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Molecular recognition of cyclophanes in water

Chinese Chemical Letters 2024年第5期35卷 32-44页

作者： Fang-Yuan Chen Wen-Chao Geng Kang Cai Dong-Sheng Guo College of Chemistry State Key Laboratory of Elemento-Organic ChemistryKey Laboratory of Functional Polymer Materials(Ministry of Education)Frontiers Science Center for New Organic MatterCollaborative Innovation Center of Chemical Science and Engineering(Tianjin)Nankai UniversityTianjin 300071China College of Chemistry Nankai UniversityTianjin 300071China

Molecular recognition in water,the biological solvent,always receives significant research focus in supramolecular *** mechanisms of molecular recognition in water is key to comprehending biological processes at the molecular *** the past five decades,supramolecular chemists have developed a vast array of synthetic receptors with highly diverse structures and recognition *** them,cyclophanes represent an important family of macrocyclic receptors that have been extensively *** aromatic moieties in cyclophanes not only facilitate chemical modifications to impart water solubility but also enable forming hydrophobic cavities for guest inclusion in aqueous *** by Koga et al.,who reported the first inclusion complex of cyclophanes in water and solid state,numerous water-soluble cyclophanes,including derivatives of blue box,calixarenes,resorcinarenes,pillararenes,octopusarenes,biphenarenes,coronarenes,and naphthotubes,etc.,have been synthesized and subjected to investigation of the recognition capabilities in aqueous *** review provides an overview of cyclophane receptors designed to bind organic guests in *** categorize them into two classes based on the modifications made to their hydrophobic cavities:those with“exo-functionalized hydrophobic cavities”and those with“endo-functionalized hydrophobic cavities”.We introduce their distinctive features and discuss strategies to enhance recognition affinity and *** review aims to inspire the development of novel synthetic receptors with intriguing properties and foster practical applications of cyclophanes.

关键词： Biomimetic receptor Cyclophane Molecular recognition Hydrophobic effect High-affinity Macrocycles

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Flexible Organic Crystal with Two-Dimensional Elastic Bending and Recoverable Plastic Twisting for Circularly Polarized Luminescence

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CCS Chemistry 2024年第6期6卷 1439-1447页

作者： Wenjie Kuang Bo Jing Songgu Wu Junbo Gong State Key Laboratory of Chemical Engineering School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072 Collaborative Innovation center of Chemical Science and Engineering Tianjin 300072

Multidimensional mechanical flexible organic crystals with tunable optoelectronic properties hold significant promise for practical application in complicated environmental ***,based on a newly designed“flexible”Schiff base small molecule with chirality,we presented a compatibly bendable and twistable organic single crystal with circularly polarized luminescence for the first ***,the twodimensional elastic bending of the chiral crystal was realized at both room and liquid nitrogen temperatures,along with recoverable plastic twisting at room ***,circular dichroism and circularly polarized luminescence spectroscopy were employed to characterize the chiral enantiomer in solution and the solid *** design strategy provides a new perspective for the future construction of chiroptical flexible crystal materials.

关键词： organic crystal multidimensional flexibility circularly polarized luminescence low-temperature resistance

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Real-time in-situ monitoring of chiral changes during a reaction at single-molecule level

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Science China Chemistry 2024年第2期67卷 422-423页

作者： Min Tan Dong Xiang Institute of Modern Optics and center of Single-Molecule Science Tianjin Key Laboratory of Micro-scale Optical Information Science and TechnologyNankai UniversityTianjin300350China School of Materials Science and Engineering Smart Sensing Interdisciplinary Science CenterNankai UniversityTianjin300350China TongLu FeiRan Garment–Nankai University Joint Laboratory Nankai UniversityTianjin300350China

Molecular chirality is a widespread phenomenon in nature,playing a critical role in various fields such as chemistry [1],life sciences [2], and materials science [3], and has therefore attracted significant attention and research by scholars [4–6].However, the chirality in chemical reactions is often dynamic, making real-time monitoring of chiral changes during chemical reactions at the single-molecule level extremely challenging.

关键词： chiral chirality critical

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Gastric cancer secreted miR 214-3p inhibits the anti-angiogenesis effect of apatinib by suppressing ferroptosis in vascular endothelial cells

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Oncology Research 2024年第3期32卷 489-502页

作者： WEIXUE WANG TONGTONG WANG YAN ZHANG TING DENG HAIYANG ZHANG YI BA Department of GI Medical Oncology Tanjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin's Clinical Research Center for CancerTianjin Key Iaboratory of Digestive CancerKey Laboratory of Cancer Prevention and TherapyTianjin300060China

Diferent from necrosis,apoptosis,autophagy and other forms of cell death,ferroptosis is a mechanism that catalyzes lipid peroxidation of polyunsaturated ftty acids under the action of iron divalent or lipoxygenase,leading to cell *** is currently used in the third line standard treatment of advanced gastric cancer,targeting the anti-angiogenesis ***,Apatinib mediated ferroptosis in vascular endothelial cells has not been reported *** exosomes can be taken up into target cells to regulate tumor development,but the mechanism related to vascular endothelial cell ferroptosis has not yet been ***,we show that exosomes secreted by gastric cancer cells carry miR-214.3p into vascular endothelial cells and directdy target zinc finger protein A20 to negatively regulate ACSL4,a key enzyme of lipid peroxidation during frroptosis thereby inhibiting ferroptosis in vascular endothelial cells and reducing the eficiency of *** conclusion,inhibition of miR-214-3p can increase the sensitivity of vascular endothelial cells to Apatinib,thereby promoting the antiangiogenic efect of Apatinib,suggesting a potential combination therapy for advanced gastric cancer.

关键词： Cellular ferroptosis Exosome Tyrosine kinase inhibitor Gastrointestinal tumors miRNA

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Dynamic Routing of Multiple QoS-Required Flows in Cloud-Edge Autonomous Multi-Domain Data center Networks

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Computers, Materials & Continua 2024年第2期78卷 2287-2308页

作者： Shiyan Zhang Ruohan Xu Zhangbo Xu Cenhua Yu Yuyang Jiang Yuting Zhao School of Computer Science(National Pilot Software Engineering School) Beijing University of Posts and TelecommunicationsBeijing100876China College of Computer Science and Technology Tianjin UniversityTianjin300072China Institute of Artificial Intelligence Nankai UniversityTianjin300071China College of Information Science and Engineering East China University of Science and TechnologyShanghai200237China

The 6th generation mobile networks(6G)network is a kind of multi-network interconnection and multi-scenario coexistence network,where multiple network domains break the original fixed boundaries to form connections and *** this paper,with the optimization objective of maximizing network utility while ensuring flows performance-centric weighted fairness,this paper designs a reinforcement learning-based cloud-edge autonomous multi-domain data center network architecture that achieves single-domain autonomy and multi-domain *** to the conflict between the utility of different flows,the bandwidth fairness allocation problem for various types of flows is formulated by considering different defined reward *** the tradeoff between fairness and utility,this paper deals with the corresponding reward functions for the cases where the flows undergo abrupt changes and smooth changes in the *** addition,to accommodate the Quality of Service(QoS)requirements for multiple types of flows,this paper proposes a multi-domain autonomous routing algorithm called LSTM+*** a Long Short-Term Memory(LSTM)layer in the actor and critic networks,more information about temporal continuity is added,further enhancing the adaptive ability changes in the dynamic network *** LSTM+MADDPG algorithm is compared with the latest reinforcement learning algorithm by conducting experiments on real network topology and traffic traces,and the experimental results show that LSTM+MADDPG improves the delay convergence speed by 14.6%and delays the start moment of packet loss by 18.2%compared with other algorithms.

关键词： Multi-Domain data center networks autonomous routing

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Changes in muscle strength and risk of cardiovascular disease among middle-aged and older adults in China:Evidence from a prospective cohort study

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Chinese Medical Journal 2024年第11期137卷 1343-1350页

作者： Ze Yang Jiemin Wei Hongbo Liu Honglu Zhang Ruifang Liu Naijun Tang Xueli Yang Department of Occupational and Environmental Health School of Public HealthTianjin Medical UniversityTianjin 300070China tianjin Key Laboratory of Environment Nutrition and Public HealthTianjin Medical UniversityTianjin 300070China center for International Collaborative Research on Environment Nutrition and Public HealthTianjin 300070China

Background:Evidence indicates that low muscle strength is associated with an increased cardiovascular diseases(CVDs)***,the association between muscle strength changes based on repeated measurements and CVD incidence remains ***:The study used data from the China Health and Retirement Longitudinal Study in 2011(Wave 1),2013(Wave 2),2015(Wave 3),and 2018(Wave 4).Low muscle strength was defined as handgrip strength<28 kg for men or<18 kg for women,or chair-rising time≥12 *** on changes in muscle strength from Waves 1 to 2,participants were categorized into four groups of Normal-Normal,Low-Normal,Normal-Low,and *** events,including heart disease and stroke,were recorded using a self-reported questionnaire during Waves 3 and 4 *** proportional hazards models were used to investigate the association between muscle strength changes and CVD incidence after multivariable *** ratios(HRs)and 95%confidence intervals(95%CIs)were estimated with the Normal-Normal group as the ***:A total of 1164 CVD cases were identified among 6608 *** to participants with sustained normal muscle strength,the CVD risks increased progressively across groups of the Low-Normal(HR=1.20,95%CI:1.01-1.43),the Normal-Low(HR=1.35,95%CI:1.14-1.60),and the Low-Low(HR=1.76,95%CI:1.49-2.07).Similar patterns were observed for the significant associations between muscle strength status and the incidence risks of heart disease and *** analyses showed that the significant associations between CVD and muscle strength changes were consistent across age,sex,and body mass index(BMI)***:The study found that muscle strength changes were associated with CVD *** suggests that continuous tracking of muscle status may be helpful in screening cardiovascular risk.

关键词： Muscle strength Cardiovascular disease Prospective cohort study Aging Body mass index Sarcopenia

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Covalent organic framework monolayer:Accurate syntheses and advanced application

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Nano Research 2024年第7期17卷 6603-6618页

作者： Guangyuan Feng Xiaojuan Li Miao Zhang Jiabi Xu Zhiping Liu Lingli Wu Shengbin Lei Key Laboratory of Organic Integrated Circuit Ministry of Education and Tianjin Key Laboratory of Molecular Optoelectronic SciencesDepartment of ChemistrySchool of Science and Collaborative Innovation Center of Chemical Science and Engineering(Tianjin)Tianjin UniversityTianjin 300072China Medical College Northwest Minzu UniversityLanzhou 730000China School of Chemistry and Chemical Engineering Lanzhou Jiaotong UniversityLanzhou 730070China

Covalent organic framework(COF)monolayers,with atomically thin,ordered networks,and rich functionality,are widely studied due to their unusual structure/property ***,synthesizing COF monolayer has remained an unmet challenge due to the difficulty of controlling reactions at the monolayer limit with large-scale *** identification and development of new reactions and polymerization conditions are critical for the further advancement of COF monolayer ***,as one-molecule-thick a freestanding films,COF monolayer offers an ideal material *** advanced applications of COF monolayer have been explored in recent *** review provides an overview of the current state of precise synthetic strategies for COF monolayer,highlighting the advantages and limitations of different synthetic approaches and key challenges related to enhancing quality,and emphasizing the unique benefits of COF monolayer as both an ideal model system and for advanced applications.

关键词： covalent organic frameworks monolayer accurate syntheses advanced application

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Deep learning-based inpainting of saturation artifacts in optical coherence tomography images

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Journal of Innovative Optical Health Sciences 2024年第3期17卷 1-10页

作者： Muyun Hu Zhuoqun Yuan Di Yang Jingzhu Zhao Yanmei Liang Institute of Modern Optics Nankai UniversityTianjin Key Laboratory of Micro-scale Optical Information Science and TechnologyTianjin 300350China Department of Thyroid and Neck Tumor Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin 300060China

Limited by the dynamic range of the detector,saturation artifacts usually occur in optical coherence tomography(OCT)imaging for high scattering *** available methods are difficult to remove saturation artifacts and restore texture completely in OCT *** proposed a deep learning-based inpainting method of saturation artifacts in this *** generation mechanism of saturation artifacts was analyzed,and experimental and simulated datasets were built based on the *** super-resolution generative adversarial networks were trained by the clear–saturated phantom image *** perfect reconstructed results of experimental zebrafish and thyroid OCT images proved its feasibility,strong generalization,and robustness.

关键词： Optical coherence tomography saturation artifacts deep learning image inpainting.

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Co-electrolysis of ethylene glycol and carbon dioxide for formate synthesis

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Science China Chemistry 2024年第5期67卷 1539-1544页

作者： Dongfeng Du Fusong Kang Shiru Yang Bin Shao Jingshan Luo Institute of Photoelectronic Thin Film Devices and Technology State Key Laboratory of Photovoltaic Materials and CellsKey Laboratory of Photoelectronic Thin Film Devices and Technology of TianjinMinistry of Education Engineering Research Center of Thin Film Photoelectronic TechnologyNankai UniversityTianjin 300350China Haihe Laboratory of Sustainable Chemical Transformations Tianjin 300192China Frontiers Science center for New Organic Matter Nankai UniversityTianjin 300071China College of Electronic Information and Optical Engineering Tianjin Key Laboratory of Optoelectronic Sensor and Sensing Network TechnologyNankai UniversityTianjin 300350China

Co-electrolysis of waste plastics and carbon dioxide(CO_(2)) into value-added chemicals or fuels is a promising pathway for a sustainable society, but efficient and selective conversion remains a challenge. Herein, a gold-mediated nickel hydroxide(Au/Ni(OH)_(2)) is developed to oxidize waste plastic-derived ethylene glycol(EG) into formate. In-situ electrochemical experiments and theoretical results reveal that the introduction of Au favors the redox properties and EG adsorption behavior of Ni(OH)_(2). The Au/Ni(OH)_(2) catalyst shows an excellent formate selectivity of >90% at high current densities of above 100 m A cm^(-2). When coupled with sputtered bismuth(Bi) cathode for CO_(2) reduction, a high formate Faradic efficiency(FE) of 188.2% at 200 m A cm^(-2)and a good formate productivity of 7.33 mmol m^(-2)s^(-1)at 10 A are obtained in a flow cell and a zero-gap membrane electrode assembly(MEA) cell, respectively. This work demonstrates a promising strategy to convert waste plastics and CO_(2) into valuable products.

关键词： waste plastic upcycling ethylene glycol oxidation carbon dioxide reduction electrocatalysis formate synthesis

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Dual-directional regulation of spinal cord injury and the gut microbiota

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Neural Regeneration Research 2024年第3期19卷 548-556页

作者： Yinjie Cui Jingyi Liu Xiao Lei Shuwen Liu Haixia Chen Zhijian Wei Hongru Li Yuan Yang Chenguang Zheng Zhongzheng Li Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina School of Medical Technology Tianjin University of Traditional Chinese MedicineTianjinChina Research center of Experimental Acupuncture Science Tianjin University of Traditional Chinese MedicineTianjinChina International Cooperation and Exchange Office Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinceChina International Cooperation Base of Spinal Cord Injury Tianjin Key Laboratory of Spine and Spinal Cord InjuryDepartment of OrthopedicsTianjin Medical University General HospitalTianjinChina Department of Orthopedics Qilu Hospital of Shandong UniversityJinanShandong ProvinceChina

There is increasing evidence that the gut microbiota affects the incidence and progression of central nervous system diseases via the brain-gut *** spinal cord is a vital important part of the central nervous system;however,the underlying association between spinal cord injury and gut interactions remains *** studies suggest that patients with spinal cord injury frequently experience intestinal dysfunction and gut *** in the gut microbiota can cause disruption in the intestinal barrier and trigger neurogenic inflammatory responses which may impede recovery after spinal cord *** review summarizes existing clinical and basic research on the relationship between the gut microbiota and spinal cord *** research identified three key ***,the gut microbiota in patients with spinal cord injury presents a key characteristic and gut dysbiosis may profoundly influence multiple organs and systems in patients with spinal cord ***,following spinal cord injury,weakened intestinal peristalsis,prolonged intestinal transport time,and immune dysfunction of the intestine caused by abnormal autonomic nerve function,as well as frequent antibiotic treatment,may induce gut ***,the gut microbiota and associated metabolites may act on central neurons and affect recovery after spinal cord injury;cytokines and the Toll-like receptor ligand pathways have been identified as crucial mechanisms in the communication between the gut microbiota and central nervous *** microbiota transplantation,probiotics,dietary interventions,and other therapies have been shown to serve a neuroprotective role in spinal cord injury by modulating the gut *** targeting the gut microbiota or associated metabolites are a promising approach to promote functional recovery and improve the complications of spinal cord injury.

关键词： chemokines cytokines gut microbiota NLRP3 spinal cord injury Toll-like receptor ligand tryptophan

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