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Dual-targeting AAV9P1-mediated neuronal reprogramming in a mouse model of traumatic brain injury

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Neural Regeneration research 2024年第3期19卷 629-635页

作者： Jingzhou Liu Xin Xin Jiejie Sun Yueyue Fan Xun Zhou Wei Gong Meiyan Yang Zhiping Li Yuli Wang Yang Yang Chunsheng Gao State Key Laboratory of Toxicology and Medical Countermeasures Beijing Institute of Pharmacology and ToxicologyBeijingChina Academy of Medical engineering and Translational Medicine Medical CollegeTianjin UniversityTianjinChina

Traumatic brain injury results in neuronal loss and glial scar *** neurons and eliminating the consequences of glial scar formation are essential for treating traumatic brain *** reprogramming is a promising strategy to convert glial scars to neural ***,previous studies have reported inconsistent *** this study,an AAV9P1 vector incorporating an astrocyte-targeting P1 peptide and glial fibrillary acidic protein promoter was used to achieve dual-targeting of astrocytes and the glial scar while minimizing off-target *** results demonstrate that AAV9P1 provides high selectivity of astrocytes and reactive ***,neuronal reprogramming was induced by downregulating the polypyrimidine tract-binding protein 1 gene via systemic administration of AAV9P1 in a mouse model of traumatic brain *** summary,this approach provides an improved gene delivery vehicle to study neuronal programming and evidence of its applications for traumatic brain injury.

关键词： AAV9P1 astrocytes astrocyte-to-neuron conversion GFAP promoter glial scar induced neurons neuronal reprogramming P1 peptide PTBP1 traumatic brain injury

Application of electromagnetic metallurgy in continuous casting: A review

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Progress in Natural Science:Materials International 2024年第1期34卷 1-11页

作者： Jiale Li Yi Nian Xiang Liu Youcheng Zong Xinyu Tang Chaojie Zhang Liqiang Zhang The Intelligent Metallurgy research institute School of Metallurgical Engineering Anhui University of Technology

The standards within the global steel industry are constantly advancing, necessitating increasingly rigorous quality control protocols during the continuous casting process. Central to the challenges faced in this domain are persistent defects such as central segregation, V-shaped segregation, and center porosity, which significantly impede the production of high-caliber steel products. The discipline of electromagnetic metallurgy has emerged as a critical solution in reducing these defects, thereby enhancing the efficiency and stability of continuous casting operations. Its demonstrated effectiveness has led to its widespread implementation across global and domestic steel production industries. This paper aims to deliver a comprehensive examination of electromagnetic metallurgy's impact on the final stages of solidification in continuous casting, along with its contributions to the heating and purification processes within the tundish. Additionally, it will explore the potential advancements and applications of this technology in the evolving sphere of continuous casting.

关键词： continuous casting Quality control Final electromagnetic stirring Induction heating Electromagnetic purification

Digital Twins for Wastewater Treatment:A Technical Review

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engineering 2024年第5期36卷 21-35页

作者： Ai-Jie Wang Hewen Li Zhejun He Yu Tao Hongcheng Wang Min Yang Dragan Savic Glen TDaigger Nanqi Ren School of Civil and Environmental engineering Harbin Institute of Technology(Shenzhen)Shenzhen 518055China State Key Laboratory of Urban water Resource and Environment Harbin Institute of TechnologyHarbin 150090China Department of Civil and Environmental engineering Cornell UniversityIthacaNY 14850USA BIOMATH Department of Data Analysis and Mathematical ModellingGhent UniversityGhent 9000Belgium KWR water research institute Nieuwegein 3430 BBNetherlands Centre for water Systems University of ExeterExeter EX44QFUK Department of Civil and Environmental engineering University of MichiganAnn ArborMI 48109USA

The digital twins concept enhances modeling and simulation through the integration of real-time data and *** review elucidates the foundational elements of digital twins,covering their concept,entities,domains,and key *** specifically,we investigate the transformative potential of digital twins for the wastewater treatment engineering *** discussion highlights the application of digital twins to wastewater treatment plants(WWTPs)and sewage networks,hardware(i.e.,facilities and pipes,sensors for water quality and activated sludge,hydrodynamics,and power consumption),and software(i.e.,knowledge-based and data-driven models,mechanistic models,hybrid twins,control methods,and the Internet of Things).Furthermore,two cases are provided,followed by an assessment of current challenges in and perspectives on the application of digital twins in *** review serves as an essential primer for wastewater engineers navigating the digital paradigm shift.

关键词： Digital twins Urban water systems Wastewater treatment

Photocatalytic reduction of CO_(2) with H_(2)O into C_(2)H_(6) mediated by dual metalation strategy

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Science China Chemistry 2024年第5期67卷 1381-1383页

作者： Mei Wang Tong-Bu Lu School of Materials Science and engineering Institute for New Energy Materials&Low Carbon TechnologiesTianjin University of TechnologyTianjin 300384China

Artificial solar-energy-driven CO_(2) reduction into value-added fuels under mild conditions provides a promising strategy to mitigate energy crisis and alleviate environmental issues around the world. Among diverse products of CO_(2) reduction reaction, C_(2+) compounds are more desirable in terms of their high energy density and commercial value [1].Thus far, various photocatalysts have been constructed for CO_(2) reduction.

关键词： reduction desirable value

Method of extracting disturbed position in φ-OTDR based on signal relevance evaluation

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Optoelectronics Letters 2024年第9期20卷 513-517页

作者： LI Chengzhi YANG Yang LIU Lijun GAO Fei DU Xuan LIANG Hu Kunlun Digital Technology Co. Ltd.Beijing 102206China tianjin Navigation Instruments research institute Tianjin 300131China

A theoretical analysis was conducted on the intrinsic bond between multi-point responses caused by the same single vibration in phase sensitive optical time-domain reflectometer(OTDR). Temporal similarity of signals collected from adjacent sample locations were investigated. Referring to correlation coefficient as well as the relative energy level, a method of extracting disturbed position in φ-OTDR based on signal relevance evaluation is proposed to perform fast screening of massive φ-OTDR raw data to pinpoint those signals with significance.

关键词： OTDR signal disturbed

Geobacter sulfurreducens promoted the biosynthesis of reduced graphene oxide and coupled it for nitrobenzene reduction

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Journal of Environmental Sciences 2024年第4期138卷 458-469页

作者： Shoujuan Zhang Qi Liu Linrui Zhong Jianhong Jiang Xiaozhe Luo Xingxin Hu Qian Liu Yue Lu College of Environmental Science and engineering Hunan UniversityChangsha 410082China Shenzhen research institute Hunan UniversityShenzhen 510082China Key Laboratory of Environment Biology and Pollution Control Hunan UniversityMinistry of EducationChangsha 410082China China Machinery International engineering Design&research institute Co. LtdChangsha 410007China Hunan engineering research Center for water Treatment Process&Equipment Changsha 410007China

In order to explore an efficient and green method to deal with nitrobenzene(NB)pollutant,reduced graphene oxide(r GO)as an electron shuttle was applied to enhance the extracellular electron transfer(EET)process of Geobacter sulfurreducens,which was a typical electrochemically active bacteria(EAB).In this study,r GO biosynthesis was achieved via the reduction of graphene oxide(GO)by *** PCA within 3 ***,the r GOPCA combining system completely reduced 50-200μmol/L of NB to aniline as end product within one *** characterization revealed that PCA cells were partly wrapped by rGO,and therefore the distance of electron transfer between strain PCA and r GO material was ***,the ID/IGof GO,r GO,and r GO-PCA combining system were 0.990,1.293 and 1.31,***,highest currents were observed in r GO-PCA-NB as 12.950μA/-12.560μA at -408 m V/156 m V,attributing to the faster electron transfer efficiency in EET ***,the NB reduction was mainly due to:(I)direct EET process from *** PCA to NB;(II)r GO served as electron shuttle and accelerated electron transfer to NB,which was the main degradation ***,the biosynthesis of r GO via GO reduction by Geobacter promoted the NB removal process,which provided a facile strategy to alleviate the problematic nitroaromatic pollution in the environment.

关键词： Reduced graphene oxide Geobacter Nitrobenzene Removal Extracellular electron transfer

Tourmaline guiding the electric field and dechlorination pathway of 2,3-dichlorophenol by Desulfitobacterium hafniense

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Journal of Environmental Sciences 2024年第1期135卷 262-273页

作者： Yue Lu Fangyi Liang Fanzhi Qin Linrui Zhong Jianhong Jiang Qi Liu Shoujuan Zhang Ming Yan Changzheng Fan Haoran Dong College of Environmental Science and engineering Hunan UniversityChangsha 410082China Shenzhen research institute Hunan UniverisyShenzhen 510082China Key Laboratory of Environment Biology and Pollution Control Hunan UniversityMinistry of EducationChangsha 410082China China Machinery International engineering Design&research institute Co. Ltd.Changsha 410007China Hunan engineering research Center for water Treatment Process&Equipment Changsha 410007China

The dehalogenation of organohalides has been a research hotspot in bioremediation field;however,the influence of tourmaline,a natural ore that can generate spontaneous electric field,on organohalide-respiring bacteria(OHRB)and their dechlorination process is not well *** this study,the effect and mechanism of tourmaline on the reductive dechlorination of 2,3-dichlorophenol(2,3-DCP)by Desulfitobacterium hafniense DCB-2Twere *** characterization results confirmed that tourmaline had good stability and the optimal dosage of tourmaline was 2.5 g/L,which shortened the total time required for dechlorination reaction to 72 ***,tourmaline amendment also increased the proportion of 2-chlorophenol(2-CP)from 18%to 30%of end products,while that of 3-CP decreased *** theoretical calculations showed that the bond charge of the orthosubstituted chlorine declined from-0.179 to-0.067,and that of meta-substituted chlorine increased from-0.111 to-0.129,which indicated that the spontaneous electric field of tourmaline affected the charge distribution of 2,3-DCP and was more conducive to the generation of ***,tourmaline with the spontaneous electric field affected the reductive dechlorination pathway of Desulfitobacterium,and the tourmaline-OHRB combining system might serve as a novel strategy for the bioremediation of environments polluted with chlorinated phenols.

关键词： Reductive dechlorination Desulfitobacterium hafniense Tourmaline Electric field 2 3-dichlorophenol

Cobalt-based heterogeneous catalysts for photocatalytic carbon dioxide reduction

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Tungsten 2024年第2期6卷 410-421页

作者： Hong Yuan Jian-Hua Mei Yun-Nan Gong Di-Chang Zhong Tong-Bu Lu MOE International Joint Laboratory of Materials Microstructure Institute for New Energy Materials and Low Carbon TechnologiesSchool of Materials Science and EngineeringTianjin University of TechnologyTianjin 300384China

Solar light-driven CO_(2)reduction to high value-added chemicals has considered as an outstanding way to solve energy crisis and climate ***,various photocatalysts have been developed to achieve this *** them,cobaltbased heterogeneous catalysts have attracted great interest because of their promising performance,product selectivity and ***,we systematically summarize the research progress of various cobalt-based heterogeneous catalysts for the photoreduction of CO_(2),such as single-atom cobalt,and cobalt-based oxides,nitrides,sulfi des,phosphides,metal-organic frameworks and covalent-organic ***,the advantages and structure-activity relationship of these catalysts in photocatalytic CO_(2)reduction reaction are ***,the challenges and prospects for constructing cobaltbased heterogeneous catalysts with high effi ciency are highlighted.

关键词： Cobalt Heterogeneous catalysts CO_(2)reduction Photocatalysis

Laser-rewritable room temperature phosphorescence based on in-situ polymerized tartaric acid

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Science China Chemistry 2024年第9期67卷 3029-3038页

作者： Tuo-Yu Zhou Tai-Wen Li Hai-Fu Zhang Rui-Lin Chai Qian Zhao Penglin Zhang Guang-Yue Li Qian-Wen Wang Chang Li Yu Shu Zhi Fan Sheng-Hua Li College of Chemical engineering and Materials Science College of SciencesTianjin University of Science&TechnologyTianjin 300457China College of Chemical engineering North China University of Science and TechnologyTangshan 063210China tianjin Key Laboratory of Multiplexed Identification for Port Hazardous Chemicals Tianjin University of Science&TechnologyTianjin 300457China

Organic room temperature phosphorescence(RTP)materials have potential applications in information technology and ***,the precise control of the afterglow in reversible manners remains challenging for organic ***,we report a kind of organic RTP material fabricated by simple heating mixtures of tartaric acid(TA)and aromatic acids,which can switch their phosphorescence by *** mixtures show tunable phosphorescence from indigo to orange with phosphorescence efficiency of up to 53.99% due to locking different organic luminogens by the TA-formed matrix through the noncovalent *** afterglow of those materials lasts a few seconds and disappears by water fumigation,which can be repeated in response to wet/heat *** drop-casting those materials on glass slides,a laser-repatternable phosphorescence is achieved by facile laser direct writing and quenched by water *** results open the opportunity for the design of smart stimuli-responsive phosphorescence materials from sustainable natural products.

关键词： room temperature phosphorescence tunable afterglows tartaric acid laser direct writing stimuli-response