检索结果-南通市图书馆

针刺对脑梗死大鼠缺血脑组织血管新生相关因子表达的影响

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acupuncture and Herbal medicine 2023年第1期3卷 46-54页

作者：孙雅洁李晶 Rainer Georgi Bernhard Kolberg 杨丽红天津中医药大学第一附属医院天津300193 国家中医针灸临床医学研究中心天津300193 Department of Chemical Biology Max Planck Institute for Medical ResearchGermany Department of Internal medicine Mannheim Medical School of Heidelberg UniversityGermany

目的:动态研究脑梗死后血管新生相关因子的变化规律和针刺干预效应,从促进血管新生角度深入揭示针刺治疗脑梗死的分子机制。方法:以MCAO模型大鼠为研究对象,分为针刺组、模型组和空白组。观察脑梗死后神经功能缺损程度改变,同时采用免... 详细信息

目的:动态研究脑梗死后血管新生相关因子的变化规律和针刺干预效应,从促进血管新生角度深入揭示针刺治疗脑梗死的分子机制。方法:以MCAO模型大鼠为研究对象,分为针刺组、模型组和空白组。观察脑梗死后神经功能缺损程度改变,同时采用免疫荧光双标记法观察缺血中心及边缘区的血管新生情况,应用RT-PCR和Western blot法检测脑梗死后缺穴区域血管新生相关因子Ang-1、Ang-2、PDGF-B和bFGF mRNA及蛋白变化规律和电针干预效应。结果:电针组各时相NSS评分均小于同时相模型组。MCAO后9h~7d时电针组血管内皮细胞增殖高于同时相模型组。电针组Ang-1、Ang-2 mRNA及蛋白表达水平明显高于模型组。电针组PDGF-B mRNA在3h~6h、3d~12d时明显高于模型组,蛋白水平在6h、3d~12d时明显高于模型组。针刺组bFGF mRNA在24h~12d、蛋白水平在3d~12d时明显高于模型组。结论:电针水沟穴能明显改善MCAO大鼠神经功能症状;能够促进MCAO模型大鼠梗死区周围血管内皮细胞增殖,并将血管内皮细胞增殖出现时间显著提前,其可能机制为电针水沟穴可上调血管新生相关因子的表达,并使表达时相前移,从而促进血管新生,对改善脑梗死的预后起到了明显的积极作用。

关键词：人中穴脑梗死电针血管新生

Auricular vagus nerve acupressure for patients with emotional distress under the COVID-19 pandemic:A smartphone-based,randomized controlled trial

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

TMR Modern Herbal medicine 2021年第2期4卷 1-14页

作者： Peijing Rong Lei Wang Lingling Yu Junying Wang Yan Ma Liting Wang Suxia Li Chunzhi Tang Liming Lu Liang Li Jiazi Dong Jiliang Fang Liwei Hou Zongshi Qin Xiaolan Su Zhangjin Zhang institute of Acupuncture and Moxibustion China Academy of Chinese Medical SciencesBeijingChina.2 Tongji Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina Department of Rehabilitation Wuhan No.1 HospitalWuhanHubeiChina Department of Electronic Engineering Tsinghua UniversityBeijingChina National institute of Drug Dependence Peking UniversityBeijingChina Medical College of Acu-Moxi and Rehabilitation Guangzhou University of Chinese MedicineGuangzhouChina School of Acupuncture Moxibustion and TuinaLiaoning University of Traditional Chinese MedicineShenyangChina Guang’anmen hospital China Academy of Chinese Medical SciencesBeijingChina School of chinese medicine LKS Faculty of Medicinethe University of Hong KongHong KongChina Wangjing hospital China Academy of Chinese Medical SciencesBeijingChina National Data Center of traditional chinese medicine China Academy of Chinese Medical SciencesBeijingChina.

Objective: To confirm whether self-administered AVNA treatment is effective in improving emotional distressunder the COVID-19 ***: A smartphone-based online, randomized, controlled trial was designed from 26 February 2020 to 28April 2020 in four study sites, including Wuhan, Beijing, Shenyang, and Guangzhou of China. Local residentswho had considerable emotional distress with a score of the hospital Anxiety and Depression Scale (HADS) ≥9 were recruited. Participants were randomly assigned to three times of AVNA (n = 191) per day, in morning,around noon, and in evening or usual care (UC, n = 215) once daily for 14 days. The primary outcome was theresponse rate, which was the proportion of participants whose hospital Anxiety and Depression Scale (HADS)score reduced from baseline by ≥ 50%. The assessment was conducted at baseline, 3 days, and 14 ***: The AVNA group had a markedly higher response rate than the UC group at 3 days (35.6% vs. 24.9%,P = 0.02) and at 14 days (70.7% vs. 60.6%, P = 0.02). The AVNA group showed significantly greater reductionin scores of HADS at the two measurement points and BAI at 3 days (P ≤ 0.03), with average respective effectsize of 0.217 and 0.195. Participants with AVNA spent less time falling asleep and rated their sleep qualitybeing remarkably higher than those with UC at ***: During COVID-19 pandemic period, treatment with self-administrated AVNA was more effectivethan UC in reducing emotional distress of isolated populations. These findings support self-administered AVNAas a treatment option for patients with emotional distress under the COVID-19 pandemic or other emergentevents.

关键词： Neurology,Psychiatry Emotional distress Auricular vagus nerve stimulation COVID-19

Biomechanics mechanism of the anti-tumor effects of sulfated polysaccharide and sulfated glycopeptide

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Tumor Microenvironment research 2020年第1期2卷 1-6页

作者： Xiong-Zhi Wu Jin-Feng Liu tianjin Medical University Cancer institute and hospital National Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin 300171China

There are also a variety of cytokines in the tumor microenvironment,which are involved in the change in the hardness of the tumor,thereby affecting the invasion and metastasis of tumor *** traditional chinese medicines,drugs of softening and dissipating firm knot contains different kinds of sulfated polysaccharide and sulfated *** inhibiting the function of cancer-associated fibroblasts,they reduce interstitial fibrosis,thereby reducing the hardness of the tumor and exerting an anti-tumor effect.

关键词： Tumor Metastasis Biomechanics Extracelluar matrix Sulfated polysaccharide Sulfated glycopeptide

A single nucleotide polymorphism in the matrix metalloproteinase 2 promoter is closely associated with high risk of nasopharyngeal carcinoma in Cantonese from southern China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

chinese Journal of Cancer 2011年第9期30卷 620-626页

作者： Jian-Yong Shao Yun Cao Xiao-Ping Miao Ma-Yan Huang Ling Deng Jian-Jun Hao Xiao-Man Liang Li-Fu Hu Ingemar Ernberg Dong-Xin Lin Yi-Xin Zeng State Key Laboratory of Oncology in South China Guangzhou Guangdong 510060 P. R. China Department of Pathology Sun Yat-sen University Cancer Center Guangzhou Guangdong 510060 P. R. China Department of Epidemiology and Biostatistics School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 430030 P. R. China Huangpu chinese traditional medicine hospital Guangzhou Guangdong 510360 P. R. China Microbiology and Tumor Biology Center Karolinska Institute Stockholm S171 77 Sweden Department of Etiology and Carcinogenesis Cancer Institute Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021 P. R. China Department of Experiment research Sun Yat-sen University Cancer Center Guangzhou Guangdong 510060 P. R. China.

Matrix metalloproteinase 2(MMP2) has been shown to play an important role in several steps of cancer ***-1306C/T polymorphism of the MMP2 gene displays a strikingly lower promoter activity than the T allele,and the CC genotype in the MMP2 promoter has been reported to associate with the development of several *** assess the contribution of the MMP2-1306C/T polymorphism to the risk of nasopharyngeal carcinoma(NPC),we conducted a case-control study and analyzed MMP2 genotypes in 370 patients with NPC and 390 frequency-matched controls using real-time PCR-based TaqMan allele *** found that subjects with the CC genotype had an increased risk(OR = 1.55,95% CI = 1.05-2.27) of developing NPC compared to those with the CT or TT ***,we found that the risk of NPC was markedly increased in subjects who were smokers(OR = 15.04,95% CI = 6.65-33.99),heavy smokers who smoked ≥20 pack-years(OR = 18.66,95% CI = 7.67-45.38),or young(<60 years) at diagnosis(OR = 1.52,95% CI = 1.01-2.29).Our results provide molecular epidemiological evidence that the MMP2-1306C/T promoter polymorphism is associated with NPC risk,and this association is especially noteworthy in heavy smokers.

关键词：单个核苷酸多态性基质金属蛋白酶鼻咽癌风险中国南部 TaqMan探针全国人民代表大会局长

TMR Non-Drug Therapy： the modernization of non-drug therapy

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

TMR Non-Drug Therapy 2018年第1期1卷 1-1页

作者： Xiong-Zhi Wu Editor-in-Chief tianjin Medical University Cancer institute and hospital Tianjin 300171 China

Role of mPTP and ER stress in NECA-induced cardioprotection against ischemia / reperfusion injury

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国病理生理杂志 2015年第10期 1785-1785页

作者： XI Jin-kun HE Yong-gui FEI Shuo ZHENG Huan HE Yi-fei LI Lu XU Zhe-long Department of Physiology and Pathophysiology Tianjin Medical University Heart institute North China University of Science and Technology

We aimed to determine whether NECA,an adenosine receptor agonist,induces cardioprotection against myocardial ischemia/reperfusion(I/R)injury by modulation of endoplasmic reticulum stress(ERS)through inhibiting the mitochondrial permeability transition pore(mP TP)opening via inactivating glycogen synthase kinase 3β(GSK-3β).Heart tissue-derived H9c2 cells exposed to 800

关键词： ER TP reperfusion injury Role of mPTP and ER stress in NECA-induced cardioprotection against ischemia PKG

Anti-tumor research progress of Herba Hedyotidis Diffusae

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Precision medicine research 2020年第1期2卷 11-16页

作者： Jin-Feng Liu tianjin Medical University Cancer institute and hospital National Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin 300060China.

Cancer,as one of the major public health problems in the world,dramatically harms human *** recent years,studies have found that Herba Hedyotidis Diffusae not only plays a huge role in anti-infection but also has a strong effect on *** studies have shown that the components contained in Herba Hedyotidis Diffusae have different levels of antitumor results in multiple *** article summarizes the antitumor elements in Herba Hedyotidis Diffusae,and describes the antitumor mechanism of Herba Hedyotidis *** new ideas for further clinical use.

关键词： Herba Hedyotidis Diffusae Antitumor Mechanism traditional chinese medicine

Network pharmacology： an important breakthrough in traditional chinese medicine research

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

TMR Integrative medicine 2018年第3期2卷 92-98页

作者： Jin-Wei Yuan Jian Hao Dan Chen School of Basic Medical Sciences Tianjin Medical University Tianjin China tianjin Medical University Cancer institute and hospital Tianjin China.

目的：探讨中药研究与网络药理学的关系。方法：通过分析中医药的特点，网络药理学的背景，探讨中药与网络药理学的共性和个性，从而更好地解读中医药的现代内涵，使传承与创新结合，深入了解中药研究与网络药理学的关系。结果：中药多... 详细信息

目的：探讨中药研究与网络药理学的关系。方法：通过分析中医药的特点，网络药理学的背景，探讨中药与网络药理学的共性和个性，从而更好地解读中医药的现代内涵，使传承与创新结合，深入了解中药研究与网络药理学的关系。结果：中药多成分多途径的特征与网络药理学的研究思路存在一定的共性，网络药理学突破传统的线性研究模式，暗合中药的复杂性，为提高中医药的安全性和合理用药提供了技术支持，为开展中医药研究提供了新的手段，成为现代中医药研究的新策略。结论：网络药理学是中药研究重要突破口，其研究策略促进了中医药的现代化和国际化进程，有助于中药新药的研究开发，对发展中医药的理论促进中西医药的融合具有重要意义。

关键词：中药网络药理学多成分多靶点

New insights into roles of basophils in initiating T helper type 2 immunity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

chinese Herbal medicines 2020年第1期12卷 14-18页

作者： Tian-xiang Ma Yuan Gao Yayuncun Outpatient Department Third Medical Center of PLA General HospitalBeijing 100101China institute of Medicinal Plant Development Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China

Allergic diseases,mainly mediated by T helper type 2(Th2)immunity,have become a worldwide public health *** chinese medicine(TCM)has long been used in treating and preventing allergic *** the new target of anti-allergy TCM,basophils,after approximately 140 years since their discovery,are just now gaining respect as important contributors in the pathogenesis underlying allergic inflammation and *** addition to their role as effector cells,basophils can release early IL-4,migrate from circulatory system into draining lymph nodes,present antigen to naive CD4^+T cells,and promote the differentiation of Th2 ***,we briefly summarized the recent research advances of the essential contributions of basophils in the initiation of Th2 immune responses.

关键词： basophils IL-4 immune response T helper type 2 traditional chinese medicines