological *** observations suggest that the two cell types act synergically boosting their mutual activities depending on the *** novel information about the biology of microglia and peripheral macrophages sheds new light about their therapeutic potential for neuroinflammatory and neurodegenerative diseases.

关键词： cell reprogramming cell therapy macrophages microglia neuroinflammation plasticity

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Expression of pituitary tumor transforming gene in human gastric carcinoma

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World Journal of Gastroenterology 2004年第4期10卷 481-483页

作者： Chun-YangWen ToshiyukiNakayama MutsumiMatsuu KazukoShichijo IchiroSekine Ai-PingWang Masahiro Nakashima Yi-Tao Ding Masahiro Ito Hiromi Ishibashi Department of Molecular Pathology Atomic Bomb Disease InstituteNagasaki University Graduate School of Biomedical Sciences1-12-4 SakamotoNagasaki 852-8523Japan Department of Digestive Disease Nanjing Drum Tower HospitalMedical School of Nanjing UniversityNanjing 210008Jiangsu ProvinceChina tissue and histopathology section division of scientific data registry Atomic Bomb Disease InstituteNagasaki University Graduate School of Biomedical Sciences1-12-4 SakamotoNagasaki 852-8523Japan Department of Hepatobiliary Surgery Nanjing Drum Tower HospitalMedical School of Nanjing UniversityNanjing 210008Jiangsu ProvinceChina Department of Pathology National Nagasaki Medical Center2-1001-1 KubaraOmuraNagasaki 856-8562Japan Clinical Research Center National Nagasaki Medical Center2-1001-1 KubaraOmuraNagasaki 856-8562Japan

AIM:Pituitary tumor transforming gene (PTTG1) is overexpressed in a variety of tumors, including carcinomas of the lung, breast, colon, as well as in leukemia, lymphoma and pituitary ***,there is little information on its expression in gastric carcinoma. We sought to investigate the expression of PTTG1 in gastric carcinoma and to explore the relationship between its expression and clinicopathological ***:We studied 75 primary human gastric adenocarcinomas, including 17 mucosal carcinomas, 21 submucosal infiltrative carcinomas, 12 carcinomas invading proprial muscle layers, 6 carcinomas reaching the subserosa,and 19 carcinomas penetrating the serosal *** analysis was performed using paraffinembedded sections of gastric ***: PTTG1 was expressed heterogeneously in carcinomas. Positive PTTG1 staining was observed in 65.3% of the carcinomas (49 of 75). Its expression did not correlate significantly with either the histological type or the depth of infiltration of the gastric ***,a statistical analysis showed significant differences between the primary adenocarcinomas and the associated metastatic lymph ***: The results of this study demonstrate that PTTG1 expression is enhanced in metastatic lymph nodes in comparison to that in primary carcinomas. We suggest that PTTG1 may contribute to lymph node metastases in gastric carcinoma.

关键词：垂体肿瘤转化基因胃癌基因表达免疫组织化学肿瘤侵袭肿瘤病理学

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Adipose-derived stem cells:Pathophysiologic implications vs therapeutic potential in systemic sclerosis

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World Journal of Stem Cells 2021年第1期13卷 30-48页

作者： Irene Rosa Eloisa Romano Bianca Saveria Fioretto Marco Matucci-Cerinic Mirko Manetti Department of Experimental and Clinical Medicine Section of Anatomy and HistologyUniversity of FlorenceFlorence 50134Italy Department of Experimental and Clinical Medicine Division of RheumatologyUniversity of FlorenceFlorence 50134Italy

Adipose-derived stem cells(ADSCs)residing in the stromal vascular fraction(SVF)of white adipose tissue are recently emerging as an alternative tool for stem cell-based therapy in systemic sclerosis(SSc),a complex connective tissue disorder affecting the skin and internal organs with fibrotic and vascular *** preclinical and clinical studies have reported promising therapeutic effects of fat grafting and autologous SVF/ADSC-based local treatment for facial and hand cutaneous manifestations of SSc ***,currently available data indicate that ADSCs may represent a double-edged sword in SSc,as they may exhibit a pro-fibrotic and anti-adipogenic phenotype,possibly behaving as an additional pathogenic source of pro-fibrotic myofibroblasts through the adipocyte-to-myofibroblast transition ***,in the perspective of a larger employ of SSc-ADSCs for further therapeutic applications,it is important to definitely unravel whether these cells present a comparable phenotype and similar immunosuppressive,anti-inflammatory,anti-fibrotic and pro-angiogenic properties in respect to healthy *** light of the dual role that ADSCs seem to play in SSc,this review will provide a summary of the most recent insights into the preclinical and clinical studies employing SVF and ADSCs for the treatment of the disease and,at the same time,will focus on the main findings highlighting the possible involvement of these stem cells in SSc-related fibrosis pathogenesis.

关键词： Systemic sclerosis Adipose-derived stromal vascular fraction Adiposederived stem cells Therapeutic approaches Pathogenesis Adipocyte-to-myofibroblast transition

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Procalcitonin in inflammatory bowel disease: Drawbacks and opportunities

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World Journal of Gastroenterology 2017年第47期23卷 8283-8290页

作者： Giuseppe Lippi Fabian Sanchis-Gomar section of Clinical Biochemistry University of Verona Leon H. Charney division of Cardiology New York University School of Medicine Department of Physiology Faculty of Medicine University of Valencia and INCLIVA Biomedical Research Institute

The measurement of procalcitonin has recently become a mainstay for the diagnosis and therapeutic management of severe bacterial infections, especially those sustained by Gram-negative bacteria. Therefore, the aim of this article is to provide a narrative overview on the potential role of procalcitonin measurement in patients with inflammatory bowel disease(IBD). According to the available scientific literature, the clinical significance of procalcitonin for diagnosing IBD or monitoring disease activity remains elusive, and its association with disease severity is confined to a limited number of case-control studies, with low sample size. Nevertheless, literature data also suggests that a supranormal procalcitonin serum concentration(i.e., > 0.5 ng/m L) may reflect the presence of a number of infective complications in IBD, especially bacterial enterocolitis, bacterial gastroenteritis, intraabdominal abscess, postsurgical infection and sepsis. Rather than for diagnosing or assessing disease activity, the measurement of this biomarker may hence retain practical clinical significance for early prediction, timely diagnosis and therapeutic monitoring of many IBDassociated infections and complications.

关键词： Intestinal bowel disease Chron’s disease Ulcerative colitis Procalcitonin

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Previous hepatitis B viral infection–an underestimated cause of pancreatic cancer

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World Journal of Gastroenterology 2022年第33期28卷 4812-4822页

作者： Sergey Batskikh Sergey Morozov Alexey Dorofeev Zanna Borunova Dmitry Kostyushev Sergey Brezgin Anastasiya Kostyusheva Vladimir Chulanov Department of Hepatology Moscow Clinical Scientific Center N.A.A.S.LoginovMoscow 111123Russia Department of Gastroenterology Hepatology and NutritionFederal Research Center of NutritionBiotechnology and Food SafetyMoscow 115446Russia Department of scientific and Clinical Laboratory Research Moscow Clinical Scientific Center N.A.A.S.LoginovMoscow 111123Russia Laboratory of Genetic Technologies Sechenov UniversityMoscow 119435Russia division of Biotechnology Scientific Center for Genetics and Life SciencesSirius University of Science and TechnologySochi 354340Russia Laboratory of Genetic Technologies and Translational Research National Medical Research Center for Tuberculosis and Infectious Diseases of Ministry of Health of RussiaMoscow 127994Russia

BACKGROUND The etiology of pancreatic cancer remains unclear. This limits the possibility of prevention and effective treatment. Hepatitis B virus(HBV) is responsible for the development of different types of cancer, but its role in pancreatic cancer is still being *** To assess the prevalence of previous HBV infection and to identify viral biomarkers in patients with pancreatic ductal adenocarcinoma(PDAC) to support the role of the virus in etiology of this *** The data of 130 hepatitis B surface antigen-negative subjects were available for the final analysis,including 60 patients with PDAC confirmed by cytology or histology and 70 sex-and age-matched controls. All the participants were tested for HBV biomarkers in blood [antibody to hepatitis B core antigen(anti-HBc), antibody to hepatitis B surface antigen(anti-HBs) and HBV DNA], and for those with PDAC, biomarkers in resected pancreatic tissues were tested(HBV DNA, HBV pregenomic RNA and covalently closed circular DNA). We performed immunohistochemistry staining of pancreatic tissues for hepatitis B virus X antigen and Ki-67 protein. Non-parametric statistics were used for the *** Anti-HBc was detected in 18/60(30%) patients with PDAC and in 9/70(13%) participants in the control group(P = 0.029). Accordingly, the odds of PDAC in anti-HBc-positive subjects were higher compared to those with no previous HBV infection(odds ratio: 2.905, 95% confidence interval: 1.191-7.084, standard error 0.455). HBV DNA was detected in 8 cases of PDAC and in 6 of them in the pancreatic tumor tissue samples only(all patients were anti-HBc positive). Blood HBV DNA was negative in all subjects of the control group with positive results of the serum anti-HBc test. Among 9 patients with PDAC, 5 revealed signs of replicative competence of the virus(covalently closed circular DNA with or without pregenomic RNA) in the pancreatic tumor tissue samples. Hepatitis B virus X antigen expression and active cell

关键词： Hepatitis B virus Previous hepatitis B Occult hepatitis B virus infection Pancreatic cancer Pancreatic ductal adenocarcinoma

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REVIEW OF PARTICLE PHYSICS Particle data Group

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Chinese Physics C 2016年第10期40卷 1-28页

作者： C. Patrignani (Particle data Group) Chinese Physics C 40 100001 (2016)

The Review summarizes much of particle physics and cosmology. Using data from previous editions, plus 3,062 new measurements from 721 papers, we list, evaluate, and average measured properties of gauge bosons and the recently discovered Higgs boson, leptons, quarks, mesons, and baryons. We summarize searches for hypothetical particles such as supersymmetric particles, heavy bosons, axions, dark photons, etc. All the particle properties and search limits are listed in Summary Tables. We also give numerous tables, figures, formulae, and reviews of topics such as Higgs Boson Physics, Supersymmetry, Grand Unified Theories, Neutrino Mixing, Dark Energy, Dark Matter, Cosmology, Particle Detectors, Colliders, Probability and Statistics. Among the 117 reviews are many that are new or heavily revised, including new reviews on Pentaquarks and Inflation. The complete Review is published online in a journal and on the website of the Particle data Group （http：//pdg. lbl. gov）. The printed PDG Book contains the Summary Tables and all review articles but no longer includes the detailed tables from the Particle Listings. A Booklet with the Summary Tables and abbreviated versions of some of the review articles is also available.

关键词： PROTON-PROTON COLLISIONS DEEP-INELASTIC SCATTERING HIGGS-BOSON PRODUCTION TO-LEADING-ORDER STRONG-COUPLING CONSTANT ANOMALOUS MAGNETIC-MOMENT PRODUCTION CROSS-section GRAND UNIFIED THEORIES QUARK-PAIR PRODUCTION ELECTROWEAK SYMMETRY-BREAKING

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