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Genome-wide association study identifies 12 new genetic loci associated with growth traits in pigs

Journal of Integrative Agriculture 2024年第1期23卷 217-227页

作者： Mu Zeng Binhu Wang Lei Liu Yalan Yang Zhonglin Tang Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise breeding/Key Laboratory of Animal Molecular Design and Precise breeding of Guangdong Higher Education Institutes School of Life Science and EngineeringFoshan UniversityFoshan 528231China Kunpeng Institute of Modern Agriculture at Foshan Agricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesFoshan 528200China Shenzhen Branch Guangdong Laboratory of Lingnan Modern Agriculture/Key Laboratory of Livestock and Poultry Multi-omics of Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518124China

Growth traits are among the most important economic traits in pigs and are regulated by polygenes with complex regulatory *** the major indicators of growth performance,the backfat thickness(BFT),loin eye area(LEA),and days to 100 kg(D100)traits are commonly used to the genetics improvement in ***,the available genetic markers for these traits are *** uncover novel loci and candidate genes associated with growth performance,we collected the phenotypic information of BFT,LEA,and D100 in 1,186 pigs and genotyped all these individuals using the Neogen GGP porcine 80K *** performed a genome-wide association study(GWAS)using 4 statistical models,including mixed linear models(MLM),fixed and random model circulating probability unification(farmCPU),settlement of MLM under progressively exclusive relationships(SUPER),Bayesian-information and linkage-disequilibrium Iteratively nested keyway(Blink),and identified 5,3,and 6 high-confidence single nucleotide polymorphisms(SNPs)associated with BFT,LEA,and D100,*** annotation and quantitative trait locus(QTL)mapping analysis suggested that6 genes(SKAP2,SATB1,PDE7B,PPP1R16B,WNT3,and WNT9B)were potentially associated with growth performance in *** analysis suggested that the expression of Src Kinase Associated Phosphoprotein 2(SKAP2)was higher in prenatal muscles than in postnatal muscles,and the expression of Phosphodiesterase 7B(PDE7B)continuously increased during the prenatal stages and gradually decreased after birth,implying their potential roles in prenatal skeletal muscle ***,this study provides new candidate loci and genes for the genetic improvement of pigs.

关键词： GWAS pig growth trait QTL mapping skeletal muscle

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MiR-106a targets ATG7 to inhibit autophagy and angiogenesis after myocardial infarction

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Animal Models and Experimental Medicine 2024年第4期7卷 408-418页

作者： Guofeng Bai Jinghao Yang Weili Liao Xiaofeng Zhou Yingting He Nian Li Liuhong Zhang Yifei Wang Xiaoli Dong Hao Zhang Jinchun Pan Liangxue Lai Xiaolong Yuan Xilong Wang Guangdong Provincial Key Laboratory of Laboratory Animals Guangdong Laboratory Animals Monitoring InstituteGuangzhouChina Guangdong Laboratory of Lingnan Modern Agriculture National Engineering Research Center for Breeding Swine IndustryState Key Laboratory of Swine and Poultry Breeding IndustryGuangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular BreedingCollege of Animal ScienceSouth China Agricultural UniversityGuangzhouGuangdongChina Huidong County Animal Quarantine and Inspection Institute HuizhouGuangdongChina Department of Cardiology Hainan General HospitalHainan Affiliated Hospital of Hainan Medical UniversityHainan Clinical Medicine Research InstitutionHaikouPeople's Republic of China Key Laboratory of Regenerative Biology Guangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhouGuangdongChina

Background:Myocardial infarction(MI)is an acute condition in which the heart mus-cle dies due to the lack of blood *** research has suggested that au-tophagy and angiogenesis play vital roles in the prevention of heart failure after MI,and miR-106a is considered to be an important regulatory factor in *** the specific mechanism remains *** this study,using cultured venous endothelial cells and a rat model of MI,we aimed to identify the potential target genes of miR-106a and discover the mechanisms of inhibiting autophagy and ***:We first explored the biological functions of miR-106a on autophagy and angiogenesis on endothelial *** we identified ATG7,which was the down-stream target gene of *** expression of miR-106a and ATG7 was investi-gated in the rat model of ***:We found that miR-106a inhibits the proliferation,cell cycle,autophagy and angiogenesis,but promoted the apoptosis of vein endothelial ***,ATG7 was identified as the target of miR-106a,and ATG7 rescued the inhibition of autophagy and angiogenesis by *** expression of miR-106a in the rat model of MI was decreased but the expression of ATG7 was increased in the infarction ***:Our results indicate that miR-106a may inhibit autophagy and angiogenesis by targeting *** mechanism may be a potential therapeutic treatment for MI.

关键词： angiogenesis ATG7 autophagy miR-106a miRNAs myocardial infarction

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Associations of genome-wide structural variations with phenotypic differences in cross-bred Eurasian pigs

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Journal of Animal Science and Biotechnology 2024年第1期15卷 68-87页

作者： Wencheng Zong Jinbu Wang Runze Zhao Naiqi Niu Yanfang Su Ziping Hu Xin Liu Xinhua Hou Ligang Wang Lixian Wang Longchao Zhang State Key Laboratory of Animal Biotech breeding Institute of Animal SciencesChinese Academy of Agricultural SciencesBeijing 100193China College of Animal Science Shanxi Agricultural UniversityJinzhong 030801China College of Animal Science and Technology Qingdao Agricultural UniversityQingdao 266109China

Background During approximately 10,000 years of domestication and selection,a large number of structural variations(SVs)have emerged in the genome of pig breeds,profoundly influencing their phenotypes and the ability to adapt to the local ***(≥50 bp)are widely distributed in the genome,mainly in the form of insertion(INS),mobile element insertion(MEI),deletion(DEL),duplication(DUP),inversion(INV),and translocation(TRA).While studies have investigated the SVs in pig genomes,genome-wide association studies(GWAS)-based on SVs have been rarely *** Here,we obtained a high-quality SV map containing 123,151 SVs from 15 Large White and 15 Min pigs through integrating the power of several SV tools,with 53.95%of the SVs being reported for the first *** high-quality SVs were used to recover the population genetic structure,confirming the accuracy of *** functional SV loci were then identified based on positional effects and breed ***,GWAS were performed for 36 traits by genotyping the screened potential causal loci in the F2 population according to their corresponding genomic *** identified a large number of loci involved in 8 carcass traits and 6 skeletal traits on chromosome 7,with FKBP5 containing the most significant SV locus for almost all *** addition,we found several significant loci in intramuscular fat,abdominal circumference,heart weight,and liver weight,*** We constructed a high-quality SV map using high-coverage sequencing data and then analyzed them by performing GWAS for 25 carcass traits,7 skeletal traits,and 4 meat quality traits to determine that SVs may affect body size between European and Chinese pig breeds.

关键词： Body size GWAS pig Skeleton Structural variations

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Lysine 2-hydroxyisobutyrylation levels determined adipogenesis and fat accumulation in adipose tissue in pigs

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Journal of Animal Science and Biotechnology 2024年第5期15卷 2093-2105页

作者： Enfa Yan Mingyang Tan Ning Jiao Linjuan He Boyang Wan Xin Zhang Jingdong Yin State Key Laboratory of Animal Nutrition and Feeding College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China College of Animal Science and Veterinary Medicine Shandong Agricultural UniversityTaian 271018Shandong ProvinceChina Molecular Design breeding Frontier Science Center of the Ministry of Education(MOE) Beijing 100193China

Background Excessive backfat deposition lowering carcass grade is a major concern in the pig industry,especially in most breeds of obese type *** mechanisms involved in adipogenesis and fat accumulation in pigs remain *** 2-hydroxyisobutyrylation(Khib),is a novel protein post-translational modification(PTM),which play an important role in transcription,energy metabolism and metastasis of cancer cells,but its role in adipogenesis and fat accumulation has not been *** In this study,we first analyzed the modification levels of acetylation(Kac),Khib,crotonylation(Kcr)and succinylation(Ksu)of fibro-adipogenic progenitors(FAPs),myogenic precursors(Myo)and mesenchymal stem cells(MSCs)with varied differentiation potential,and found that only Khib modification in FAPs was significantly higher than that in ***,in parallel with its regulatory enzymes lysine acetyltransferase 5(KAT5)and histone deacetylase 2(HDAC2)protein levels,the Khib levels increased quadratically(Ppigs(Laiwu pigs)and lean-type pigs(Duroc pigs),***,the expression patterns of KAT5 and HDAC2 matched well to the degree of backfat accumulation in obese-and lean-type *** From the perspective of protein translational modification,we are the first to reveal the role of Khib in adipogenesis and fat deposition in pigs,and provided new clues for the improvement of fat accumulation and distribution as expected via genetic selection and nutritional strategy in obese-type pigs.

关键词： Adipogenesis Backfat Fat accumulation 2-Hydroxyisobutyrylation Intramuscular fat content pigs

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Effect of vacuum negative pressure aerobic hydrolysis pretreatment on corn stover anaerobic fermentation

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International Journal of Agricultural and Biological Engineering 2023年第2期16卷 241-248页

作者： Yonghua Xu Yunong Song Hao Jiang Hongqiong Zhang Yong Sun Northeast Agriculture University Harbin 150030China Key Laboratory of pig-breeding Facilities Engineering Ministry of AgricultureHarbin 150030China

Lignin degradation restricts corn stover anaerobic fermentation *** vacuum negative pressure aerobic hydrolysis pretreatment of corn stover was tested,and the optimal combined pretreatment conditions were presented in this *** of the physical characteristics of light weight and large specific porosity of stover,it led to the formation of a scum layer during the fermentation process and thus reduced the gas production *** the pretreatment design,the vacuum conditions(0.02-0.08 MPa)and dwell time(5-20 min)were selected to see the changes of volumetric weight,swelling and specific porosity of corn stover,resulting in an increase of the volumetric weight by 7.18%-28.72%,an increase of the swelling by 3.18%-58.59%,and a decrease of the specific porosity by 9.34%-38.59%,as compared with the CK *** vacuum negative pressure treatment could discharge the air inside the stover destroy the microstructure,and cause the stover to settle more easily during the aerobic hydrolysis *** optimal aerobic hydrolysis temperature and time were determined to be 39°C and 12.65 h,*** the optimal pretreatment,the corn stover anaerobic fermentation test realized a cumulative methane yield of 260.44 mL/g VS,22.71%higher than CK group;meanwhile,the hydraulic retention time was shortened by 32.39%.

关键词： corn stover vacuum negative pressure pretreatment aerobic hydrolysis anaerobic fermentation

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Automatic Monitoring of Chilling Requirement for Sweet Cherry and Its Application in Protected Cultivation

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Agricultural Biotechnology 2016年第3期5卷 16-20,34页

作者： Daohui ZHANG Hongjun ZHAO Hechun GAO Yue TAN Jiawei WANG Xin CHEN Hairong WEI Qing-zhong LIU Shandong Institute of Pomology/Key Laboratory for Fruit Biotechnology breeding of Shandong Province Taian 271000China Scientific Research Office Shandong Academy of Agricultural ScienceJinan 250100China Breeder Seed farm of ninghe County Ninghe 301500China

For sweet cherry, the economic benefit of protected cultivation is much higher than that of open field cultivation. However, problems such as nonuniform germination, aberrant flower, abortion, bad fruit setting and delayed maturation appear frequently due to the inaccurate regulation of chilling requirement. In order to solve the problems, an automatic system for monitoring, selecting and recording of chilling requirement in protected cultivation of sweet cherry was designed and developed. The system, which consisted of temperature detection, effective chilling temperature selection, signal conversion and output and chilling accumulation display, had been continuously used in protected cultivation of sweet cherry for 3 years and good effects had been achieved. The system monitored chilling accumu- lation accurately and made it more reasonable for the time selection of greenhouse covering, thus avoiding risks of nonuniform germination, bad fruit setting and de- layed maturation, etc. Under the coordinate application of this system with other modern measuring and controlling techniques such as automatic detection and alarming of temperature and humidity, the environment in greenhouses was regulated precisely that the uniform fruits were obtained and the expected yield, quality and harvest time were achieved.

关键词： Chilling requirement Sweet cherry Protected cultivation Automatic monitoring High quality and yield

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The influence of selected agronomic factors on the chemical composition of spelt wheat(Triticum aestivum ssp. spelta L.) grain

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Journal of Integrative Agriculture 2016年第8期15卷 1763-1769页

作者： Wioletta Biel Slawomir Stankowski Anna Jaroszewska Stanislaw Puzyński Paulina Bosko Department of pig breeding Animal Nutrition and Food West Pomeranian University of Technology in Szczecin Szczecin 71-460 Poland Department of Agronomy West Pomeranian University of Technology in Szczecin Szczecin 71-459 Poland

supported by the Polish Ministry of Science and Higher Education （MNiSW） of Poland （NN 310436938） in 2010–2013

关键词： new breeding strains sowing rate spelt weed control

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Ammonia-induced oxidative stress triggered proinflammatory response and apoptosis in pig lungs

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Journal of Environmental Sciences 2023年第4期126卷 683-696页

作者： Daojie Li Long Shen Di Zhang Xiaotong Wang Qiankun Wang Wenhao Qin Yun Gao Xiaoping Li Key Lab of Agricultural Animal Genetics Breeding and Reproduction of Ministry of EducationCollege of Animal Science and TechnologyThe Cooperative Innovation Center for Sustainable Pig ProductionHuazhong Agricultural UniversityWuhan 430070China College of Science Huazhong Agricultural UniversityWuhan 430070China College of Engineering The Cooperative Innovation Center for Sustainable Pig ProductionHuazhong Agricultural UniversityWuhan 430070China

Ammonia,a common toxic gas,is not only one of the main causes of haze,but also can enter respiratory tract and directly affect the health of humans and *** was used as an animal model for exploring the molecular mechanism and dose effect of ammonia toxicity to *** this study,the apoptosis of type II alveolar epithelial cells was observed in high ammonia exposure group using transmission electron *** and protein expression analysis using transcriptome sequencing and western blot showed that low ammonia exposure induced T-cell-involved proinflammatory response,but high ammonia exposure repressed the expression of DNA repair-related genes and affected ion ***,high ammonia exposure significantly increased 8-hydroxy-2-deoxyguanosine (8-OHdG) level,meaning DNA oxidative damage *** addition,both low and high ammonia exposure caused oxidative stress in pig *** analysis of transcriptome and metabolome revealed that the up-regulation of LDHB and ND2 took part in high ammonia exposure-affected pyruvate metabolism and oxidative phosphorylation progress,***,oxidative stress mediated ammonia-induced proinflammatory response and apoptosis of porcine *** findings may provide new insights for understanding the ammonia toxicity to workers in livestock farms and chemical fertilizer plants.

关键词： Ammonia Lung Proinflammatory response Oxidative stress Apoptosis Energy metabolism

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Dietary lysozyme improves growth performance and intestinal barrier function of weaned piglets

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Animal Nutrition 2023年第3期14卷 249-258页

作者： Yuying Wu Bei Cheng Longxiang Ji Xiangyun Lv Yingying Feng Liu’an Li Xin Wu tianjin Key Laboratory of Agricultural Animal breeding and Healthy Husbandry College of Animal Science and Veterinary MedicineTianjin Agricultural UniversityTianjin300384China tianjin Institute of Industrial Biotechnology Chinese Academy of SciencesTianjin300308China Zhumadian Huazhong Chia Tai Co. Ltd.Zhumadian463000China

Lysozyme(LZ)is a purely natural,nonpolluting and nonspecific immune factor,which has beneficial effects on the healthy development of *** this study,the influences of LZ on the growth performance and intestinal barrier of weaned piglets were studied.A total of 48 weaned piglets(Landrace×Yorkshire,22 d old)were randomly divided into a control group(basal diet)and a LZ group(0.1%LZ diet)for 19 *** results showed that LZ could significantly improve the average daily gain(ADG,Ppig production.

关键词： Lysozyme Growth performance Intestinal barrier Intestinal flora Weaned piglet

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Localization of Porcine Neturopetide Y-Y1 mRNA in Hypothalamus-Pituitary-Ovary Axis during Puberty

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Animal Husbandry and Feed Science 2010年第1期2卷 8-10页

作者： ZHOU Chun-bao WANG Ri-jun NI Li-gang HAN Da-yong Jiangsu Animal Husbandry & Veterinary College Taizhou 225300 China Jiangsu Jiangquhai breeding pig farm Taizhou 225300 China

[ Objective] To observe the disposition and localization of neturopetide Y-Y1 （ NPY-Y1 ） mRNA in hypothalamus, pituitary and ovary during puberty. [ Methed] Three 60-day-old Sujiang sows weighing 20 kg and three 160-day-old Sujiang sows weighing 80 kg were selected and anaesthetized. The hypothalamus, pituitary and ovary were taken out for preparation of frozen sections. The expression and localization of the NPY-Y1 mRNA in hypothalamus-pituitary-ovary axis was observed by the in situ hybridization. The PBS was substituted for hybridization solution to set up a control. ~ Result] Positive hybridization signals of the NPY-Y1 mRNA were detected in the hypothalamus, pituitary and ovary at different develop- mental stages, and these signals were stronger in the 60-day-old sows （before the puberty） than in the 160-day-old sows （during the puberty）. E Conclusion] The NPY-Y1 mRNA is distributed in the hypothalamus-pituitary-ovary axis and can regulate reproductive process of sows.

关键词： Sujiang sows Neturopetide Y-Y1 Puberty Hypothalamus-pituitary-ovary axis In situ hybridization

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