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Catch organism assemblages along artificial reefs area and adjacent waters in Haizhou Bay

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Acta Oceanologica Sinica 2024年第2期43卷 34-42页

作者： Shike Gao Bin Xie Chengyu Huang Xiao Zhang Shuo Zhang Wenwen Yu College of Marine Living Resource Sciences and Management Shanghai Ocean UniversityShanghai 201306China Jiangsu Research Institute of Marine Fisheries Nantong 226007China third Institute of Oceanography Ministry of Natural ResourcesXiamen361005China Joint Laboratory for Monitoring and Conservation of Aquatic Living Resources In the Yangtze Estuary Shanghai 200000China

To better understand the community patterns mediated by connectivity in artificial reefs of coastal areas, it is necessary to understand the distribution and coexistence of organisms with artificial reefs area and adjacent waters. This study was conducted to examine main catches assemblages collected by trawls in Haizhou Bay,which included five habitats: the artificial reef area(AR), aquaculture area(AA), natural area(NA), estuary area(EA) and comprehensive effect area(CEA). The result shows that the total abundances of species in the five habitats were highly different(univariate PERMANOVA: P = 0.001, n = 24), but some species were also unique in their habitat(e.g. Scapharca subcrenata and Glossaulax didyma in AA). The body size distribution of specific species between habitats are different. For Collichthys lucidus, their body size in AR(14.63 cm ± 1.64 cm) and EA(14.3 cm ± 0.85 cm) is higher than that in NA(10.65 cm ± 1.64 cm), CEA(11.28 cm ± 1.85 cm) and AA(12.1 cm ±0.43 cm), which indicates the potential connection from AR to EA mediated by their adult population. We concluded that artificial reefs in AR can be considered key components that have the ability to support species assemblages in adjacent habitats. This study has implications for the conservation and monitoring of species assemblages in coastal areas in terms of that artificial reefs can be applied in different stages of habitat protection implementation and in different combinations of scenarios.

关键词： assemblage artificial reefs adjacent water Haizhou Bay

Methylation of Dickkopf-3 as a prognostic factor in cirrhosis-related hepatocellular carcinoma

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World Journal of Gastroenterology 2010年第6期16卷 755-763页

作者： Yang, Bin Du, Zhi Gao, Ying-Tang Lou, Cheng Zhang, Shi-Guang Bai, Tong Wang, Yi-Jun Song, Wen-Qin third cent hosp Key Lab Artificial Cells Tianjin 300170 Peoples R China third cent hosp Dept Hepatobiliary Surg Tianjin 300170 Peoples R China Tianjin Med Univ Grad Sch Tianjin 300070 Peoples R China Nankai Univ Coll Life Sci Tianjin 300071 Peoples R China TEDA Tianjin 300457 Peoples R China

AIM:To investigate the prevalence and time of Dickkopf(DKK) family methylation and its clinical significance in hepatocarcinogenesis. METHODS:Methylation of DKK family genes was quantitatively analyzed in 115 liver tissue samples,including 50 pairs of primary hepatocellular carcinoma(HCC) and matched noncancerous cirrhotic tissue samples,as well as 15 liver cirrhosis biopsy samples. RESULTS:The methylation level of DKK3 was significantly higher in HCC tissue samples than in matched noncancerous cirrhotic tissue samples(Pcent of methylated reference(PMR) values of DKK3 could effectively discriminate HCC tissue samples from noncancerous tissue samples(AUC=0.8146) or liver cirrhosis biopsy samples(AUC=0.7093) .Kaplan-Meier survival curves revealed that the progression-free survival time of patients with a higher DKK3 methylation level(PMR >1%) was significantly shorter than that of those with a lower DKK3 methylation level(PMR≤1%)(P=0.0255) . Multivariate Cox analysis indicated that methylated DKK3 was significantly and independently related with a shorter survival time(relative risk=2.527,95%CI:1.063-6.008,P=0.036) of HCC patients. CONCLUSION:Methylation of DKK3 is an important event in early malignant transformation and HCC progression,and therefore might be a prognostic indicator for risk assessment of HCC.

关键词： Dickkopf Hepatocellular carcinoma Methylation Biomarker Prognosis

Body mass index and outcomes of patients with cardiogenic shock:A systematic review and meta-analysis

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World Journal of Clinical Cases 2022年第30期10卷 10956-10966页

作者： Wen-Xia Tao Guo-Ying Qian Hong-Dan Li Feng Su Zhou Wang Department of Cardiovascular Medicine Huzhou Cent HospitalAffiliated Cent Hospital Huzhou UniversityHuzhou 313000Zhejiang ProvinceChina

BACKGROUND Cardiogenic shock continues to be a highly morbid complication that affects around 7%-10% of patients with acute myocardial infarction or heart failure.Similarly,obesity has become a worldwide epidemic.AIM To analyze the impact of higher body mass index(BMI) on outcomes of patients with cardiogenic shock.METHODS A systematic and comprehensive search was undertaken on the electronic databases of PubMed,Embase,ScienceDirect,centRAL,and Google Scholar for all types of studies comparing mortality outcomes of patients with cardiogenic shock based on BMI.All studies defined overweight or obese patients based on the World Health Organization BMI criteria.The data were then extracted and assessed on the basis of the Reference Citation Analysis(https://***/).RESULTS Five studies were included.On pooled analysis of multivariable-adjusted ratios,we noted a statistically significantly reduced risk of mortality in overweight/obese vs normal patients(three studies;odds ratio [OR] = 0.92,95% confidence interval [CI]:0.85-0.98,I~2 = 85%).On meta-analysis,we noted that crude mortality rates did not significantly differ between overweight/obese and normal patients after cardiogenic shock(OR = 0.95,95%CI:0.79-1.15,I~2 = 99%).The results were not stable on sensitivity analysis and were associated with substantial heterogeneity.CONCLUSION Current evidence on the association between overweight/obesity and mortality after cardiogenic shock is scarce and conflicting.The obesity paradox might exist in patients with cardiogenic shock but could be confounded by the use of mechanical circulatory support.There is a need for further studies to clarify this relationship.

关键词： Obese Overweight Myocardial infarction Shock Mortality

Two stomach-originated lactobacillus strains improve Helicobacter pylori infected murine gastritis

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World Journal of Gastroenterology 2010年第4期16卷 445-452页

作者： Cui, Yi Wang, Chun-Lian Liu, Xiao-Wei Wang, Xue-Hong Chen, Lin-Lin Zhao, Xin Fu, Nian Lu, Fang-Gen cent S Univ Xiangya Hosp 2 Dept Gastroenterol Changsha 410011 Hunan Peoples R China cent S Univ Xiangya Hosp Dept Gastroenterol Changsha 410008 Hunan Peoples R China

AIM:To investigate the potential anti-Helicobacter pylori(H.pylori ) and anti-inflammation in vivo effects of two lactobacillus strains from human stomach.METHODS:Forty H.pylori infected Balb/c mice were randomly divided into 4 groups:proton pump inhibitor and antibiotics triple treated group,Lactobacillus fermenti(L.fermenti ) treated group,Lactobacillus acidophilus treated group and normal saline control group.Ten uninfected mice were also included as blank control group.The infection of H.pylori was detected by rapid urease tests,Giemsa staining and bacterial culture.The colonization of H.pylori was assessed in bacterial density score and gastric inflammation was assessed in histological score.The colonization of L.fermenti was performed by fluorescent probe.RESULTS:Histopathologic evaluation showed significant release of mucosal inflammation in gastric antrum and gastric body in lactobacillus treated groups and triple treated group.H.pylori eradication rate in both lactobacillus treated groups and triple treated group were higher than normal saline control group.Lactobacillus treated groups and triple treated group showed significant decrease of H.pylori bacterial density.CONCLUSION:Both lactobacillus strains have a significant anti-H.pylori activity;L.fermenti displays more efficient antagonistic activity in vivo against H.pylori infection.

关键词： Helicobacter pylori Lactobacillus fermenti Murine gastritis Lactobacillus acidophilus Therapy

Difference of dilation resistance to coronary stenting between fibrous plaques and lipid-rich plaques

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Chinese Medical Journal 2013年第21期126卷 4149-4153页

作者： Zhou Yi Chen Man-hua Yang Kai Xiong Cai-jin Chen Gang Yang Fei-yan Tan Gang Wuhan cent hosp Dept Cardiol Wuhan 430014 Hubei Peoples R China

Background Dilation resistance to stenting in non-calcified coronary plaques was compared in patients with percutaneous coronary intervention （PCI） in order to confirm the clinical usefulness of multislice computed tomography in examining coronary plaque type and to provide information pertaining to the effects of plaque type on dilatation resistance.

关键词： coronary disease lipid-rich plaque fibrous plaque percutaneous coronary intervention computedtomography

Clinical significance of Fas and FasL protein expression in gastric carcinoma and local lymph node tissues

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World Journal of Gastroenterology 2010年第10期16卷 1274-1278页

作者： Li, Qian Peng, Jie Li, Xin-Hua Liu, Ting Liang, Qing-Chun Zhang, Gui-Ying cent S Univ Dept Gastroenterol Xiangya Hosp Changsha 410008 Hunan Peoples R China cent S Univ Dept Pathol Affiliated Xiangya Hosp 2 Changsha 410011 Hunan Peoples R China

AIM:To investigate the relation of Fas and Fas ligand (FasL) protein expression with carcinogenesis and metastasis of gastric carcinoma.METHODS: Immunohistochemistry was used to detect Fas and FasL protein expression in 64 gastric carcinoma tissue samples and 20 normal gastric tissue samples. Relation between FasL and Fas expression, age and gender of gastric cancer patients, and pathological subtype and lymph node metastasis of gastric cancer was analyzed.RESULTS: The Fas expression level was significantly higher in normal gastric tissue samples than in gastric carcinoma tissue samples (85.0% vs 25.0%, P<0.001), while the FasL expression level was signif icantly lower in normal gastric tissue samples than in gastric carcinoma tissue samples (30.0% vs 81.3%, P<0.001). The Fas expression level was significantly higher in invasive lymph nodes than in non-invasive lymph nodes (82.9% vs 56.5%, P<0.003) and in well-differentiated gastric carcinoma tissue samples than in poorly-differentiated gastric carcinoma tissue samples (50.0% vs 18.0%, P=0.015). The FasL expression level was significantly lower in well-differentiated gastric carcinoma tissue samples than in poorly-differentiated gastric carcinoma tissue samples (42.9% vs 84.0%, P=0.021). The Fas and FasL expression levels (25.0% and 81.3%) were signif icantly different in gastric carcinoma tissue samples (P<0.001), but had a non-linear correlation (P=0.575).CONCLUSION: Abnormal Fas and FasL expressions in gastric carcinoma and lymph node tissues are involved in carcinogenesis and metastasis of gastric cancer.

关键词： Gastric carcinoma Lymph nodes Fas Fas ligand FasL

Pathological differential diagnosis of solid-pseudopapillary neoplasm and endocrine tumors of the pancreas

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World Journal of Gastroenterology 2010年第8期16卷 1025-1030页

作者： Liu, Bao-An Li, Zhuo-Ming Su, Zhan-San She, Xiao-Ling cent S Univ Xiangya Basic Med Sch Dept Pathol Changsha 410013 Hunan Peoples R China cent S Univ Xiangya Hosp 3 Dept Pathol Changsha 410013 Hunan Peoples R China cent S Univ Xiangya Hosp 2 Dept Pathol Changsha 410006 Hunan Peoples R China

AIM:To investigate differential points of solid-pseudo-papillary neoplasm (SPN) of the pancreas and pancre-atic endocrine tumor (PET).METHODS:Ten cases of SPN and fourteen cases of PET were studied in this retrospective study. Clinical and pathologic features,immunostaining reactions and β-catenin gene mutations were analyzed.RESULTS:The mean age of SPN patients was 25.6 years and these patients had no specific symptoms. The mean diameter of the tumors was 11.0 cm,9/10 cases were cystic or a mixture of solid and cystic structures,and there was hemorrhage and necrosis on the cut surface in 8/10 (80%) cases. Characteristic pseudo-papillary structure and discohesive appearance of the neoplastic cells were observed in all 10 (100%) cases. The results of immunostaining showed that nuclear expression of β-catenin and loss of E-cadherin in all the cases,was only seen in SPN. Molecular studies discov-ered that 9/10 (90%) cases harbored a point mutation of exon 3 in β-catenin gene. On the other hand,the mean age of PET patients was 43.1 years. Eight of 14 cases presented with symptoms caused by hypoglyce-mia,and the other 6 cases presented with symptoms similar to those of SPN. The mean size of the tumors was 2.9 cm,most of the tumors were solid,only 3/14 (21%) were a mixture of solid and cystic structures,and macroscopic hemorrhage and necrosis were much less common (3/14,21%). Histologically,tumor cells were arranged in trabecular,acinar or solid patterns and demonstrated no pseudopapillary structure and discohesive appearance in all 14 (100%) cases. The results of immunostaining and mutation detection were completely different with SPN that membrane and cytoplastic expression of β-catenin without loss of E-cadherin,as well as no mutation in β-catenin gene in all the cases. CONCLUSION:Both macroscopic and microscopic features of SPN are quite characteristic. It is not difficult to distinguish it from PET. If necessary,immunos-taining of β-catenin and E-cadherin is quite helpful to make the differential diagnosis.

关键词： Solid-pseudopapillary neoplasm of the pan-creas Pancreatic endocrine tumor Immunohistochem-istry β-catenin gene Differential diagnosis

Suppressing SNAP-25 and reversing glial glutamate transporters relieves neuropathic pain in rats by ameliorating imbalanced neurotransmission

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Chinese Medical Journal 2013年第21期126卷 4100-4104页

作者： Liu Chang Guo Qu-lian Huang Chang-sheng Zou Wang-yuan Song Zong-bin Xiangya hosp cent South Univ Dept Anesthesiol Changsha 410008 Hunan Peoples R China

Background Neuropathic pain results from a lesion or disease affecting the somatosensory system at either the peripheral or central level. The transmission of nociception within the central nervous system is subject to modulation by release and reuptake of neurotransmitters, which maintain a dynamic balance through the assembly and disassembly of the SNARE complex as well as a series of neurotransmitter transporters （inhibitory GABA transporters GAT and excitatory glutamate transporters GT）. Neuronal hyper-excitability or defected inhibition involved in neuropathic pain is one of the outcomes caused by imbalanced neurotransmission. SNAP-25, which is one of the SNARE complexes, can modulate the release of neurotransmitters. Glia glutamate transporter （GLT） is one of the two glutamate transporters which account for most synaptic glutamate uptake in the CNS. The role of SNAP-25 and GLT as well as GAT is not clearly understood.

关键词： neuropathic pain SNAP-25 glia glutamate transporter,＂ gamma aminobutyric acid transporter,＂ neurotransmission

Evaluation of hepatocellular carcinoma using contrast-enhanced ultrasonography:correlation with microvessel morphology

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Hepatobiliary & Pancreatic Diseases International 2010年第6期9卷 605-610页

作者： Xiao, Ji-Dong Zhu, Wen-Hui Shen, Shou-Rong cent S Univ Xiangya Hosp 3 Dept Diagnost Ultrasound Changsha 410013 Hunan Peoples R China cent S Univ Xiangya Hosp 3 Dept Gastroenterol Changsha 410013 Hunan Peoples R China

BACKGROUND: Contrast-enhanced ultrasonography (CEUS) is an important technique for depiction and assessment of tumor vascularity. This study aimed to explore the relationship between the morphological characteristics of tumor microvessels and enhancement patterns on CEUS in hepatocellular carcinoma (HCC). METHODS: Eighty patients with HCC underwent CEUS using SonoVue before hepatectomy. Contrast-enhanced ultrasonographic enhancement patterns and quantitative parameters were recorded. The tumor tissue sections were immunostained with human CD34 monoclonal antibody. The patients were classified into a point-line type group (n=36) and a loop-strip type group (n=44) according to microvessel morphology. The microvascular density (MVD) in the different types of microvessels was calculated. The relationship between enhancement patterns of HCC lesions and morphological characteristics of tumor microvessels was analyzed. RESULTS:TS: The mean MVD in HCC was 22.4 +/- 3.5 per 0.2 mm(2) in the point-line group, and 19.6 +/- 6.7 per 0.2 mm(2) in the loop-strip group, and there was no significant difference between them (t=0.948, P=0.354). In the portal vein phase, hypoenhancement was significantly more frequent in HCC (chi(2)=4.789, P=0.029) in the loop-strip group (40/44, 90.9%) than in the point-line group (26/36, 72.2%). The time to hypoenhancement in the loop-strip group (mean 64.84 +/- 26.16 seconds) was shorter than that in the point-line group (mean 78.39 +/- 28.72 seconds) (t=2.247, P=0.022). The time to hypoenhancement was correlated with MVD in the loop-strip group (r=-0.648, P=0.001). CONCLUSIONS: The enhancement patterns on CEUS are related to tumor microvascular morphology, and the type of microvascular morphology influences CEUS characterization. CEUS, an important noninvasive imaging technique, is used to evaluate microvascular morphology and angiogenesis, providing valuable information for antiangiogenic therapy in HCC. (Hepatobiliary Pancreat Dis Jut 2010; 9:605-610)

关键词： hepatocellular carcinoma contrast-enhanced ultrasonography microvessel morphology