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中华医学图书情报杂志 2018年第1期27卷 45-49页

作者： Whitney A.Townsend Uniesity of michigan's A. Alfred Taubman Health Sciences Library

To address the ultimate mission to be ＂ a valued partner,fully integrated into the work of the university and providing leadership in knowledge management for education, research, patient care, and community outreach＂,the university of michigan A. Alfred Taubman Health Sciences Library(THL） has transformed from retitling librarians as informationists to shifting from a service to a collaboration focus. Infomationists at THL have spent several years building relationships and expertise to be true partners in curriculum integration and innovation within the health sciences schools and colleges at the university of michigan and the curricular integration has becoming a constantly evolving process for THL informationists. Current article focus on how THL convert the librarian into informationist and how to make collaborations in curriculum innovation within different departments to furtherly improve the status of THL library in the university.

关键词： Mission Integrated Informationist Collaboration focus Curriculum innovation

Molecules “buckle up” to drive layered hybrid perovskites into single-crystal nanowires in water

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Science China Chemistry 2025年第01期 3-4页

作者： Seokhyoung Kim Department of Chemistry Michigan State University

Layered 2D metal halide perovskites (MHPs) are one of the most exciting candidates for next-generation light sources owing to their outstanding optoelectronic properties. These properties are readily tunable by controlling the halide composition, number of inorganic layers, and the chemistry of organic cations. Another key element that can substantially impact the materials’ functionalities is crystal morphology [1].

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Multisensory mechanisms of gait and balance in Parkinson’s disease:an integrative review

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Neural Regeneration Research 2025年第1期20卷 82-92页

作者： Stiven Roytman Rebecca Paalanen Giulia Carli Uros Marusic Prabesh Kanel Teus van Laar Nico I.Bohnen Department of Radiology University of MichiganAnn ArborMIUSA Department of Neurology University of MichiganAnn ArborMIUSA Morris K.Udall Center of Excellence for Parkinson’s Disease Research University of MichiganAnn ArborMIUSA Institute for Kinesiology Research Science and Research Centre KoperKoperSlovenia Department of Health Sciences Alma Mater Europaea–ECMMariborSlovenia Parkinson’s Foundation Research Center of Excellence University of MichiganAnn ArborMIUSA Department of Neurology University of GroningenUniversity Medical Center GroningenGroningenThe Netherlands Neurology Service and GRECC VA Ann Arbor Healthcare SystemAnn ArborMIUSA

Understanding the neural underpinning of human gait and balance is one of the most pertinent challenges for 21st-century translational neuroscience due to the profound impact that falls and mobility disturbances have on our aging *** and gait control does not happen automatically,as previously believed,but rather requires continuous involvement of central nervous *** effectively exert control over the body,the brain must integrate multiple streams of sensory information,including visual,vestibular,and somatosensory *** mechanisms which underpin the integration of these multisensory signals are the principal topic of the present *** multisensory integration theories focus on how failure of cognitive processes thought to be involved in multisensory integration leads to falls in older *** emphasis,however,has been placed on specific contributions of individual sensory modalities to multisensory integration processes and cross-modal interactions that occur between the sensory modalities in relation to gait and *** the present work,we review the contributions of somatosensory,visual,and vestibular modalities,along with their multisensory intersections to gait and balance in older adults and patients with Parkinson’s *** also review evidence of vestibular contributions to multisensory temporal binding windows,previously shown to be highly pertinent to fall risk in older ***,we relate multisensory vestibular mechanisms to potential neural substrates,both at the level of neurobiology(concerning positron emission tomography imaging)and at the level of electrophysiology(concerning electroencephalography).We hope that this integrative review,drawing influence across multiple subdisciplines of neuroscience,paves the way for novel research directions and therapeutic neuromodulatory approaches,to improve the lives of older adults and patients with neurodegenerative diseases.

关键词： aging balance encephalography functional magnetic resonance imaging gait multisensory integration Parkinson’s disease positron emission tomography somatosensory vestibular visual

Bioanalytical methods for metabolomic profiling:Detection of head and neck cancer,including oral cancer

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Chinese Chemical Letters 2015年第4期26卷 407-415页

作者： Nirbhay S.Jain Ulrich H.N.Drr Ayyalusamy Ramamoorthy Department of Chemistry University of Michigan Biophysics University of Michigan

Metabolomics is an emerging field dealing with the measurement and interpretation of small molecular byproducts of biochemical processes, or metabolites, which can be used to generate profiles from biological samples. Promising for use in pathophysiology, metabolomic profiles give the immediate biological state of a sample. These profiles are altered in diseases and are detectable in biological samples, such as tissue, blood, urine, saliva, and others. Most remarkably, metabolic profiles usually are altered before symptoms appear in a patient. For this reason, metabolomics has potential as a reliable method for an early diagnosis of diseases through disease biomarker identification. This application is most prevalent in cancer, such as head and neck cancer （HNC）. Metabolomic studies offer avenues to improve on current medical techniques through the application of mass spectrometry （MS）, nuclear magnetic resonance spectroscopy （NMR）, and statistical analysis to determine better biomarkers than those currently known. In this review, we discuss the use of MS and NMR tools for detecting biomarkers in tissue and fluid samples, and the appropriateness of metabolomics in analyzing cancer. Advantages, disadvantages, and recent studies on metabolomic profiling techniques in HNC analysis are also discussed herein.

关键词： MetabolomicsNMRMSCancerBiomarker discoveryMetabolites

Autonomous Vehicles—the Remaining Challenges

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汽车工程 2021年第4期43卷 451-458页

作者： Huei Peng Department of Mechanical Engineering University of MichiganMichigan 48105USA

Autonomous vehicles are essential for mobility in big cities,just like how elevators make high-rise buildings *** significant progress has been achieved over the last 15 years,there are still several remaining challen... 详细信息

关键词： autonomous vehicles testing and evaluation

Structure-based design of conformationally constrained cyclic peptidomimetics to target the MLL1-WDR5 protein–protein interaction as inhibitors of the MLL1 methyltransferase activity

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Chinese Chemical Letters 2015年第4期26卷 455-458页

作者： Hacer Karatas Shirley Y.Lee Elizabeth C.Townsend Fang Cao Jing Xu Denzil Bernard Liu Liu Yali Dou Shaomeng Wang Department of Medicinal Chemistry University of Michigan Department of Internal Medicine University of Michigan Department of Pathology University of Michigan Comprehensive Cancer Center University of Michigan Department of Pharmacology University of Michigan

We described herein structure-based design, synthesis and evaluation of conformationally constrained, cyclic peptidomimetics to block the MLL1-WDR5 protein-protein interaction as inhibitors of the MLL1 histone methyltransferase activity. Our study has yielded cyclic peptidomimetics with very high binding affinities to WDR5 （Ki values 〈1 nmol/L） and function as antagonists of the MLL1 histone methyltransferase activity.

关键词： EpigeneticsMLL1 histone methyltransferaseWDRS-MLLI interactionSmall-molecule inhibitorsCyclic peptidomemtics

Stability and orientation of cecropin P1 on maleimide self-assembled monolayer(SAM) surfaces and suggested functional mutations

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Chinese Chemical Letters 2015年第4期26卷 485-490页

作者： Shuai Wei Charles L.Brooks Ⅲ Department of Chemistry University of Michigan Department of Biophysics University of Michigan

One of the main challenges of biosensor design is to understand the protein or peptide stability on the chip in high resolution structural detail. Since conventional experimental methods are limited by the resolution for their applications on surface tethered peptides/proteins, a recently developed coarse grained simulation method is employed to explore the peptide/surface interaction in residue-level resolution. This work shows how the coarse grained model successfully describes peptide-surface interactions by evaluating thermal stability of the peptide cecropin PI in bulk solution and on surfaces by physical adsorption and chemical tethering. The simulation also reproduces observations of peptide orientations on the self-assembled monolayer surface from earlier experimental work. Additionally, using knowledge obtained from the simulations, specific mutations are suggested and the desired structure and pose on the surface is obtained. In summary, this work sheds a light on the reasonable biosensor design that is ~uided by simulations.

关键词： Coarse grained simulationKB Go-like modelPeptide-surface interactionThermal stabilityOrientationMutation

Combined risk modelling approach to identify the optimal carotid revascularisation approach

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Stroke & Vascular Neurology 2021年第3期6卷 476-482,I0080-I0084页

作者： James Francis Burke Lewis B Morgenstern Nicholas H Osborne Rodney A Hayward Neurology University of Michigan Michigan MedicineAnn ArborMichiganUSA Vascular Surgery Univerity of Michigan MedicineAnn ArborMichiganUSA Internal Medicine University of Michigan Michigan MedicineAnn ArborMichiganUSA

Background Carotid endarterectomy(CEA)results in fewer perioperative strokes,but more myocardial infarctions(MI)than carotid artery stenting(CAS).We explored a combined modelling approach that stratifies patients by baseline stroke and *** Baseline registry-based risk models for perioperative stroke and MI were identified via literature *** then selected treatment risk models in the Carotid Revascularisation Stenting versus Endarterectomy(CREST)trial by serially adding covariates(baseline risk,treatment(CEA vs CAS),treatment-risk interaction and age-treatment interaction terms).Treatment risk models were externally validated using data from the Society for Vascular Surgery(SVS)Vascular Quality Initiative(VQI)CEA and carotid stenting registries and treatment models were recalibrated to the SVS-VQI *** net benefit was estimated by summing the predicted stroke and MI risk differences with CEA versus *** Perioperative treatment models had moderate predictiveness(c-statistic 0.69 for stroke and 0.68 for MI)and reasonable calibration across the risk spectrum for both stroke and MI within *** external validation in SVS-VQI,predictiveness was substantially reduced(c-statistic 0.61 for stroke and 0.54 for MI)and models substantially overpredicted *** patients(86.7%)were predicted to have net benefit from CEA in CREST(97.0%of symptomatic patients vs 75%of asymptomatic patients).Discussion A combined modelling approach that separates risk elements has potential to inform optimal ***,our current approach is not ready for clinical *** data support guidelines that suggest that CEA should be the preferred revascularisation modality in most patients with symptomatic carotid stenosis.

关键词： carotid Surgery optimal

Recent advances in multipactor physics and mitigation

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High Voltage 2023年第6期8卷 1095-1114页

作者： Asif Iqbal De‐Qi Wen John Verboncoeur Peng Zhang Department of Electrical and Computer Engineering Michigan State UniversityEast LansingMichiganUSA Department of Computational Mathematics Scienceand EngineeringMichigan State UniversityEast LansingMichiganUSA

Recent progress made in the prediction,characterisation,and mitigation of multipactor discharge is reviewed for single‐and two‐surface ***,an overview of basic concepts including secondary electron emission,electron kinetics under the force law,multipactor susceptibility,and saturation mechanisms is provided,followed by a discus-sion on multipactor mitigation *** strategies are categorised into two broad areas–mitigation by engineered devices and engineered radio frequency(rf)*** approach is useful in different *** advances in multipactor physics and engineering during the past decade,such as novel multipactor prediction methods,un-derstanding space charge effects,schemes for controlling multipacting particle trajec-tories,frequency domain analysis,high frequency effects,and impact on rf signal quality are *** addition to vacuum electron multipaction,multipactor‐induced ioni-zation breakdown is also reviewed,and the recent advances are summarised.

关键词： multip kinetics susceptibility

SOLITARY WAVES IN STRATIFIED FLUIDS AND THEIR INTERACTION

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Acta Mechanica Sinica 1993年第3期9卷 193-209页

作者：易家训 the university of michigan Ann Arbor Michigan 48109 USA

A systematic procedure is proposed for obtaining solutions for soli- tary waves in stratified fluids. The stratification of the fluid is assumed to be expo- nential or linear. Its comparison with existing results for an exponentially stratified fluid shows agreement, and it is found that for the odd series of solutions the direc- tion of displacement of the streamlines from their asymptotic levels is reversed when the stratification is changed from exponential to linear. Finally the interaction of solitary waves is considered, and the Korteweg-de Vries equation and the Boussinesq equation are derived. Thus the known solutions of these equations can be rehed upon to provide the answers to the interaction problem.

关键词： internal solitary waves stratified liquids exponential stratification linear stratification systematic use of the solubility condition in successive approximations interaction of internal solitary waves detailed derivation of the KdV equa