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Controlled release of FK506 from micropatterned PLGA films:potential for application in peripheral nerve repair

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Neural Regeneration Research 2018年第7期13卷 1247-1252页

作者： Brett Davis Susan Wojtalewicz Pratima Labroo Jill Shea Himanshu Sant Bruce Gale Jayant Agarwal Department of Bioengineering University of Utah Department of Surgery University of Utah Department of Mechanical Engineering University of Utah

After decades of research,peripheral nerve injury and repair still frequently results in paralysis,chronic pain and neuropathies leading to severe disability in *** clinically available nerve conduits only provide crude guidance of regenerating axons across nerve gap without additional ***506（Tacrolimus）,an FDA approved immunosuppressant,has been shown to enhance peripheral nerve regeneration but carries harsh side-effects when delivered *** objective of this study was to develop and evaluate a bioresorbable drug delivery system capable of local extended delivery of FK506 that also provides topological guidance cues to guide axon growth via *** was used to create micropatterned poly（lactide-co-glycolic acid）（PLGA） films embedded with ***-patterned,10/10 μm（ridge/groove width）,and 30/30 μm patterned films loaded with 0,1,and 3 μg/cm2 FK506 were manufactured and *** vitro FK506 rate of release testing indicated that the films are capable of an extended（at least 56 days）,controlled,and scalable release of *** extension bioactivity assay indicated that FK506 released from the films（concentration of samples tested ranged between 8.46–19.7 ng/m L） maintained its neural bioactivity and promoted neurite extension similar to control FK506 dosages（10 ng/m L FK506）.The multi-functional FK506 embedded,micropatterned poly（lactide-co-glycolic acid） films developed in this study have potential to be used in the construction of peripheral nerve repair devices.

关键词： nerve regeneration FK506 controlled release micropatterns topological cues PLGA

Plasmonic-enhanced electrochemical detection of volatile biomarkers with gold functionalized TiO_2 nanotube arrays

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Journal of Materials Science & Technology 2018年第6期34卷 905-913页

作者： Dhiman Bhattacharyya Pankaj Kumar York R.Smith Swomitra K.Mohanty Mano Misra Department of Metallurgical Engineering University of Utah Department of Chemical Engineering University of Utah

Titania nanotubular arrays （TNA） synthesized via electrochemical anodization is a stable and versatile material, widely studied for photocatalytic and sensing applications, whereas nano-sized gold particles are a known plasmonic material. Semiconductor-metal nanocomposites in isolated, embedded, or encapsulated form, when irradiated with proper light frequency can exhibit localized surface plasmon resonance （LSPR） effect. This effect can result in improved light adsorption and electrical properties of a material. In this study, we report the enhanced visible light photo-response of LSPR induced volatile organic biomarker vapor sensing at room temperature using a Au-embedded TNA electrochemical sensor. Two mechanisms are proposed. One based on classical physics （band theory）, which explains operation under non-irradiated conditions. The second mechanism is based on the coupling of classical and quantum physics （molecular orbitals）, and explains sensor operation under irradiated conditions.

关键词： TiO2 nanotube arrays Au particles Surface plasmon resonance Electrochemical sensor

Comparison of closure measurements with finite element model results in an underground coal mine in central utah

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International Journal of Mining Science and Technology 2019年第1期29卷 9-15页

作者： William G.Pariseau Michael K.McCarter Jessica M.Wempen Department of Mining Engineering University of Utah

Quantitative analysis of mine-wide subsidence at the kilometer scale and details of stress distribution about an advancing longwall face are estimated using an adaptation of the finite element method. The method is well suited to the tasks at hand. For greater realism, variability of strata properties is taken into account as are the effects of joints and cleats on elastic moduli and strengths. Evolution of pillar stress and entry closure remote from the face is readily quantified in a series of analyses that simulate face advance. Computed results compare favorably with the evolution of closure measurements about an instrumented pillar in a two-entry headgate. The appropriateness of the finite element method is confirmed. This method is based on first principles that avoid empirical schemes of uncertain applicability and numerical models ‘‘calibrated" by fitting computer output to mine measurements.

关键词： Finite element modeling Longwall mining Mine subsidence Stress modeling

Metabolomic evidence of independent biotransformation pathways for terpenes in two specialist mammalian herbivores (genus Neotoma)

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Integrative Zoology 2024年第1期19卷 143-155页

作者： Katharina SCHRAMM Michele SKOPEC Denise DEARING Department of Biology University of UtahSalt Lake CityUtahUSA Department of Zoology Weber State UniversityOgdenUtahUSA

Herbivory is common in mammals,yet our understanding of detoxification processes used by mammals to biotrans-form plant secondary compounds(PSCs)is *** herbivores are thought to have evolved detoxifica-tion mechanisms that rely more heavily on energetically cheap Phase I biotransformation reactions to process high levels of PSCs in their *** explored this hypothesis by comparing the urinary metabolite patterns of two spe-cialist herbivores(genus Neotoma).Neotoma stephensi is an obligate specialist on one-seeded juniper(Juniperus monosperma).Neotoma lepida is a generalist forager across its range,yet populations in the Great Basin specialize on utah juniper(***).While both juniper species have high levels of terpenes,the terpene profiles and quantities differ between the *** from both woodrat species were fed diets of each juniper in a cross-over ***,collected over a 24-h period,was extracted and analyzed in an untargeted metabolomics approach using both GC-MS and HPLC-MS/*** obligate specialist *** excreted a unique pattern of Phase I metabolites when fed its native juniper,while *** excreted a unique pattern of Phase II metabolites when fed its native *** woodrat species utilized the Phase II metabolic pathway of glucuronidation more heavily when consuming the more chemically diverse ***,and *** utilized less glucuronida-tion than *** when consuming *** results are consistent with the hypothesis that obligate specialists may have evolved unique and efficient biotransformation mechanisms for dealing with PSCs in their diet.

关键词： dietary specialization herbivory juniper metabolomics Neotoma

Determinants of the impact of blood pressure variability on neurological outcome after acute ischaemic stroke

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Stroke & Vascular Neurology 2017年第1期2卷 1-6页

作者： Adam de Havenon Alicia Bennett Gregory J Stoddard Gordon Smith Lee Chung Steve O’Donnell J Scott McNally David Tirschwell Jennifer J Majersik Department of Neurology University of UtahSaltLake CityUtahUSA university of utah SaltLake CityUtahUSA university of Washington SeattleWashingtonUSA

Introduction: Increased blood pressure variability (BPV) is detrimental after acute ischaemic stroke, but the interaction between BPV and neuroimaging factors that directly influence stroke outcome has not been explored. Methods: We retrospectively reviewed inpatients from 2007 to 2014 with acute anterior circulation ischaemic stroke, CT perfusion and angiography at hospital admission, and a modified Rankin Scale (MRS) 30- 365 days after stroke onset. BPV indices included SD, coefficient of variation and successive variation of the systolic blood pressure between 0 and 120 hours after admission. Ordinal logistic regression models were fitted to MRS with predictor variables of BPV indices. Models were further stratified by CT perfusion volumetric measurements, proximal vessel occlusion and collateral score. Results: 110 patients met the inclusion criteria. The likelihood of a 1-point rise in the MRS increased with every 10 mm Hg increase in BPV (OR for the 3 BPV indices ranged from 2.27 to 5.54), which was more pronounced in patients with larger ischaemic core volumes (OR 8.37 to 18.0) and larger hypoperfused volumes (OR 6.02 to 15.4). This association also held true for patients with larger mismatch volume, proximal vessel occlusion and good collateral vessels. Conclusions: These results indicate that increased BPV is associated with worse neurological outcome after stroke, particularly in patients with a large lesion core volume, concurrent viable ischaemic penumbra, proximal vessel occlusion and good collaterals. This subset of patients, who are often not candidates for or fail acute stroke therapies such as intravenous tissue plasminogen activator or endovascular thrombectomy, may benefit from interventions aimed at reducing BPV.

关键词： impaired perfusion cerebral

Adult mammalian neurogenesis and motivated behaviors

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Integrative Zoology 2018年第6期13卷 655-672页

作者： Claudia JORGENSEN Behavioral Science Department Utah Valley UniversityOremUtahUSA

Adult neurogenesis continues to captivate the curiosity of the scientific community;and researchers seem to have a particular interest in identifying the functional implications of such *** the majority of research focuses on the association between adult neurogenesis and learning and memory(including spatial learning associated with hippocampal neurogenesis and olfactory discrimination associated with neurogenesis in the olfactory system),the following review will explore the link to motivated *** particular,goal-directed behaviors such as sociosexual,parental,aggressive,as well as depression-and anxiety-like behaviors and their reciprocal association to adult neurogenesis will be *** review will detail research in humans and other mammalian ***,the potential mechanisms underlying these neurogenic alterations will be ***,the review will conclude with a discussion on the functional significance of these newly generated cells in mediating goal-directed behaviors.

关键词： adult neurogenesis aggression anxiety depression reproduction

Animal models of genetic causes of male infertility

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Asian Journal of Andrology 2002年第3期4卷 213-219页

作者： Greg L. Christensen Douglas T. Carrell Andrology Department University of Utah School of Medicine Salt Lake City Utah 84132 USAAndrology Department University of Utah School of Medicine Salt Lake City Utah 84132 USA

Introduction In the past 10 years, more than 100 different genetically engineered mice have been developed with an abnormality in spermatogenesis. More than half of these male infertility animal models have been reported in the past three years alone. Spermatogenic defects in these models vary considerably, ranging from the inappropriate migration of primordial germ cells to the inability of mature spermatozoa to bind the zona pellucida. Many of

关键词： animal models genes genetics knockout male infertility

Automation in detection of recirculation in a booster fan ventilation network

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International Journal of Mining Science and Technology 2018年第3期28卷 513-517页

作者： Mahesh Shriwas Felipe Calizaya Department of Mining Engineering University of Utah

Recirculation is prohibited in many coal mining countries because of the fear that the re-use of return air would allow the build-up of air contaminants at the workings. The incorrect design and location of a booster fan in any ventilation network can create unsafe condition due to recirculation. The current approach to investigating recirculation using simulation software requires manual effort which becomes tedious in a complex and a large network. An algorithm-based C++ program was designed to detect the recirculation in a booster fan ventilation networks. This program needed an input file prepared from output file generated by any ventilation simulator. This program created an output file for recirculation. This program demonstrated the strong capability to detect the recirculation in a sample network and a coal mine ventilation network. The outcomes of this program were documented in this paper.

关键词： Recirculation Ventilation Booster fan

Engineering the Divide-and-Conquer Closest Pair Algorithm

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Journal of Computer Science & Technology 2007年第4期22卷 532-540页

作者：江铭辉古熙悠 Department of Computer Science Utah State University

We improve the famous divide-and-conquer algorithm by Bentley and Shamos for the planar closest-pair problem. For n points on the plane, our algorithm keeps the optimal O（n log n） time complexity and, using a circle-packing property, computes at most 7n/2 Euclidean distances, which improves Ge et al.＇s bound of （3n log n）/2 Euclidean distances. We present experimental results of our comparative studies on four different versions of the divide-and-conquer closest pair algorithm and propose two effective heuristics.

关键词： algorithmic engineering analysis of algorithms circle packing closest pair computational geometry