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Analysis of the Expression of Fas,FasL and Bcl-2 in the Pathogenesis of Autoimmune Thyroid Disorders

Cellular & Molecular Immunology 2004年第3期1卷 224-228页

作者： ShenrenChen S.M.FazleAkbar ZhichaoZhen YipingLuo LijuanDeng HaihuaHuang LinxinChen WeiLi TheSecondHospitalofShantouUniversityMedicalCollege Guangdong.Shantou515041.China thirddepartmentofinternalmedicine.EhimeUniversity.SchoolofMedicine.Ehime.Japan

To investigate the expression of apoptosis-related protein(Fas,FasL,and Bcl-2)in the pathogenesis of autoimmune thyroid disorders (ATDs),immunohistochemical staining was performed on 20 Hashimoto's thyroiditis(HT),20 Graves'disease(GD),and 20 thyroid follicular adenoma(TFA,as control).All the cases expressed Fas,mainly on the cell surface and *** was found in 17 cases of the ***-2 was detected in 15 cases of HT,19 of GD and 17 of *** TFA,a moderate Fas expression and a minimal or no FasL expression was detected on follicular *** HT,the follicles adjacent to infiltrating lymphocytes showed increased levels of Fas and FasL expression.A weaker staining of Fas and FasL was exhibited on infiltrating lymphocytes than on *** a comparison of GD with HT,thyrocytes and lymphocytes showed similar Fas staining,but for FasL the staining was rather weaker in *** expression of Bcl-2 was nearly identical in GD and TFA,but much weaker on the follicular cells in vicinity of lymphocytes and on the lymphocytes located in germinal centers of HT *** expression of Fas,FasL,Bcl-2 in Hashimoto's thyroiditis and Graves' disease were almost *** strong expression and Bcl-2 weak expression on the follicles in HT may induce *** results provided evidence for expression of Fas,FasL and Bcl-2 in the pathogenesis of autoimmune thyroid *** lymphocytes seem not to be directly engaged in the process via their own FasL,but they may provide some cytokines that,in turn,upregulate Fas and/or FasL expression to induce *** & Molecular Immunology.2004;1(3):224-228.

关键词： ATD HT GD Fas FasL Bcl-2

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UTILITY OF ALBUSURE TEST IN SCREENING FOR EARLY STAGE OF DIABETIC NEPHROPATHY

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Chinese Medical Journal 1994年第9期 61-64页

作者：张锦 KaoruLnoue NaokiNakashima ShinsukeHiramatsu MasaoOhashi FumioUmeda HajimeNawata DepartmentofEndocrinology ChinaMedicalUniversity.Shenyang110001 thirddepartmentofinternalmedicine.FacultyofMedicine KyushuUniversityJapan thirddepartmentofinternalmedicine.FacultyofMedicine KyushuUniversityJapanalldiabeticpatientsshouldbescreenedfortheearlystageofdiabeticnephropathybecausemicroalbuminuriahasagreatprognosticsignificance.Thealbusuretest(AT)alatexagglutinationnephelometricimmunoassayisarapidandlowcosttestforthedetectionofmicroalbuminuraiof30mg/Lormore.

all diabetic patients should be screened for the early stage of diabetic nephropathy,because microalbuminuria has a great prognostic *** albusure test(AT),alatex agglutination nephelometric immunoassay,is a rapid and ... 详细信息

关键词： AT UTILITY OF ALBUSURE TEST IN SCREENING FOR EARLY STAGE OF DIABETIC NEPHROPATHY

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Impact of Helicobacter pylori infection on ghrelin and various neuroendocrine hormones in plasma

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World Journal of Gastroenterology 2005年第11期11卷 1644-1648页

作者： HajimeIsomoto HiroakiUeno YoshitoNishi Chun-YangWen MasamitsuNakazato ShigeruKohno SecondDepartmentofInternalMedicine NagasakiUniversitySchoolofMedicineSakamoto1-7-1NagasakiJapan DepartmentofMolecularPathology AtomicBombDiseaseInstituteNagasakiUniversitySchoolofMedicineSakamoto12-4NagasakiJapan thirddepartmentofinternalmedicine MiyazakiMedicalCollegeKiyotakeMiyazakiJapan

AIM: Ghrelin, an endogenous ligand for growth hormone secretagogue receptor, influences appetite, energy balance, gastric motility and acid secretion. The stomach is the main source of circulating ghrelin. There are inconsistent reports on the influence of Helicobacter pylori (H pylori) infection on circulating ghrelin levels. We sought to elucidate the relationship between ghrelin and various peptides in plasma, with special reference to H ***: Plasma ghrelin levels were measured by radioimmunoassay in 89 subjects who were referred for upper gastrointestinal endoscopy, consisting of 42 H pylori infected and 47 uninfected ones. Plasma gastrin,somatostatin, leptin, insulin-like growth hormone 1 (IGF-1)and chromogranin A concentrations were also *** patients were treated with anti- H pylori ***: Ghrelin circulating levels were greatly decreased in H pylori-positive than negative individuals (194.2±90.2fmol/mL and 250.4±84.1 respectively, P＜0.05), but did not significantly alter following the cure of infection (176.5±79.5 vs 191.3±120.4). There was a significant negative correlation between circulating ghrelin and leptin levels, as well as body mass index, for the whole and uninfected population, but not in H pylori-infected patients. Plasma ghrelin concentrations correlated positively with IGF-1 in H pylori-negative group and negatively with chromogranin A in the infected *** were no significant correlations among circulating levels of ghrelin, gastrin and somatostatin irrespective of H pylori ***: H pylori infection influences plasma ghrelin dynamics and its interaction with diverse bioactive peptides involved in energy balance, growth and neuroendocrine function.

关键词： Helicobacter pylori Ghrelin Leptin Gastrin Insulin-like growth factor

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Effect of Human Interleukin-8(IL-8) on Highighly Purified Murine Hematopoietic Progenitor Cells

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中国肿瘤生物治疗杂志 1995年第4期2卷 272-273页

作者： T,Zhang T.Ito S.Nakao N,Mukaida K,Matsushima Departmtntofpharmacology CancerResearchInstituteKanazawaUniversity13-1Takara-machiKanazawaIshikawa920Japan thirddepartmentofinternalmedicine SchoolofMedicineKanazawaUniversity13-1Takara-machiKanazawaIshikawa920Japan

Gene targeting of mouse homolog of interleukin-8 receptor (IL-8R) resulted in the increase of myeloid cells in the bone marrow and peripheral blood, sugesting a potential ro le of IL-8 mregulating hematopoiesis of the... 详细信息

关键词：白细胞介素-8 造血干细胞大鼠基因表达

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Concentrations of α-and β-defensins in gastric juice of patients with various gastroduodenal diseases

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World Journal of Gastroenterology 2005年第1期11卷 99-103页

作者： YoshitoNishi HajimeIsomoto HiroshiMukae HiroshiIshimoto Chun-YangWen AkihiroWada KenOhnita YoheiMizuta IkuoMurata ToshiyaHirayama MasamitsuNakazato ShigeruKohno SecondDepartmentofInternalMedicine NagasakiUniversitySchoolofMedicineSakamoto1-7-1NagasakiJapan DepartmentofMolecularPathology AtomicBombDiseaseInstituteNagasakiUniversitySchoolofMedicineSakamoto12-4NagasakiJapan DepartmentofBacteriology InstituteofTropicalMedicineNagasakiUnive~itySchoolofMedicineSakamoto12-4NagasakiJapan thirddepartmentofinternalmedicine MiyazakiMedicalCollegeKiyotakeMiyazakiJapan

AIM: To determine the concentration of α-and β-defensins in gastric juice of patients with various gastroduodenal diseases. METHODS: Concentrations of human neutrophil peptides (HNPs) 1-3, the major forms of α-defensins, and human β-defensin (HBD)-1and HBD-2were measured by radioimmunoassay in plasma and gastric juice of 84 subjects, consisting of 54 Helicobacter pylori-infected and 30 uninfected subjects. They included 33 patients with chronic gastritis (CG), 12 with gastric ulcer (GU), 11 with duodenal ulcer (DU), 11 with benign gastric polyp (BGP) and 16 with normal mucosa (N group) on upper endoscopy. Plasma pepsinogen Ⅰ and Ⅱ levels, biomarkers for gastric mucosal inflammation and atrophy, were also measured. RESULTS: Gastric juice HNPs 1-3 levels in patients with CG, GU and BGP were significantly higher than those in patients with DU and N. Gastric juice HBD-2 concentrations in patients with CG and GU were significantly higher than those in the N group, but were significantly lower in DU patients than in GU patients. Gastric juice HBD-1 levels and plasma levels of these peptides were similar in the patient groups. Concentrations of gastric juice HNPs 1-3 and HBD-2 of in H pylori-infected patients were significantly different from those in uninfected subjects. HNPs 1-3 concentrations in gastric juice correlated negatively with plasma pepsinogen I levels and Ⅰ/Ⅱ ratios. HBD-2 levels in gastric juice correlated positively and negatively with plasma pepsinogen Ⅱ concentrations and Ⅰ/Ⅱratios, respectively. CONCLUSION: HNPs 1-3 and HBD-2 levels in gastric juice are diverse among various gastrointestinal diseases, reflecting the inflammatory and atrophic events of the background gastric mucosa affected by H pylori.

关键词： Helicobacter pylori infection Gastroduodenal diseases α-defensins β-defensin

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日本职业性过敏性肺炎

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中华结核和呼吸杂志 1997年第Z1期20卷 89-89页

作者： Nishiura Y Nakagawa K Suga M Arima K Yoneda R Tamura M Ando M 沈玲(译) FirstDepartmentofInternalMedicine KuamotoUniversitySchoolofMedicineLumamoto FirstDepartmentofInternalMedicine KumamotoUniversitySchoolofMedicineLumamoto TokyoNationalChestHospital Tokyo thirddepartmentofinternalmedicine IwateUniversityIwateJapan

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