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Chlorinated Polyfluoroalkyl Ether Sulfonic Acids(Cl-PFESAs)Are Associated with Eye Diseases in Humans and Eye Toxicity in Zebrafish

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Environment & Health 2024年第6期2卷 390-400页

作者： Lu-Yin Wu Li-Xia Liang Yang Zhou Zeeshan Mohammed Zhengmin Min Qian Stephen Edward McMillin Maya Tabet Chu Chu Yuan-Yuan Fan Jia-Xin Zhou Jing-Wen Huang Wei-Hong Tan Guang-Hui Dong Li-Zi Lin Joint International Research Laboratory of Environment and Health Ministry of EducationGuangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk AssessmentDepartment of Occupational and Environmental HealthSchool of Public HealthSun Yat-sen UniversityGuangzhou 510080China State Environmental Protection Key Laboratory of Environmental Pollution Health Risk Assessment South China Institute of Environmental SciencesMinistry of Environmental ProtectionGuangzhou 510655China Department of Developmental Biology&Genetics School of Biological SciencesIndian Institute of ScienceBangalore 400060India Department of Epidemiology and Biostatistics College for Public Health&Social JusticeSaint Louis UniversitySt.LouisMissouri 63104United States School of Social Work Saint Louis UniversitySt.LouisMissouri 63103United States College of Global Population Health University of Health Sciences and Pharmacy in St.LouisSt.LouisMissouri 63110United States Guangdong Cardiovascular Institute Department of Reproductive MedicineDepartment of Obstetrics and GynecologyGuangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Department of Reproductive Medicine and Genetics Center The People’s Hospital of Guangxi Zhuang Autonomous RegionNanning 530021China

Evidence from animal experiments has shown that chlorinated polyfluoroalkyl ether sulfonic acids(Cl-PFESAs)can induce vision dysfunction in ***,environmental epidemiological evidence supporting this hypothesis remains *** our case−control study,samples collected from 270 individuals(135 controls and 135 cases)from the Isomers of C8 Health Project data were analyzed for *** also repeated our analysis on zebrafish to support our findings in humans and to decipher the mechanism underlying Cl-PFESA eye *** serum levels of per-and polyfluoroalkyl substances(PFASs)and alternatives were significantly higher in the cases than in the *** serum Cl-PFESA levels were associated with greater odds of eye diseases,and the trend showed a statistically significant dose-dependent *** Shapley additive explanations(SHAP)value indicated that 8:2 Cl-PFESA was the dominant eye disease risk factor among the 13 studied *** zebrafish experiments,Cl-PFESAs induced eye toxicity in adult zebrafish by oxidative damage and cell *** to the control group,there was significantly reduced thicknesses of the inner plexiform layer(IPL),outer plexiform layer(OPL),and retinal tissue in the zebrafish exposed to *** study provides human clinical and animal experimental data,showing that exposure to PFASs increases the odds of the development of eye toxicity.

关键词： eye diseases chlorinated polyfluoroalkyl ether sulfonic acids(Cl-PFESAs) case−control study shapley additive explanations(SHAP) zebrafish experiment

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Alterations in fibrinolytic system proteins PAI-1,MMP-3,MMP-8,TIMP-1 and TIMP-2 in post-cholecystectomy bile duct injury

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Journal of Biomedical Science and engineering 2013年第8期6卷 58-67页

作者： Jose Manuel Hermosillo-Sandoval Luis Miguel Román-Pintos Adolfo Daniel Rodriguez-Carrizález Ernesto Germán Cardona-Munoz Fermin Paul Pacheco-Moisés Genaro Gabriel Ortiz Alejandra Guillermina Miranda-Diaz Department of Surgery Specialties Hospital of the National Occidental Medical CentreSocial Security Institute of Mexico(Departamento de CirugíaHospital de Especialidades del Centro Médico Nacional de OccidenteInstituto Mexicano del Seguro Social)GuadalajaraMéxico University Health Sciences Centre University of Guadalajara(Centro Universitario de Ciencias de la SaludUniversidad de Guadalajara)GuadalajaraMéxico University Centre for Exact and engineering Sciences University of Guadalajara(Centro Universitario de Ciencias Exactas e IngenieríasUniversidad de Guadalajara)GuadalajaraMéxico Pathology and Oxidative Stress Laboratory Division of NeurosciencesOccidental Biomedical Research CentreSocial Security Institute of Mexico(Laboratorio de Estrés Oxidativo&PatologíaDivision de NeurocienciasCentro de Investigacion Biomédica de OccidenteInstituto Mexicano del Seguro Social)GuadalajaraMéxico

Introduction: In bile duct injuries (BDI), cholestasis and cholangitis can alter the fibrinolytic system by promoting an increase of extracellular matrix depositions which favor an imbalance between metalloproteinases (MMPs) and their tissue inhibitors (TIMPs). Materials and Methods: Levels of PAI-1, MMP-3, MMP-8, TIMP-1 and TIMP-2 in 35 patients with post-cholecystectomy BDI by complete biliary obstruction were measured and compared to a healthy control group. Sirius red staining and immune staining for MMP-3 and MMP-8 were also undertaken in liver biopsies. Results: Levels of PAI-1, TIMP-1, TIMP-2 and MMP-8 were higher in BDI than healthy controls: 15 ± 2 ng/mL vs 7.1 ± 2 ng/mL (p 0.024);539 ± 64 ng/mL vs 256 ± 13 ng/mL (p p p 2 vs. 22865.7 ± 3865 μm2 in healthy controls (p 2 vs. 30744.2 ± 5810.2 μm2 (p 2 vs. 116337.9 ± 24803.3 μm2 (p 0.55). These results suggest an imbalance between fibrogenic/fibrinolytic protein levels. Interestingly, expression of the fibrinolytic protein MMP-8 was increased in serum and liver biopsies in BDI. Conclusion: We found an imbalance of profibrogenic molecules which promote extracellular matrix deposition. The over-expression of fibrinolytic proteins such as MMP-8 could limit liver fibrosis, preventing hepatic dysfunction in post-cholecystectomy BDI.

关键词： Cholecystectomy Bile Duct Injury(BDI) Plasminogen Activator Inhibitor Type 1(PAI-1) tissue Inhibitors of Metalloproteinases(TIMP’s) Metalloproteinases(MMP’s)

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From the microspheres to scaffolds:advances in polymer microsphere scaffolds for bone regeneration applications

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Biomaterials Translational 2024年第3期5卷 274-299页

作者： Shuhao Yang Haoming Wu Chao Peng Jian He Zhengguang Pu Zhidong Lin Jun Wang Yingkun Hu Qiao Su Bingnan Zhou Xin Yong Hai Lan Ning Hu Xulin Hu Department of Orthopaedics The First Affiliated Hospital of Chongqing Medical UniversityChongqingChina Orthopedic Laboratory of Chongqing Medical University ChongqingChina Clinical Medical College and Affiliated Hospital of Chengdu University Chengdu UniversityChengduSichuan ProvinceChina Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengduSichuan ProvinceChina School of Preclinical Medicine of Chengdu University Chengdu UniversityChengduSichuan ProvinceChina College of Basic Medicine and Forensic Medicine Henan University of Science and TechnologyLuoyangHenan ProvinceChina The Second Affiliated Hospital of Chinese Medicine Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina West China School of Stomatology Sichuan UniversityChengduSichuan ProvinceChina School of engineering Massachusetts Institute of TechnologyCambridgeMAUSA Key Laboratory of Birth Defects and Related Diseases of Women and Children Department of PaediatricsWest China Second University HospitalState Key Laboratory of BiotherapySichuan UniversityChengduSichuan ProvinceChina

The treatment and repair of bone tissue damage and loss due to infection,tumours,and trauma are major challenges in clinical *** bone scaffolds offer a safer,simpler,and more feasible alternative to bone transplantation,serving to fill bone defects and promote bone tissue ***,these scaffolds should possess osteoconductive,osteoinductive,and osseointegrative ***,the current first-generation implants,represented by titanium alloys,have shown poor bone-implant integration performance and cannot meet the requirements for bone tissue *** has led to increased research on second and third generation artificial bone scaffolds,which focus on loading bioactive molecules and *** microspheres,known for their high specific surface areas at the micro-and nanoscale,exhibit excellent cell and drug delivery ***,with their unique rigid structure,microsphere scaffolds can be constructed using methods such as thermal sintering,injection,and microsphere *** scaffolds not only ensure the excellent cell drug loading performance of microspheres but also exhibit spatial modulation behaviour,aiding in bone repair within a three-dimensional network *** article provides a summary and discussion of the use of polymer microsphere scaffolds for bone repair,focusing on the mechanisms of bone tissue repair and the current status of clinical bone grafts,aimed at advancing research in bone repair.

关键词： biomimetic scaffolds bone tissue engineering polymer microspheres regenerative medicine

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由肺泡2型细胞产生的PAI-1驱动了与衰老相关的肺纤维化（英文）

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engineering 2024年第11期 74-87页

作者：全蕊石晨宏孙亚楠张承英毕然张怡然毕昕 Bin Liu 董子衡金德奎李依璇 Key Laboratory of Functional Dairy Co-Constructed by the Ministry of Education and Beijing Municipality Department of General Practice The Third Medical Center of the Chinese PLA General Hospital Department of Thoracic Surgery The Third Medical Center of the Chinese PLA General Hospital Center for Nanomedicine and Department of Anesthesiology Brigham and Women's Hospital Harvard Medical School School of Computer and Information engineering Luoyang Institute of Science and Technology

Pulmonary fibrosis(PF) is a lethal lung disease that predominantly affects older adults; however, whether and how aging triggers fibrosis remains unclear. To pinpoint the predominant initiating factors of PF, we first analyzed single-cell RNA sequencing(scRNA-seq) data from the lung tissues of 45 normal donors and51 PF patients and found that aging might serve as the primary catalyst for PF development. To further investigate the influence of aging on PF formation, we conducted a comprehensive and thorough study employing a natural aging mouse model. We found that dynamic alterations in the quantity and types of collagen fibers during aging-induced PF progression, especially in collagenous(Col) I, emerged as the predominant driver of PF. We then investigated the regulation of Col I synthesis during aging using primary alveolar type 2(AT2) cells and A549 cells line through conditioned media and Transwell coculture, and found that secretions-particularly plasminogen activator inhibitor(PAI)-1-from aged AT2 cells promoted fibrosis and enhanced collagen type I alpha 1(Col1al) production via the transforming growth factor(TGF)-β/small mother against decapentaplegic(Smad)2/3 pathway. Furthermore, scRNA-seq and a histological analysis of human lung tissue demonstrated a significant upregulation of SERPINE1(the gene encoding PAI-1) and PAI-1 expression in both aging lung tissue and AT2 cells, which was consistent with our findings from animal experiments, providing additional evidence for the pivotal role of PAI-1 during aging and the development of PF. Our research demonstrates that PAI-1, a crucial factor secreted by aging AT2 cells, exerts a pivotal role in promoting the synthesis of Col1a1 in fibroblasts, subsequently leading to Col I deposition, and in driving the progression of PF by mediating the TGF-β/Smad2/3 pathway. Our findings offer critical evidence for the involvement of epithelial dysfunction in age-related PF and provides potential novel therapeutic targets

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Investigation of the Role of Mast cells in Acupuncture Effects and Their Sensitivity to Physical Stimuli During TCM Treatment

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Journal of Acupuncture and Tuina Science 2008年第6期6卷 365-365页

作者：张迪丁光宏顾全保 Wolfgang Schwarz Shanghai Research Center for Acupuncture and Meridians Shanghai 201203P.R.China Department of Mechanics and Engineering ScienceFudan UniversityShanghai 200433P.R.China Shanghai Research Center for Acupuncture and Meridians Shanghai 201203P.R.China Shanghai Research Center for Acupuncture and Meridians Shanghai 201203P.R.China Max-Planck-Institute for BiophysicsFrankfurt/MainGermany

Objective:To better understand the function of mast cells in acupuncture points(acupoints)inacupuncture-induced *** author tested their sensitivity to mechanical,thermo and ***:The tail flick model was applied to measure analgesia in rats,and the authordetermined the density of mast cells in tissue slices and their degranulation ratio before/after *** author also applied the patch-clamp technique to investigate activation of human mast cells(HMC1cell line)by mechanical stress or noxious heat,and the author optically observed degranulation

关键词：针刺疗法中医灵敏性镇痛

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Live Birth with or without Preimplantation Genetic Testing for Aneuploidy

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四川生理科学杂志 2021年第10期43卷 1825-1825页

作者： Junhao Yan From the Center for Reproductive Medicine Cheeloo College of Medicine Key Laboratory of Reproductive Endocrinology of the Ministry of Education and the National Research Center for Assisted Reproductive Technology and Reproductive Genetics Shandong University Shandong Key Laboratory of Reproductive Medicine and Shandong Provincial Clinical Research Center for Reproductive Health Jinan (J.Y. Y.Q. H.Z. D.W. J.L. T.N. W.Z. K.W. Y.G. Y.S. Z.-J.C.) the Center for Reproductive Medicine Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics (Y.S. Z.-J.C. Y.L. T.Z.) and the Obstetrics and Gynecology Hospital of Fudan University Shanghai JIAI Genetics and IVF Institute Key Laboratory of Female Reproductive Endocrine Related Diseases Obstetrics and Gynecology Hospital of Fudan University (X.S. J.F.) Shanghai the Institute of Reproductive and Stem Cell Engineering School of Basic Medical Science Central South University and Reproductive and Genetic Hospital of CITIC-Xiangya Changsha (F.G. H.M.) the Center for Reproductive Medicine Department of Obstetrics and Gynecology Peking University Third Hospital National Clinical Research Center for Obstetrics and Gynecology Key Laboratory of Assisted Reproduction Ministry of Education and Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology Beijing (R.L.) the Department of Reproductive Medicine the Affiliated Obstetrics and Gynecology Hospital with Nanjing Medical University Nanjing Maternity and Child Health Care Hospital (X.L. J.Z.) and the Department of Reproductive Medicine First Affiliated Hospital of Nanjing Medical University-Jiangsu Province Hospital (X.M. W.W.) Nanjing the Affiliated Suzhou Hospital of Nanjing Medical University Suzhou Municipal Hospital Suzhou (H.L. Q.M.) the Center for Reproductive Medicine of Yantai Yuhuangding Hospital Yantai (C.H.) the Center of Reproductive Medicine Depa

Background:Embryo selection with preimplantation genetic testing for aneuploidy(PGT-A)may improve pregnancy outcomes after initial embryo ***,it remains uncertain whether PGT-A improves the cumulative live-birth rate as compared with conventional in vitro fertilization(IVF).Methods:In this multicenter,randomized,controlled trial,we randomly assigned subfertile women with three or more goodquality blastocysts to undergo either PGT-A or conventional IVF;all the women were between 20 and 37 years of *** blastocysts were screened by next-generation sequencing in the PGT-A group or were chosen by morphologic criteria in the conventional-IVF group and then were successively transferred one by *** primary outcome was the cumulative live-birth rate after up to three embryo-transfer procedures within 1 year after *** hypothesized that the use of PGT-A would result in a cumulative live-birth rate that was no more than 7 percentage points higher than the rate after conventional IVF,which would constitute the noninferiority margin for conventional IVF as compared with PGT-A.

关键词： implantation sized transferred

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星形胶质细胞源性腺苷激发腹外侧视前核中的促睡眠神经元:星形胶质细胞-神经元相互作用对睡眠的调节

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神经损伤与功能重建 2022年第6期17卷 372-372页

作者： In-Sun Choi Jae-Hong Kim Ji-Young Jeong Maan-Gee Lee Kyoungho Suk Il-Sung Jang 杜一星(编译) Department of Pharmacology School of DentistryKyungpook National UniversityDaeguSouth Korea Department of Pharmacology School of MedicineKyungpook National UniversityDaeguSouth Korea Brain Science&engineering Institute Kyungpook National UniversityDaeguSouth Korea 不详

尽管已知来自星形胶质细胞的ATP和/或腺苷可调节睡眠,但ATP和腺苷促眠作用的确切机制仍不清楚。我们在参与睡眠促进的重要脑核腹外侧视前核(VLPO)内的星形胶质细胞中选择性表达光敏离子通道视紫红质通道2(ChR2)。然后,我们用全细胞膜片... 详细信息

尽管已知来自星形胶质细胞的ATP和/或腺苷可调节睡眠,但ATP和腺苷促眠作用的确切机制仍不清楚。我们在参与睡眠促进的重要脑核腹外侧视前核(VLPO)内的星形胶质细胞中选择性表达光敏离子通道视紫红质通道2(ChR2)。然后,我们用全细胞膜片钳记录检查了光刺激星形细胞ChR2对VLPO两种不同功能类型的神经元兴奋性的影响:分别为促进睡眠的GABA能投射神经元和非促进睡眠的局部GABA能神经元。VLPO星形胶质细胞的光遗传学刺激在两种类型的VLPO神经元中表现出相反的结果:导致了非睡眠促进神经元的抑制和睡眠促进神经元的兴奋。通过阻断腺苷A1受体或组织非特异性碱性磷酸酶(TNAP)可减弱这些反应。相反,外源性腺苷降低了两个VLPO神经元群的兴奋性。此外,TNAP在甘丙肽阴性的VLPO神经元中表达,但在甘丙肽阳性促进睡眠的投射神经元中不表达。总之,这些结果表明星形胶质细胞源性的ATP在非睡眠促进神经元中通过TNAP转化为腺苷。腺苷进而降低了局部GABA能神经元的兴奋性,从而增加了促进睡眠的GABA能投射神经元的兴奋性。我们提出了一种涉及星形胶质细胞-神经元相互作用在睡眠调节中的新机制,其中来自星形胶质细胞的内源性腺苷激发促进睡眠的VLPO神经元,从而降低大脑中与唤醒相关区域的神经元兴奋性。

关键词：腺苷星形胶质细胞胶质递质光遗传学睡眠腹外侧视前核

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High-energy collider parameters

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Chinese Physics C 2014年第9期 392-396页

作者： K.A.Olive K.Agashe C.Amsler M.Antonelli J.-F.Arguin D.M.Asner H.Baer H.R.Band R.M.Barnett T.Basaglia C.W.Bauer J.J.Beatty V.I.Belousov J.Beringer G.Bernardi S.Bethke H.Bichsel O.Biebe E.Blucher S.Blusk G.Brooijmans O.Buchmueller University of Minnesota School of Physics and Astronomy 116 Church St.S.E. Minneapolis MN 55455 USA University of Maryland Department of Physics College Park MD 20742-4111 USA Albert Einstein Center for Fundamental Physics Universitat Bern CH-3012 Bern Switzerland Lab.Nazionali di Frascati dell'INFN CP 13 via E.Fermi 40 I-00044 Frascati(Roma) Italy Departement de physique Universite de Montreal C.P.6128 succ.centre-ville Montreal(Quebec) H3C 3J7 Canada Pacific Northwest National Laboratory 902 Battelle Boulevard Richland WA 99352 USA Department of Physics and Astronomy University of Oklahoma Norman OK 73019 USA Department of Physics University of Wisconsin Madison WI 53706 USA Physics Division Lawrence Berkeley National Laboratory 1 Cyclotron Road Berkeley CA 94720 USA CERN European Organization for Nuclear Research CH-1211 Geneve 23 Switzerland Department of Physics The Ohio State University 191 W.Woodruff Ave. Columbus OH 43210 COMPAS group Institute for High Energy Physics RU- 142284 Protvino Russia LPNHE IN2P3-CNRS et Universites de Paris 6 et 7 F-75252 Paris France Max-Planck-Institute of Physics 80805 Munich Germany Department of Physics University of Washington Seattle WA 98195 USA Ludwig-Maximilians-Universitat Fakultdt für Physik Schellingstr.4 D-80799 München Germany Enrico Fermi Institute and Department of Physics University of Chicago Chicago IL 60637-1433 USA Department of Physics Syracuse University Syracuse NY 13244 USA Department of Physics Columbia University 538 W.120th Street New York NY 10027 USA High Energy Physics group Blackett Laboratory Imperial College Prince Consort Road London SW7 2AZ UK Jefferson Lab 12000 Jefferson Ave. Newport News VA 23606 USA Department of Physics University of Virginia PO Box 400714 Charlottesville VA 22904 USA Fermi National Accelerator Laboratory P.O.Box 500 Batavia IL 60510 USA Kavli Institute for Cosmological Physics University of Chicago Chicago IL 60637-1433 USA Department of Physics and Astronomy University of Sussex Falmer Brighton BN1 9QH UK Department o

HIGH-ENERGY COLLIDER PARAMETERS:e+e-Colliders（I）Updated in September 2013 with numbers received from representatives of the colliders（contact ***,LBNL）.The table shows parameter values as achieved by July 1,*** are,where appropriate,r.m.s.;unless noted otherwise,energies refer to beam energy;H and V indicate horizontal and vertical directions;*** for *** for the defunct SPEAR,DORIS,PETRA,PEP,TRISTAN,and VEPP-2M colliders may be found in our 1996 edition（***.D54,1 July 1996,Part I）.

关键词： LHC Pb High-energy collider parameters length CERN BEPC high MHz exp cell KEK

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