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High-Bandwidth,Low-Power CMOS Transistor Based CAB for Field Programmable Analog Array

Computers, Materials & Continua 2023年第3期74卷 5885-5900页

作者： Ameen Bin Obadi Alaa El-Din Hussein Samir Salem Al-Bawri Kabir Hossain Abdullah Abdulhameed Muzammil Jusoh Thennarasan Sabapathy Ahmed Jamal Abdullah Al-Gburi Mahmoud A.Albreem Advanced Communication Engineering(ACE) Centre of ExcellenceUniversiti Malaysia Perlis(UniMAP)Faculty of Electronic Engineering TechnologyKangar01000Malaysia Electrical Engineering King Fahd University of Petroleum and MineralsDhahranEastern31261Saudi Arabia Space science Centre Climate Change InstituteUniversiti Kebangsaan MalaysiaBangi43600Malaysia Department of Electronics&Communication Engineering Faculty of Engineering&PetroleumHadhramout UniversityAl-MukallaHadhramout50512Yemen Faculty of Engineering Norwegian University of Science and Technology(NTNU)GjovikN-2815Norway Faculty of Electronic Engineering Technology Universiti Malaysia Perlis(UniMAP)Kampus Alam UniMAP Pauh PutraArau02600Malaysia Department of General Educational Development Faculty of Science and Information Technology(FSIT)Daffodil International UniversityDhaka1207Bangladesh Department of Electronics and Computer Engineering(FKEKK) Center for Telecommunication Research and Innovation(CeTRI)Universiti Teknikal Malaysia Melaka(UTeM)Durian Tungal76100Malaysia Department of Electrical Engineering University of SharjahSharjah27272United Arab Emirates

This article presents an integrated current mode configurable analog block(CAB)system for field-programmable analog array(FPAA).The proposed architecture is based on the complementary metal-oxide semiconductor(CMOS)transistor level design where MOSFET transistors operating in the saturation region are *** proposed CAB architecture is designed to implement six of thewidely used current mode operations in analog processing systems:addition,subtraction,integration,multiplication,division,and pass *** functionality of the proposed CAB is demonstrated through these six operations,where each operation is chosen based on the user’s selection in the CAB interface *** architecture of the CAB system proposes an optimized way of designing and integrating only three functional cells with the interface circuitry to achieve the six ***,optimized programming and digital tuning circuitry are implemented in the architecture to control and interface with the functional ***,these designed programming and tuning circuitries play an essential role in optimizing the performance of the proposed *** of the proposed CMOS Transistor Based CAB system is carried out using Tanner EDA Tools in 0.35μm standard CMOS *** design uses a±1.5 V power supply and results in maximum 3 dB bandwidth of 34.9 MHz and an approximate size of 0.0537 *** demonstrates the advantages of the design over the current state-of-the-art designs presented for comparison in this ***,the proposed design has a clear aspect of simplicity,low power consumption,and high bandwidth operation,which makes it a suitable candidate for mobile telecommunications applications.

关键词： CMOS field programmable analog array configurable analog block current mode circuit

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Microstructural evolution during semisolid processing of Al-Si-Cu alloy with different Mg contents

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Transactions of Nonferrous Metals Society of China 2017年第7期27卷 1483-1497页

作者： K.S.ALHAWARI M.Z.OMAR M.J.GHAZALI M.S.SALLEH M.N.MOHAMMED Department of Mechanical and Materials Engineering Faculty of Engineering and Built EnvironmentUniversiti Kebangsaan MalaysiaSelangor 43600Malaysia Department of Manufacturing Process Faculty of Manufacturing EngineeringUniversiti Teknikal Malaysia MelakaMelaka 76100Malaysia Department of Engineering&Technology Faculty of Information Sciences and EngineeringManagement&Science UniversitySelangor 40100Malaysia

A series of Al-6Si-3Cu-(0.3-2)Mg alloys were produced by a conventional casting *** slope technique wasemployed to produce feedstocks before they were thixoformed at50%liquid *** effect of Mg on the microstructure ofAl-Si-Cu aluminium alloys under as-cast and semisolid conditions was *** was found that by adding Mg to Al-Si-Cualloy,some of the Al2Cu phase and silicon were consumed to form Al5Cu2Mg3Si5and Mg2Si *** needle-likeβ-Al5FeSi phasetransformed to Chinese-script-likeπ-Al8Mg3FeSi6with the addition of *** the as-cast alloys,the primaryα(Al)was dendritic,butas the Mg content increased,the phase became less ***,the Mg addition considerably modified the size of theα(Al)phase,but it had no significant effect on the silicon *** the thixoformed alloys,the microstructure showed a fine globularprimary phase surrounded by uniformly distributed silicon and fragmented intermetallic *** eutectic silicon was modifiedfrom a flaky and acicular shape to fine fibrous *** effect of Mg on eutectic silicon during semisolid processing *** primary Mg2Si particles were modified from big polygonal particles to become smaller and more globular,whereas themorphology of the Chinese-script-likeπ-Al8Mg3FeSi6changed to a compact *** results also exhibit that as the Mg content inthe A319alloy increased,the hardness,yield strength and ultimate tensile strength of the thixoformed alloys significantly improved,but the elongation to fracture dropped.

关键词： Al-Si-Cu alloy magnesium microstructure semisolid processing

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Pegylated interferon alfa and ribavirin for children with chronic hepatitis C

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World Journal of Gastroenterology 2013年第7期19卷 1098-1103页

作者： Irit Rosen Michal Kori Orly Eshach Adiv Baruch Yerushalmi Nataly Zion Ron Shaoul Pediatric Gastroenterology and Nutrition Unit Meyer Children's HospitalRambam Medical CenterBruce Rappaport Faculty of MedicineTechnionHaifa 31096Israel Pediatric Gastroenterology and Nutrition Unit Kaplan Medical CenterRehovot 76100Israel Pediatric Gastroenterology and Nutrition Unit Soroka Medical CenterBen Gurion University Faculty of MedicineBe'er Sheva 84101Israel

AIM:To study current treatment options for pediatric hepatitis C infection and their associated success ***:We retrospectively reviewed charts of thirty children who had been treated with combination therapy of pegylated interferon alfa plus ribavirin for chronic hepatitis C *** had been treated with ribavirin(15 mg/kg per day) and either pegylated interferon alfa 2a(180 mg/m 2 once weekly) or pegylated interferon alfa 2b(1.5 mg/kg once weekly).Patients' follow-up included subjective assessment of complaints,physical examination including weight and height,as well as laboratory evaluations for viral load [before treatment,at 12 wk,and 6 mo following treatment completion,as determined by sustained viral response(SVR)],complete blood count,liver enzymes,alkaline phosphatase,bilirubin,renal function tests,and thyroid function *** patients not achieving a two log decrease in viral load at treatment week 12,treatment was discontinued and the patient was considered a treatment ***:Thirty children aged 3-18 years were included in the *** patients(11 males,9 females) received pegylated interferon alfa 2b and ten patients(6 males,4 females) received pegylated interferon alfa ***-three patients were infected with genotype 1,six patients were infected with genotype 3,and one patient was infected with genotype *** patients(67%) achieved *** success rates were 90% with pegylated interferon alfa 2a vs 55% with pegylated interferon alfa *** a trend was noted for improved outcomes in the group receiving pegylated interferon alfa 2a,there were no statistically significant outcome differences between the two treatment groups(P = 0.1).Treatment success was 56.5% for patients infected with genotype 1 virus,compared to 100% for patients infected with other genotypes(P = 0.064).There was no difference in treatment response between males and females.A cut-off age of twelve years was used to dichotomize

关键词： Hepatitis C virus Interferon alfa Ribavirin Children Sustained viral response

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Assessment of the Bemisia tabaci C YP6CM l vQ transcript and protein levels in laboratory and field-derived imidacloprid-resistant insects and cross-metabolism potential of the recombinant enzyme

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Insect science 2011年第1期18卷 23-29页

作者： Emmanouil Roditakis Evangelia Morou Anastasia Tsagkarakou Maria Riga Ralf Nauen Mark Paine Shai Morin John Vontas Laboratory of Entomology and Agricultural Zoology Plant Protection Institute of Heraklion National Agricultural Research Foundation Heraklion (N.AG.RE.F.) Heraklio Greece Faculty of Applied Biology and Biotechnology Department of Biology University of Crete Heraklion Greece Vector Group Liverpool School of Tropical Medicine Liverpool UK Bayer Cropscience AG Research Insecticides Insect Toxicology and Resistance Monheim Germany Department of Entomology Faculty of Agricultural Food and Environmental Quality Sciences Hebrew University of Jerusalem Rehovot Israel

Over-expression of the cytochrome P450 CYP6CM1 gene has been associated with imidacloprid resistance in a number of Q and B biotype Bemisia tabaci laboratory strains from distinct geographical origins worldwide. We recently demonstrated that the Q biotype version of the CYP6CM 1 protein （CYP6CMlvQ） is capable of metabolizing imida- cloprid. Here, we show that the levels of BtCYP6CMlvQ were also elevated in laboratory- resistant strains and field-derived populations, with variable imidacloprid resistance levels, collected in Crete. High levels of CYP6CMlvQ transcripts were also determined in survivors of a heterogeneous field population, after exposure to discriminating imidacloprid dosage. Using peptide antibody-based detection assays, we demonstrated that in line with transcriptional data, the CYP6CMlvQ protein levels were higher in imidacloprid-resistant insects, which further implicates the gene as the causal factor of resistance. Finally, assess- ment of the cross-metabolism potential of CYP6CMlvQ against additional neonicotinoid molecules used for B. tabaci control revealed that clothianidin and thiacloprid, but not acetamiprid or thiamethoxam, are metabolized by the recombinant enzyme in vitro.

关键词： detoxification neonicotinoids peptide antibodies P450

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Activating Silent Glycolysis Bypasses in Escherichia coli

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BioDesign Research 2022年第1期2022卷 295-311页

作者： Camillo Iacometti Katharina Marx Maria Hönick Viktoria Biletskaia Helena Schulz-Mirbach Beau Dronsella Ari Satanowski Valérie A.Delmas Anne Berger Ivan Dubois Madeleine Bouzon Volker Döring Elad Noor Arren Bar-Even Steffen N.Lindner Max Planck institute of Molecular Plant Physiology Am Mühlenberg 114476 Potsdam-GolmGermany Génomique Métabolique GenoscopeInstitut François JacobCEACNRSUniv EvryUniversitéParis-Saclay91057 Evry-CourcouronneFrance institute of Molecular Systems Biology ETH ZürichOtto-Stern-Weg 38093 ZürichSwitzerland Department of Plant and Environmental sciences Weizmann Institute of ScienceRehovotIsrael Department of Biochemistry CharitéUniversitätsmedizinVirchowweg 610117 BerlinGermany

All living organisms share similar reactions within their central metabolism to provide precursors for all essential building blocksand reducing power. To identify whether alternative metabolic routes of glycolysis can operate in E. coli, we complementarilyemployed in silico design, rational engineering, and adaptive laboratory evolution. First, we used a genome-scale model andidentified two potential pathways within the metabolic network of this organism replacing canonical Embden-Meyerhof-Parnas(EMP) glycolysis to convert phosphosugars into organic acids. One of these glycolytic routes proceeds via methylglyoxal andthe other via serine biosynthesis and degradation. Then, we implemented both pathways in E. coli strains harboring defectiveEMP glycolysis. Surprisingly, the pathway via methylglyoxal seemed to immediately operate in a triosephosphate isomerasedeletion strain cultivated on glycerol. By contrast, in a phosphoglycerate kinase deletion strain, the overexpression ofmethylglyoxal synthase was necessary to restore growth of the strain. Furthermore, we engineered the “serine shunt” whichconverts 3-phosphoglycerate via serine biosynthesis and degradation to pyruvate, bypassing an enolase deletion. Finally, toexplore which of these alternatives would emerge by natural selection, we performed an adaptive laboratory evolution studyusing an enolase deletion strain. Our experiments suggest that the evolved mutants use the serine shunt. Our study reveals theflexible repurposing of metabolic pathways to create new metabolite links and rewire central metabolism.

关键词： convert rational sugar

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子宫内膜息肉的潜在恶变性

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世界核心医学期刊文摘（妇产科学分册） 2005年第1期1卷 21-22页

作者： Ben-Arie A. Goldchmit C. Laviv Y. A. Ben-Arie 张剑萍 Dept. of Obstetrics an d Gynecology Kaplan Med. Ctr.(Affil. Hadassah M. Jerusalem) P.O. Box 1 76100 RehovotIsrael

Objectives: To determine the pre-malignant and malignant potential o f endomet rial polyps and to assess whether different clinical parameters are associated w ith malignancy in the polyps. Study design: Four hundred and thirty consecutive cases of hysteroscopic diagnosis of endometrial polyp were retriev ed. The medical records, preoperative vaginal sonography results and histopathol ogy findings were reviewed. Statistical analysis was performed. Results: Hystero scopy truly identi-fied endometrial polyps in 95.7%of the cases. In 11.4%case s, hyperplasia without atypia was found in the endometrial polyp. In 3.3 and 3.0 %of women pre-malignant or malignant conditions were found in the polyp. Older age, menopause status and polyps larger than 1.5 cm were associated with signif icant pre-malignant or malignant changes, although the positive predictive valu e for malignancy was low. All the malignant polyps were diagnosed only in postme nopausal women. The presence of postmenopausal or irregular vaginal bleeding, wa s not a predictor of malignancy in the polyp. Conclusions: Postmenopausal women with endometrial polyps are at increased risk of malignancy in the polyp. Those patients, whether symptomatic or not should be evaluated by hysteroscopic resect ion of the polyps. Asymptomatic premenopausal patients with polyps smaller than 1.5 cm can be observed.

关键词：宫内膜息肉癌前病变病理学结果子宫内膜息肉患者非典型增生前阴道息肉恶变宫腔镜检查息肉直径

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Chlorella across latitudes: investigating biochemical composition and antioxidant activities for biotechnological applications

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Advances in Polar science 2023年第4期34卷 340-351页

作者： Chloe Zi-En WONG Ming-Li TEOH Sook Wah CHAN Nallammai SINGARAM Wendy Ming-Yen TEOH John BEARDALL School of Biosciences Faculty of Health and Medical SciencesTaylor’s UniversitySubang Jaya 47500Malaysia Clean Technology Impact Lab Taylor’s UniversitySubang Jaya 47500Malaysia Food Security&Nutrition Impact Lab Taylor’s UniversitySubang Jaya 47500Malaysia institute of Technology Management and Entrepreneurship Universiti Teknikal Malaysia Melaka(UTeM)Durian Tunggal 76100Malaysia School of Biological sciences Monash UniversityClayton VIC 3800Australia

With the present day rise of interest in acquiring sustainability in the pharmaceutical industry,there has been an emphasis on finding natural resources to replace the use of synthetic compounds used in *** have garnered significant attention owing to their natural and sustainable capability to produce a diverse array of bioactive ***,this study aims to evaluate the biochemical composition and antioxidant properties of Chlorella strains from a tropical region(Chlorella UMACC 051 and Chlorella UMACC 038)and a polar region(Chlorella UMACC 250 and Chlorella UMACC 234).The cultures were grown for 10 *** the end of the experiment,the specific growth rate,chlorophyll-a content,carotenoid content,biomass,and biochemical composition such as carbohydrate,protein and lipid content were *** addition,the phytochemical properties were determined using a total phenolic assay while the antioxidant activities were determined using 2,2-diphenyl-1-picrylhydrazyl(DPPH).Of all Chlorella strains tested,the tropical Chlorella UMACC 051 showed the fastest growth rate and biomass while the polar Chlorella UMACC 234 contained the highest pigment content and tropical Chlorella UMACC 038 has the highest total phenolic *** biochemical composition analysis showed all strains have a high lipid content ranging from 45.36%to 60.30%dry *** Chlorella strains exhibited a small amount of antioxidant activity(15.42%to 30.15%)and total phenolic content ranging from 1.91±0.04 to 4.43±0.10 mg GAE·g–1 dry *** results indicated that polar Chlorella UMACC 234 has the most potential in containing significant amounts of bioactive compounds.

关键词： Chlorella polar tropical biochemical composition total phenolic content DPPH

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Surface modification and functionalization by electrical discharge coating:a comprehensive review

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International Journal of Extreme Manufacturing 2020年第1期2卷 68-99页

作者： Pay Jun Liew Ching Yee Yap Jingsi Wang Tianfeng Zhou Jiwang Yan Fakulti Kejuruteraan Pembuatan Universiti Teknikal Malaysia MelakaHang Tuah Jaya76100Durian TunggalMelakaMalaysia Marine Engineering College Dalian Maritime University1 Linghai RoadGanjingzi DistrictDalian 116026People’s Republic of China Key Laboratory of Fundamental science for Advanced Machining Beijing Institute of TechnologyNo.5 Zhongguancun South StreetHaidian DistrictBeijing 100081People’s Republic of China Department of Mechanical Engineering Faculty of Science and TechnologyKeio UniversityHiyoshi 3-14-1Kohoku-kuYokohama 223-8522Japan

Hard coatings are extensively required in industry for protecting mechanical/structural parts that withstand extremely high temperature,stress,chemical corrosion,and other hostile *** discharge coating(EDC)is an emerging surface modification technology to produce such hard coatings by using electrical discharges to coat a layer of material on workpiece surface to modify and enhance the surface characteristics or create new surface *** paper presents a comprehensive overview of EDC technologies for various materials,and summarises the types and key parameters of EDC processes as well as the characteristics of resulting *** provides a systematic summary of the fundamentals and key features of the EDC processes,as well as its applications and future trends.

关键词： electrical discharge coating(EDC) surface modification material characteristics mechanical properties extreme conditions

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肠道微生物群在营养和健康中的作用

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英国医学杂志中文版 2021年第3期24卷 151-158页

作者： Ana M Valdes Jens Walter Eran Segal Tim D Spector 朱一丹(译) 武阳丰(校) School of Medicine University of NottinghamCity HospitalNottingham NG51PBUK NIHR Nottingham Biomedical Research Centre NottinghamUK Department of Agricultural Foodand Nutritional Science and Department of Biological SciencesUniversity of AlbertaEdmontonCanada Department of Computer science and Applied Mathematics Weizmann Institute of ScienceRehovotIsrael Department of Twin Research and Genetic Epidemiology King′s College LondonLondonUK 北京大学临床研究所

Ana M Valdes及同事探讨了通过饮食和益生菌调节肠道微生物群的策略。微生物基因组(Microbiome)是指在特定环境中微生物的基因组集合,而微生物群(Microbiota)是指微生物自身组成的群落(译者注:国内文献通常将微生物群称为菌群,微生物基... 详细信息

Ana M Valdes及同事探讨了通过饮食和益生菌调节肠道微生物群的策略。微生物基因组(Microbiome)是指在特定环境中微生物的基因组集合,而微生物群(Microbiota)是指微生物自身组成的群落(译者注:国内文献通常将微生物群称为菌群,微生物基因组称为微生物组)(框图1)。约有100万亿微生物(大多数是细菌,也有病毒、真菌和原生动物)存在于人体胃肠道中1-2。

关键词：微生物群微生物组国内文献益生菌特定环境原生动物胃肠道

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Effects of Gamma-Irradiation Mutagenesis for Induction of Seedlessness, on the Quality of Mandarin Fruit

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Food and Nutrition sciences 2014年第10期5卷 943-952页

作者： Livnat Goldenberg Yossi Yaniv Ron Porat Nir Carmi Department of Fruit Tree Crops Agricultural Research Organization Bet Dagan Israel Department of Postharvest science of Fresh Produce Agricultural Research Organization Bet Dagan Israel Department of Postharvest science of Fresh Produce Agricultural Research Organization Bet Dagan Israel Faculty of Agricultural Food and Environmental Quality Sciences Hebrew University of Jerusalem Rehovot Israel

Gamma irradiation mutagenesis is a technique commonly used to induce seedlessness in citrus fruits. We compared fruit quality traits of eight different seeded mandarin varieties within the Israeli citrus breeding collection with those of their corresponding gamma-irradiated low-seeded mutants. The mandarin varieties compared were: “Rishon” with “Kedem”;“Michal” with irradiated “Michal”;“Merav” with “Meravit”;“Vered” with “Vardit”;“Ora” with “Or”;“Murcott” with “Mor”;“Shani” with irradiated “Shani”;“King” with irradiated “King”. Mutational breeding by gamma irradiation reduced average fruit seed number by 70% - 92%. Furthermore, mutational breeding by gamma irradiation delayed ripening of the early-season mandarin varieties “Rishon” and “Michal” by 8 - 13 days, but did not delay ripening of most mid- and late-season varieties. Gamma-irradia- tion mutagenesis also reduced fruit weight of seven of the eight tested low-seeded varieties by 6 - 41 g per fruit. Gamma-irradiation mutagenesis had variable effects on biochemical composition and nutritional quality, in that some irradiated clones presented no changes whereas other had either higher or lower levels of juice total soluble solids, acidity, vitamin C and total antioxidant activity. Finally, sensory evaluations by a trained panel revealed that the flavor of most of the low-seeded, gamma-irradiated varieties was slightly or significantly preferable to that of unirradiated varieties.

关键词： Citrus Gamma Irradiation Flavor Fruit Quality Mandarin

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