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Virtual ballistic impact testing of Kevlar soft armor:Predictive and validated finite element modeling of the V0-V100 probabilistic penetration response

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Defence Technology（防务技术） 2018年第3期14卷 213-225页

作者： Gaurav Nilakantan Suzanne Horner Virginia Halls James Zheng Teledyne Scientific&Imaging Thousand OaksCA 91360USA Program Executive Office Soldier Fort BelvoirVA 22060USA

This works presents the first fully validated and predictive capability to model the V_0-V_(100) probabilistic penetration response of a woven fabric using a yarn-level fabric finite element model. The V_0-V_(100) curve describes the probability of complete fabric penetration as a function of projectile impact velocity. The exemplar case considered in this paper comprises of a single-layer, fully-clamped, plain-weave Kevlar fabric impacted at the center by a 17-gr, 0.22 cal FSP or fragment-simulating projectile. Each warp and fill yarn in the fabric is individually modeled using 3 D finite elements and the virtual fabric microstructure is validated in detail against the experimental fabric microstructure. Material and testing sources of statistical variability including yarn strength and modulus, inter-yarn friction, precise projectile impact location, and projectile rotation are mapped into the finite element model. A series of impact simulations at varying projectile impact velocities is executed using LS-DYNA on the fabric models, with each model comprising unique mappings. The impact velocities together with the outcomes(penetration, nonpenetration) are used to generate the numerical V_0-V_(100) curve which is then validated against the experimental V_0-V_(100) curve. The numerical Vi-Vrdata(impact, residual velocities) is also validated against the experimental Vi-Vrdata. For completeness, this paper also reports the experimental characterization data and its statistical analysis used for model input, viz. the Kevlar yarn tensile strengths, moduli, and inter-yarn friction, and the experimental ballistic test data used for model validation.

关键词： Kevlar 有限元素测试数据验证概率预兆弹道虚拟

任使用肖特基二极管-FET逻辑的GaAS集成电路中多级逻辑门的实现

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电子器件 1980年第S1期 176-181页

作者： RichardC.Eden,FrankS.Lee,StephenI.Long,BryantM.Weich,RicardoZucca Rockwell International Electronics Reseach Center thousand oaks Rockwell International Electronics Reseach Center thousand oaks Rockwell International Electronics Reseach Center thousand oaks Rockwell International Electronics Reseach Center thousand oaks Rockwell International Electronics Reseach Center thousand oaks CA CA CA CA CA

AT ISSCC78～1,报导过GaAs集成电路—肖特基二极管—FET逻辑(SDFL)。这些电路利用一个很小的、高电导的开关二极管以得到正—或逻辑功能,和低功率耗尽型(正常为导通)GaAs金属半导体(MES)FET组合构成反相和或非门。在100个门的中规模集... 详细信息

AT ISSCC78～1,报导过GaAs集成电路—肖特基二极管—FET逻辑(SDFL)。这些电路利用一个很小的、高电导的开关二极管以得到正—或逻辑功能,和低功率耗尽型(正常为导通)GaAs金属半导体(MES)FET组合构成反相和或非门。在100个门的中规模集成电路(MSI)复杂性的3.4高产量平面集成电路2中,这些门的高密度使提供高的开关速度、低的功率电平(P0～100μw到1mw/门)成为可能,速度-功率乘积低到16fJ。这篇论文将叙述SDFL电路方法的发展,这优于简单的单级或非门,而发展到在一个门延迟时间内被执行的许可至三级逻辑功能的门结构。

关键词：门功 FET GaAS

Antibody responses in COVID-19 patients

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The Journal of Biomedical Research 2020年第6期34卷 410-415页

作者： Shuying Liu Shan Lu SL Consulting Thousand OaksCA 91320USA Department of Medicine University of Massachusetts Medical SchoolWorcesterMA 01605USA.

Measuring virus-specific antibody responses to emerging pathogens is a well-established and highly useful tool to diagnose such infections,understand interactions between the immune system and pathogens,and provide potential clues for the development of vaccines or therapeutic agents against such *** the beginning of 2020,the discovery of SARS-CoV-2 as the emerging virus responsible for the COVID-19 pandemic has provided new insight into the complexity of antibody responses to this dangerous *** current review aims to sort out diverse and sometimes seemingly confusing findings to put together a cohesive understanding on the profile of antibody responses elicited in COVID-19 patients.

关键词： COVID-19 antibody serology SARS-CoV-2

On the fracture resistance of adhesively jointing structures

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第8期7卷 1289-1295页

作者： ZHOU Zhi-qiang YANG Qing-da CHEN Wel-qlu Department of Civll Engineering. Zhejiang University Hangzhou 310027 China Rockweell Scientific Co. LLC 1049 Camino Dos Rios Thousand Oaks CA 91360 USA

The interface toughness of adhesively bonded structural members is one of the critical parameters for adhesive joint design. It is often assumed that the joint toughness is a material constant so that its value can be obtained from fracture tests of simple geometries such as DCB for Mode-I, ENF for Mode-II, using linear elastic fracture mechanics (LEFM). However, the LEFM assumption of point-wise crack-tip fracture process is overly simplistic and may cause significant error in interpreting fracture test data. In this paper, the accuracy and applicability of various traditional beam-bending-theory based methods for fracture toughness evaluation, such as simple beam theory (SBT), corrected beam theory (CBT) and experimental compliance method (ECM), were assessed using the cohesive zone modelling (CZM) approach. It was demonstrated that the fracture process zone (FPZ) size has profound influence on toughness calculation and unfortunately, all the classic beam-bending theories based methods fail to include this important element and are erroneous especially when the ratio of crack length to FPZ size is relatively small (<5.0). It has also been demonstrated that after the FPZ size is incorporated into simple beam formulations, they provide much improved evaluation for fracture toughness. Formulation of first order estimate of FPZ size is also given in this paper.

关键词：断裂力学粘合剂粘合区模型断裂阻力焊接结构

Kalman Filtering: Theory and Practice Using MATLAB®, Third Edition 3rd ed.

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The Pattern and Cost of Palliative Surgeries in Patients with Metastatic Melanoma

2008年

作者： Mohinder S. Grewal Angus P. Andrews

ISBN: (数字)9780470377819

ISBN: (纸本)9780470173664

This book provides readers with a solid introduction to the theoretical and practical aspects of Kalman filtering. It has been updated with the latest developments in the implementation and application of Kalman filtering, including adaptations for nonlinear filtering, more robust smoothing methods, and developing applications in navigation. All software is provided in MATLAB, giving readers the opportunity to discover how the Kalman filter works in action and to consider the practical arithmetic needed to preserve the accuracy of results. Note: CD-ROM/DVD and other supplementary materials are not included as part of eBook file. An Instructor's Manual presenting detailed solutions to all the problems in the book is available from the Wiley editorial department -- to obtain the manual, send an email to ialine@*** .

关键词： Kalman filtering.

来源：畅想之星图书光盘版（南... 评论

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Journal of Cancer Therapy 2015年第3期6卷 245-250页

作者： Zhongyun Zhao Song Wang Beth L. Barber Amgen Inc Thousand Oaks CA USA

Objective: To investigate the pattern of palliative surgeries and associated costs in patients with metastatic melanoma in the USA. Methods: This was a retrospective claims-based study of patients identified using administrative claims from MarketScan®?databases among patients with metastatic melanoma diagnosed between 2005 and 2011. Patient characteristics, patterns and cost of surgery, and length of hospital stay were evaluated. Results: Of the 2399 patients identified, 888 (37.0%) underwent at least one surgical procedure either in the outpatient or inpatient setting. The subgroup of patients who underwent surgery included significantly more patients with distant skin metastases compared to the subgroup who did not receive surgery;whereas significantly more patients in the non-surgery group had brain or bone metastases. Surgery performed in the outpatient setting was predominantly on the skin, whereas surgery on the brain was generally performed in the inpatient setting. The mean cost of the surgical procedures performed in the outpatient setting was $3393 (median: $1419) per procedure, which varied according to the location of the metastasis. For surgical procedures that were performed in the inpatient setting, the mean length of stay in hospital due to surgery was 4.4 (± 5.1) days, at a mean cost of $37,649 (median: $28,067) per hospitalization. Conclusions: Surgery is prevalent and costly in patients with metastatic melanoma.

关键词： Metastatic Melanoma Surgery Cost Healthcare Costs Claims Analysis

High Efficiency Photorefractive BaTiO_3 Plate for Optical Image Processing

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Chinese Science Bulletin 1993年第17期38卷 1424-1427页

作者：顾向光朱镛张大鹏叶伯琦 Institute of Physics Department of Electrical and Computer Engineering University of Califomia at Santa Barbara Pochi Yeh is also a principal technical advisor at Rockwell International Science Center Rockwell Intermational Science Center Thousand Oaks

45°-cut BaTiO3 crystals have been studied and used for their enhanced photorefractive performance. Theoretically, BaTiO3 crystal has its maximum two-wave mixing （TWM） gain when the grating wave vector Kg is about 45° tilted with respect to its C-axis. However, for thick samples, the effective gain is usually reduced because of the fanning problem. At steady states, the effective TWM gain of a 45°-cut BaTiO3 is normally

关键词： two-wave mixing optical image processing 45°-cut BaTiO3 crystals.

Immunostimulation in the era of the metagenome

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Cellular & Molecular Immunology 2011年第3期8卷 213-225页

作者： Amy D Proal Paul J Albert Greg P Blaney Inge A Lindseth Chris Benediktsson Trevor G Marshall Murdoch University PerthWAAustralia Weill Cornell Medical College New YorkNYUSA Stillpoint Centre VancouverBCCanada 4M-Klinikken OsloNorway Autoimmunity Research Foundation Thousand OaksCAUSA

Microbes are increasingly being implicated in autoimmune *** calls for a re-evaluation of how these chronic inflammatory illnesses are routinely *** standard of care for autoimmune disease remains the use of medications that slow the immune response,while treatments aimed at eradicating microbes seek the exact opposite-stimulation of the innate immune *** is complicated by a cascade of sequelae,including exacerbated inflammation,which occurs in response to microbial *** the past 8 years,we have collaborated with American and international clinical professionals to research a model-based treatment for inflammatory *** intervention,designed to stimulate the innate immune response,has required a reevaluation of disease progression and *** is the inherent conflict between palliation and microbicidal *** microbicidal activity was experienced as immunopathology-a temporary worsening of *** studies are needed,but they will require careful planning to manage this immunopathology.

关键词： antimicrobial peptides autoimmune disease immune reconstitution inflammatory syndrome immunopathology innate immunity metagenomics

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美国和欧洲生物类似药的发展（英文）

药物分析杂志 2015年第5期35卷 777-787页

作者： Richard Markus Victor Fung Sundar Ramanan Biosimilars Development Amgen Inc. Thousand Oaks CA 91320 USA Global Biosimilars Regulatory Policy Amgen Inc. Thousand Oaks CA 91320 USA

生物类似药(biosimilars)是与已批准上市的生物制品高度相似的药物,与小分子仿制药物(generics)不同,生物类似药并不是他们参比制品的精确复制品。尽管高度相似,生物类似药在某些方面仍然可能与参比制品不同,生物类似药间也会互不相同... 详细信息

生物类似药(biosimilars)是与已批准上市的生物制品高度相似的药物,与小分子仿制药物(generics)不同,生物类似药并不是他们参比制品的精确复制品。尽管高度相似,生物类似药在某些方面仍然可能与参比制品不同,生物类似药间也会互不相同。生物制品不仅由于其复杂的性质和生产过程,还由于存在独特的免疫原性和活性的安全隐患,给研发和监管带来了相当大的挑战。欧洲药品管理局和美国食品药品管理局的指导原则建议采用"证据链完备性"(totality-of-evidence)的方法全面覆盖生物类似药物开发的各个步骤,包括分析表征化、结构相似性和功能等效性等的证据。这种"证据链完备性"是生物类似药整个研发过程中其余工作的基石,包括必须的动物试验研究、人体药代动力学/药效学研究,以及至少1个临床研究,以证实生物类似药功效等效,并且免疫原性或安全性风险没有增加。临床研究应选择敏感人群来进行试验,以便发现任何有临床意义的差异。工艺稳定质量恒定的生物类似药的研发需要丰富的经验和专业技能,只有这样才能够确保患者得到良好治疗。

关键词：生物类似药的研发监管指导原则欧洲药品管理局指导原则美国食品药品管理局指导原则证据链完备性生物相似性