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Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

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Neural Regeneration Research 2025年第2期20卷 518-532页

作者： conglin Wang Fangyuan Cheng Zhaoli Han Bo Yan Pan Liao Zhenyu Yin Xintong Ge Dai Li Rongrong Zhong Qiang Liu Fanglian Chen Ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K

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A rethinking of nitrate， nitrite， and nitric oxide for food preservation and human health

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Food Science and Human Wellness 2025年

作者： Xiaojing Tian Yanan Tian Shaohua Meng Jiansheng Zhao Lele Shao Yu Li Wenhang Wang tianjin Key Laboratory of Food Quality and Health， tianjin University of Science & technology college of Food Science and Engineering， tianjin University of Science & technology Henan Shuanghui Investment & Development co.， ltd. Key Laboratory of Jianghuai Agricultural Product Fine Processing and Resource Utilization， Ministry of Agriculture and Rural Affairs， Anhui Engineering Research Center for High Value Utilization of Characteristic Agricultural Products， college of Tea & Food Science and technology， Anhui Agricultural University college of Biotechnology， tianjin University of Science & technology

Nitrate and nitrite， as long-standing additives used in food industry and particularly prevalent in meat products， are often perceived negatively by consumers due to their potential to produce carcinogenic nitrosamines. Within the past decades， the importance of nitric oxide (NO) has been established for human health， including cardiovascular health， immunizing and defending system， skeletal muscle contraction and relaxation， nervous system， and cognitive function. Gradually， nitrate and nitrite， as the main NO donors， have also been demonstrated to have numerous health benefits in clinical studies. Likewise， NO has showed positive effect on postharvest fruits and vegetables. In view of different controversies， this review comprehensively discussed the effect of nitrate， nitrite on meat products and NO on fruits and vegetables， the intake of nitrate and nitrite by diet， the physiological functions， synthesis and metabolism of nitrate， nitrite， and NO in human body. It is hoped to provide some new understanding for nitrate， nitrite， and NO in food preservation and human health.

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A novel mitigator of enzymatic browning--hawthorn leaf extract and its application in the preservation of fresh-cut potatoes

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Food Quality and Safety 2021年第3期5卷 247-255页

作者： Liping Qiao Hailin Wang Jinsheng Shao Laifeng Lu Jinhu Tian Xia Liu State Key Laboratory of Food Nutrition and Safety Ministry of EducationTianjin Key Laboratory of Food Nutrition and SafetyCollege of Food Science and EngineeringTianjin University of Science&TechnologyTianjinChina college of Biosystems Engineering and Food Science National-Local Joint Engineering Laboratory of Intelligent Food Technology and EquipmentZhejiang Key Laboratory for Agro-Food ProcessingZhejiang Engineering Laboratory of Food Tech no logy and EquipmentFuli Institute of Food ScienceZhejiang Un iversityHangzhouChina tianjin gasin-dh preservation technology co.ltd. TianjinChina

Objectives:The purpose of this study was to evaluate the antibrowning functions of hawthorn leaf extract on fresh-cut potato and its possible *** and Methods:Fresh-cut potatoes were treated with different concentrations(0.01%,0.05%,and 0.1%)of hawthorn leaf extract and preserved at 4 C for 8 *** appears nee and colour of potato slices were evaluated,along with the content of the phenol,malondialdehyde(MDA),and hydrogen peroxide(H2O2)during cold ***,the activities of polyphenol oxidase(PPO),peroxidase(POD),phenylalanine ammonia-lyase(PAL),lipoxygenase(LOX),catalase(CAT),superoxide dismutase(SOD),and the antioxidant capacity were determ in ***,the composition of hawthorn leaf extract was analyzed by high-performance liquid chromatographytandem mass spectrometry(HPLC-MS/MS).Results:The addition of hawthorn leaf extract effectively delayed the browning *** not only enhanced the CAT activity and antioxidant capacity but also reduced the LOX activity and accumulation of MDA and H_(2)O_(2).Meanwhile,the activities of PPO,POD,and PAL as well as the content of phe nol were con ***,25 phe nols,34 flavonoids,and 5 proa nthocya nidins were identified through high-performance liquid chromatography-tandem mass spectrometry(HPLC-MS/MS),ideluding caffeic acid,quercetin and ***:Hawthorn leaf extract significantly alleviated the browning of fresh-cut *** could serve as a n atural an tibrowning alter native by stabilizing the membra ne and modulating reactive oxygen species and redox reactions.

关键词： Hawthorn leaf extract enzymatic browning fresh-cut potatoes.

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Heat Transfer Model Founded and Regional Suitability Analysis of Photovoltaic Walls with Different Structures

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Journal of Thermal Science 2022年第6期31卷 1970-1989页

作者： ZHANG Wenjie ZHAO Yingbo LIU Wei GONG Tongdan LIU Kangyong School of Energy and Power Engineering Nanjing University of Science and TechnologyNanjing 210094China China construction Sixth Division construction&Development co.ltd. Tianjin 300451China

The heat transfer performance and suitability of photovoltaic walls with different structures in different regions have been studied. First, a quasi-two-dimensional calculation model was established to realize the simulation of photovoltaic walls with three structural forms(ordinary wall with air layer opening, air layer closed and no air layer);combined with the experimental data, the accuracy of the two-dimensional calculation model was verified. Based on the simulation results, the suitability of different structural forms of photovoltaic walls in areas with different climatic conditions were compared and analyzed. The results of the study show that the southern China that emphasize the purpose of ventilation and heat dissipation should adopt photovoltaic walls with open air layers, and the northern regions that emphasize the purpose of heat preservation and heat insulation should adopt photovoltaic walls with closed air layers;for transitional areas, the type of photovoltaic wall should be considered comprehensively according to environmental conditions and local building conditions.

关键词： photovoltaic wall thermal performance numerical simulation regional suitability

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Research progress on indoor environment of mushroom factory

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International Journal of Agricultural and Biological Engineering 2022年第1期15卷 25-32页

作者： Long Chen Lei Qian Xiao Zhang Jiazheng Li Zhijun Zhang Xiaoming Chen tianjin Academy of Agricultural Sciences Tianjin 300192China National Engineering and technology Research Center for preservation of Agricultural Products/Key Laboratory of Storage of Agricultural Products Ministry of Agriculture and Rural Affairs/Tianjin Key Laboratory of Postharvest Physiology and Storage of Agricultural ProductsTianjin 300384China

Mushroom factory is an emerging production mode that is relied on facility and equipment by creating a suitable,steady,and uniform growing environment to accommodate the demand of edible fungus at each stage of ***,an optimal range of key environmental factors(temperature,humidity,light,and co_(2) concentrations)in mushroom facilities is crucial to achieving satisfactory production *** research aimed to provide an overview of recent progress on indoor environmental studies of mushroom cultivation facilities from three perspectives,1)the development of environmental monitoring and controlling systems;2)the application of computer modelling in addressing indoor environmental issues;3)the refinement of mushroom facility design,including structure and ventilation *** the aid of cutting-edge technologies,accomplishments have been made in developing smart farming systems that facilitate real-time recording of environmental parameters and automatic regulation of equipment,which helps the establishment of growth model for specific mushroom *** Fluid Dynamics(CFD)modelling has been adopted by researchers to investigate indoor airflow patterns and assess the distribution of critical environmental *** have been conducted to modify the design of mushroom facility to improve the performance in structural stability,ventilation efficiency,and internal environmental ***,some existing problems still need further investigations,such as the lack of design guidelines,energy-saving strategies,and Artificial Intelligent(AI)quality ***,this overview was expected to provide constructive insights for future studies in addition to references of previous studies.

关键词： modern farming mushroom factory indoor environment control computational fluid dynamics remote sensing

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Effects of Edible coatings on Quality and Antioxidant Activity of Zizyphus Jujuba Miller cv. Dongzao During Storage

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Transactions of tianjin University 2017年第1期23卷 51-61页

作者： Xiaohong Kou Yunfei Li Jiyun Wu Qiong Chen Zhaohui Xue School of Chemical Engineering and technology Tianjin University Tianjin 300354 China

The development of edible coatings has been lauded with respect to their safety and effectiveness. In this study, we researched the effects of edible coatings (2% CaCl2, 1% chitosan and 1% pullulan) on the nutrient content and antioxidant abilities of jujube (Zizyphus jujuba Miller cv. Dongzao). Using the new analysis technique for order of preference by similarity to ideal solution (TOPSIS), we evaluated the effects of these coatings. compared with the control fruit group, test results showed that coating treatment significantly delayed fruit senescence. Specifically, CaCl2treatment not only maintained fruit storage quality and antioxidant activity but also restrained the production and accumulation of malondialdehyde in jujube. Chitosan treatment delayed decreases in secondary metabolites and superoxide dismutase and catalase activity. Pullulan coatings performed better in terms of proanthocyanidin and cyclic adenosine monophosphate (cAMP). We also used TOPSIS to evaluate the preservation effect of different film coatings and found 2% CaCl2to be the best treatment for jujube, followed by 1% chitosan and 1% pullulan. Based on the appropriate materials and concentration of the film coatings, edible coatings have the potential to retain the quality and antioxidant capacity of the Chinese jujube cv. Dongzao. © 2016, tianjin University and Springer-Verlag Berlin Heidelberg.

关键词： Agents Antioxidants Chitin Chitosan Enzymes Flavonoids Food additives Fruits Metabolites Oxygen Plants (botany) Storage (materials)

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Features of the fault system and its relationship with migration and accumulation of hydrocarbon in Liaodong Bay

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Petroleum Science 2011年第3期8卷 251-263页

作者： Xu Guosheng Ma Ruolong Gong Deyu Zhou Donghong Li Jianping Guo Yonghua Yuan Haifeng Wu Changrong State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Chengdu University of Technology Chengdu Sichuan 610059 China Exploration and Development Research Institute Tianjin Branch of CNOOC （China） Co. Ltd. Tanggu Tianjin 300452 China

The fault system of Liaodong Bay developed extensively under the control of the Tanlu Fault. The fault system can be grouped into strike-slip faults of grade Ⅰ, trunk faults of grade Ⅱand branch faults （induced faults） of grade Ⅲ respectively based on its developmental scale. The faults of grade Ⅰ and Ⅱwere deep, early and large while the faults of grade Ⅲwere shallow, late and small. The formation, evolution and distribution features played a significant role in controlling the migration of oil and gas in both horizontal and vertical directions. The fluid transfer in the fault system occurred in the process of faulting. The strike-slip and trunk faults moved actively forming predominant pathways for oil and gas migration. The branch faults, with weak activity, generally controlled the development of traps and were beneficial for the accumulation and preservation of oil and gas. The faults of grade Ⅰ and Ⅱ formed the major migration pathways for oil and gas, but their fault activity rates appeared to vary along their strikes. The zones with a relatively low fault activity rate might be favorable for oil and gas accumulation. When the activities of strike-slip, trunk, and branch faults came to a halt, the fault seal behavior had a vitally important effect on the accumulation of oil and gas. The controlling role of the fault over fluid distribution was further analyzed by calculating the fault activity quantitatively.

关键词： Liaodong Bay fault system fault activity rate fault seal behavior migration andaccumulation of oil and gas

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Enhanced hydrodeoxygenation of lignin-derived anisole to arenes catalyzed by Mn-doped Cu/Al_(2)O_(3)

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Green Energy & Environment 2023年第3期8卷 927-937页

作者： Xiaofei Wang Shixiang Feng Yue Wang Yujun Zhao Shouying Huang Shengping Wang Xinbin Ma Key Laboratory for Green Chemical technology of Ministry of Education Collaborative Innovation Centre of Chemical Science and EngineeringSchool of Chemical Engineering and TechnologyTianjin UniversityTianjin300072China Joint School of National University of Singapore and tianjin University International Campus of Tianjin UniversityBinhai New CityFuzhou350207China

Lignin is a renewable carbon resource to produce arenes due to its abundant aromatic *** the liquid-phase hydrodeoxygenation(HDO)based on metallic catalysts,the preservation of aromatic rings in lignin or its derivatives remains a ***,we synthesized Mndoped Cu/Al_(2)O_(3) catalysts from layered double hydroxides(Ldhs)for liquid-phase HDO of lignin-derived *** doping significantly enhanced the selective deoxygenation of anisole to arenes and inhibited the saturated hydrogenation on Cu/Al_(2)O_(3).With Mn doping increasing,the surface of Cu particles was modified with MnO_(x) along with enhanced generation of oxygen vacancies(Ov).The evolution of active sites structure led to a controllable adsorption geometry of anisole,which was beneficial for increasing arenes *** a result,the arenes selectivity obtained on 4Cu/8Mn4AlO_(x) was increased to be more than 6 folds of that value on 4Cu/4Al_(2)O_(3) over the synergistic sites between metal Cu and Ov generated on MnO_(x).

关键词： Anisole Hydrodeoxygenation Oxygen vacancy Arenes Metal oxide

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Advanced Biotechnology for Cell Cryopreservation

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Transactions of tianjin University 2020年第6期26卷 409-423页

作者： Jing Yang Lei Gao Min Liu Xiaojie Sui Yingnan Zhu Chiyu Wen Lei Zhang Department of Biochemical Engineering School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300350China Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering(MOE) School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300350China Qingdao Institute for Marine technology of tianjin University Qingdao 266235China

Cell cryopreservation has evolved as an important technology required for supporting various cell-based applications,such as stem cell therapy,tissue engineering,and assisted *** times have witnessed an increase in the clinical demand of these applications,requiring urgent improvements in cell ***,cryopreservation technology suff ers from the issues of low cryopreservation effi ciency and cryoprotectant(CPA)*** of advanced biotechnology tools can signifi cantly improve post-thaw cell survival and reduce or even eliminate the use of organic solvent CPAs,thus promoting the development of ***,based on the diff erent cryopreservation mechanisms available,we provide an overview of the applications and achievements of various biotechnology tools used in cell cryopreservation,including trehalose delivery,hydrogel-based cell encapsulation technique,droplet-based cell printing,and nanowarming,and also discuss the associated challenges and perspectives for future development.

关键词： Cell cryopreservation Biotechnology Trehalose delivery Hydrogel-based cell encapsulation Droplet-based cell printing Nanowarming

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Biological Characteristics of Morel and Analysis of Its Cultivation Adaptability in tianjin

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Asian Agricultural Research 2019年第2期11卷 92-93,99页

作者： Shufang LI Xiaoming CHEN Jianhua LIU Shichun YANG Jinze YU Na ZHANG Zhijun ZHANG tianjin Research Institution of Forestry and Pomology National Engineering and technology Research Center for preservation of Agricultural Products (tianjin) tianjin Agricultural University

Biological characteristics of morel,climatic conditions and characteristics of tianjin,and facilities of greenhouses in tianjin were introduced firstly,and then the cultivation adaptability of morel in tianjin was analyzed. This study aims to let farmers learn more about the rare edible fungus——morel and provide relevant theoretical basis and feasibility reference for the promotion and application of morel cultivation in tianjin.

关键词： Morel Biological characteristics Cultivation adaptability

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