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Low-cost surface modification of a biomedical Zr-2.5Nb alloy fabricated by electron beam melting

Journal of Materials Science & Technology 2023年第12期143卷 178-188页

作者： Caixu Wang Xiaoli Zhao Shujun Li Lu Liu Deliang Zhang Mitsuo Niinomi School of Materials Science and Engineering Northeastern UniversityShenyang 110819China Shi-changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China key laboratory of Data Analytics and Optimization for Smart Industry(Ministry of Education) Northeastern UniversityShenyang 110819China tianjin key laboratory of bone implants interface functionalization and personalization Tianjin 300190China Institute for Materials Research Tohoku UniversitySendaiMiyagi 9808577Japan Division of Materials and Manufacturing Science Graduate School of EngineeringOsaka UniversityOsaka 565-0871Japan Department of Materials Science and Engineering Graduate School of Science and TechnologyMeijo UniversityNagoya 468-8502Japan Faculty of Chemistry Materials and BioengineeringKansai UniversityOsaka 564-860Japan

The Zr-2.5Nb alloy with a fine microstructure consisting ofαlaths was successfully prepared by electron beam melting(EBM).The thermal oxidation behaviors and kinetics of the as-built,and the EBM-built and hot isostatically pressed(HIPed)Zr-2.5Nb materials in a temperature range of 450-600°C were in-vestigated and compared with those of the alloy prepared by conventional casting and forging.It was found that the oxidation kinetics of the as-built and the forged materials followed the parabolic rate law during isothermal oxidation at 550°C,but the HIPed materials exhibited a parabolic-to-linear kinetic transition,suggesting that the larger grain sizes enhanced the oxidation.The oxide layers of all materials were composed of a large fraction of monoclinic zirconia phase(m-ZrO_(2))and a small fraction of tetrago-nal zirconia phase(t-ZrO_(2)),and transformed from t-ZrO_(2)to m-ZrO_(2)with increasing oxidation time.The surface hardness of the as-built,the forged and the HIPed materials increased from 215,204,and 188 HV before oxidation to 902,1070,and 1137 HV after oxidation,respectively.The cross-sections of the materi-als showed the presence of micropores and microcracks inside the oxide layers with thicknesses ranging from 4 to 8μm.With the oxidation temperature of 600°C and oxidation time duration of 3 h,a dense black m-ZrO_(2)oxide layer with smooth surface and 902 HV hardness was obtained on the EBM as-built Zr-2.5Nb materials.

关键词： Zr-2.5Nb alloy Electron beam melting Thermal oxidation Oxidation behaviors and kinetics Grain size

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Inhibition of furin by bone targeting superparamagnetic iron oxide nanoparticles alleviated breast cancer bone metastasis

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Bioactive Materials 2021年第3期6卷 712-720页

作者： Yichuan Pang Li Su Yao Fu Fan Jia Chenxi Zhang Xiankun Cao Wenxin He Xueqian Kong Jiake Xu Jie Zhao An Qin Shanghai key laboratory of Orthopedic implants Department of OrthopaedicsShanghai Ninth People's HospitalShanghai Jiaotong University School of MedicineShanghai200011China Department of Nuclear Medicine Shanghai Tenth People's HospitalTongji University School of MedicineShanghai200072China Hongqiao International Institute of Medicine Shanghai Jiaotong University School of Medicine201103China Center for Chemistry of High-Performance&Novel Materials Department of ChemistryZhejiang UniversityHangzhou310027China MOE key laboratory of Macromolecular Synthesis and functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou310027China School of Biomedical Sciences The University of Western AustraliaPerthWestern Australia6009Australia

Breast cancer bone metastasis poses significant challenge for therapeutic strategies.Inside the metastatic environment,osteoclasts and tumor cells interact synergistically to promote cancer progression.In this study,the proprotein convertase furin is targeted due to its critical roles in both tumor cell invasion and osteoclast function.Importantly,the furin inhibitor is specifically delivered by bone targeting superparamagnetic iron oxide(SPIO)nanoparticles.Our in vitro and in vivo data demonstrate that this system can effectively inhibit both osteoclastic bone resorption and breast cancer invastion,leading to alleviated osteolysis.Therefore,the bone targeting&furin inhibition nanoparticle system is a promising therapeutic and diagnostic strategy for breast cancer bone metastasis.

关键词： Breast cancer metastasis Osteoclast Furin bone targeting Iron oxide nanoparticles

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Surface modification of titanium substrate via combining photothermal therapy and quorum-sensing-inhibition strategy for improving osseointegration and treating biofilm-associated bacterial infection

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Bioactive Materials 2022年第12期7卷 228-241页

作者： Jingwei Hu Yao Ding Bailong Tao Zhang Yuan Yulu Yang Kun Xu Xuan Li Peng liu Kaiyong Cai key laboratory of Biorheological Science and Technology Ministry of EducationCollege of BioengineeringChongqing UniversityChongqing400044China laboratory Research Center The First Affiliated Hospital of Chongqing Medical UniversityChongqing400016China Institute of Medical Research Northwestern Polytechnical UniversityXi’an710072China

Insufficient osseointegration and biofilm-associated bacterial infection are important challenges for clinical application of titanium(Ti)-based implants.Here,we constructed mesoporous polydopamine(MPDA)nanoparticles(NPs)loaded with luteolin(LUT,a quorum sensing inhibitor),which were further coated with the shell of calcium phosphate(CaP)to construct MPDA-LUT@CaP nanosystem.Then,MPDA-LUT@CaP NPs were immobilized on the surface of Ti implants.Under acidic environment of bacterial biofilm-infection,the CaP shell of MPDA-LUT@CaP NPs was rapidly degraded and released LUT,Ca^(2+)and PO_(4)^(3-)􀀀from the surface of Ti implant.LUT could effectively inhibit and disperse biofilm.Furthermore,under near-infrared irradiation(NIR),the thermotherapy induced by the photothermal conversion effect of MPDA destroyed the integrity of the bacterial membrane,and synergistically led to protein leakage and a decrease in ATP levels.Combined with photothermal therapy(PTT)and quorum-sensing-inhibition strategy,the surface-functionalized Ti substrate had an antibacterial rate of over 95.59%against Staphylococcus aureus and the elimination rate of the formed biofilm was as high as 90.3%,so as to achieve low temperature and efficient treatment of bacterial biofilm infection.More importantly,the modified Ti implant accelerated the growth of cell and the healing process of bone tissue due to the released Ca^(2+)and PO_(4)^(3-)􀀀.In summary,this work combined PTT with quorum-sensing-inhibition strategy provides a new idea for surface functionalization of implant for achieving effective antibacterial and osseointegration capabilities.

关键词： Titanium implant Biofilm infection Osseointegration Photothermal therapy Quorum sensing

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Advanced surface engineering of titanium materials for biomedical applications:From static modification to dynamic responsive regulation

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Bioactive Materials 2023年第9期27卷 15-57页

作者： Pinliang Jiang Yanmei Zhang Ren Hu Bin Shi Lihai Zhang Qiaoling Huang Yun Yang Peifu Tang Changjian Lin South China Advanced Institute for Soft Matter Science and Technology School of Emergent Soft MatterGuangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and DevicesSouth China University of TechnologyGuangzhou510640China State key Lab of Physical Chemistry of Solid Surfaces Department of ChemistryCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen361005China Department of Orthopaedics General Hospital of Chinese PLABeijing100853China Research Institute for Biomimetics and Soft Matter Fujian Provincial Key Laboratory for Soft Functional Materials ResearchCollege of Physical Science and TechnologyXiamen UniversityXiamen361005China

Titanium(Ti)and its alloys have been widely used as orthopedic implants,because of their favorable mechanical properties,corrosion resistance and biocompatibility.Despite their significant success in various clinical applications,the probability of failure,degradation and revision is undesirably high,especially for the patients with low bone density,insufficient quantity of bone or osteoporosis,which renders the studies on surface modification of Ti still active to further improve clinical results.It is discerned that surface physicochemical properties directly influence and even control the dynamic interaction that subsequently determines the success or rejection of orthopedic implants.Therefore,it is crucial to endow bulk materials with specific surface properties of high bioactivity that can be performed by surface modification to realize the osseointegration.This article first reviews surface characteristics of Ti materials and various conventional surface modification techniques involving mechanical,physical and chemical treatments based on the formation mechanism of the modified coatings.Such conventional methods are able to improve bioactivity of Ti implants,but the surfaces with static state cannot respond to the dynamic biological cascades from the living cells and tissues.Hence,beyond traditional static design,dynamic responsive avenues are then emerging.The dynamic stimuli sources for surface functionalization can originate from environmental triggers or physiological triggers.In short,this review surveys recent developments in the surface engineering of Ti materials,with a specific emphasis on advances in static to dynamic functionality,which provides perspectives for improving bioactivity and biocompatibility of Ti implants.

关键词： Titanium materials Orthopedic implants Bioactivity Static modification Dynamic responsive regulation

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Surface Modification of NiTi Alloy via Cathodic Plasma Electrolytic Deposition and its Effect on Ni Ion Release and Osteoblast Behaviors

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Plasma Science and Technology 2013年第7期15卷 648-653页

作者：燕颖蔡开勇杨维虎刘鹏 key laboratory of Biorheological Science and Technology of Ministry of Education College of Bioengineering Chongqing University

To reduce Ni ion release and improve biocompatibility of NiTi alloy, the cathodic plasma electrolytic deposition （CPED） technique was used to fabricate ceramic coating onto a NiTi alloy surface. The formation of a coating with a rough and micro-textured surface was confirmed by X-ray diffraction, scanning electron microscopy, and energy-dispersive X-ray spectroscopy, re- spectively. An inductively coupled plasma mass spectrometry test showed that the formed coating significantly reduced the release of Ni ions from the NiTi alloy in simulated body fluid. The in- fluence of CPED treated NiTi substrates on the biological behaviors of osteoblasts, including cell adhesion, cell viability, and osteogenic differentiation function （alkaline phosphatase）, was inves- tigated in vitro. Immunofluorescence staining of nuclei revealed that the CPED treated NiTi alloy was favorable for cell growth. Osteoblasts on CPED modified NiTi alloy showed greater cell viability than those for the native NiTi substrate after 4 and 7 days cultures. More importantly, osteoblasts cultured onto a modified NiTi sample displayed significantly higher differentiation lev-els of alkaline phosphatase. The results suggested that surface functionalization of NiTi alloy with ceramic coating via the CPED technique was beneficial for cell proliferation and differentiation. The approach presented here is useful for NiTi implants to enhance bone osseointegration and reduce Ni ion release in vitro.

关键词： surface modification plasma applications biomaterials cathodic plasma elec-trolytic deposition

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Promoting osteointegration effect of Cu-alloyed titanium in ovariectomized rats

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Regenerative Biomaterials 2022年第1期9卷 143-155页

作者： Xiyue Zhang Hui Liu Ling Li Cuishan Huang Xiangbo Meng Junzuo Liu Xueling Bai Ling Ren Xinluan Wang Ke Yang Ling Qin Institute of Metal Research Chinese Academy of ScienceShenyang 110016PR China Translational Medicine Research Center Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenPR China Musculoskeletal Research laboratory of Department of Orthopaedis&Traumatology The Chinese University of Hong KongHK SARPR China

Osteoporosis is a common skeletal disease making patients be prone to the osteoporotic fracture.However,the clinical implants made of titanium and its alloys with a poor osseointegration need a long time for healing and easily to loosening.Thus,a new class of Cu-alloyed titanium(TiCu)alloys with excellent mechanical properties and bio-functionalization has been developed.In this study,the osteoporosis modeled rats were used to study the osteointegration effect and underlying mechanism of TiCu.The results showed that after implantation for 4 weeks,TiCu alloy could promote the reconstruction of vascular network around the implant by up-regulating vascular endothelial growth factor expression.After 8weeks,it could further promote the proliferation and differentiation of osteoblasts,mineralization and deposition of collagens,and then significantly increasing bone mineral density around the implant.In conclusion,TiCu alloy would enhance the fixation stability,accelerate the osteointegration,and thus reduce the risk of aseptic loosening during the long-term implantation in the osteoporosis environment.This study was the first to report the role and mechanism of a Cu-alloyed metal in promoting osteointegration in osteoporosis environment,which provides a new attractive support for the improvement of future clinical applications of Cu-alloyed antibacterial titanium alloys.

关键词： copper-alloyed titanium alloy osteoporosis implant osseointegration vascularization

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