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World Journal of Gastroenterology 2005年第32期11卷 5079-5081页

作者： Constantine I.Fotiadis Ilias A.Kouerinis Ioannis Papandreou George C.Zografos George Agapitos third department of propaudeutic surgeryuniversity of athens Sotiria HospitalAthens Greece First department of propaudeutic surgeryuniversity of athens Hippokration HospitalAthensGreece third department of propaudeutic surgeryuniversity of athens Sotiria HospitalAthensGreece

Schwannomas are rare tumors derived from the cells of Schwann that form the neural sheath. When located in the gastrointestinal tract, they constitute together with leiomyoma, leiomyoblastoma, and leiomyosarcoma, the gastrointestinal stromal tumors (GIST). Peripheral nerve sheath tumors represent 2-6% GIST with most common location, the stomach and the small intestine. Schwannomas of the colon and rectum are extremely rare and radical excision with wide margins is mandatory, due to their tendency to recur locally and become malignant, if left untreated. In the present study, we report a rare case of a sigmoid schwannoma, which was successfully treated in our department and reviewed the literature.

关键词： S形神经鞘瘤病例报告平滑肌瘤治疗方法

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Management of carbon tetrachloride-induced acute liver injury in rats by syngeneic hepatocyte transplantation in spleen and peritoneal cavity

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World Journal of Gastroenterology 2004年第14期10卷 2099-2102页

作者： Charalampos Pilichos Despina Perrea Maria Demonakou Athena Preza Ismini Donta third department of propaudeutic Surgery University of AthensSotiria HospitalAthensHellas Laboratory of Experimental Surgery University of AthensHellas Laboratory of Pathological Anatomy Sismanogleion General HospitalAthensHellas

AIM: Acute hepatitis may seldom have a fulminant *** the treatment of this medical emergency, potential liver support measure must provide immediate and sufficient assistance to the hepatic function. The goal of our study was to study the adequacy of hepatocyte transplantation (HCTx) in two different anatomical sites, splenic parenchyma and peritoneal cavity, in a rat model of reversible acute hepatitis induced by carbon tetrachloride (CCl4).METHODS: After CCl4 intoxication, 84 male Wistar rats used as recipients were divided in to four experimental groups accordingly to their treatment: Group A (n=24): intrasplenic transplantation of 10±10^6 isolated hepatoo/tes, Group B (n=24):intrapedtoneal transplantation of 20×10^6 isolated hepatocytes attached on plastic microcarriers, Group C (n= 18): intrasplenic injection of 1 mL normal saline (sham-operated controls),Group D (n=18): intraperitoneal injection of 2.5 mL normal saline (sham-operated controls). Survival, liver function tests (LIT) and histology were studied in all four groups, on d 2,5 and 10 ***: The ten-day survival (and mean survival) in the 4 groups was 72.2% (8.1±3.1), 33.3% (5.4±3.4), 0%(3.1±1.3) and 33.3% (5.4±3.6) in groups A, B, C, D,respectively (PAB＜0.05, PAc＜0.05, P80=NS). In the final survivors, LIT (except alkaline phosphatase) and hepatic histology retumed to normal, independently of their previous therapy. Viable hepatocytes were identified within splenic parenchyma (in group A on d 2) and both in the native liver and the fatty tissue of abdominal wall (in group B on d 5).CONCLUSION: A significantly better survival of the intrasplenically transplanted animals has been demonstrated,Intraperitoneal hepatocytes failed to promptly engraft. A different timing between liver injury and intraperitoneal HCTx may give better results and merits further investigation.

关键词：碳氧化物急性肝损害老鼠同源性肝细胞移植脾脏腹膜腔 HCTx

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