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Endovascular therapy for Acute ischemic Stroke Trial (EAST): study protocol for a prospective, multicentre control trial in China

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Stroke & Vascular Neurology 2016年第2期1卷 44-51页

作者： Zhongrong Miao Xiaochuan Huo Feng Gao Xiaoling Liao Chunjuan Wang Ya Peng Yibin Cao Shengli Chen Meng Zhang Changchun Jiang Xiaoxiang Peng Cunfeng Song Liping Wei Qiyi Zhu Zaiyu Guo Li Liu Hang Lin Hua Yang Wei Wu Hui Liang Anding Xu Kangning Chen Xingquan Zhao Yuesong Pan Hao Li Liping Liu Yilong Wang Yongjun Wang EAST investigators Department of Interventional Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Vascular Neurology Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurology Tiantan Clinical Trial and Research Center for StrokeBeijing Tiantan HospitalCapital Medical UniversityBeijingChina Center of Stroke Beijing Institute for Brain DisordersBeijingChina Department of Neurosurgery Changzhou No 1 People’s HospitalChangzhouChina Department of Neurology Tangshan Gongren HospitalTangshanChina Department of Neurology Chongqing Sanxia Central HospitalChongqingChina Department of Neurology Daping HospitalChongqingChina Department of Neurology Baotou Central HospitalBaotouChina Department of Neurology Hubei Zhongshan HospitalWuhanChina Department of Neurology Liaocheng Third People’s HospitalLiaochengChina Department of Neurology Luoyang Central Hospital affiliated to Zhengzhou UniversityChina Department of Neurology People’s Hospital of Linyi CityChina Department of Neurology Tianjin TEDA HospitalChina Department of Neurology Chifeng Municipal HospitalChina Department of Neurology Fuzhou PLA General HospitalChina Department of Neurology Affiliated Hospital of Guiyang Medical CollegeChina Department of Neurology Qilu Hospital of Shandong UniversityChina Department of Neurology Yantai Hill HospitalChina Department of Neurology The First Affiliated Hospital of Jinan UniversityChina Department of Neurology Xinan HospitalChina Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease BeijingChina Neuro-intensive Care Unit Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina 不详

Background and purpose:5 recent trials have shown the benefit of endovascular treatment for acute ischaemic stroke(AIS)due to large vessel occlusion of the anterior *** study aims to evaluate the safety and efficacy of Solitaire thrombectomy in patients with moderate-to-severe stroke in the Chinese population,which has a high prevalence of intracranial *** and analysis:This multicentre prospective control study will involve 17 stroke centres in China,and plans to recruit 150 patients in the intervention group,and 150 patients in the medical group,in which patients meet enrolment criteria but refuse *** with AIS due to large vessel occlusion indicated for treatment with Solitaire stent retriever within 12 hours of symptom onset,and who meet the inclusion and exclusion criteria,will be enrolled in this *** primary efficacy endpoint is functional independence as defined by a modified Rankin Scale(mRS)score≤2 at 90 days or by functional improvement as defined by mRS,using shift *** procedural efficacy endpoint is arterial recanalisation of the occluded target vessel measured by a modified Thrombolysis in Cerebral Infarction(mTICI)score equal or superior to 2b right following the use of the study *** primary safety endpoint is symptomatic intracranial haemorrhage(sICH)within 24±3 hours *** and dissemination:The protocol was approved by the Ethics Committee at the coordinating centre and by the local Institutional Review Board of each participating *** registration number:NCT02350283.

关键词： prospective centre occlusion

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Tackling global health security by building an academic community for One Health action

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Infectious Diseases of Poverty 2023年第4期12卷 93-98页

作者： Xiao-Xi Zhang Xin-Chen Li Qi-Yu Zhang Jing-Shu Liu Le-Fei Han Zohar Lederman Janna M.Schurer Patrícia Poeta Md.Tanvir Rahman Shi-Zhu Li Kokouvi Kassegne Kun Yin Yong-Zhang Zhu Shang Xia Lu He Qin-Qin Hu Le-Shan Xiu Jing-Bo Xue Han-Qing Zhao Xi-Han Wangv Logan Wu Xiao-Kui Guo Zhao-Jun Wang Bernhard Schwartländer Ming-Hui Ren Xiao-Nong Zhou School of Global Health Chinese Center for Tropical Diseases ResearchShanghai Jiao Tong University School of MedicineShanghaiPeople’s Republic of China Institute of One Health Shanghai Jiao Tong UniversityShanghaiPeople’s Republic of China Medical Ethics and Humanities Unit Hong Kong UniversityHong KongPeople’s Republic of China Center for One Health University of Global Health EquityButaroRwanda Microbiology and Antibiotic Resistance Team Department of Veterinary SciencesUniversity of Trás-os-Montes and Alto DouroVila RealPortugal Associate Laboratory for Green Chemistry Chemistry DepartmentUniversity Nova of LisbonLisbonPortugal Veterinary and Animal Research centre University of Trás-os-Montes and Alto DouroVila RealPortugal Associate Laboratory for Animal and Veterinary Sciences University of Trás-os-Montes and Alto DouroVila RealPortugal Department of Microbiology and Hygiene Bangladesh Agricultural UniversityMymensinghBangladesh National Institute of Parasitic Diseases at Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research) NHC Key Laboratory of Parasite and Vector BiologyWHO Collaborating Centre for Tropical DiseasesShanghaiPeople’s Republic of China Walter and Eliza Hall Institute ParkvilleAustralia Department of Medical Biology University of MelbourneMelbourneAustralia German Ministry of Foreign Affairs(Former Assistant Director General and Chef de Cabinet of Dr Tedros at the World Health Organization) BerlinGermany School of Public Health Peking UniversityBeijingPeople’s Republic of China

Background One Health approach is crucial to tackling complex global public health threats at the interface of humans, animals, and the environment. As outlined in the One Health Joint Plan of Action, the international One Health community includes stakeholders from different sectors. Supported by the Bill & Melinda Gates Foundation, an academic community for One Health action has been proposed with the aim of promoting the understanding and real-world implementation of One Health approach and contribution towards the Sustainable Development Goals for a healthy *** text The proposed academic community would contribute to generating high-quality scientific evidence, distilling local experiences as well as fostering an interconnected One Health culture and mindset, among various stakeholders on different levels and in all sectors. The major scope of the community covers One Health governance, zoonotic diseases, food security, antimicrobial resistance, and climate change along with the research agenda to be developed. The academic community will be supported by two committees, including a strategic consultancy committee and a scientific steering committee, composed of influential scientists selected from the One Health information database. A workplan containing activities under six objectives is proposed to provide research support, strengthen local capacity, and enhance global *** The proposed academic community for One Health action is a crucial step towards enhancing communication, coordination, collaboration, and capacity building for the implementation of One Health. By bringing eminent global experts together, the academic community possesses the potential to generate scientific evidence and provide advice to local governments and international organizations, enabling the pursuit of common goals, collaborative policies, and solutions to misaligned interests.

关键词： One Health Global health Academic community

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Global carbon sequestration potential of agroforestry and increased tree cover on agricultural land

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Circular Agricultural Systems 2022年第1期2卷 38-47页

作者： Robert J.Zomer Deborah A.Bossio Antonio Trabucco Meine van Noordwijk Jianchu Xu Center for Mountain Futures Kunming Institute of BotanyChinese Academy of Science(CAS)Kunming 650201China centre for International Forestry Research and World Agroforestry(CIFOR-ICRAF) Kunming 650201China Global Evergreening Alliance Surat Thani 84280Thailand The Nature Conservatory(TNC) OaklandCalifornia 94609USA Centro Euro-Mediterraneo sui Cambiamenti Climatici(CMCC) Sardinia 73100Italy centre for International Forestry Research and World Agroforestry(CIFOR-ICRAF) Bogor 16115Indonesia

Biomass is fundamental to circular agricultural *** of above-and below-ground biomass on agricultural land based upon IPCC Tier 1 estimates are compared with an updated carbon density map based on remote sensing,with results indicating the methodology and initial estimations are *** scenarios are evaluated to estimate carbon sequestration potential of increasing tree cover on agricultural land:1)incremental change and 2)a systemic change to *** of above-and below ground biomass carbon were combined with a tree cover analysis to estimate the increase in *** increases(4−6 PgC for incremental change;12−19 PgC for systemic change)highlight substantial mitigation *** global tree cover on agricultural land by 10%would sequester more than 18 *** America has the highest potential,followed by Southeast Asia,West and Central Africa,and North ***,Indonesia,Philippines,India,the United States and China are among the top countries with the highest carbon sequestration potential on agricultural land with increased tree cover.

关键词： carbon potential agricultural

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Motorists’Perceptions and Attitudes towards Ethanol Blended Fuel in Zimbabwe

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Journal of Energy and Power Engineering 2019年第2期13卷 68-79页

作者： Decide Mabumbo Paramu Mafongoya centre for the Advancement of Scholarship University of PretoriaPrivate Bag x20Hatfield 0027South Africa School of Agriculture Earth and Environmental Sciences: University of KwaZulu-NatalPietermaritzburg 3209South Africa

Most developing and developed countries have enacted mandatory legislation for use of biofuels(bioethanol)in the transport *** most developing countries,the use of biofuels meant to increase energy security,save foreign currency,mitigate climate change,create jobs and rural ***,motorists have limited knowledge on blended *** study seeks to investigate the level of awareness and prevailing attitudes of motorists in Zimbabwe where a mandatory ethanol blending policy was recently *** study uses data derived from 200 respondents,to whom a questionnaire was *** major challenge faced by motorists is the lack of sufficient information on ethanol blends in general including how they can get their engines modified to take high ethanol *** 63.1% were not clear about the technical attributes of ethanol blended fuel especially as it relates to engine ***,some motorists experienced a number of problems ranging from poor idling(36%),lack of power(19.5%)and difficulties with engine starting(16.5%).Despite all these complaints,54% of the respondents generally exhibit a positive attitude towards ethanol blended fuel and 60.3% said that they were keen to recommend blended fuel to other *** appropriate institutional,legal and policy framework that supports massive awareness campaigns for use of bioethanol for the transport sector can go a long way to dispel negative perceptions associated with ethanol blends.

关键词： Biofuels motorists knowledge attitude perceptions

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A painful experience

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英国医学杂志中文版 2020年第3期23卷 42-42页

作者： Liam Farrell centre for Perinatal Neuroscience Imperial College London London UK. Neonatal Unit Imperial Healthcare NHS Trust London UK. Oliver Fisher Neonatal Unit Medway NHS Hospital Foundation Trust Gillingham UK. Perinatal-Neonatal Medicine Wayne State University Detroit Michigan USA.

I was on an Airtours flight from Florida recently when medical assistance was called *** patient had benign prostatic hyperplasia and was in *** we had another seven hours to fly,holding on was not an *** needed a catheter,so I was reassured that the plane's inventory of medical equipment included catheters and collecting *** I then found that there was no lignocaine gel,no lubricating jelly,and no gloves.

关键词： prostatic holding assistance

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RegCM4.0对一个全球模式20世纪气候变化试验的中国区域降尺度：温室气体和自然变率的贡献

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科学通报 2015年第17期60卷 1631-1642页

作者：张冬峰高学杰罗勇夏军 GIORGI Filippo 山西省气候中心太原030006 中国科学院大气物理研究所气候变化研究中心北京100029 清华大学地球系统科学研究中心北京100084 中国科学院地理科学与资源研究所北京100101 武汉大学水资源与水电工程科学国家重点实验室武汉430072 The Abdus Salam International centre for Theoretical Physics Trieste 34100Italy

近几十年来,中国区域气候经历了以变暖和东部降水呈现＂南涝北旱＂分布特征为主的变化.这里基于一个区域气候模式（Reg CM4.0）历史模拟和归因试验的对比,探讨了温室气体排放和自然变率分别对上述特征形成及各大水文流域气候变化成因的... 详细信息

近几十年来,中国区域气候经历了以变暖和东部降水呈现＂南涝北旱＂分布特征为主的变化.这里基于一个区域气候模式（Reg CM4.0）历史模拟和归因试验的对比,探讨了温室气体排放和自然变率分别对上述特征形成及各大水文流域气候变化成因的可能贡献.试验中Reg CM4.0的分辨率取为50 km,积分时间为1961~2005年,两个试验的驱动场分别来自于BCC_CSM1.1全球气候模式的历史试验和归因试验结果.分析结果表明,1961~2005年观测中出现的气候变暖现象,在所有流域均主要是由于人为温室气体排放引起的,在大部分流域自然变率亦有所贡献,中国区域平均的变暖中,人为温室气体排放所产生的作用达到80%.中国东部降水的＂南涝北旱＂分布变化,则可能主要是自然变率起了主导作用,人为温室气体排放在一定程度上减弱了这种变化的强度;中国西北地区的降水增加,可能主要源于人为温室气体排放的贡献,自然变率的作用与其相反,是导致降水减少的.同时指出,分析结果中关于气温的结论相对可靠性较高,降水的结论尚存在较大不确定性,未来需开展进一步的深入研究.

关键词：温室气体自然变率中国区域气候变化区域气候模式

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Innovative Solutions in Induction Heating for Better Energy Efficiency:Presentation of ISIS Project

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Journal of Iron and Steel Research International 2012年第S2期19卷 646-652页

作者： PAYA Bernard GAGNOUD Annie MAUSSION Pascal ROEHR Philippe BREVILLE Thierry NEMER Maroun GOUPIL Christophe Coordinator of ISIS Project EDF R&DEco-Efficiency & Industrial Processes DptCentre des RenardieresF-77818 Morêt sur Loing CedexFrance SIMAP/EPM 1340Rue de la Piscine BP 75F-38402 Saint Martin d'Hères CedexFrance LAPLACE/CODIASE 2.Rue Charles CamichelBP 7122F-31071 Toulouse Cedex 7France FIVES CELES 89bisRue PrincipaleF-68610 LautenbachFrance ATYS CONSULTANTS ZA du pré ROBELIN358 route d'UriageF-38320 HerbeysFrance ARMINES/CEP ZI Les Glaizes5 rue Leon BlumF-91120 Palaiseau France CRISMAT ENSICAEN6Boulevard du Marechal JuinF-14050 CaenFrance

The Energy climate Package is the EU response to the Global Warming *** heating processes can contribute to the energy saving goal:20%saving within *** induction manufacturer already propose many efficient solutions at industrial *** improve induction devices for an always better energy efficiency, EDF R&D set up a French cooperative project called ISIS with a financial support of the French National Research *** objective is to promote induction heating as Best Available Technology(BAT)and to develop innovative solutions to increase its *** ISIS innovations concern the electroheat conversion of induction devices(auto-adaptive multi-coil power supply,low losses coils)and the recovering of fatally lost *** paper shows the mid-term results of this *** control algorithms were successfully tested on a 100 kW 3-coil power supply.A homogenization technique is proposed to model a multi-strand coil.A heat recovery test bench is build and equipped with a PFC control loop to fit with the production fluctuations.

关键词： induction heating energy efficiency multi-coil power supply multi-strand coil energy recovery PFC

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Taxonomy and the evolutionary history of Micropeltidaceae

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Fungal Diversity 2019年第4期97卷 393-436页

作者： Xiang-Yu Zeng Hai-Xia Wu Sinang Hongsanan Rajesh Jeewon Ting-Chi Wen Sajeewa S.N.Maharachchikumbura Putarak Chomnunti Kevin D.Hyde International Fungal Research and Development centre Key Laboratory of Resource Insect Cultivation&Utilization State Forestry AdministrationThe Research Institute of Resource InsectsChinese Academy of ForestryKunming 650224China The Engineering Research Center of the Utilization for Characteristic Bio-Pharmaceutical Resources in Southwest Guizhou UniversityGuiyang 550025China Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand Shenzhen Key Laboratory of Microbial Genetic Engineering College of Life Sciences and OceanographyShenzhen UniversityShenzhen 518000China Shenzhen Key Laboratory of Laser Engineering College of Optoelectronic EngineeringShenzhen UniversityShenzhen 518000China Department of Health Sciences Faculty of ScienceUniversity of MauritiusReduit 80837Mauritius Department of Crop Sciences College of Agricultural and Marine SciencesSultan Qaboos UniverstyPO Box 8123 Al KhoudOman School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of Sciences132 Lanhei RoadKunming 650201Chin

Micropeltidaceae species are flyspeck fungi which have been subjected to few systematic *** re-examined 27 genera which were accepted in the Micropeltidaceae and re-described them based on herbaria materials and *** on morphology and phylogenetic investigations,we transfer Micropeltidaceae to a new order,Micropeltidales(Lecanoromycetes).Genera with bluish or greenish upper walls(Dictyopeltella,Dictyothyriella,Dictyothyrina,Dictyothyrium,Haplopeltheca,Micropeltis,Scolecopeltidium and Stomiopeltopsis)are accepted in the new taxonomic concept for Micropeltidaceae.A molecular clock approach estimated the divergence time of the Micropeltidaceae crown group at 130(165–104)Mya,which also supports its rank as an order(diverging from 220–100 Mya).The evolutionary histories between Micropeltidaceae species and host plants are interpreted by cophylogenetic analyses calibrated by their divergence *** result indicates that the diversification of Angiospermae(130–80 Mya)fosters the formation of genera of Micropeltidaceae mainly via cospeciation events,and this codivergent period would be an important reference when establishing generic boundaries of epifoliar fungi.

关键词： Codivergence Cophylogeny Dating Lecanoromycetes Micropeltidales

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Temporal Microbial Response to Wetting-Drying Cycles in Soils within and Outside the Influence of a Shrub in the Sahel

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Open Journal of Soil Science 2019年第12期9卷 284-297页

作者： Sally Diatta Sidy Diakhaté Hassna Founoune-Mboup Charlotte J. Alster Diégane Diouf Richard P. Dick Lydie Chapuis-Lardy Laurent Cournac Ndeye Yacine Badiane-Ndour ISRA_LNRPV Laboratoire National de Recherches sur les productions Végétales (LNRPV) Dakar Senegal Université Cheikh Anta Diop (UCAD) Département Biologie Végétale Laboratoire Commun de Microbiologie IRD/ISRA/UCAD Dakar Senegal IRD LMI IESOL Centre IRD-ISRA Dakar Senegal Department of Ecology and Evolutionary Biology University of California Irvine CA USA School of Environment and Natural Resources Ohio State University Columbus OH USA IRD Institut de Recherche pour le Développement UMR Eco & Sols Montpellier France

Piliostigma reticulatum is a native woody shrub found in cropped fields in the Sahel and has been shown to increase crop productivity and soil quality. Frequently occurring drying and rewetting cycles (DRW) may alter the soil quality beneath these shrubs. We investigated the effect of DRW cycles on microbial community in soil beneath and outside the P. reticulatum canopy and the roles of this shrub in the adaptation of the microbial community to abiotic stress. Soils were incubated in a climate controlled chamber for 45 days, after exposure to 10 consecutive days of DRW cycles at 75% of water holding capacity (WHC). Basal respiration, β-glucosidase activity, microbial biomass carbon (MBC), and available nitrogen (;) were measured at 2, 30, and 45 days after soil exposed to the DRW cycles. MBC increased significantly two days after the DRW cycles and was greater for soil beneath the shrub canopy compared with soil outside the shrub canopy. PCA analysis based on basal respiration, microbial biomass carbon, available nitrogen, and β-Glucosidase activity resulted in a tight clustering in the beneath shrub soil samples. Soils incubated for more than 30 days after DRW cycles had higher available nitrogen content than soils incubated for less than 30 days. Soil from beneath the shrub canopy significantly improved soil resilience based on β-glucosidase activity. Soil from beneath the shrub canopy also had higher nutrient levels and greater microbial activity even when subjected to DRW cycles, potentially improving the ability of crops to withstand in-season drought when they are adjacent to shrubs. The work should bring our scientific community into a more comprehensive assessment of potential effects of a crop-shrub intercropping that may allow for increased crop yields in semi-arid ecosystems under drought conditions.

关键词： Sub-Saharan Africa Shrub-Based Cropping System climate Change Wetting and Drying Cycles climate Chamber Experiment

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Effect of Water Stress Induced by Polyethylene Glycol 6000 on Somatic Embryogenesis in Cocoa (<i>Theobroma cacao</i>L.)

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Agricultural Sciences 2019年第9期10卷 1240-1254页

作者： Manlé Tokpapon Eliane Kouassi Kan Modeste Soumahoro Brahima André Koffi Kouablan Edmond Koné Mongomaké Laboratoire Central de Biotechnologie (LCB) Centre National de Recherche Agronomique (CNRA) Abidjan C&#244 te d’Ivoire Laboratoire de Biologie et Amélioration des Productions Végétales UFR Sciences de la Nature Université Nangui Abrogoua Abidjan C&#244 te d’Ivoire Laboratoire de Physiologie Végétale Université Félix Houphou&#235 t-Boigny Abidjan C&#244 te d’Ivoire Section SVT Département des Sciences et Technologies Ecole Normale Supérieure d’Abidjan Abidjan C&#244 te d’Ivoire

climate change, coupled with insufficient and irregular rains, led to a decline in the productivity of Ivorian cocoa production. The present study aimed to screen three cocoa (Theobroma cacao L.) genotypes in order to evaluate their response to water stress at callus and somatic embryos induction and proliferation stages. Staminode and petal explants of the genotypes C1, C14 and C16 from the collection of National Center of Agronomic Research (CNRA) of Ivory Coast, were placed on medium DKW (Driver & Kuniyuki Walnut) in the presence of different concentrations of Polyethylene glycol (PEG) 6000 (0, 25, 50, 75, 100 and 125 g/l). This polymer was used as osmoticum to stimulate water stress. Data were recorded for callus induction frequency, callus fresh weight, embryogenic callus percentage and average number of somatic embryos. The results obtained showed that intensity of callus proliferation decreased with increasing concentration of PEG 6000. In all genotypes tested, only the petal explants underwent somatic embryogenesis. The induction rates and average number of somatic embryos per explant were reduced with the increase in the concentration of PEG 6000. Among the tested genotypes, C1 produced somatic embryos with all concentrations of PEG 6000 and expressed highest frequencies of induction (62%) and average number of somatic embryos per explant (6.22). This genotype would be the most tolerant to water stress. Somatic embryos obtained with high concentrations of PEG 6000 in this study provide an important basis for the selection and further production of water stress-tolerant varieties of cocoa.

关键词： Water Stress Cocoa PEG 6000 Somatic Embryogenesis Selection

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