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Giant neurogenic tumors of mediastinum: report of two cases and literature review

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Chinese Journal of Cancer Research 2013年第2期25卷 259-262页

作者： Jingwei Wang Jidong Yan Shuhua Ren Yu Guo Yang Gao Lijun Zhou Department of thoracic surgery Tangshan Gongren Hospital

Neurogenic tumors are commonly found in the mediastinum, especially in the posterior mediastinum or in the chest wall, neurogenic tumors may reach large size before becoming symptomatic. If the neurogenic tumor occupied more than half size of the chest wall accompanied by mediastinal shift, tracheal compression, or superior vena reflux disorder, it may be called giant intrathoracic neurogenic tumors. Giant intrathoracic neurogenic tumors are relatively rare. Most of intrathoracic neurogenic tumors were benign or low-grade malignant tumors in nature. Complete surgical excision should be the rule for these patients. We report two cases of giant neurogenic tumors, and study the clinical manifestations, diagnostic methods, surgical management, and prognosis in the light of the most important published data.

关键词： Mediastinal neoplasms giant intrathoracic neurogenic tumors

Undetected traumatic cardiac herniation like playing hide-and-seek-delayed incidental findings during surgical stabilization of flail chest:A case report

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World Journal of Clinical Cases 2022年第36期10卷 13396-13401页

作者： Su Young Yoon Jin-Bong Ye Junepill Seok Department of thoracic and cardiovascular surgery Chungbuk National University HospitalCheongju 28644South Korea Department of Trauma surgery Chungbuk National University HospitalCheongju 28644South Korea

BACKGROUND Post-traumatic blunt pericardial injury is a rare condition with only a few reported cases which were generally diagnosed during initial examinations upon ***,pericardial injuries not bad enough to dislocate the heart may only cause intermittent electrocardiogram(ECG)changes or be *** SUMMARY In this case,we report a blunt pericardial injury undetected on preoperative transthoracic echocardiography and chest computed *** misjudged intermittent ECG changes and blood pressure fluctuations as minor symptoms resulting from cardiac contusion and did not provide intensive *** pericardial injury was found incidentally during surgical stabilization of rib fractures and was successfully *** Post-traumatic blunt pericardial ruptures should be considered in patients with blunt chest trauma showing abnormal vital signs and ECG changes.

关键词： Cardiac herniation Flail chest Multiple rib fractures Pericardial rupture Surgical stabilization of rib fractures Case report

Diagnosis and surgical treatment of intraveneous leiomyomatosis extending into the heart:two cases report and review of the literature

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Journal of Nanjing Medical University 2009年第5期23卷 305-310页

作者： Xiaowei Wang Lin Zhang Yijiang Chen Shijiang Zhang Jianwei Qin Yanhu Wu Jinhua Luo Department of thoracic & cardiovascular surgery the First Affiliated Hospital of Nanjing Medical University Nanjing 210029 China

Objective： To investigate the clinical characteristics, diagnosis and surgical treatment of intravenous leiomyomatosis （IVL）, and outline the differences between Chinese and overseas cases. Methods： Clinical data of two IVL cases, treated in our hospital, were analyzed retrospectively and the related literature was also reviewed. The data of preoperative diagnostic rate, surgical procedures, and postoperative recurrence between patients in China and other countries were compared. Results： The first stage operation was performed successfully in 2 patients. However, they refused subsequent therapies, including a second stage operation to excise the remnants Of the tumor, uterus, bilateral oviducts and ovaries, and anti-estrogen therapy. Both suffered from IVL recurrence, one at 6-month and the other at 9-month, and died at 16-month and 12-month respectively after the first stage surgery. Worldwide reports of 110 IVL cases were reviewed, which included 28 cases in China and 82 cases in other countries. In the majority of the Chinese patients, tumors only extended into the fight atrium rather than the right ventricle （RA 22 cases vs RV 4 cases）. However, among the overseas patients, the rate of extension into the right atrium was similar to that of extension into the right ventricle （RA 41 cases vs RV 38 cases）. The rate of hysterectomies was not significantly different between Chinese and overseas patients （ 67.86% vs 55.9%, P=0.278）. The rate of correct preoperative diagnosis in the Chinese patients was significantly lower than that in the overseas patients （32.14% vs 80%, P=0.000002.）, as well asthe rate of complete excision of the tumor （22.7@0 vs 75.5%, P=0.000001）. The proportion of patients who undergoing a single-stage or a two-stage operation was similar in Chinese and overseas patients. The recurrence rate was significantly higher in the Chinese patients than in the overseas patients （36.8% vs 9.1%, P=0.0055）, and the patients with tumor recurrence were partia

关键词： Intravenous leiomyomatosis (IVL) Heart Diagnosis Surgical treatment

Video-Assisted thoracic surgery for Residual Aneurysm after Total Arch Replacement

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Open Journal of thoracic surgery 2021年第1期11卷 25-30页

作者： Kayo Sugiyama Hirotaka Watanuki Yasuhiro Futamura Masaho Okada Hiroki Numanami Masayuki Yamaji Satoshi Makino Katsuhiko Matsuyama Department of Cardiac surgery Aichi Medical University Nagakute Japan Department of thoracic surgery Aichi Medical University Nagakute Japan

Background: Residual aneurysms after graft replacement are rare, but they can be detrimental if they are saccular and large. The etiology of residual aneurysms remains unknown, and their management is controversial. One treatment option is late open surgical conversion;however, postoperative respiratory complications resulting from the dissection of pleural adhesions, which is frequently necessary with this approach, are often unavoidable. Case presentation: Herein, we report a case of open surgical repair of a residual distal aortic arch aneurysm that occurred after total arch replacement and thoracic endovascular aortic repair. Contrast-enhanced magnetic resonance imaging was not possible in this case due to the patient’s severe renal dysfunction;however, contrast-enhanced computed tomography using minimal contrast did not detect remarkable leakage through the graft or stent graft into the aneurysm. Late open surgical conversion using video-assisted thoracic surgery was performed by thoracic surgeons, and the adhesion between the aortic wall and the lung was safely and effectively dissected. Because there was no significant pulsation or evidence of feeding arteries in the aortic wall, the aortic wall was opened carefully. No bleeding or backflow from any branch arteries into the aneurysm was noted, so the aortic wall was ligated with continuous sutures. The patient recovered without experiencing any major complications. Conclusions: This case report demonstrates that video-assisted thoracic surgery is safe and effective for late open conversion in cases of residual aneurysm;furthermore, this case suggests that video-assisted thoracic surgery may be particularly beneficial for the dissection of adhesions between the aortic wall and lung in these cases.

关键词： Late Open Surgical Conversion Total Arch Replacement Video-Assisted thoracic surgery

Reconstruction of a new pulmonary artery in arterial switch operation

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World Journal of Pediatrics 2015年第2期11卷 177-180页

作者： Bai-Ping Sun Shu Fang Ze-Wei Zhang Fang-Xia Chen Jian-Hua Li Ru Lin Qiang Shu Jian-Gen Yu Department of thoracic and cardiovascular surgery Children's Hospital of Zhejiang University School of Medicine57 Zhugan XiangHangzhou 310003China

Background:This study was undertaken to evaluate the new method for the reconstruction of the pulmonary artery in arterial switch operation(ASO).Methods:A total of 108 consecutive infants with congenital heart disease were treated with ASO in our department between January 2004 and June *** new pulmonary arterial root was reconstructed with a fresh autologuos pericardium which was clipped pantslike with continuous mattress suture of 6-0 Prolene *** were reexamined consecutively at 3 and 6 months and 1,2 and 6 years after *** pulmonary arterial blood velocity was measured by continuous Doppler during *** pulmonary flow of healthy children of same age was also measured in the control *** Bernoulli formula was used to calculate the pressure gradient via the pulmonary artery for determining whether there was pulmonary ***:In this series,96 infants survived after the surgery and 88 were followed up with a mean peirod of(22±4)*** pulmonary stenosis was detected with the simplified Bernoulli ***:No pulmonary stenosis was detected with the simplified Bernoulli formula.

关键词： arterial switch operation fresh autologuos pericardium pulmonary arterial reconstruction

Effects of Ethyl Pyruvate on Myocardial Apoptosis and Expression of Bcl-2 and Bax Proteins after Ischemia-reperfusion in Rats

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2008年第3期28卷 281-283页

作者：郭家龙张凯伦季艳梅蒋雄刚左顺庆 Department of cardiovascular surgery Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Department of Intensive Care unit Taihe Hospital Affiliated to Yunyang Medical College Department of thoracic surgery Taihe Hospital Affiliated to Yunyang Medical College

In order to study the effects of ethyl pyruvate on cardiomyocyte apoptosis following ischemia/reperfusion （I/R） in vitro and the expression of Bcl-2 and Bax proteins, isolated rat hearts were perfused in a Langendorff model. Twenty-four rats were randomly divided into 3 groups （n=8 in each group）： control group was perfused for 120 min. In the I/R group, after 30 min stabilization the injury was induced by 30 min global ischemia followed by 60 min reperfusion. Ethyl pyruvate （EP） group was set up with the same protocol as I/R group except that it was supplied with 2 mmol/L EP 15 rain before ischemia and throughout reperfusion. Myocardial malonaldehyde （MDA） content was measured. Myocardial apoptotic index （AI） was tested by terminal deoxynucleotidyl transferase mediated dUTP nick end labeling （TUNEL） method. The expression of anti-apoptotic protein Bcl-2 and pro-apoptotic protein Bax in cardiac myocytes was detected by immunohistochemistry. As compared with control group, the content of MDA, myocardial AI and the expression of Bcl-2, Bax proteins were increased significantly in I/R group, but the content of MDA, myocardial AI and the expression of Bax protein were decreased obviously and the expression of Bcl-2 protein was up-regulated in EP group （P〈0.05）. These results demonstrate that EP could inhibit apoptosis of cardiac myocytes possibly via alleviating oxidative stress, up-regulating Bcl-2 and down-regulating Bax proteins.

关键词： ethyl pyruvate myocardial reperfusion injury apoptosis Bcl-2 protein Bax protein

Debulking surgery and hyperthermic intrathoracic chemotherapy(HITHOC)for lung cancer

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Chinese Journal of Cancer Research 2017年第6期29卷 533-534页

作者： Marcello Migliore thoracic surgery unit A.O.U.Policlinico-Vittorio EmanueleDepartment of Surgery and Medical SpecialitiesUniversity of CataniaCatania 95123Italy

One hundred years ago, the first patients with lung cancer have been reported （1）. Since then long term survival in patients with lung cancer remains disappointing, and this is not only due to the delayed diagnosis ... 详细信息

关键词： Lung cancer NSCLC advanced stage cytoreduction hyperthermic intraoperative intrapleuralchemotherapy

Immunological effect of local ablation combined with immunotherapy on solid malignancies

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Chinese Journal of Cancer 2017年第6期36卷 252-257页

作者： Yusuke Takahashi Noriyuki Matsutani Takashi Nakayama Hitoshi Dejima Hirofumi Uehara Masafumi Kawamura Department of General thoracic surgery Teikyo University School of Medicine

Recent comprehensive investigations clarified that immune microenvironment surrounding tumor cells are deeply involved in tumor progression,metastasis,and response to ***,several immunotherapeutic trials have achieved successful results,and the immunotherapeutic agents are available in clinical *** enhance their demonstrated efficacy,combination of immunotherapy and ablation has begun to *** ablations have considerable advantages as an alternative therapeutic option,especially its minimal *** addition,local ablations have shown immune-regulatory effect in preclinical and clinical *** the corresponding mechanisms are still unclear,the local ablations combined with immunotherapy have been suggested in the treatment of several solid *** article aims to review the published data on the immune-regulatory effects of local ablations including stereotactic body radiotherapy,cryoablation,radiofrequency ablation,and high-intensityfocused *** also discuss the value of local ablations combined with *** ablations have the potential to improve future patient outcomes;however,the effectiveness and safety of local ablations combined with immunotherapy should be further investigated.

关键词：免疫治疗剂免疫效应实体瘤免疫调节作用高强度聚焦超声肿瘤细胞临床实践综合调查

A Rare Case of Infective Mediastinitis after Melody Valve Implantation

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Congenital Heart Disease 2022年第2期17卷 187-192页

作者： Veronica Lorenz Karlien Carbonez Geoffroy de Beco Alain Poncelet Department of cardiovascular and thoracic surgery Cliniques Universitaires Saint-LucBrusselsBelgium Department of Pediatric Cardiology Cliniques Universitaires Saint-LucBrusselsBelgium

Pulmonary valve implant is frequently necessary in children and adults with congenital heart *** endocarditis represents a rare but life-threatening complication after transcatheter pulmonary valve *** are various treatments for native or prosthetic valve *** intervention,combined with intravenous antibiotic treatment,is of paramount importance,in case of concomitant mediastinal infection,in order to ensure the radical debridement of all infected tissue,avoiding any recurrent *** this report,we describe a rare case of mediastinitis,associated with an infected endocarditis,occurring 8 months after Melody(Medtronic,Minneapolis,USA)valve implant,successfully treated with the implantation of a homograft to reconstruct the right ventricular outflow tract.

关键词： Transcatheter valve prosthesis infective endocarditis cardiac surgery congenital heart disease homograft