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Dynamic modulation of nodulation factor receptor levels by phosphorylation-mediated functional switch of a RING-type E3 ligase during legume nodulation

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Molecular Plant 2024年第7期17卷 1090-1109页

作者： Hao Li Yajuan Ou Jidan Zhang Kui Huang Ping Wu Xiaoli Guo Hui Zhu Yangrong Cao national Key lab of Agricultural Microbiology Hubei Hongshan LaboratoryHuazhong Agricultural UniversityWuhan 430070China national Key lab of Agricultural Microbiology College of Plant Science and TechnologyHuazhong Agricultural UniversityWuhan 430070China

The precise control of receptor levels is crucial for initiating cellular signaling transduction in response to specific ligands;however,such mechanisms regulating nodulation factor(NF)receptor(NFR)-mediated perception of NFs to establish symbiosis remain *** this study,we unveil the pivotal role of the NFR-interacting RING-type E3 ligase 1(NIRE1)in regulating NFR1/NFR5 homeostasis to optimize rhizobial infection and nodule development in Lotus *** demonstrated that NiRE1 has a dual function in this regulatory *** associates with both NFR1 and NFR5,facilitating their degradation through K48-linked polyubiquitination before rhizobial ***,following rhizobial inoculation,NFR1 phosphorylates NIRE1ata conserved residue,Tyr-109,inducing a functional switch in NIRE1,which enables NIRE1tomediateK63-linkedpolyubiquitination,thereby stabilizing NFR1/NFR5 in infected root *** introduction of phospho-dead NIRE1Y1osF leads to delayed nodule development,underscoring the significance of phosphorylation at Tyr-1o9 in orchestrating symbiotic ***,expression of the phospho-mimic NIRE1Y0E results in the formation of spontaneous nodules in ***,further emphasizing the critical role of the phosphorylation-dependent functional switch in *** summary,these findings uncover a fine-tuned symbiotic mechanism that a single E3 ligase could undergo a phosphorylationdependent functional switch to dynamically and precisely regulate NF receptor protein levels.

关键词： nodule symbiosis nodulation factor receptors E3 ligase ubiquitination phosphorylation protein degradation protein stabilization Lotus japonicus

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Efficient elimination of carbamazepine using polyacrylonitrile-supported pyridine bridged iron phthalocyanine nanofibers by activating peroxymonosulfate in dark condition

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Journal of Environmental Sciences 2024年第3期137卷 224-236页

作者： Zhexin Zhu Wenjie Qian Zhiguo Shang Xiaoji Ma Zhendong Wang Wangyang Lu Wenxing Chen national Engineering lab for Textile Fiber Materials and Processing Technology(Zhejiang) Zhejiang Sci-Tech UniversityHangzhou 310018China

The monoaminotrinitro iron phthalocyanine(FeMATNPc)is used to connect with isonicotinic acid(INA)for amide bonding and axial coordination to synthetic a unique catalyst FeMATNPc-INA,which is loaded in polyacrylonitrile(PAN)nanofibers by *** introduction of INA destroys theπ-πconjugated stack structure in phthalocyanine molecules and exposes more active *** FeMATNPc-INA structure is characterized by X-ray photoelectron spectroscopy and UV-visible absorption spectrum,and the FeMATNPcINA/PAN structure is characterized by Fourier transform infrared spectroscopy and X-ray *** FeMATNPc-INA/PAN can effectively activate peroxymonosulfate(PMS)to eliminate carbamazepine(CBZ)within 40 minutes(PMS 1.5 mmol/L)in the *** effects of catalyst dosage,PMS concentration,pH and inorganic anion on the degradation of CBZ are *** has been confirmed by electron paramagnetic resonance,gas chromatography–mass spectroscopy and free radical capture experiments that the catalytic system is degraded by·OH,SO4^(·-)and Fe(IV)=O are the major active species,the singlet oxygen(^(1)O_(2))is the secondary active *** degradation process of CBZ is analyzed by ultra-high performance liquid chromatography-mass spectrometry and the aromatic compounds have been degraded to small molecular acids.

关键词： Pyridine bridged iron phthalocyanine Isonicotinic chloride hydrochloride Efficient elimination Peroxymonosulfate activation Degradation pathway

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Precise control of page cache for containers

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Frontiers of Computer Science 2024年第2期18卷 17-30页

作者： Kun WANG Song WU Shengbang LI Zhuo HUANG Hao FAN Chen YU Hai JIN national Engineering Research Center for Big Data Technology and System Services Computing Technology and System LabCluster and Grid Computing Lab School of Computer Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China

Container-based virtualization isbecoming increasingly popular in cloud computing due to its efficiency and *** isolation is a fundamental property of *** works have indicated weak resource isolation could cause significant performance degradation for containerized applications and enhanced resource ***,current studies have almost not discussed the isolation problems of page cache which is a key resource for *** leverage memory cgroup to control page cache ***,existing policy introduces two major problems in a container-based ***,containers can utilize more memory than limited by their cgroup,effectively breaking memory ***,the Os kernel has to evict page cache to make space for newly-arrived memory requests,slowing down containerized *** paper performs an empirical study of these problems and demonstrates the performance impacts on containerized *** we propose pCache(precise control of page cache)to address the problems by dividing page cache into private and shared and controlling both kinds of page cache separately and *** do so,pCache leverages two new technologies:fair account(f-account)and evict on demand(EoD).F-account splits the shared page cache charging based on per-container share to prevent containers from using memory for free,enhancing memory *** EoD reduces unnecessary page cache evictions to avoid the performance *** evaluation results demonstrate that our system can effectively enhance memory isolation for containers and achieve substantial performance improvement over the original page cache management policy.

关键词： page cache memory cgroup container isolation cloud computing

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Answering reachability queries with ordered label constraints over labeled graphs

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Frontiers of Computer Science 2024年第1期18卷 105-117页

作者： Daoliang HE Pingpeng YUAN Hai JIN national Engineering Research Center for Big Data Technology and System Services Computing Technology and System LabCluster and Grid Computing LabSchool of Computer Science&TechnologyHuazhong University of Science and TechnologyWuhan 430074China

Reachability query plays a vital role in many graph analysis *** researches proposed many methods to efficiently answer reachability queries between vertex *** many real graphs are labeled graph,it highly demands label-Constrained Reachability(LCR)query inwhich constraint includes a set of labels besides vertex *** researches proposed several methods for answering some LCR queries which require appearance of some labels specified in constraints in the *** that constraint may be a label set,query constraint may be ordered labels,namely OLCR(Ordered-label-Constrained Reachability)queries which retrieve paths matching a sequence of ***,no solutions are available for ***,we propose DHL,a novel bloom filter based indexing technique for answering OLCR *** can be used to check reachability between vertex *** the answers are not no,then constrained DFS is ***,we employ DHL followed by performing constrained DFS to answer OLCR *** show that DHL has a bounded false positive rate,and it's powerful in saving indexing time and *** experiments on 10 real-life graphs and 12 synthetic graphs demonstrate that DHL achieves about 4.8-22.5 times smaller index space and 4.6-114 times less index construction time than two state-of-art techniques for LCR queries,while achieving comparable query response *** results also show that our algorithm can answer OLCR queries effectively.

关键词： graph ordered-label-constrained reachability partial index bloom filter query processing

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Stereoselective recognition of morphine enantiomers by μ-opioid receptor

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national Science Review 2024年第3期11卷 183-191页

作者： Yibo Wang Van A.Ngo Xiaohui Wang laboratory of Chemical Biology Changchun Institute of Applied ChemistryChinese Academy of Sciences Advanced Computing for Life Sciences and Engineering Group Science Engagement Section National Center for Computational Sciences Oak Ridge National Lab School of Applied Chemistry and Engineering University of Science and Technology of China Beijing national laboratory for Molecular Sciences

Stereospecific recognition of chiral molecules plays a crucial role in biological systems. The μ-opioid receptor（MOR） exhibits binding affinity towards（-）-morphine, a well-established gold standard in pain management, while it shows minimal binding affinity for the（+）-morphine enantiomer, resulting in a lack of analgesic activity. Understanding how MOR stereoselectively recognizes morphine enantiomers has remained a puzzle in neuroscience and pharmacology for over half-a-century due to the lack of direct observation techniques. To unravel this mystery, we constructed the binding and unbinding processes of morphine enantiomers with MOR via molecular dynamics simulations to investigate the thermodynamics and kinetics governing MOR's stereoselective recognition of morphine enantiomers. Our findings reveal that the binding of（-）-morphine stabilizes MOR in its activated state, exhibiting a deep energy well and a prolonged residence time. In contrast,（+）-morphine fails to sustain the activation state of ***, the results suggest that specific residues, namely D1142.50and D1473.32, are deprotonated in the active state of MOR bound to（-）-morphine. This work highlights that the selectivity in molecular recognition goes beyond binding affinities, extending into the realm of residence time.

关键词： stereoselective recognition thermodynamics and kinetics residence time morphine enantiomers μ-opioid receptor

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Revolutionary entrapment model of uniformly distributed swarm robots in morphogenetic formation

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Defence Technology（防务技术） 2024年第1期31卷 496-509页

作者： Chen Wang Zhaohui Shi Minqiang Gu Weicheng Luo Xiaomin Zhu Zhun Fan Shantou University ShantouGuangdongChina national University of Defense Technology ChangshaChina Key lab of Digital Signal and Image Processing of Guangdong Province China

This study proposes a method for uniformly revolving swarm robots to entrap multiple targets,which is based on a gene regulatory network,an adaptive decision mechanism,and an improved *** the gene regulatory network method,the robots can generate entrapping patterns according to the environmental input,including the positions of the targets and ***,an adaptive decision mechanism is proposed,allowing each robot to choose the most well-adapted capture point on the pattern,based on its *** robots employ an improved Vicsek-model to maneuver to the planned capture point smoothly,without colliding with other robots or *** proposed decision mechanism,combined with the improved Vicsek-model,can form a uniform entrapment shape and create a revolving effect around targets while entrapping *** study also enables swarm robots,with an adaptive pattern formation,to entrap multiple targets in complex *** robots can be deployed in the military field of unmanned aerial vehicles’(UAVs)entrapping multiple *** experiments demonstrate the feasibility and superiority of the proposed gene regulatory network method.

关键词： Swarm intelligence Revolutionary entrapment Flocking Robots Gene regulatory network Vicsek-model Entrapping multiple targets

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Efficient implementation of majority-inverter graph logic and arithmetic functions with memristor arrays

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Science China(Information Sciences) 2024年第7期67卷 345-346页

作者： Zhouchao GAN Dongdong ZHANG Chenyu ZHANG Yinghao MA Xiangshui MIAO Xingsheng WANG School of Integrated Circuits & Wuhan national lab. for Optoelectronics Huazhong University of Science and Technology Hubei Yangtze Memory laboratories

Memristors are characterized by several outstanding features that permit them to function both as memory and logic units, enabling logic-in-memory (LIM) computing that potentially breaks the von Neumann bottleneck. Typically,in-memory logic is categorized into stateful logic and nonstateful logic based on the physical quantities of inputs and outputs.

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Deer antler stem cell niche: An interesting perspective

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World Journal of Stem Cells 2024年第5期16卷 479-485页

作者： Claudia Cavallini Elena Olivi Riccardo Tassinari Chiara Zannini Gregorio Ragazzini Martina Marcuzzi Valentina Taglioli Carlo Ventura national laboratory of Molecular Biology and Stem Cell Engineering National Institute of Biostructures and Biosystems-Eldor LabBologna 40128Italy Eldor lab Bologna 40128Italy Department of Medical and Surgical Sciences(DIMEC) University of BolognaBologna 40138Italy

In recent years,there has been considerable exploration into methods aimed at enhancing the regenerative capacity of transplanted and/or tissue-resident ***,in particular,have garnered significant interest for their potential to serve as natural scaffolds for *** this editorial,we provide commentary on the study by Wang et al,in a recently published issue of World J Stem Cells,which investigates the use of a decellularized xenogeneic extracellular matrix(ECM)derived from antler stem cells for repairing osteochondral defects in rat knee *** focus lies specifically on the crucial role of biological scaffolds as a strategy for augmenting stem cell potential and regenerative capabilities,thanks to the establishment of a favorable microenvironment(niche).Stem cell differen-tiation heavily depends on exposure to intrinsic properties of the ECM,including its chemical and protein composition,as well as the mechanical forces it can ***,these physicochemical cues contribute to a bio-instructive signaling environment that offers tissue-specific guidance for achieving effective repair and *** interest in mechanobiology,often conceptualized as a form of“structural memory”,is steadily gaining more validation and momen-tum,especially in light of findings such as these.

关键词： Extracellular matrix Antler stem cells Stem cell niche Regenerative medicine Decellularized scaffolds Cell memory

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Analysis of photocatalytic degradation of polyamide microplastics in metal salt solution by high resolution mass spectrometry

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Journal of Environmental Sciences 2024年第5期139卷 473-482页

作者： Yunjin Zhong Lebing Zhuo Wangyang Lu national Engineering lab for Textile Fiber Materials&Processing Technology(Zhejiang) School of Materials Science&EngineeringZhejiang Sci-Tech UniversityHangzhou 310018China

Microplastic pollution has become one of the most concerned focuses in the *** many treatment methods,photocatalysis is considered to be one of the most environmentally friendly *** this work,the photodegradation behavior of polyamide microplastics is studied by using polyamide 6(PA6)as model microplastics and FeCl_(3) as *** is hoped that the PA6 fiber can be effectively degraded by utilizing the strong oxidizing active species that can be produced after FeCl_(3) is irradiated in *** results shows that PA6 fiber can be almost completely degraded after 10 days of irradiation in FeCl_(3) aqueous solution,indicating that it is promising to use this new method to solve the problem of PA6type *** addition,the chain scission mechanism and degradation process of PA6 are analyzed in detail by ultra-high performance liquid chromatography-tandem mass spectrometry(UPLC-MS),which provides a new insight for the study of polymer degradation mechanism.

关键词： FeCl_(3) Photocatalysis Polyamide 6 Chain scission

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Impact Force Localization and Reconstruction via ADMM-based Sparse Regularization Method

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Chinese Journal of Mechanical Engineering 2024年第3期37卷 170-188页

作者： Yanan Wang Lin Chen Junjiang Liu Baijie Qiao Weifeng He Xuefeng Chen national Key lab of Aerospace Power System and Plasma Technology Xi’an Jiaotong UniversityXi’an 710049China School of Mechanical Engineering Xi’an Jiaotong UniversityXi’an 710049China

In practice,simultaneous impact localization and time history reconstruction can hardly be achieved,due to the illposed and under-determined problems induced by the constrained and harsh measuring *** l_(1) regularization can be used to obtain sparse solutions,it tends to underestimate solution amplitudes as a biased *** address this issue,a novel impact force identification method with l_(p) regularization is proposed in this paper,using the alternating direction method of multipliers(ADMM).By decomposing the complex primal problem into sub-problems solvable in parallel via proximal operators,ADMM can address the challenge *** mitigate the sensitivity to regularization parameters,an adaptive regularization parameter is derived based on the K-sparsity ***,an ADMM-based sparse regularization method is developed,which is capable of handlingl_(p) regularization with arbitrary p values using adaptively-updated *** effectiveness and performance of the proposed method are validated on an aircraft skin-like composite ***,an investigation into the optimal p value for achieving high-accuracy solutions vial_(p) regularization is *** turns out that?_(0.6)regularization consistently yields sparser and more accurate solutions for impact force identification compared to the classicl_(1) regularization *** impact force identification method proposed in this paper can simultaneously reconstruct impact time history with high accuracy and accurately localize the impact using an under-determined sensor configuration.

关键词： Impact force identification Non-convex sparse regularization Alternating direction method of multipliers Proximal operators

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