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Clinical Practice Guideline on Acupuncture and Moxibustion: Adult Major Depressive Disorder (Mild-Moderate Degree) : Determination of clinical questions

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WORLD JOURNAL OF ACUPUNCTURE-MOXIBUSTION 2024年第3期34卷 246-251页

作者： Tang, Han Fan, Qi Guo, Li-hua Zhang, Yu-qing Feng, Yi-xuan Xu, Yu-qing Kuang, Hong-jun Yang, Yun-hong Gou, Yi Zhao, Hong Shanghai univ tradit chinese med Shenzhen Hosp Shenzhen 518004 Peoples R China Shanghai univ tradit chinese med Shanghai 201203 Peoples R China Qingdao univ Taian City Cent Hosp Tai An 271000 Peoples R China McMaster univ Hamilton ON L8S 4L8 Canada Beijing Coll Social Adm Beijing 102600 Peoples R China Guangzhou univ chinese med Guangzhou 510006 Peoples R China

Determining clinical questions is fundamental to the development of clinical practice guidelines (CPGs), which bridges the initial phases and the final recommendations. It is essential for evidence retrieval and the formulation of recommendations. The scientific rigor and precision in determination of clinical questions directly influence the future implementation and applicability of guidelines. In 2020, the World Federation of Acupuncture-Moxibustion Societies initiated the project of clinical practice guideline on acupuncture and moxibustion for adult major depressive disorder (mild-moderate degree) to address clinical and medical decision-making issues in acupuncture treatment for adult mild to moderate major depressive disorder. This CPG provides systematic recommendations based on clinical evidence, patient values, and other factors, aiding decision-makers, clinicians, and patients in selecting appropriate interventions. This paper discusses and analyzes the determination process of clinical questions, and the related issues during the development of this guideline, aiming to provide a reference for determining clinical questions and developing CPGs in the field of acupuncture and exploring more scientific tools and methods for determining clinical questions in future CPGs. (c) 2024 World Journal of Acupuncture - Moxibustion House. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY-NC-ND license ( http://***/licenses/by-nc-nd/4.0/ )

关键词： Major depressive disorder Acupuncture and moxibustion Guideline Clinical questions PICO COLLEGE MOOD

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World Federation of Acupuncture-Moxibustion Societies (WFAS) Clinical Practice Guidelines on Acupuncture and Moxibustion: Female Urinary Incontinence recommendation summaries

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WORLD JOURNAL OF ACUPUNCTURE-MOXIBUSTION 2024年第3期34卷 189-196页

作者： Du, Shi-hao Du, Shuo Chen, Sheng Wang, Shan-ze Wang, Guan-qun Xie, Xiao-long Peng, Bi-hui Guo, Wei Zhao, Ji-ping Yang, Chao Beijing univ chinese med Dongzhimen Hosp Dept Acupuncture & Moxibust Beijing 100700 Peoples R China China Acad chinese med Sci Inst Acupuncture & Moxibust Beijing 100700 Peoples R China Guangdong Prov Hosp chinese med Dept Acupuncture & Moxibust Guangzhou 510120 Peoples R China Shanghai Jiao Tong univ Sch Med Dept Tradit Chinese Med Shanghai Peoples Hosp 9 Shanghai 200011 Peoples R China

Urinary incontinence (UI) is common in women and affects the quality of life in female patients severely. But the clinical consideration and treatment are insufficient. Acupuncture and-moxibustion has been proposed as a potentially effective intervention for female UI. Hence, the World Federation of Acupuncturemoxibustion Societies (WFAS) have initiated a project to develop the clinical practice guideline (CPG) on acupuncture and moxibustion for female UI towards global acupuncture practitioners. The CPG was developed according to the Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) methodology, referring to the principles of the World Health Organization Handbook for Guideline Development . During the development of the CPG, the guideline development group (GDG) played an important role, which is composed of multi-national and multi-disciplinary experts. The clinical questions, recommendations and therapeutic protocols were all formulated by GDG using the modified Delphi method and basing on the results of the latest systematic review. This article focuses on the recommendations in the CPG. The CPG contains ten recommendations for ten clinical questions, including nine conditional recommendations for the intervention, one conditional recommendations for either the intervention or the comparison. The CPG also provides one conventional filiform needle therapy protocol, two deep puncturing stimulation on lumbosacral acupoints therapy protocols, and four moxibustion therapy protocols, extracted from the included clinical evidence of this CPG. (c) 2024 World Journal of Acupuncture - Moxibustion House. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY-NC-ND license ( http://***/licenses/by-nc-nd/4.0/ )

关键词： Acupuncture Moxibustion Clinical practice guideline Clinical question Female urinary incontinence Important outcome OVERACTIVE BLADDER WOMEN ELECTROACUPUNCTURE

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Full process of recommendation formulation for clinical practice guidelines: Taking World Federation of Acupuncture-Moxibustion Societies Clinical Practice Guideline on Acupuncture and Moxibustion: Allergic Rhinitis as an example

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WORLD JOURNAL OF ACUPUNCTURE-MOXIBUSTION 2024年第3期34卷 252-257页

作者： Yang, Chao Wang, Guan-qun Chen, Sheng Du, Shuo Wang, Shan-ze Xie, Xiao-long Peng, Bi-hui Guo, Wei Du, Shi-hao Zhao, Ji-ping Beijing univ chinese med Dongzhimen Hosp Dept Acupuncture & Moxibust Beijing Peoples R China China Acad chinese med Sci Inst Acupuncture & Moxibust Beijing 100700 Peoples R China Guangdong Prov Hosp chinese med Dept Acupuncture & Moxibust Guangzhou 510120 Peoples R China Shanghai Jiao Tong univ Shanghai Peoples Hosp 9 Sch Med Dept Tradit Chinese Med Shanghai 200011 Peoples R China

The formulation of recommendations is a crucial step in the development of clinical practice guidelines, which requires tools provided by the GRADE methodology. These tools include the evidence quality assessment tool, the evidence summary tool, and the evidence-to-decision (EtD) framework. Although there is a methodologically guided standard pathway for formulating recommendations in clinical practice guidelines, it remains unclear how to translate this theoretical pathway into the practical process for formulating recommendations and what the specific steps in this process entail. Therefore, this paper takes the World Federation of Acupuncture-Moxibustion Societies Clinical Practice Guidelines on Acupuncture and Moxibustion: Allergic Rhinitis as an example to detail the full process of formulating recommendations and summaries it into a three-step method. Step one: Collect original materials from different sources to create EtD table. Step two: Distribute and collect EtD table, and preliminarily gather the recommendation voting results. Step three: Organize "salami-slicing pattern" guideline development group consensus meeting to formulate recommendations. The three-step method for formulating recommendations in clinical practice guidelines fully utilizes the GRADE EtD table to provide guideline development group with decision-making foundation and reference from multiple dimensions, including the importance of clinical questions, balance of benefits and harms, quality of evidence, resource required, values and preferences, health equity, acceptability, and feasibility. This approach enhances the scientific and practical nature of guideline recommendations. This paper provides a standard operating procedure to formulate recommendations for the incoming clinical practice guidelines, which aims to establish a standard pathway for the formulation of acupuncture clinical practice guideline recommendations. (c) 2024 World Journal of Acupuncture - Moxibustion House. Pub

关键词： Clinical practice guidelines GRADE Evidence-to-decision (EtD) Acupuncture Moxibustion Allergic rhinitis Paradigm Standard operating procedure (SOP) Three-step method Salami-slicing pattern GRADE

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Single-cell RNA-seq reveals the transcriptional program underlying tumor progression and metastasis in neuroblastoma

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FRONTIERS OF medICINE 2024年第4期18卷 690-707页

作者： Nian, Zhe Wang, Dan Wang, Hao Liu, Wenxu Ma, Zhenyi Yan, Jie Cao, Yanna Li, Jie Zhao, Qiang Liu, Zhe tianjin med univ Sch Basic Med Sci Dept Immunol Tianjin 300070 Peoples R China Hangzhou Normal univ Sch Basic Med Sci Dept Cell Biol Zhejiang Key Lab Med Epigenet Hangzhou 311121 Peoples R China Nanjing med univ Collaborat Innovat Ctr Canc Personalized Med Nanjing 211166 Peoples R China tianjin med univ Canc Inst & Hosp Depr Pediat Oncol Natl Clin Res Ctr Canc Tianjins Clin Res Ctr CancKey Lab Canc Prevent & Tianjin 300060 Peoples R China

Neuroblastoma (NB) is one of the most common childhood malignancies. Sixty percent of patients present with widely disseminated clinical signs at diagnosis and exhibit poor outcomes. However, the molecular mechanisms triggering NB metastasis remain largely uncharacterized. In this study, we generated a transcriptomic atlas of 15 447 NB cells from eight NB samples, including paired samples of primary tumors and bone marrow metastases. We used time-resolved analysis to chart the evolutionary trajectory of NB cells from the primary tumor to the metastases in the same patient and identified a common 'starter' subpopulation that initiates tumor development and metastasis. The 'starter' population exhibited high expression levels of multiple cell cycle-related genes, indicating the important role of cell cycle upregulation in NB tumor progression. In addition, our evolutionary trajectory analysis demonstrated the involvement of partial epithelial-to-mesenchymal transition (p-EMT) along the metastatic route from the primary site to the bone marrow. Our study provides insights into the program driving NB metastasis and presents a signature of metastasis-initiating cells as an independent prognostic indicator and potential therapeutic target to inhibit the initiation of NB metastasis.

关键词： single-cell RNA sequencing metastasis neuroblastoma epithelial-to-mesenchymal transition MESENCHYMAL TRANSITION TGF-BETA MYCN IDENTIFICATION EXPRESSION PLASTICITY PHENOTYPES DYNAMICS

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Determination of liquid viscosity based on dual-frequency-band particle tracking

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chinese PHYSICS B 2024年第9期33卷 359-364页

作者： Yan, Lihua Xue, Boyin Li, Yuanji Feng, Jinxia Wu, Xingkang Zhang, Kuanshou Shanxi univ Inst Optoelect State Key Lab Quantum Opt & Quantum Opt Devices Taiyuan 030006 Peoples R China Shanxi univ Collaborat Innovat Ctr Extreme Opt Taiyuan 030006 Peoples R China Shanxi univ Modern Res Ctr Tradit Chinese Med Taiyuan 030006 Peoples R China

An optical-tweezers-based dual-frequency-band particle tracking system was designed and fabricated for liquid viscosity detection. On the basis of the liquid viscosity dependent model of the particle's restricted Brownian motion with the Fax & eacute;n correction taken into account, the liquid viscosity and optical trap stiffness were determined by fitting the theoretical prediction with the measured power spectral densities of the particle's displacement and velocity that were derived from the dual-frequency-band particle tracking data. When the SiO2 beads were employed as probe particles in the measurements of different kinds of liquids, the measurement results exhibit a good agreement with the reported results, as well as a detection uncertainty better than 4.6%. This kind of noninvasive economical technique can be applied in diverse environments for both in situ and ex situ viscosity detection of liquids.

关键词： liquid viscosity optical tweezers dual-frequency-band particle tracking power spectral density 07.07.Df 42.79.Pw OPTICAL TWEEZERS MICRORHEOLOGY SYSTEM

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An iron-based metal-organic framework nanoplatform for enhanced ferroptosis and oridonin delivery as a comprehensive antitumor strategy

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ACTA PHARMACEUTICA SINICA B 2024年第9期14卷 4073-4086页

作者： Cai, Mengru Fu, Tingting Zhu, Rongyue Hu, Panxiang Kong, Jiahui Liao, Shilang Du, Yuji Zhang, Yongqiang Qu, Changhai Dong, Xiaoxv Yin, Xingbin Ni, Jian Beijing univ chinese med Sch Chinese Mat Med Beijing 102488 Peoples R China

Ferroptosis is a recently discovered pathway for regulated cell death pathway. However, its efficacy is affected by limited iron content and intracellular ion homeostasis. Here, we designed a metal-organic framework (MOF)-based nanoplatform that incorporates calcium peroxide (CaO2) and oridonin (ORI). This platform can improve the tumor microenvironment and disrupt intracellular iron homeostasis, thereby enhancing ferroptosis therapy. Fused cell membranes (FM) were used to modify nanoparticles (ORI@CaO2@Fe-TCPP, NPs) to produce FM@ORI@CaO2@Fe-TCPP (FM@NPs). The encapsulated ORI inhibited the HSPB1/PCBP1/IREB2 and FSP1/COQ10 pathways simultaneously, working in tandem with Fe3+ to induce ferroptosis. Photodynamic therapy (PDT) guided by porphyrin (TCPP) significantly enhanced ferroptosis through excessive accumulation of reactive oxygen species (ROS). This self-amplifying strategy promoted robust ferroptosis, which could work synergistically with FM-mediated immunotherapy. In vivo experiments showed that FM@NPs inhibited 91.57% of melanoma cells within six days, a rate 5.6 times higher than chemotherapy alone. FM@NPs were biodegraded and directly eliminated in the urine or faeces without substantial toxicity. Thus, this study demonstrated that combining immunotherapy with efficient ferroptosis induction through nanotechnology is a feasible and promising strategy for melanoma treatment.

关键词： Metal-organic frameworks Immunotherapy Self-amplifying ferroptosis Photodynamic therapy Chemodynamic therapy Oridonin Fused cell membrane coating Metabolization NANOPARTICLES THERAPY NANOmedICINE EXPRESSION CELLS

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Frequency-modulated continuous-wave multiplexed gas sensing based on optical frequency comb calibration

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chinese PHYSICS B 2024年第9期33卷 152-163页

作者： Jia, Linhua Qu, Xinghua Zhang, Fumin tianjin univ State Key Lab Precis Measurement Technol & Instrum Tianjin 300072 Peoples R China

Laser absorption spectroscopy has proven to be an effective approach for gas sensing, which plays an important role in the fields of military, industry, medicine and basic research. This paper presents a multiplexed gas sensing system based on optical frequency comb (OFC) calibrated frequency-modulated continuous-wave (FMCW) tuning nonlinearity. The system can be used for multi-parameter synchronous measurement of gas absorption spectrum and multiplexed optical path. Multi-channel parallel detection is realized by combining wavelength division multiplexing (WDM) and frequency division multiplexing (FDM) techniques. By introducing nonlinear optical crystals, broadband spectrum detection is simultaneously achieved over a bandwidth of hundreds of nanometers. An OFC with ultra-high frequency stability is used as the frequency calibration source, which guarantees the measurement accuracy. The test samples involve H13C14N, C2H2 and Rb vapor cells of varying densities and 5 parallel measurement experiments are designed. The results show that the measurement accuracies of spectral absorption line and the optical path are 150 MHz and 20 mu m, respectively. The scheme offers the advantages of multiplexed, multi-parameter, wide spectrum and high resolution detection, which can realize the identification of multi-gas components and the high-precision inversion of absorption lines under different environments. The proposed sensor demonstrates great potential in the field of high-resolution absorption spectrum measurement for gas sensing applications.

关键词： frequency-modulated continuous-wave (FMCW) technology optical frequency comb multiplexing absorption spectroscopy 42.15.Eq 06.20.-f 42.62.Fi 42.62.-b SPECTROSCOPY CONVERSION LIDAR

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Vitri fi cation cryopreservation of ligaments based on zwitterionic betaine

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chinese JOURNAL OF CHEMICAL ENGINEERING 2024年第8期72卷 1-9页

作者： Zhang, Liming Liu, Xinmeng Li, Haoyue Zhang, Lei tianjin univ Frontier Sci Ctr Synthet Biol Dept Biochem Engn Tianjin 300350 Peoples R China tianjin univ Sch Chem Engn & Technol Key Lab Syst Bioengn MOE Tianjin 300350 Peoples R China Haihe Lab Sustainable Chem Transformat Tianjin 300192 Peoples R China

Ligament cryopreservation enables a prolonged shelf life of allogeneic ligament grafts, which is fundamentally important to ligament reconstruction. However, conventional cryopreservation techniques fail to eliminate the damage caused by ice crystal growth and the toxicity of cryopreservation agents (CPAs). Here, we report a novel CPA vitrification formulation primarily composed of betaine for ligament cryopreservation. Comprehensive optimization was conducted on the methods for vitrification and rewarming, as well as the loading and unloading conditions, based on the critical cooling rate (CCR), critical warming rate (CWR), and permeation properties of the CPA. Using biomechanical and histological level tests, we demonstrate the superior performance of our method in ligament cryopreservation. After 30 days of vitrification cryopreservation, parameters such as the Young's modulus, tensile stress, denaturation temperature, and glycosaminoglycans content of the ligament remained essentially unchanged. This work pioneers the application of ice-free cryopreservation for ligament and holds great potential for improving the long-term storage of ligament, providing valuable insights for future cryopreservation technique development. (c) 2024 The Chemical Industry and Engineering Society of China, and Chemical Industry Press Co., Ltd. All rights reserved.

关键词： Ligament Betaine Vitrification Cryopreservation INDUCTION MEMBRANE

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Thermal stable Pt clusters anchored by K/TiO2-Al2O3 for efficient cycloalkane dehydrogenation

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chinese JOURNAL OF CHEMICAL ENGINEERING 2024年第8期72卷 187-198页

作者： Wang, Zhendong Zhang, Bofeng Liu, Guozhu Zhang, Xiangwen tianjin univ Sch Chem Engn & Technol Key Lab Green Chem Technol Minist Educ Tianjin 300072 Peoples R China tianjin univ Zhejiang Inst Ningbo 315201 Peoples R China

Catalytic dehydrogenation of cycloalkanes is considered a valuable endothermic process for alleviating the thermal barrier issue of hypersonic vehicles. However, conventional Pt-based catalysts often face the severe problem of metal sintering under high-temperature conditions. Herein, we develop an efficient K2CO3-modified Pt/TiO2-Al2O3 (K-Pt/TA) for cycloalkane dehydrogenation. The optimized K-Pt/TA showed a high specific activity above 27.9 mol center dot mol-1 center dot s-1(H2/Pt), with toluene selectivity above 90.0% at 600 degrees C with a high weight hourly space velocity of 266.4 h-1. The introduction of alkali metal ions could generate titanate layers after high-temperature hydrogen reduction treatment, which promotes the generation of oxygen vacancy defects to anchored Pt clusters. In addition, the titanate layers could weaken the surface acidity of catalysts and inhibit side reactions, including pyrolysis, polymerization, and isomerization reactions. Thus, this work provides a modification method to develop efficient and stable dehydrogenation catalysts under high-temperature conditions. (c) 2024 The Chemical Industry and Engineering Society of China, and Chemical Industry Press Co., Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.

关键词： Cycloalkane dehydrogenation Pt clusters Oxygen vacancy defects Coking Stability Deactivation METAL-SUPPORT INTERACTIONS CATALYSTS CRACKING OXIDE FUEL DEACTIVATION PERFORMANCE VACANCIES ZEOLITES PLATINUM

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World Federation of Acupuncture-Moxibustion Societies (WFAS) Clinical Practice Guideline on Acupuncture and Moxibustion: Gastroesophageal Reflux Disease (GERD) recommendation summaries

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WORLD JOURNAL OF ACUPUNCTURE-MOXIBUSTION 2024年第3期34卷 197-203页

作者： Zhang, Xue-ping Zhou, Juan Pan, Wei-bing Huang, Xue Chen, Ruo-han Liu, Zhen-wen Lan, Xin Chen, Chen-chen Fan, Qian Kazemi, Amir Hooman Bai, Xing-hua Beijing univ chinese med Sch Acupuncture Moxibust & Tuina Beijing 100105 Peoples R China Andingmen Community Hlth Serv Ctr Beijing 100007 Peoples R China Beijing univ chinese med Dongzhimen Hosp Beijing 100700 Peoples R China Gen Hosp Peoples Liberat Army China Beijing 100094 Peoples R China Beijing Fengtai Dist Hosp tradit chinese med Beijing 100076 Peoples R China Changshu Hosp chinese med Changshu 215516 Jiangsu Peoples R China univ Tehran med Sci Tehran Iran

The Clinical Practice Guideline on Acupuncture and Moxibustion: Gastroesophageal Reflux Disease (GERD) (WFAS 007.9-2023), officially released by the World Federation of Acupuncture-Moxibustion Societies (WFAS) on October 9, 2023, represents the inaugural acupuncture and moxibustion clinical practice guideline dedicated to GERD globally. This guideline outlines its purpose, scope, target audience, and relevant environments, along with detailing the acupuncture and moxibustion treatment methodology for GERD, as well as the guideline development process and recommendations. This article specifically emphasizes the recommendations of the guideline, highlighting the crucial importance of both the dissemination and adherence to this guideline to standardize acupuncture and moxibustion treatments for GERD. Such standardization plays a pivotal role in the advancement and widespread utilization of acupuncture and moxibustion in the management of GERD. (c) 2024 World Journal of Acupuncture - Moxibustion House. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY-NC-ND license

关键词： Clinical practice guideline Gastroesophageal reflux disease Esophageal and gastrointestinal motility Acid suppression Acupuncture and moxibustion DISEASE

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