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Effects of octaco.anol extracted from rice bran on blood hormone levels and gene expressions of gluco.e transporter protein-4 and adenosine monophosphate protein kinase in weaning piglets

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Animal Nutrition 2015年第4期1卷 293-298页

作者： Lei Long Shugeng Wu Jing Sun Jing Wang Haijun Zhang Guanghai Qi Key Laboratory of Feed biotechnology of Ministry of Agriculture Feed Research Institute Chinese Academy of Agriculture Sciences tianjin naer biotechnology co. Ltd.

The object of this study was to explore the regulatory mechanism of octaco.anol to the body of animals and the effects of octaco.anol on blood hormone levels and gene expressions of gluco.e transporter protein（GLUT-4） and adenosine monophosphate protein kinase（AMPK） in liver and muscle tissue of weaning piglets. A total of 105 crossbred piglets（[Yorkshire x Landrace] x Duroc） with an initial BW of5.70 ± 1.41 kg（21 d of age） were used in a 6-wk trial to evaluate the effects of octaco.anol and tiamulin supplementation on co.tents of triiodothyronine（T3）,thyroxine（T4）,growth hormone（GH）,glucagon（GU） and adrenaline（AD） in blood and gene expressions of GLUT-4 and AMPK in liver and muscle. Piglets were randomly distributed into 3 dietary treatments on the basis of BW and sex. Each treatment had 7 replicate pens with 5 piglets per pen. Treatments were as followed: co.trol group, tiamulin group and octaco.anol group. The results showed that co.pared with co.trol group and tiamulin group, octaco.anol greatly promoted the secretion of T3, GH, GU and AD（P co.trol group and tiamulin group in T3, T4, GH,GU or AD（P> 0.05）, Results of the present study has co.firmed that octaco.anol affects energy metabolism of body by regulating secretion of blood hormones and related gene expression in tissue of weaning piglets, which can reduce stress response and has an impact on performance.

关键词： Octaco.anol Weaning piglets Hormone GLUT-4 AMPK

Rapid evaluating caking tendency of nonspherical crystals by developing a shape-based crystal bridge growth model

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Particuology 2024年第12期95卷 265-278页

作者： Mingxuan Li Mengdi Zhang Wei Zhao Leida Zhang Mingyang Chen Dandan Han Junbo Gong State Key Laboratory of Chemical Engineering School of Chemical Engineering and TechnologyTianjin UniversityTianjin300072China Institute of Shaoxing Tianjin UniversityShaoxing312300China Shandong Fuyang biotechnology co. Ltd.Dezhou253100China

Crystal caking is a decisive factor affecting the quality of high-end fine chemicals,whereas lack of shape-to-caking understanding results in co.siderable waste of time,severely delaying high-end fine chemical *** this basis,a morphology-based caking evaluation model is developed with 74%and 96%time savings co.pared to previous modeling and non-modeling experiments,respectively,while guaranteeing superior *** crystal morphology is expressed as a function of the aspect ratio and the particle size *** quantitative relationships between these parameters and the caking tendency are deduced,firstly achieving morphology anti-caking criterion *** D-allulose crystals,co.sidering humidity,and particle size,an aspect ratio is below 3 is the standard for co.bating caking,which has not been reported ***,the specific effect of crystal morphology on caking behavior is quantitatively *** knowledge obtained can be applied to rapidly and quantitatively design anti-caking storage systems for products in warehouses.

关键词： Caking evaluation Crystal morphology D-allulose Rod-like crystal Crystal bridge growth model

Induction of nucleoside phosphorylase in Enterobacter aerogenes and enzymatic synthesis of adenine arabinoside

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Journal of Zhejiang University-Science B(Biomedicine & biotechnology) 2008年第7期9卷 520-526页

作者： Xiao-kun WEI Qing-bao DING Lu ZHANG Yong-li GUO Lin OU Chang-lu WANG co.lege of biotechnology Tianjin University of Science and Technology Tianjin 300457 China State Key Lab of Bioreactor Engineering East China University of Science and Technology Shanghai 200237 China Shanghai Weiping Bioscience and biotechnology co. Ltd. Shanghai 200237 China

Nucleoside phosphorylases (NPases) were found to be induced in Enterobacter aerogenes DGO-04, and cytidine and cytidine 5′-monophosphate (CMP) were the best inducers. Five mmol/L to fifteen mmol/L cytidine or CMP co.ld distinctly increase the activities of purine nucleoside phosphorylase (PNPase), uridine phosphorylase (UPase) and thymidine phosphorylase (TPase) when they were added into medium from 0 to 8 h. In the process of enzymatic synthesis of adenine arabinoside from adenine and uracil arabinoside with wet cells of Enterobacter aerogenes DGO-04 induced by cytidine or CMP, the reaction time co.ld be shortened from 36 to 6 h. After enzymatic reaction the activity of NPase in the cells induced remained higher than that in the cells uninduced.

关键词： Nucleoside phosphorylase (NPase) Enterobacter aerogenes Cytidine Cytidine 5'-monophosphate (CMP) Adenine arabinoside

Particle size distribution design of limited agglomeration via geometric morphology in erythritol crystallization

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Particuology 2024年第11期94卷 158-172页

作者： Mingxuan Li Suoqing Zhang Jiansong Wang Jiahui Li Wei Zhao Leida Zhang Mingyang Chen Dandan Han Junbo Gong State Key Laboratory of Chemical Engineering School of Chemical Engineering and TechnologyTianjin UniversityTianjin300072China Institute of Shaoxing Tianjin UniversityZhejiang312300China Shandong Fuyang biotechnology co. Ltd.Shandong253100China Haihe Laboratory of Sustainable Chemical Transformations Tianjin300192China

Regarding sugar and salt crystallization with large single crystals,the agglomerate thermodynamics and geometric morphologies,not the dynamics,dominate the particle size distribution(PSD).To co.sider this issue,a PSD design model is proposed for limited large crystal *** this model,the agglomeration thermodynamic criticality is determined by estimating the adhesion and dispersion forces between single *** geometric agglomerate morphologies are described by co.responding single crystal units stacking with *** seed well-co.trolled of population,the key parameters of PSD(D01,D50 and D99)are precisely *** erythritol,the model design accuracies are 92%–99%in the 1.2 L and 10 L crystallizers,indicating that it can design PSD at various crystallization *** the general research attention to microcrystal agglomeration kinetics(mostly active pharmaceutical ingredients),this model effectively guides the sugar and salt PSD design with limited large crystal agglomeration.

关键词： Particle size distribution design Agglomeration Crystal geometric morphology Mathematic model Erythritol

Dietary lysozyme improves growth performance and intestinal barrier function of weaned piglets

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Animal Nutrition 2023年第3期14卷 249-258页

作者： Yuying Wu Bei Cheng Longxiang Ji Xiangyun Lv Yingying Feng Liu’an Li Xin Wu tianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry College of Animal Science and Veterinary MedicineTianjin Agricultural UniversityTianjin300384China tianjin Institute of Industrial biotechnology Chinese Academy of SciencesTianjin300308China Zhumadian Huazhong Chia Tai co. Ltd.Zhumadian463000China

Lysozyme(LZ)is a purely natural,nonpolluting and nonspecific immune factor,which has beneficial effects on the healthy development of *** this study,the influences of LZ on the growth performance and intestinal barrier of weaned piglets were studied.A total of 48 weaned piglets(Landrace×Yorkshire,22 d old)were randomly divided into a co.trol group(basal diet)and a LZ group(0.1%LZ diet)for 19 *** results showed that LZ co.ld significantly improve the average daily gain(ADG,Pco.ld effectively improve the growth performance,relieve inflammation and improve the intestinal barrier function of weaned *** findings provided an important theoretical basis for the application of LZ in pig production.

关键词： Lysozyme Growth performance Intestinal barrier Intestinal flora Weaned piglet

Blood cell co.nting based on U-Net++ and YOLOv5

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Optoelectronics Letters 2023年第6期19卷 370-376页

作者： BAI Hua WANG Xuechun GUAN Yingjian GAO Qiang HAN Zhibo tianjin Key Laboratory of Optoelectronic Detection Technology and Systems School of Electronic and Information EngineeringTiangong UniversityTianjin 300387China Shenzhen Weian co.create biotechnology co. Ltd.Shenzhen 518000China tianjin Key Laboratory of Engineering Technologies for Cell Phamaceutical Tianjin 300457China National Engineering Research Center of Cell Products/AmCellGene co. Ltd.Tianjin 300457China

Clinical information about a variety of disorders is available through blood cell co.nting,which is usually done by manual ***,manual methods are co.plex,time-co.suming and susceptible to the subjective experience of *** many efforts have been made to develop automated blood cell co.nting algorithms,the co.plexity of blood cell distribution and the highly overlapping nature of some red blood cells(RBCs) remain significant challenges that limit the improvement of analytical ***,we proposed an end-to-end method for blood cell co.nting based on deep ***,U-Net++ was used to segment the whole blood cell image into several regions of interest(ROI),and each ROI co.tains only one single cell or multiple overlapping ***,YOLOv5 was used to detect blood cells in each ***,we proposed several strategies,including fine classification of RBCs,adaptive adjustment for non-maximal suppression(NMS) threshold and blood cell morphology co.straints to improve the accuracy of ***,the detection outco.es for each ROI were co.bined and *** results show that our method can effectively address the issue of high overlap and precisely segment and detect blood cells,with a 98.18% accuracy rate for blood cell co.nting.

关键词： Blood co.suming overlap

De novo transcriptome assembly of Aureobasidium melanogenum CGMCC18996 to analyze theβ-poly(L-malic acid)biosynthesis pathway under the Caco.(3) addition

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Food Science and Human Wellness 2023年第4期12卷 1248-1256页

作者： Genan Wang Haisong Yin Tingbin Zhao Donglin Yang Shiru Jia Changsheng Qiao Key Laboratory of Industrial Fermentation Microbiology(tianjin University of Science and Technology) Ministry of EducationTianjin 300457China tianjin Engineering Research Center of Microbial Metabolism and Fermentation Process co.trol College of BiotechnologyTianjin University of Science and TechnologyTianjin 300457China School of Bioengineering Tianjin Modern Vocational Technology CollegeTianjin 300350China tianjin Huizhi Biotrans Bioengineering co. Ltd.Tianjin 300457China

β-Poly(L-malic acid)(PMLA)is a water-soluble biopolymer used in food,medicine and other *** date,the biosynthesis pathway of PMLA has not been fully *** this study,we sequenced the transcriptom e of strain Aureobasidium melanogenum under 20 g/L Caco.(3) *** resulting sequencing reads were assembled and annotated for the differentially expressed genes(DEGs)analysis and novel transcripts *** result indicated that with the Caco.(3) addition,the tricarboxylic cycle(TCA)cycle and glyoxylate pathway were up-regulated,and it also found that a non-ribosomal peptide synthetase(NRPS)like protein was highly *** DEGs analysis showed a high expression level of malate dehydrogenase(MDHC)and phosphoenolpyruvate carboxykinase(PCKA)in the Caco.(3) group,which indicated a cytosolic malate *** speculated that the malate should be transported to or synthesized in the cytoplasm,which was then polymerized to PMLA by the NRPS-like protein,acco.panied by the up-regulated TCA cycle providing ATP for the *** on the analysis,we assumed that an NRPS-like protein,the TCA cycle,and the cytosolic malate together are co.tributing to the PMLA biosynthesis.

关键词： De novo transcriptome analysis β-Poly(L-malic acid) Aureobasidium melanogenum

Phosphatidylserine:An overview on functionality,processing techniques,patents,and prospects

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Grain & Oil Science and Technology 2023年第4期6卷 206-218页

作者： Jingnan Chen Jun Li Haoyu Xu Jiaxi Li Yonghong Yuan Xuebing Xu Yanlan Bi co.lege of Food Science and Engineering Henan University of TechnologyZhengzhou 450001China Wilmar(Shanghai)biotechnology Research and Development Center co. Ltd.Shanghai 200137China Enzymeco.e biotechnology co. Ltd.Binhai New DistrictTianjin 300457China

Phosphatidylserine(PS)is the part of cell structure in the body and has many beneficial functions especially in brain-related aging *** daily foods can provide PS to human body,the amount is very limited due to its poverty in most *** overco.e the issue,numerous studies based on PS have been reported to develop PS-related *** this review,PS was co.prehensively and critically reviewed from the view of resources,functions,processing techniques,patents,and *** resources,animal,plant,and microorganism origins were all co.ered with their differences in co.position *** functions,benefits regarding memory,co.nitive enhancement,exercise performance,reducing Alzheimer’s disease,and attention-deficit hyperactivity disorder symptoms were co.ered as well as the functional differences among animal-,plant-,and microorganism-based PS-related *** processing techniques,traditional extracting methods from animal,plant,and microorganism tissues were co.paratively discussed with enzymatic synthesis based on different reaction ***,patents of PS-related supplements were evaluated as well as their *** review co.ld provide scientific and valuable support for PS industry.

关键词： Phosphatidylserine Functionality Processing techniques Patents evaluation Prospects

Artificial Bear Bile:A Novel Approach to Balancing Medical Requirements and Animal Welfare

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Engineering 2024年第7期38卷 100-112页

作者： Yong Li Yuhong Huang Nan Feng Heping Zhang Jing Qu Shuanggang Ma Yunbao Liu Jiang Li Shaofeng Xu Ling Wang Mi Zhang Jie Cai Weiping Wang Ru Feng Hang Yu Bo Yu Dailiang Liang Heping Qin Suxiang Luo Yanfen Li Meifeng Li Ruihua Wang Chen Ma Yan Wang Xiaobo Cen Xiaoxian Xu Boli Zhang Xiaoliang Wang Shishan Yu State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China The Seco.d Affiliated Hospital of tianjin University of Traditional Chinese Medicine Tianjin 300250China Zhongshan Belling biotechnology co. Ltd.Zhongshan 528437China Zhongshan Anshi Biopharmaceutical co. Ltd.Zhongshan 528437China WestChina-Frontier Pharma Tech co. Ltd.Chengdu 610041China tianjin University of Traditional Chinese Medicine Tianjin 301617China

Bear bile has been a valuable and effective medicinal material in traditional Chinese medicine(TCM)for over 13 ***,the current practice of obtaining it through bear farming is under scrutiny for its adverse impact on bear ***,we present a new approach for creating artificial bear bile(ABB)as a high-quality and sustainable alternative to natural bear *** study addresses the scientific challenges of creating bear bile alternatives through interdisciplinary co.laborations across various fields,including resources,chemistry,biology,medicine,pharmaco.ogy,and TCM.A co.prehensive efficacy assessment system that bridges the gap between TCM and modern medical terminology has been established,allowing for the systematic screening of therapeutic *** the utilization of chemical synthesis and enzyme engineering technologies,our research has achieved the environmentally friendly,large-scale production of bear bile therapeutic co.pounds,as well as the optimization and reco.position of ABB *** resulting ABB not only closely resembles natural bear bile in its co.position but also offers advantages such as co.sistent product quality,availability of raw materials,and independence from threatened or wild *** preclinical efficacy evaluations have demonstrated the equivalence of the therapeutic effects from ABB and those from co.mercially available drained bear bile(DBB).Furthermore,preclinical toxico.ogical assessment and phase I clinical trials show that the safety of ABB is on par with that of the currently used *** innovative strategy can serve as a new research paradigm for developing alternatives for other endangered TCMs,thereby strengthening the integrity and sustainability of TCM.

关键词： Artificial bear bile Chemical profile Formula optimization Pharmaco.ynamic co.sistency Preclinical toxico.ogical assessment